Jennifer I. Luebke, PhD
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University

The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Chair ad interim of Anatomy & Neurobiology
Boston University School of Medicine
Anatomy & Neurobiology

Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey
04/01/2018 - 01/31/2023 (PI)
NIH/National Institute on Aging

RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2020 (SP Co-PI of Sub-Project / SP)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging

Empirical and Computational Analyses of Striatal MSN's and FSI's and of L5 CPN's in the Q175 and DN17 Models
04/01/2016 - 03/31/2019 (PI)
CHDI Foundation, Inc.

Neural Substrates of cognitive decline and curcumin intervention in aging monkeys
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute on Aging

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute of Neurological Disorders & Stroke

Modeling Cellular Determinants of Cognitive Decline in Aging
09/30/2010 - 05/31/2015 (PI)
Icahn School of Medicine at Mount Sinai NIH NIA

Intraneuronal Beta Amyloid and Synaptic Plasticity in the Prefrontal Cortex
09/01/2013 - 08/30/2014 (PI)
Rhode Island Hospital

Functional Consequences of Cholinergic Degeneration in Aged Rhesus Monkeys
07/01/2000 - 06/30/2002 (PI)
American Federation for Aging Research

Inhibitory Roles of Layer I Neurons in Rat Barrel Cortex
03/01/2000 - 02/28/2002 (PI)
National Science Foundation

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2018 Feb 03.View Related Profiles. PMID: 29415216.
  2. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 Jan; 21(1):72-80.View Related Profiles. PMID: 29273772.
  3. Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 03; 37(18):4717-4734.View Related Profiles. PMID: 28381592; DOI: 10.1523/JNEUROSCI.3757-16.2017;.
  4. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15; 525(9):2175-2191.View Related Profiles. PMID: 28256708; DOI: 10.1002/cne.24196;.
  5. Luebke JI. Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks. Front Neuroanat. 2017; 11:11. PMID: 28326020; DOI: 10.3389/fnana.2017.00011;.
  6. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2017 Mar 01; 27(3):2078-2094.View Related Profiles. PMID: 26965903; DOI: 10.1093/cercor/bhw062;.
  7. Rumbell TH, Draguljic D, Yadav A, Hof PR, Luebke JI, Weaver CM. Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. J Comput Neurosci. 2016 08; 41(1):65-90. PMID: 27106692; DOI: 10.1007/s10827-016-0605-9;.
  8. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
  9. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles. PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.
  10. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27.View Related Profiles. PMID: 25568107; PMCID: PMC4287137; DOI: 10.1523/JNEUROSCI.3426-14.2015;.
Showing 10 of 52 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 24 distinct years, with a maximum of 5 publications in 2017

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

morphological analyses
whole-cell patch-clamping
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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