Jeffrey Moore | Profiles RNS

Jeffrey R. Moore, PhD

Adjunct Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, University of Vermont
MS, University of Massachusetts Lowell
BS, University of Massachusetts Lowell

Websites

	ResearchGate
	Google Scholar

ORCID : 0000-0001-7190-9332

Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.

BU Research
NIH RePORTER Research

IDBR: Type A: Collaborative Research: High-Speed AFM Imaging of Dynamics on Biopolymers Through Non-Raster Scanning
08/15/2014 - 07/31/2018 (Co-Investigator)
National Science Foundation
DBI-1352729

Myosin ELC, A Novel Therapeutic Target for FHC
12/01/2011 - 11/30/2015 (Subcontract PI)
University of Miami NIH NHLBI
5R01HL108343-04

Molecular Mechanics of Mutant Cardiac Myosin
07/01/2004 - 01/16/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL077280-09

Functional Consequences of FHC-Linked RLC Mutations
04/07/2008 - 03/31/2013 (Subcontract PI)
University of Miami NIH NHLBI
5R01HL071778-08

Isotonic in Vitro Studies of Myosin Regulatory Light Chain Familial Hypertrophic Cardiomyopathy Mutations
07/01/2008 - 06/30/2010 (Co-PI)
American Heart Association - Northeast Affliate

The Role of Myosin Regulatory Light Chain Phosphorylation in Striated Muscle Function
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Computational Pipeline for Identification of Disease-Causing Variants in Genes of the Cardiac Sarcomere	2R01HL136590-06
2019	Cooperativity in the Cardiac Myofilament Interactome in Health and Disease	5R01HL123774-04	10
2018	Cooperativity in the Cardiac Myofilament Interactome in Health and Disease	5R01HL123774-03	10
2017	Cooperativity in the Cardiac Myofilament Interactome in Health and Disease	5R01HL123774-02	10
2016	Cooperativity in the Cardiac Myofilament Interactome in Health and Disease	1R01HL123774-01A1	10
2014	Molecular Mechanics of Mutant Cardiac Myosin	5R01HL077280-09	29
2014	Molecular mechanics of mutant cardiac myosin	7R01HL077280-10	29
2013	Molecular Mechanics of Mutant Cardiac Myosin	5R01HL077280-08	29
2012	Molecular Mechanics of Mutant Cardiac Myosin	5R01HL077280-07	29
2011	Molecular Mechanics of Mutant Cardiac Myosin	5R01HL077280-06	29

Showing 10 of 18 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. J Mol Cell Cardiol. 2024 Mar; 188:30-37.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael

PMID: 38266978

Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. PNAS Nexus. 2023 Mar; 2(3):pgad011.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael

PMID: 36896133; PMCID: PMC9991458; DOI: 10.1093/pnasnexus/pgad011;

Doran MH, Rynkiewicz MJ, Rassici D, Bodt SML, Barry ME, Bullitt E, Yengo CM, Moore JR, Lehman W. Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J Gen Physiol. 2023 Mar 06; 155(3).View Related Profiles.

Bullitt, Esther
Moore, Jeffrey
Rynkiewicz, Michael

PMID: 36633586; PMCID: PMC9859928; DOI: 10.1085/jgp.202213267;

Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci D, Moore JR, Yengo CM, Bullitt E, Lehman W. Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J Gen Physiol. 2023 Feb 06; 155(2).View Related Profiles.

Bullitt, Esther
Moore, Jeffrey
Rynkiewicz, Michael

PMID: 36459134; PMCID: PMC9723511; DOI: 10.1085/jgp.202213274;

Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. J Gen Physiol. 2021 09 06; 153(9).View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael

PMID: 34319370; PMCID: PMC8321830; DOI: 10.1085/jgp.202012640;

Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end. J Biol Chem. 2020 Dec 11; 295(50):17128-17137.View Related Profiles.

Ghosh, Anita
Moore, Jeffrey
Rynkiewicz, Michael

PMID: 33453963

Ghosh, Anita
Moore, Jeffrey
Rynkiewicz, Michael

PMID: 33020181; PMCID: PMC7863880; DOI: 10.1074/jbc.RA120.014713;

Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophys J. 2020 08 18; 119(4):821-830.View Related Profiles.

