Jeffrey R. Moore, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, University of Vermont
MS, University of Massachusetts Lowell

Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.

IDBR: Type A: Collaborative Research: High-Speed AFM Imaging of Dynamics on Biopolymers Through Non-Raster Scanning
08/15/2014 - 07/31/2018 (Co-PI)
National Science Foundation

Myosin ELC, A Novel Therapeutic Target for FHC
12/01/2011 - 11/30/2015 (Subcontract PI)
University of Miami NIH NHLBI

Molecular Mechanics of Mutant Cardiac Myosin
07/01/2004 - 01/16/2015 (PI)
NIH/National Heart, Lung, and Blood Institute

Functional Consequences of FHC-Linked RLC Mutations
04/07/2008 - 03/31/2013 (Subcontract PI)
University of Miami NIH NHLBI

Isotonic in Vitro Studies of Myosin Regulatory Light Chain Familial Hypertrophic Cardiomyopathy Mutations
07/01/2008 - 06/30/2010 (Co-PI)
American Heart Association - Northeast Affliate

The Role of Myosin Regulatory Light Chain Phosphorylation in Striated Muscle Function
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate


Yr Title Project-Sub Proj Pubs
2019 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-04 10
2018 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-03 10
2017 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-02 10
2016 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 1R01HL123774-01A1 10
2014 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-09 29
2014 Molecular mechanics of mutant cardiac myosin 7R01HL077280-10 29
2013 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-08 29
2012 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-07 29
2011 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-06 29
2010 Molecular Mechanics of Mutant Cardiac Myosin 2R01HL077280-05A1 29
Showing 10 of 17 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin-binding and filament regulation: the beginning affects the middle and end. J Biol Chem. 2020 Oct 05.View Related Profiles. PMID: 33020181
  2. Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophys J. 2020 Aug 18; 119(4):821-830.View Related Profiles. PMID: 32730789
  3. Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophys J. 2020 01 21; 118(2):303-312.View Related Profiles. PMID: 31882250
  4. Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophys J. 2019 06 18; 116(12):2275-2284.View Related Profiles. PMID: 31130236
  5. Lehman W, Rynkiewicz MJ, Moore JR. A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. J Muscle Res Cell Motil. 2020 03; 41(1):23-38.View Related Profiles. PMID: 30771202
  6. Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophys J. 2018 09 18; 115(6):1082-1092.View Related Profiles. PMID: 30195938
  7. Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked a-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018 06 01; 647:84-92.View Related Profiles. PMID: 29626422
  8. Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J. 2017 Dec 05; 113(11):2444-2451.View Related Profiles. PMID: 29211998
  9. Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA. Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8618-E8627. PMID: 28973866
  10. Egan PF, Moore JR, Ehrlicher AJ, Weitz DA, Schunn C, Cagan J, LeDuc P. Robust mechanobiological behavior emerges in heterogeneous myosin systems. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8147-E8154. PMID: 28900011
Showing 10 of 54 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 20 distinct years, with a maximum of 6 publications in 2014


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

molecular motors
muscle contraction
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72 E. Concord St Instructional (L)
Boston MA 02118
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