Jennifer I. Luebke, PhD
Waterhouse Professor & Chair
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, Boston University
BS, Randolph–Macon College



The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Multimodal characterization of prefrontal and premotor circuits underlying perceptual decision making in therhesus monkey
09/01/2021 - 06/30/2026 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS122969-03

Multimodal characterization of the mechanisms of selective vulnerability of entorhinal cortical neurons
05/01/2024 - 04/30/2026 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute on Aging
1R21AG084041-01A1

CRCNS: Age-related changes to cortical dynamics underlying working memory
09/11/2020 - 05/31/2025 (PI)
NIH/National Institute on Aging
5R01AG071230-03

Substrates of selective neuronal vulnerability in aging: neocortical pyradmidal neurons and their surrounding neuropil environment in visual versus frontal cortex of young and aged rhesus monkeys
05/01/2021 - 10/31/2024 (PI)
NIH/National Institute on Aging
5R21AG072154-02

Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey
09/30/2021 - 05/31/2024 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute on Aging
5R21AG072069-02

Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey
04/01/2018 - 01/31/2024 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute on Aging
5R01AG059028-05

RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2021 (Co-Investigator of Sub-Project / SP)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging
5R01AG050471-05

Empirical and Computational Analyses of Striatal MSN's and FSI's and of L5 CPN's in the Q175 and DN17 Models
04/01/2016 - 06/30/2019 (PI)
CHDI Foundation, Inc.


Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
09/23/2015 - 06/30/2019 (Key Person / Mentor)
PI: Maria Medalla, PhD
NIH/National Institute of Mental Health
5R00MH101234-05

Neural Substrates of cognitive decline and curcumin intervention in aging monkeys
09/30/2016 - 08/31/2018 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute on Aging
1R56AG049870-01A1

Showing 10 of 16 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Multimodal characterization of the mechanisms of selective vulnerability of entorhinal cortical neurons 1R21AG084041-01A1
2024 Multimodal Characterization of Prefrontal and Premotor Circuits Underlying Perceptual Decision Making in Therhesus Monkey 5R01NS122969-04
2023 Multimodal Characterization of Prefrontal and Premotor Circuits Underlying Perceptual Decision Making in Therhesus Monkey 5R01NS122969-03
2022 Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey 5R21AG072069-02
2022 Multimodal characterization of prefrontal and premotor circuits underlying perceptual decision making in therhesus monkey 5R01NS122969-02
2022 Substrates of selective neuronal vulnerability in aging: neocortical pyramidal neurons and their surrounding neuropil environment in visual versus frontal cortex of young and aged rhesus monkeys 5R21AG072154-02
2022 CRCNS: Age-related changes to cortical dynamics underlying working memory 5R01AG071230-03
2022 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-05
2021 Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey 1R21AG072069-01
2021 Multimodal characterization of prefrontal and premotor circuits underlying perceptual decision making in therhesus monkey 1R01NS122969-01
Showing 10 of 27 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Castro-Mendoza PB, Weaver CM, Chang W, Medalla M, Rockland KS, Lowery L, McDonough E, Varghese M, Hof PR, Meyer DE, Luebke JI. Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17. Brain Struct Funct. 2024 Jun 28.View Related Profiles. PMID: 38943018
     
  2. Amaral DG, Augustinack J, Barbas H, Frosch M, Gabrieli J, Luebke J, Rakic P, Rosene D, Rushmore RJ. The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive. Hippocampus. 2024 Feb; 34(2):52-57.View Related Profiles. PMID: 38189522
     
  3. He S, Guan Y, Cheng CH, Moore TL, Luebke JI, Killiany RJ, Rosene DL, Koo BB, Ou Y. Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age. Front Aging Neurosci. 2023; 15:1249415.View Related Profiles. PMID: 38020785; PMCID: PMC10646581; DOI: 10.3389/fnagi.2023.1249415;
     
  4. Ibañez S, Sengupta N, Luebke JI, Wimmer K, Weaver CM. Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study. bioRxiv. 2023 Sep 01. PMID: 37693412; PMCID: PMC10491254; DOI: 10.1101/2023.08.30.555476;
     
  5. Medalla M, Mo B, Nasar R, Zhou Y, Park J, Luebke JI. Comparative features of calretinin, calbindin, and parvalbumin expressing interneurons in mouse and monkey primary visual and frontal cortices. J Comp Neurol. 2023 Dec; 531(18):1934-1962. PMID: 37357562; PMCID: PMC10749991; DOI: 10.1002/cne.25514;
     
  6. Moore TL, Medalla M, Ibañez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. Geroscience. 2023 Jun; 45(3):1317-1342.View Related Profiles. PMID: 37106282; PMCID: PMC10400510; DOI: 10.1007/s11357-023-00798-2;
     
  7. Medalla M, Mo B, Nasar R, Zhou Y, Park J, Luebke JI. Comparative Features of Calretinin, Calbindin and Parvalbumin Expressing Interneurons in Mouse and Monkey Primary Visual and Frontal Cortices. bioRxiv. 2023 Feb 28. PMID: 36909556; PMCID: PMC10002648; DOI: 10.1101/2023.02.27.530269;
     
  8. Moore TL, Medalla M, Iba Ez S, Wimmer K, Mojica CA, Killiany RJ, Moss MB, Luebke JI, Rosene DL. Neuronal properties of pyramidal cells in lateral prefrontal cortex of the aging rhesus monkey brain are associated with performance deficits on spatial working memory but not executive function. bioRxiv. 2023 Feb 08.View Related Profiles. PMID: 36798388; PMCID: PMC9934587; DOI: 10.1101/2023.02.07.527321;
     
  9. Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2022 05 14; 32(10):2170-2196.View Related Profiles. PMID: 34613380; PMCID: PMC9113240; DOI: 10.1093/cercor/bhab347;
     
  10. Chang W, Weaver CM, Medalla M, Moore TL, Luebke JI. Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin. Neurobiol Aging. 2022 01; 109:113-124.View Related Profiles. PMID: 34715442; PMCID: PMC8671373; DOI: 10.1016/j.neurobiolaging.2021.09.012;
     
Showing 10 of 70 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 70 publications over 30 distinct years, with a maximum of 6 publications in 2023

YearPublications
19891
19924
19932
19942
19951
19971
19981
20001
20011
20033
20042
20052
20074
20081
20092
20103
20112
20124
20134
20141
20153
20161
20175
20181
20191
20204
20214
20221
20236
20242

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

morphological analyses
neuroanatomy
Neurophysiology
whole-cell patch-clamping
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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