Jeffrey R. Moore, PhD
Adjunct Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Vermont
MS, University of Massachusetts Lowell
BS, University of Massachusetts Lowell



Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.


IDBR: Type A: Collaborative Research: High-Speed AFM Imaging of Dynamics on Biopolymers Through Non-Raster Scanning
08/15/2014 - 07/31/2018 (Co-Investigator)
National Science Foundation
DBI-1352729

Myosin ELC, A Novel Therapeutic Target for FHC
12/01/2011 - 11/30/2015 (Subcontract PI)
University of Miami NIH NHLBI
5R01HL108343-04

Molecular Mechanics of Mutant Cardiac Myosin
07/01/2004 - 01/16/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL077280-09

Functional Consequences of FHC-Linked RLC Mutations
04/07/2008 - 03/31/2013 (Subcontract PI)
University of Miami NIH NHLBI
5R01HL071778-08

Isotonic in Vitro Studies of Myosin Regulatory Light Chain Familial Hypertrophic Cardiomyopathy Mutations
07/01/2008 - 06/30/2010 (Co-PI)
American Heart Association - Northeast Affliate

The Role of Myosin Regulatory Light Chain Phosphorylation in Striated Muscle Function
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate



Title


Yr Title Project-Sub Proj Pubs
2023 Computational Pipeline for Identification of Disease-Causing Variants in Genes of the Cardiac Sarcomere 2R01HL136590-06
2019 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-04 10
2018 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-03 10
2017 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 5R01HL123774-02 10
2016 Cooperativity in the Cardiac Myofilament Interactome in Health and Disease 1R01HL123774-01A1 10
2014 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-09 29
2014 Molecular mechanics of mutant cardiac myosin 7R01HL077280-10 29
2013 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-08 29
2012 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-07 29
2011 Molecular Mechanics of Mutant Cardiac Myosin 5R01HL077280-06 29
Showing 10 of 18 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. J Mol Cell Cardiol. 2024 Jan 22; 188:30-37.View Related Profiles. PMID: 38266978
     
  2. Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. PNAS Nexus. 2023 Mar; 2(3):pgad011.View Related Profiles. PMID: 36896133; PMCID: PMC9991458; DOI: 10.1093/pnasnexus/pgad011;
     
  3. Doran MH, Rynkiewicz MJ, Rassici D, Bodt SML, Barry ME, Bullitt E, Yengo CM, Moore JR, Lehman W. Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J Gen Physiol. 2023 Mar 06; 155(3).View Related Profiles. PMID: 36633586; PMCID: PMC9859928; DOI: 10.1085/jgp.202213267;
     
  4. Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci D, Moore JR, Yengo CM, Bullitt E, Lehman W. Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J Gen Physiol. 2023 Feb 06; 155(2).View Related Profiles. PMID: 36459134; PMCID: PMC9723511; DOI: 10.1085/jgp.202213274;
     
  5. Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. J Gen Physiol. 2021 09 06; 153(9).View Related Profiles. PMID: 34319370; PMCID: PMC8321830; DOI: 10.1085/jgp.202012640;
     
  6. Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end. J Biol Chem. 2020 Dec 11; 295(50):17128-17137.View Related Profiles. PMID: 33453963
     
  7. Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end. J Biol Chem. 2020 12 11; 295(50):17128-17137.View Related Profiles. PMID: 33020181; PMCID: PMC7863880; DOI: 10.1074/jbc.RA120.014713;
     
  8. Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophys J. 2020 08 18; 119(4):821-830.View Related Profiles. PMID: 32730789; PMCID: PMC7451941; DOI: 10.1016/j.bpj.2020.07.006;
     
  9. Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophys J. 2020 01 21; 118(2):303-312.View Related Profiles. PMID: 31882250; PMCID: PMC6976805; DOI: 10.1016/j.bpj.2019.11.3396;
     
  10. Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophys J. 2019 06 18; 116(12):2275-2284.View Related Profiles. PMID: 31130236; PMCID: PMC6588729; DOI: 10.1016/j.bpj.2019.05.009;
     
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 24 distinct years, with a maximum of 6 publications in 2014

YearPublications
19971
19982
19991
20002
20012
20041
20072
20082
20093
20103
20115
20123
20133
20146
20154
20164
20173
20182
20193
20203
20211
20221
20232
20241

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

actin
cardiomyopathy
cytoskeleton
molecular motors
muscle contraction
myosin
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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