Bullitt, Esther
Moore, Jeffrey
Rynkiewicz, Michael
Lehman, William

PMID: 32730789; PMCID: PMC7451941; DOI: 10.1016/j.bpj.2020.07.006;

Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophys J. 2020 01 21; 118(2):303-312.View Related Profiles.

Ghosh, Anita
Moore, Jeffrey
Rynkiewicz, Michael

PMID: 31882250; PMCID: PMC6976805; DOI: 10.1016/j.bpj.2019.11.3396;

Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophys J. 2019 06 18; 116(12):2275-2284.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael
Lehman, William

PMID: 31130236; PMCID: PMC6588729; DOI: 10.1016/j.bpj.2019.05.009;

Showing 10 of 60 results. Show More

Lehman W, Rynkiewicz MJ, Moore JR. A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. J Muscle Res Cell Motil. 2020 03; 41(1):23-38.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael
Lehman, William

PMID: 30771202; PMCID: PMC6697252; DOI: 10.1007/s10974-019-09501-5;

Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophys J. 2018 09 18; 115(6):1082-1092.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael
Lehman, William

PMID: 30195938; PMCID: PMC6139885; DOI: 10.1016/j.bpj.2018.08.017;

Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked a-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018 06 01; 647:84-92.View Related Profiles.

Moore, Jeffrey
Orzechowski, Marek
Rynkiewicz, Michael
Lehman, William

PMID: 29626422; PMCID: PMC5958618; DOI: 10.1016/j.abb.2018.04.002;

Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J. 2017 Dec 05; 113(11):2444-2451.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael
Lehman, William

PMID: 29211998; PMCID: PMC5768522; DOI: 10.1016/j.bpj.2017.10.004;

Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA. Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8618-E8627. PMID: 28973866; PMCID: PMC5642688; DOI: 10.1073/pnas.1705179114;

Egan PF, Moore JR, Ehrlicher AJ, Weitz DA, Schunn C, Cagan J, LeDuc P. Robust mechanobiological behavior emerges in heterogeneous myosin systems. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8147-E8154. PMID: 28900011; PMCID: PMC5625935; DOI: 10.1073/pnas.1713219114;

Sewanan LR, Moore JR, Lehman W, Campbell SG. Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling. Front Physiol. 2016; 7:473.View Related Profiles.

Moore, Jeffrey
Lehman, William

PMID: 27833562; PMCID: PMC5081029; DOI: 10.3389/fphys.2016.00473;

Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. J Mol Biol. 2016 Jun 05; 428(11):2446-61. PMID: 27107639; PMCID: PMC4884507; DOI: 10.1016/j.jmb.2016.04.021;

Moore JR, Campbell SG, Lehman W. Structural determinants of muscle thin filament cooperativity. Arch Biochem Biophys. 2016 Mar 15; 594:8-17.View Related Profiles.

Moore, Jeffrey
Lehman, William

PMID: 26891592; PMCID: PMC4792785; DOI: 10.1016/j.abb.2016.02.016;

Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan; 3(1):012002.View Related Profiles.

Moore, Jeffrey
Rynkiewicz, Michael
Lehman, William

PMID: 26798831; PMCID: PMC4714992; DOI: 10.1063/1.4940223;

Schmidt WM, Lehman W, Moore JR. Direct observation of tropomyosin binding to actin filaments. Cytoskeleton (Hoboken). 2015 Jun; 72(6):292-303.View Related Profiles.

Moore, Jeffrey
Lehman, William
Schmidt, William

PMID: 26033920; PMCID: PMC4529784; DOI: 10.1002/cm.21225;

Karabina A, Kazmierczak K, Szczesna-Cordary D, Moore JR. Myosin regulatory light chain phosphorylation enhances cardiac ß-myosin in vitro motility under load. Arch Biochem Biophys. 2015 Aug 15; 580:14-21.View Related Profiles.

