Jayandra Himali | Profiles RNS

Jayandra J. Himali, PhD

Adjunct Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Neurology

PhD, Boston University School of Public Health
MSc, Tribhuvan University
BSc, Tribhuvan University

Websites

	School of Public Health Faculty
	Google Scholar
	Scinapse.io
	ResearchGate

ORCID : 0000-0003-1391-9481

Jayandra Jung Himali, PhD, serves as an adjunct Associate Professor of Neurology and Biostatistics at Boston University Schools of Medicine and of Public Health, and a Center Faculty Member of the Framingham Heart Study (FHS). He has been engaged in collaborative public health research and teaching for over a decade. As a senior Biostatistician at the Neurology core of FHS, his research efforts are focused on the interrelated areas of: (1) the epidemiology of dementia and Alzheimer’s disease (AD) and relating traditional and novel biomarkers to the risk of dementia and AD; (2) the epidemiology of stroke and vascular cognitive impairment; (3) understanding vascular contributions to cognitive impairment and dementia including AD; and (4) investigating the role of modifiable lifestyle factors: sleep, diet and physical activity on the incidence of dementia, cognitive decline and MRI-defined brain aging. His research is also focused on outcome assessment in Epilepsy, Parkinson’s disease, and neuropathology. He has received the Nepal Bidhya Bhusan Class ‘A’ Medal from the government of Nepal for highest academic achievement in doctoral studies.

Investigator
Framingham Heart Study

BU Research

Identification of a missing key element underlying apoE2 neuroprotection in Alzheimers disease and the aging brain
09/30/2018 - 09/30/2019 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
1RF1AG061872-01

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Yiallourou S, Baril AA, Wiedner C, Misialek JR, Kline CE, Harrison S, Cannon E, Yang Q, Bernal R, Bisson A, Himali D, Cavuoto M, Weihs A, Beiser A, Gottesman RF, Leng Y, Lopez O, Lutsey PL, Purcell SM, Redline S, Seshadri S, Stone KL, Yaffe K, Ancoli-Israel S, Xiao Q, Vaou EO, Himali JJ, Pase MP. Sleep architecture and dementia risk in adults: An analysis of 5 cohorts from the Sleep and Dementia Consortium. Sleep. 2025 May 16.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 40377976

Young VM, Bernal R, Baril AA, Zeynoun J, Wiedner C, Gaona C, Beiser A, Teixeira AL, Salardini A, Pase MP, Himali JJ, Seshadri S. Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study. Alzheimers Dement. 2025 Apr; 21(4):e70160.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 40257009; PMCID: PMC12010301; DOI: 10.1002/alz.70160;

Salardini A, Himali JJ, Abdullah MS, Chaudhari R, Young V, Zilli EM, McGrath ER, Gonzales MM, Thibault EG, Salinas J, Aparicio HJ, Himali D, Ghosh S, Buckley RF, Satizabal CL, Johnson KA, DeCarli C, Fakhri GE, Vasan RS, Beiser AS, Seshadri S. Elevated serum cortisol associated with early-detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study. Alzheimers Dement. 2025 Apr; 21(4):e70179.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 40271551; PMCID: PMC12019305; DOI: 10.1002/alz.70179;

van Lent DM, Mesa HG, Short MI, Gonzales MM, Aparicio HJ, Salinas J, Yuan C, Jacques PF, Beiser A, Seshadri S, Jacob ME, Himali JJ. Association between dietary inflammatory index score and incident dementia. Alzheimers Dement. 2025 Jan; 21(1):e14390.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 39641390; PMCID: PMC11772702; DOI: 10.1002/alz.14390;

Young VM, Bernal R, Baril AA, Zeynoun J, Wiedner C, Gaona C, Beiser A, Teixeira AL, Salardini A, Pase MP, Himali JJ, Seshadri S. Long Sleep Duration, Cognitive Performance, and the Moderating Role of Depression: A Cross-Sectional Analysis in the Framingham Heart Study. medRxiv. 2024 Dec 03.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 39677456; PMCID: PMC11643162; DOI: 10.1101/2024.12.02.24318350;

van Lent DM, Jacques PF, Charisis SM, Mesa HG, Satizabal C, Yuan C, Vasan RS, Seshadri S, Beiser A, Himali JJ, Jacob ME. Dietary inflammatory index scores and cognitive aging: results from the Framingham heart Study offspring cohort. medRxiv. 2024 Nov 28.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 39649578; PMCID: PMC11623757; DOI: 10.1101/2024.11.27.24318084;

