Jeffrey R. Moore, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, University of Vermont
MS, University of Massachusetts Lowell



Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.


IDBR: TYPE A: COLLABORATIVE RESEARCH: HIGH-SPEED AFM IMAGING OF DYNAMICS ON BIOPOLYMERS THROUGH NON-RASTER SCANNING
08/15/2014 - 07/31/2018 (Co-PI)
National Science Foundation
DBI-1352729

MYOSIN ELC, A NOVEL THERAPEUTIC TARGET FOR FHC
12/01/2011 - 11/30/2015 (PI)
University of Miami NIH NHLBI
1R01HL108343

MOLECULAR MECHANICS OF MUTANT CARDIAC MYOSIN
07/01/2004 - 01/16/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL077280-09

FUNCTIONAL CONSEQUENCES OF FHC-LINKED RLC MUTATIONS
04/07/2008 - 03/31/2013 (PI)
University of Miami NIH NHLBI
5R01HL071778-08

Isotonic in Vitro Studies of Myosin Regulatory Light Chain Familial Hypertrophic Cardiomyopathy Mutations
07/01/2008 - 06/30/2010 (Co-PI)
American Heart Association - Northeast Affliate

The Role of Myosin Regulatory Light Chain Phosphorylation in Striated Muscle Function
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate




Yr Title Project-Sub Proj Pubs
2018 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-03
2016 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 1R01HL123774-01A1
2014 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-09 17
2014 Molecular mechanics of mutant cardiac myosin 7R01HL077280-10 17
2013 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-08 17
2012 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-07 17
2011 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-06 17
2010 Molecular Mechanics of Mutant Cardiac Myosin 2R01HL077280-05A1 17
2008 Molecular mechanics of mutant cardiac myosin 5R01HL077280-04 17
2007 Molecular mechanics of mutant cardiac myosin 5R01HL077280-03 17
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophys J. 2018 Sep 18; 115(6):1082-1092.View Related Profiles. PMID: 30195938.
     
  2. Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked a-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018 Jun 01; 647:84-92.View Related Profiles. PMID: 29626422.
     
  3. Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J. 2017 Dec 05; 113(11):2444-2451.View Related Profiles. PMID: 29211998.
     
  4. Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA. Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8618-E8627. PMID: 28973866.
     
  5. Egan PF, Moore JR, Ehrlicher AJ, Weitz DA, Schunn C, Cagan J, LeDuc P. Robust mechanobiological behavior emerges in heterogeneous myosin systems. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8147-E8154. PMID: 28900011.
     
  6. Sewanan LR, Moore JR, Lehman W, Campbell SG. Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling. Front Physiol. 2016; 7:473.View Related Profiles. PMID: 27833562.
     
  7. Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. J Mol Biol. 2016 Jun 05; 428(11):2446-61. PMID: 27107639; PMCID: PMC4884507; DOI: 10.1016/j.jmb.2016.04.021;.
     
  8. Moore JR, Campbell SG, Lehman W. Structural determinants of muscle thin filament cooperativity. Arch Biochem Biophys. 2016 Mar 15; 594:8-17.View Related Profiles. PMID: 26891592; PMCID: PMC4792785; DOI: 10.1016/j.abb.2016.02.016;.
     
  9. Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan; 3(1):012002.View Related Profiles. PMID: 26798831; DOI: 10.1063/1.4940223;.
     
  10. Schmidt WM, Lehman W, Moore JR. Direct observation of tropomyosin binding to actin filaments. Cytoskeleton (Hoboken). 2015 Jun; 72(6):292-303.View Related Profiles. PMID: 26033920; PMCID: PMC4529784; DOI: 10.1002/cm.21225;.
     
Showing 10 of 49 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 18 distinct years, with a maximum of 6 publications in 2014

YearPublications
19971
19982
19991
20002
20012
20041
20072
20082
20093
20103
20115
20123
20133
20146
20154
20164
20173
20182
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

actin
cardiomyopathy
cytoskeleton
molecular motors
muscle contraction
myosin
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72 E. Concord St Instructional (L)
Boston MA 02118
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