Karabina, Anastasia
Moore, Jeffrey

PMID: 26116789; PMCID: PMC4790447; DOI: 10.1016/j.abb.2015.06.014;

Egan P, Moore J, Schunn C, Cagan J, LeDuc P. Emergent systems energy laws for predicting myosin ensemble processivity. PLoS Comput Biol. 2015 Apr; 11(4):e1004177. PMID: 25885169; PMCID: PMC4401713; DOI: 10.1371/journal.pcbi.1004177;

Lehman W, Medlock G, Li XE, Suphamungmee W, Tu AY, Schmidtmann A, Ujfalusi Z, Fischer S, Moore JR, Geeves MA, Regnier M. Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain. Arch Biochem Biophys. 2015 Apr 1; 571:10-5.View Related Profiles.

Moore, Jeffrey
Lehman, William
Suphamungmee, Worawit
Li, Xiaochuan Li

PMID: 25726728; PMCID: PMC4385494; DOI: 10.1016/j.abb.2015.02.026;

Farman GP, Muthu P, Kazmierczak K, Szczesna-Cordary D, Moore JR. Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on ß-myosin cross-bridge mechanics. J Appl Physiol (1985). 2014 Dec 15; 117(12):1471-7. PMID: 25324513; PMCID: PMC4269682; DOI: 10.1152/japplphysiol.00798.2014;

Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP. Energy landscapes reveal the myopathic effects of tropomyosin mutations. Arch Biochem Biophys. 2014 Dec 15; 564:89-99.View Related Profiles.

Moore, Jeffrey
Orzechowski, Marek
Lehman, William

PMID: 25241052; PMCID: PMC4258436; DOI: 10.1016/j.abb.2014.09.007;

Guo M, Ehrlicher AJ, Jensen MH, Renz M, Moore JR, Goldman RD, Lippincott-Schwartz J, Mackintosh FC, Weitz DA. Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy. Cell. 2014 Aug 14; 158(4):822-32. PMID: 25126787; PMCID: PMC4183065; DOI: 10.1016/j.cell.2014.06.051;

Huang W, Liang J, Kazmierczak K, Muthu P, Duggal D, Farman GP, Sorensen L, Pozios I, Abraham TP, Moore JR, Borejdo J, Szczesna-Cordary D. Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice. J Mol Cell Cardiol. 2014 Sep; 74:318-29. PMID: 24992035; PMCID: PMC4115013; DOI: 10.1016/j.yjmcc.2014.06.011;

Jensen MH, Morris EJ, Gallant CM, Morgan KG, Weitz DA, Moore JR. Mechanism of calponin stabilization of cross-linked actin networks. Biophys J. 2014 Feb 18; 106(4):793-800.View Related Profiles.

Moore, Jeffrey
Morgan, Kathleen

PMID: 24559982; PMCID: PMC3944828; DOI: 10.1016/j.bpj.2013.12.042;

Orzechowski M, Moore JR, Fischer S, Lehman W. Tropomyosin movement on F-actin during muscle activation explained by energy landscapes. Arch Biochem Biophys. 2014 Mar 1; 545:63-8.View Related Profiles.

Moore, Jeffrey
Orzechowski, Marek
Lehman, William

PMID: 24412204; PMCID: PMC3943668; DOI: 10.1016/j.abb.2014.01.001;

Muthu P, Liang J, Schmidt W, Moore JR, Szczesna-Cordary D. In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain. Arch Biochem Biophys. 2014 Jun 15; 552-553:29-39. PMID: 24374283; PMCID: PMC4043912; DOI: 10.1016/j.abb.2013.12.011;

Guo M, Ehrlicher AJ, Mahammad S, Fabich H, Jensen MH, Moore JR, Fredberg JJ, Goldman RD, Weitz DA. The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics. Biophys J. 2013 Oct 1; 105(7):1562-8. PMID: 24094397; PMCID: PMC3791300; DOI: 10.1016/j.bpj.2013.08.037;

Saphirstein RJ, Gao YZ, Jensen MH, Gallant CM, Vetterkind S, Moore JR, Morgan KG. The focal adhesion: a regulated component of aortic stiffness. PLoS One. 2013; 8(4):e62461.View Related Profiles.