Luckey AM, Ghosh S, Wang CP, Beiser A, Bernal R, Li Z, Mbangdadji D, Fadaee E, Snoussi H, Dediós AGV, Trevino HA, Goss M, Hillmer LJ, Bauer CE, Staffaroni AM, Stables L, Albert M, Himali JJ, Mosley TH, Forsberg L, Guðnason V, Singh B, Singh H, Schwab K, Kramer JH, Rosenberg GA, Helmer KG, Greenberg SM, Habes M, Wang DJJ, Gold BT, Lu H, Caprihan A, Fornage M, Launer LJ, Arfanakis K, Seshadri S, DeCarli C, Maillard P, Satizabal CL. Biological validation of peak-width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium. Alzheimers Dement. 2024 Dec; 20(12):8814-8824.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 39569745; PMCID: PMC11667514; DOI: 10.1002/alz.14345;

Stefanidou M, Himali JJ, Bernal R, Satizabal C, Devinsky O, Romero JR, Beiser AS, Seshadri S, Friedman D. Association of cognitive and structural correlates of brain aging and incident epilepsy. The Framingham Heart Study. Epilepsia. 2025 Jan; 66(1):160-169.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Romero, Jose
Stefanidou, Maria
Seshadri, Sudha

PMID: 39555677; PMCID: PMC11875459; DOI: 10.1111/epi.18160;

Liou JJ, Santini T, Li J, Gireud-Goss M, Patel V, Adeyemi OF, de Erausquin GA, Garbarino VR, Habes M, Himali JJ, Karmonik C, Snitz BE, Mettenburg JM, Wu M, Aizenstein HJ, Marsland AL, Gianaros PJ, Bowtell R, Mougin O, Vahidy FS, Girard TD, Jacobs HIL, Hosseini AA, Seshadri S, Ibrahim TS. Examining Brain Structures and Cognitive Functions in Patients with Recovered COVID-19 Infection: A Multicenter Study Using 7T MRI. medRxiv. 2024 Nov 15.View Related Profiles.

Himali, Jayandra
Seshadri, Sudha

PMID: 39606361; PMCID: PMC11601693; DOI: 10.1101/2024.11.13.24317121;

Yiallourou S, Baril AA, Wiedner C, Misialek JR, Kline CE, Harrison S, Cannon E, Yang Q, Bernal R, Bisson A, Himali D, Cavuoto M, Weihs A, Beiser A, Gottesman RF, Leng Y, Lopez O, Lutsey PL, Purcell SM, Redline S, Seshadri S, Stone KL, Yaffe K, Ancoli-Israel S, Xiao Q, Vaou EO, Himali JJ, Pase MP. Sleep macro-architecture and dementia risk in adults: Meta-analysis of 5 cohorts from the Sleep and Dementia Consortium. medRxiv. 2024 Nov 05.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 39802761; PMCID: PMC11722510; DOI: 10.1101/2024.11.05.24316677;

Showing 10 of 146 results. Show More

Fongang B, Ayele BA, Wadop YN, Epenge E, Nkouonlack CD, Njamnshi WY, Jian X, Sargurupremraj M, Djotsa ABSN, Seke Etet PF, Bernal R, Atangana A, Cavazos JE, Himali JJ, Fonteh AN, Maestre G, Njamnshi AK, Seshadri S. The African Initiative for Bioinformatics Online Training in Neurodegenerative Diseases (AI-BOND): Investing in the next generation of African neuroscientists. Alzheimers Dement (N Y). 2024; 10(4):e70002.View Related Profiles.

