Jennifer I. Luebke, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University



The overall interest of our laboratory is in the functional properties of neurons in the mammalian prefrontal cortex (PFC), which play a central role in higher cognitive abilities such as abstract thinking, problem solving and cognitive flexibility. We seek to gain an understanding of the signaling properties of these neurons (in young and aged monkeys and APP and tau transgenic mice) by examining characteristics such as repetitive action potential firing patterns, synaptic response properties and underlying ionic currents, using whole-cell patch-clamp recordings of individual neurons identified under IR-DIC optics. By filling neurons from which recordings are obtained with dyes, we are able to subsequently reconstruct the neurons in 3-D and learn a great deal about important structure-function relationships. Most recently we are working with biomathematicians to perform computational modeling of PFC pyramidal cells using our empirically derived data.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




RNA binding proteins as novel targets in Alzheimer's disease
09/15/2015 - 04/30/2020 (SP Co-PI of Sub-Project / SP)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute on Aging
5R01AG050471-02

Empirical and Computational Analyses of Striatal MSN's and FSI's and of L5 CPN's in the Q175 and DN17 Models
04/01/2016 - 03/31/2019 (PI)
CHDI Foundation, Inc.


Neural Substrates of cognitive decline and curcumin intervention in aging monkeys
09/30/2016 - 08/31/2018 (PI)
NIH/National Institute on Aging
1R56AG049870-01A1

Effects of Neural Precursor Lineage on Pyramidal Neuron Function and Morphology
09/15/2014 - 08/31/2017 (Multi-PI)
PI: Jennifer I. Luebke, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS089340-02

Modeling Cellular Determinants of Cognitive Decline in Aging
09/30/2010 - 05/31/2015 (PI)
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG035071-05

Intraneuronal Beta Amyloid and Synaptic Plasticity in the Prefrontal Cortex
09/01/2013 - 08/30/2014 (PI)
Rhode Island Hospital


Functional Consequences of Cholinergic Degeneration in Aged Rhesus Monkeys
07/01/2000 - 06/30/2002 (PI)
American Federation for Aging Research

Inhibitory Roles of Layer I Neurons in Rat Barrel Cortex
03/01/2000 - 02/28/2002 (PI)
National Science Foundation
IOS-9982184




Yr Title Project-Sub Proj Pubs
2018 Mechanisms of Age-related Cognitive Decline in the Rhesus Monkey 1R01AG059028-01
2016 Neural substrates of cognitive decline and curcumin intervention in aging monkeys 1R56AG049870-01A1
2015 Effects of neural precursor lineage on pyramidal neuron function and morphology 5R21NS089340-02
2014 Effects of neural precursor lineage on pyramidal neuron function and morphology 1R21NS089340-01A1
2009 AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS 5R01AG025062-05 19
2008 AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS 5R01AG025062-04 19
2007 AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS 5R01AG025062-03 19
2006 AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS 5R01AG025062-02 19
2005 AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS 1R01AG025062-01A1 19
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2018 Feb 03.View Related Profiles. PMID: 29415216.
     
  2. Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018 Jan; 21(1):72-80.View Related Profiles. PMID: 29273772.
     
  3. Medalla M, Gilman JP, Wang JY, Luebke JI. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017 May 03; 37(18):4717-4734.View Related Profiles. PMID: 28381592; DOI: 10.1523/JNEUROSCI.3757-16.2017;.
     
  4. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15; 525(9):2175-2191.View Related Profiles. PMID: 28256708; DOI: 10.1002/cne.24196;.
     
  5. Luebke JI. Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks. Front Neuroanat. 2017; 11:11. PMID: 28326020; DOI: 10.3389/fnana.2017.00011;.
     
  6. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2017 Mar 01; 27(3):2078-2094.View Related Profiles. PMID: 26965903; DOI: 10.1093/cercor/bhw062;.
     
  7. Rumbell TH, Draguljic D, Yadav A, Hof PR, Luebke JI, Weaver CM. Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons. J Comput Neurosci. 2016 08; 41(1):65-90. PMID: 27106692; DOI: 10.1007/s10827-016-0605-9;.
     
  8. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
     
  9. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles. PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.
     
  10. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27.View Related Profiles. PMID: 25568107; PMCID: PMC4287137; DOI: 10.1523/JNEUROSCI.3426-14.2015;.
     
Showing 10 of 52 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 24 distinct years, with a maximum of 5 publications in 2017

YearPublications
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19981
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20052
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20081
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20103
20112
20124
20134
20141
20153
20161
20175
20181
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

morphological analyses
neuroanatomy
Neurophysiology
whole-cell patch-clamping
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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