My current research centers on understanding the interplay between the pathogen Neisseria gonorrhoeae and human macrophages. While Neisseria gonorrhoeae has been inducing infection for hundreds of years, little is known on about its interactions with macrophages. Our studies have shown that not only does this pathogen induce macrophage cell death but in a highly pro-inflammatory manner. Current studies are focused on understanding the cell death pathways responsible for Neisseria gonorrhoeae induced macrophage cell death.
Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Pathology & Laboratory Medicine
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Ritter JL, Genco CA. Neisseria gonorrhoeae-Induced Inflammatory Pyroptosis in Human Macrophages is Dependent on Intracellular Gonococci and Lipooligosaccharide. J Cell Death. 2018; 11:1179066017750902. PMID: 29434478; PMCID: PMC5805002; DOI: 10.1177/1179066017750902;
DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):5133-8.View Related Profiles. PMID: 23479618; PMCID: PMC3612635; DOI: 10.1073/pnas.1215840110;
Simeonov DR, Kenny K, Seo L, Moyer A, Allen J, Paluh JL. Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity. Cell Cycle. 2009 Nov 1; 8(21):3571-83. PMID: 19838064
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