Moore, Jeffrey
Morgan, Kathleen

PMID: 23626821; PMCID: PMC3633884; DOI: 10.1371/journal.pone.0062461;

Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. Cardiomyopathies: classification, clinical characterization, and functional phenotypes. Biochem Res Int. 2012; 2012:870942. PMID: 23304510; PMCID: PMC3529434; DOI: 10.1155/2012/870942;

Moore JR, Leinwand L, Warshaw DM. Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor. Circ Res. 2012 Jul 20; 111(3):375-85. PMID: 22821910; PMCID: PMC3947556; DOI: 10.1161/CIRCRESAHA.110.223842;

Jensen MH, Morris EJ, Huang R, Rebowski G, Dominguez R, Weitz DA, Moore JR, Wang CL. The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex. J Biol Chem. 2012 Sep 7; 287(37):31447-53. PMID: 22791711; PMCID: PMC3438974; DOI: 10.1074/jbc.M112.350421;

Jensen MH, Watt J, Hodgkinson JL, Gallant C, Appel S, El-Mezgueldi M, Angelini TE, Morgan KG, Lehman W, Moore JR. Effects of basic calponin on the flexural mechanics and stability of F-actin. Cytoskeleton (Hoboken). 2012 Jan; 69(1):49-58.View Related Profiles.

Moore, Jeffrey
Morgan, Kathleen
Lehman, William

PMID: 22135101; PMCID: PMC3355516; DOI: 10.1002/cm.20548;

Moore JR, Li X, Nirody J, Fischer S, Lehman W. Structural implications of conserved aspartate residues located in tropomyosin's coiled-coil core. Bioarchitecture. 2011 Sep 01; 1(5):250-255.View Related Profiles.

Moore, Jeffrey
Lehman, William

PMID: 22754618; PMCID: PMC3384579; DOI: 10.4161/bioa.18117;

Collins A, Huang R, Jensen MH, Moore JR, Lehman W, Wang CL. Structural studies on maturing actin filaments. Bioarchitecture. 2011 May; 1(3):127-133.View Related Profiles.

Moore, Jeffrey
Lehman, William

PMID: 21922043; PMCID: PMC3173961; DOI: 10.4161/bioa.1.3.16714;

Lu X, Kazmierczak K, Jiang X, Jones M, Watt J, Helfman DM, Moore JR, Szczesna-Cordary D, Lossos IS. Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin. FEBS J. 2011 Jun; 278(11):1922-31. PMID: 21447067; PMCID: PMC3097272; DOI: 10.1111/j.1742-4658.2011.08109.x;

Lin T, Greenberg MJ, Moore JR, Ostap EM. A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity. Biochemistry. 2011 Mar 22; 50(11):1831-8. PMID: 21265502; PMCID: PMC3059334; DOI: 10.1021/bi1016777;

Greenberg MJ, Kazmierczak K, Szczesna-Cordary D, Moore JR. Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17403-8. PMID: 20855589; PMCID: PMC2951453; DOI: 10.1073/pnas.1009619107;

Greenberg MJ, Moore JR. The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors. Cytoskeleton (Hoboken). 2010 May; 67(5):273-85. PMID: 20191566; PMCID: PMC2861725; DOI: 10.1002/cm.20441;

Greenberg MJ, Mealy TR, Jones M, Szczesna-Cordary D, Moore JR. The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R989-96. PMID: 20089714; PMCID: PMC2853388; DOI: 10.1152/ajpregu.00566.2009;

Greenberg MJ, Moore JR. Actin in action and inaction: the differential effects of hypertrophic and dilated cardiomyopathy actin mutations on thin filament regulation. J Mol Cell Cardiol. 2010 Feb; 48(2):277-8. PMID: 19879279; DOI: 10.1016/j.yjmcc.2009.10.015;

Pant K, Watt J, Greenberg M, Jones M, Szczesna-Cordary D, Moore JR. Removal of the cardiac myosin regulatory light chain increases isometric force production. FASEB J. 2009 Oct; 23(10):3571-80. PMID: 19470801; PMCID: PMC2747675; DOI: 10.1096/fj.08-126672;