Himali, Jayandra
Seshadri, Sudha

PMID: 39748840; PMCID: PMC11694528; DOI: 10.1002/trc2.70002;

Satizabal CL, Himali JJ, Conner SC, Beiser AS, Maillard P, Vasan RS, DeCarli C, Seshadri S. Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community. J Alzheimers Dis. 2024 Nov; 102(2):449-458.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 39625328; DOI: 10.1177/13872877241289043;

Yiallourou S, Baril AA, Wiedner C, Song X, Bernal R, Himali D, Cavuoto MG, DeCarli C, Beiser A, Seshadri S, Himali JJ, Pase MP. Short Sleep Duration and Hypertension: A Double Hit for the Brain. J Am Heart Assoc. 2024 Nov 05; 13(21):e035132.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 39450742; PMCID: PMC11935671; DOI: 10.1161/JAHA.124.035132;

García-Marín LM, Campos AI, Diaz-Torres S, Rabinowitz JA, Ceja Z, Mitchell BL, Grasby KL, Thorp JG, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen OA, Arfanakis K, Arias-Vasquez A, Armstrong NJ, Athanasiu L, Bastin ME, Beiser AS, Bennett DA, Bis JC, Boks MPM, Boomsma DI, Brodaty H, Brouwer RM, Buitelaar JK, Burkhardt R, Cahn W, Calhoun VD, Carmichael OT, Chakravarty M, Chen Q, Ching CRK, Cichon S, Crespo-Facorro B, Crivello F, Dale AM, Smith GD, de Geus EJC, De Jager PL, de Zubicaray GI, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher SE, Fleischman DA, Fletcher E, Fornage M, Forstner AJ, Francks C, Franke B, Ge T, Goldman AL, Grabe HJ, Green RC, Grimm O, Groenewold NA, Gruber O, Gudnason V, Håberg AK, Haukvik UK, Heinz A, Hibar DP, Hilal S, Himali JJ, Ho BC, Hoehn DF, Hoekstra PJ, Hofer E, Hoffmann W, Holmes AJ, Homuth G, Hosten N, Ikram MK, Ipser JC, Jack CR, Jahanshad N, Jönsson EG, Kahn RS, Kanai R, Klein M, Knol MJ, Launer LJ, Lawrie SM, Hellard SL, Lee PH, Lemaître H, Li S, Liewald DCM, Lin H, Longstreth WT, Lopez OL, Luciano M, Maillard P, Marquand AF, Martin NG, Martinot JL, Mather KA, Mattay VS, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley TH, Mühleisen TW, Müller-Myhsok B, Maniega SM, Nauck M, Nho K, Niessen WJ, Nöthen MM, Nyquist PA, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Psaty BM, Pütz B, Reppermund S, Rietschel MD, Risacher SL, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin GV, Rotter JI, Sachdev PS, Sämann PG, Saremi A, Sargurupremraj M, Saykin AJ, Schmaal L, Schmidt H, Schmidt R, Schofield PR, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya SM, Smith AV, Smoller JW, Soininen HS, Steen VM, Stein DJ, Stein JL, Thomopoulos SI, Toga AW, Tordesillas-Gutiérrez D, Trollor JN, Valdes-Hernandez MC, van T Ent D, van Bokhoven H, van der Meer D, van der Wee NJA, Vázquez-Bourgon J, Veltman DJ, Vernooij MW, Villringer A, Vinke LN, Völzke H, Walter H, Wardlaw JM, Weinberger DR, Weiner MW, Wen W, Westlye LT, Westman E, White T, Witte AV, Wolf C, Yang J, Zwiers MP, Ikram MA, Seshadri S, Thompson PM, Satizabal CL, Medland SE, Rentería ME. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nat Genet. 2024 Nov; 56(11):2333-2344.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Lin, Honghuang
Himali, Jayandra
Seshadri, Sudha

