Jennifer I. Luebke, PhD
Waterhouse Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University




The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

Chair
Boston University School of Medicine
Anatomy & Neurobiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




CRCNS: Age-related changes to cortical dynamics underlying working memory
09/11/2020 - 05/31/2023 (PI)
NIH/National Institute on Aging
1R01AG071230-01

Substrates of selective neuronal vulnerability in aging: neocortical pyradmidal neurons and their surrounding neuropil environment in visual versus frontal cortex of young and aged rhesus monkeys
05/01/2021 - 04/30/2023 (PI)
NIH/National Institute on Aging
1R21AG072154-01

Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey
04/01/2018 - 01/31/2023 (PI)
NIH/National Institute on Aging
5R01AG059028-04

RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2021 (Co-Investigator of Sub-Project / SP)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging
5R01AG050471-05

Empirical and Computational Analyses of Striatal MSN's and FSI's and of L5 CPN's in the Q175 and DN17 Models
04/01/2016 - 06/30/2019 (PI)
CHDI Foundation, Inc.


Neural Substrates of cognitive decline and curcumin intervention in aging monkeys
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute on Aging
1R56AG049870-01A1

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS089340-02

Modeling Cellular Determinants of Cognitive Decline in Aging
09/30/2010 - 05/31/2015 (Subcontract PI)
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG035071-05

Intraneuronal Beta Amyloid and Synaptic Plasticity in the Prefrontal Cortex
09/01/2013 - 08/30/2014 (PI)
Rhode Island Hospital


Functional Consequences of Cholinergic Degeneration in Aged Rhesus Monkeys
07/01/2000 - 06/30/2002 (PI)
American Federation for Aging Research

Showing 10 of 11 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Effects of normal aging on the transcriptomic and physiological profiles of layer 3 pyramidal neurons in diverse neocortical areas of the monkey 1R21AG072069-01
2021 Multimodal characterization of prefrontal and premotor circuits underlying perceptual decision making in therhesus monkey 1R01NS122969-01
2021 Substrates of selective neuronal vulnerability in aging: neocortical pyramidal neurons and their surrounding neuropil environment in visual versus frontal cortex of young and aged rhesus monkeys 1R21AG072154-01
2021 CRCNS: Age-related changes to cortical dynamics underlying working memory 5R01AG071230-02
2021 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-04
2020 CRCNS: Age-related changes to cortical dynamics underlying working memory 1R01AG071230-01
2020 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-03
2020 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-03
2019 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 5R01AG059028-02
2018 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 3R01AG059028-01S2
Showing 10 of 20 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2021 Oct 06.View Related Profiles. PMID: 34613380
     
  2. Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021 Sep 15; 13(611):eabe8455.View Related Profiles. PMID: 34524859
     
  3. Freire-Cobo C, Edler MK, Varghese M, Munger E, Laffey J, Raia S, In SS, Wicinski B, Medalla M, Perez SE, Mufson EJ, Erwin JM, Guevara EE, Sherwood CC, Luebke JI, Lacreuse A, Raghanti MA, Hof PR. Comparative neuropathology in aging primates: A perspective. Am J Primatol. 2021 Jul 13; e23299. PMID: 34255875
     
  4. Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain. 2021 02 12; 144(1):288-309.View Related Profiles. PMID: 33246331; PMCID: PMC7880668; DOI: 10.1093/brain/awaa376;
     
  5. Goodliffe J, Rubakovic A, Chang W, Pathak D, Luebke J. Structural and functional features of medium spiny neurons in the BACHD?N17 mouse model of Huntington's Disease. PLoS One. 2020; 15(6):e0234394.View Related Profiles. PMID: 32574176; PMCID: PMC7310706; DOI: 10.1371/journal.pone.0234394;
     
  6. LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy. Front Neurosci. 2020; 14:285.View Related Profiles. PMID: 32327969; PMCID: PMC7161592; DOI: 10.3389/fnins.2020.00285;
     
  7. Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2021 06; 26(6):1808-1831.View Related Profiles. PMID: 32071385; PMCID: PMC7431382; DOI: 10.1038/s41380-020-0671-2;
     
  8. Ibañez S, Luebke JI, Chang W, Draguljic D, Weaver CM. Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys. Front Comput Neurosci. 2019; 13:89. PMID: 32009920; PMCID: PMC6979278; DOI: 10.3389/fncom.2019.00089;
     
  9. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2019 03 01; 29(3):1121-1138.View Related Profiles. PMID: 29415216; PMCID: PMC6373699; DOI: 10.1093/cercor/bhy019;
     
  10. Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease. PLoS One. 2018; 13(8):e0200626.View Related Profiles. PMID: 30118496; PMCID: PMC6097649; DOI: 10.1371/journal.pone.0200626;
     
Showing 10 of 61 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 61 publications over 27 distinct years, with a maximum of 5 publications in 2017

YearPublications
19891
19924
19932
19942
19951
19971
19981
20001
20011
20033
20042
20052
20074
20081
20092
20103
20112
20124
20134
20141
20153
20161
20175
20181
20191
20204
20214

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

morphological analyses
neuroanatomy
Neurophysiology
whole-cell patch-clamping
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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