Greenberg MJ, Mealy TR, Watt JD, Jones M, Szczesna-Cordary D, Moore JR. The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation. Am J Physiol Regul Integr Comp Physiol. 2009 Aug; 297(2):R265-74. PMID: 19458282; PMCID: PMC2724231; DOI: 10.1152/ajpregu.00171.2009;

Greenberg MJ, Watt JD, Jones M, Kazmierczak K, Szczesna-Cordary D, Moore JR. Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics. J Mol Cell Cardiol. 2009 Jan; 46(1):108-15. PMID: 18929571; PMCID: PMC2675789; DOI: 10.1016/j.yjmcc.2008.09.126;

Greenberg MJ, Wang CL, Lehman W, Moore JR. Modulation of actin mechanics by caldesmon and tropomyosin. Cell Motil Cytoskeleton. 2008 Feb; 65(2):156-64.View Related Profiles.

Moore, Jeffrey
Lehman, William

PMID: 18000881; PMCID: PMC2975105; DOI: 10.1002/cm.20251;

Szczesna-Cordary D, Jones M, Moore JR, Watt J, Kerrick WG, Xu Y, Wang Y, Wagg C, Lopaschuk GD. Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients. FASEB J. 2007 Dec; 21(14):3974-85. PMID: 17606808

Debold EP, Schmitt JP, Patlak JB, Beck SE, Moore JR, Seidman JG, Seidman C, Warshaw DM. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H284-91. PMID: 17351073

Moore JR, Krementsova EB, Trybus KM, Warshaw DM. Does the myosin V neck region act as a lever? J Muscle Res Cell Motil. 2004; 25(1):29-35. PMID: 15160485

Moore JR, Krementsova EB, Trybus KM, Warshaw DM. Myosin V exhibits a high duty cycle and large unitary displacement. J Cell Biol. 2001 Nov 12; 155(4):625-35. PMID: 11706052; PMCID: PMC2198872

Irving T, Bhattacharya S, Tesic I, Moore J, Farman G, Simcox A, Vigoreaux J, Maughan D. Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. J Muscle Res Cell Motil. 2001; 22(8):675-83. PMID: 12222828

Moore JR, Dickinson MH, Vigoreaux JO, Maughan DW. The effect of removing the N-terminal extension of the Drosophila myosin regulatory light chain upon flight ability and the contractile dynamics of indirect flight muscle. Biophys J. 2000 Mar; 78(3):1431-40. PMID: 10692328; PMCID: PMC1300741

Vigoreaux JO, Moore JR, Maughan DW. Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. Adv Exp Med Biol. 2000; 481:237-47; discussion 247-50. PMID: 10987076

Moore JR, Vigoreaux JO, Maughan DW. The Drosophila projectin mutant, bentD, has reduced stretch activation and altered indirect flight muscle kinetics. J Muscle Res Cell Motil. 1999 Nov; 20(8):797-806. PMID: 10730582

Vigoreaux JO, Hernandez C, Moore J, Ayer G, Maughan D. A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles. J Exp Biol. 1998 Jul; 201(Pt 13):2033-44. PMID: 9622575

Maughan D, Moore J, Vigoreaux J, Barnes B, Mulieri LA. Work production and work absorption in muscle strips from vertebrate cardiac and insect flight muscle fibers. Adv Exp Med Biol. 1998; 453:471-80. PMID: 9889859

Dickinson MH, Hyatt CJ, Lehmann FO, Moore JR, Reedy MC, Simcox A, Tohtong R, Vigoreaux JO, Yamashita H, Maughan DW. Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys J. 1997 Dec; 73(6):3122-34. PMID: 9414224; PMCID: PMC1181215

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 24 distinct years, with a maximum of 6 publications in 2014

Bar chart showing 60 publications over 24 distinct years, with a maximum of 6 publications in 2014

Year	Publications
1997	1
1998	2
1999	1
2000	2
2001	2
2004	1
2007	2
2008	2
2009	3
2010	3
2011	5
2012	3
2013	3
2014	6
2015	4
2016	4
2017	3
2018	2
2019	3
2020	3
2021	1
2022	1
2023	2
2024	1

2011 Emerging Leaders Forum participant, BU School of Medicine

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

actin
cardiomyopathy
cytoskeleton
molecular motors
muscle contraction
myosin

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