Jennifer I. Luebke, PhD
Waterhouse Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University

The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

Boston University School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

CRCNS: Age-related changes to cortical dynamics underlying working memory
09/11/2020 - 05/31/2023 (PI)
NIH/National Institute on Aging

Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey
04/01/2018 - 01/31/2023 (PI)
NIH/National Institute on Aging

RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2021 (SP Co-PI of Sub-Project / SP)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging

Empirical and Computational Analyses of Striatal MSN's and FSI's and of L5 CPN's in the Q175 and DN17 Models
04/01/2016 - 06/30/2019 (PI)
CHDI Foundation, Inc.

Neural Substrates of cognitive decline and curcumin intervention in aging monkeys
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute on Aging

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute of Neurological Disorders & Stroke

Modeling Cellular Determinants of Cognitive Decline in Aging
09/30/2010 - 05/31/2015 (Subcontract PI)
Icahn School of Medicine at Mount Sinai NIH NIA

Intraneuronal Beta Amyloid and Synaptic Plasticity in the Prefrontal Cortex
09/01/2013 - 08/30/2014 (PI)
Rhode Island Hospital

Functional Consequences of Cholinergic Degeneration in Aged Rhesus Monkeys
07/01/2000 - 06/30/2002 (PI)
American Federation for Aging Research

Inhibitory Roles of Layer I Neurons in Rat Barrel Cortex
03/01/2000 - 02/28/2002 (PI)
National Science Foundation


Yr Title Project-Sub Proj Pubs
2021 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-04
2020 CRCNS: Age-related changes to cortical dynamics underlying working memory 1R01AG071230-01
2020 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-03
2020 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-03
2019 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-02
2018 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 3R01AG059028-01S2
2018 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 1R01AG059028-01
2018 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 3R01AG059028-01S1
2016 Neural substrates of cognitive decline and curcumin intervention in aging monkeys 1R56AG049870-01A1
2015 Effects of neural precursor lineage on pyramidal neuron function and morphology 5R21NS089340-02 1
Showing 10 of 16 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain. 2021 Feb 12; 144(1):288-309.View Related Profiles. PMID: 33246331
  2. Goodliffe J, Rubakovic A, Chang W, Pathak D, Luebke J. Structural and functional features of medium spiny neurons in the BACHD?N17 mouse model of Huntington's Disease. PLoS One. 2020; 15(6):e0234394.View Related Profiles. PMID: 32574176
  3. LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020; 14:285.View Related Profiles. PMID: 32327969
  4. Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2020 Feb 18.View Related Profiles. PMID: 32071385
  5. Ibañez S, Luebke JI, Chang W, Draguljic D, Weaver CM. Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys. Front Comput Neurosci. 2019; 13:89. PMID: 32009920
  6. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2019 03 01; 29(3):1121-1138.View Related Profiles. PMID: 29415216
  7. Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One. 2018; 13(8):e0200626.View Related Profiles. PMID: 30118496
  8. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 01; 21(1):72-80.View Related Profiles. PMID: 29273772
  9. Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 03; 37(18):4717-4734.View Related Profiles. PMID: 28381592; DOI: 10.1523/JNEUROSCI.3757-16.2017;
  10. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15; 525(9):2175-2191.View Related Profiles. PMID: 28256708; DOI: 10.1002/cne.24196;
Showing 10 of 58 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 27 distinct years, with a maximum of 5 publications in 2017


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

morphological analyses
whole-cell patch-clamping
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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