PMID: 39433889

García-Marín LM, Campos AI, Diaz-Torres S, Rabinowitz JA, Ceja Z, Mitchell BL, Grasby KL, Thorp JG, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen OA, Arfanakis K, Vasquez AA, Armstrong NJ, Athanasiu L, Bastin ME, Beiser AS, Bennett DA, Bis JC, Boks MP, Boomsma DI, Brodaty H, Brouwer RM, Buitelaar JK, Burkhardt R, Cahn W, Calhoun VD, Carmichael OT, Chakravarty M, Chen Q, Ching CRK, Cichon S, Crespo-Facorro B, Crivello F, Dale AM, Smith GD, de Geus EJ, De Jager PL, de Zubicaray GI, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher SE, Fleischman DA, Fletcher E, Fornage M, Forstner AJ, Francks C, Franke B, Ge T, Goldman AL, Grabe HJ, Green RC, Grimm O, Groenewold NA, Gruber O, Gudnason V, Håberg AK, Haukvik UK, Heinz A, Hibar DP, Hilal S, Himali JJ, Ho BC, Hoehn DF, Hoekstra PJ, Hofer E, Hoffmann W, Holmes AJ, Homuth G, Hosten N, Ikram MK, Ipser JC, Jack CR, Jahanshad N, Jönsson EG, Kahn RS, Kanai R, Klein M, Knol MJ, Launer LJ, Lawrie SM, Hellard SL, Lee PH, Lemaître H, Li S, Liewald DC, Lin H, Longstreth WT, Lopez OL, Luciano M, Maillard P, Marquand AF, Martin NG, Martinot JL, Mather KA, Mattay VS, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley TH, Mühleisen TW, Müller-Myhsok B, Muñoz Maniega S, Nauck M, Nho K, Niessen WJ, Nöthen MM, Nyquist PA, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Psaty BM, Pütz B, Reppermund S, Rietschel MD, Risacher SL, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin GV, Rotter JI, Sachdev PS, Sämann PG, Saremi A, Sargurupremraj M, Saykin AJ, Schmaal L, Schmidt H, Schmidt R, Schofield PR, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya SM, Smith AV, Smoller JW, Soininen HS, Steen VM, Stein DJ, Stein JL, Thomopoulos SI, Toga AW, Tordesillas-Gutiérrez D, Trollor JN, Valdes-Hernandez MC, van 't Ent D, van Bokhoven H, van der Meer D, van der Wee NJ, Vázquez-Bourgon J, Veltman DJ, Vernooij MW, Villringer A, Vinke LN, Völzke H, Walter H, Wardlaw JM, Weinberger DR, Weiner MW, Wen W, Westlye LT, Westman E, White T, Witte AV, Wolf C, Yang J, Zwiers MP, Ikram MA, Seshadri S, Thompson PM, Satizabal CL, Medland SE, Rentería ME. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. medRxiv. 2024 Aug 15.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Lin, Honghuang
Himali, Jayandra
Seshadri, Sudha

PMID: 39371125; PMCID: PMC11451674; DOI: 10.1101/2024.08.13.24311922;

Charisis S, Short MI, Bernal R, Kautz TF, Treviño HA, Mathews J, Dediós AGV, Muhammad JAS, Luckey AM, Aslam A, Himali JJ, Shipp EL, Habes M, Beiser AS, DeCarli C, Scarmeas N, Ramachandran VS, Seshadri S, Maillard P, Satizabal CL. Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age. Alzheimers Dement. 2024 Sep; 20(9):5849-5860.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 39132759; PMCID: PMC11497668; DOI: 10.1002/alz.13879;

Young VM, Bernal R, Pollet E, Serrano-Rubio L, Gaona C, Himali JJ, Seshadri S, González DA, Gonzales MM. Deep Sleep, Olfactory Loss, and Cognition in Early-stage Parkinson's Disease: Pilot Study Results. Gerontol Geriatr Med. 2024; 10:23337214241262925.View Related Profiles.

Himali, Jayandra
Seshadri, Sudha

PMID: 39045212; PMCID: PMC11265233; DOI: 10.1177/23337214241262925;

Martirosian RA, Wiedner CD, Sanchez J, Mun KT, Marla K, Teran C, Thirion M, Liebeskind DS, McGrath ER, Zucker JM, Bernal R, Beiser AS, DeCarli C, Himali JJ, Seshadri S, Hinman JD. Association of Incident Stroke Risk With an IL-18-Centered Inflammatory Network Biomarker Composite. Stroke. 2024 Jun; 55(6):1601-1608.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 38690658; DOI: 10.1161/STROKEAHA.123.044719;

DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024 May 01; 81(5):471-480.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 38526486; PMCID: PMC10964161; DOI: 10.1001/jamaneurol.2024.0469;

Krefman AE, Stephen J, Carolan P, Sedaghat S, Mansolf M, Soumare A, Gross AL, Aiello AE, Singh-Manoux A, Ikram MA, Helmer C, Tzourio C, Satizabal C, Levine DA, Lloyd-Jones D, Briceño EM, Sorond FA, Wolters FJ, Himali J, Launer LJ, Zhao L, Haan M, Lopez OL, Debette S, Seshadri S, Judd SE, Hughes TM, Gudnason V, Scholtens D, Allen NB. Cohort Profile: Dementia Risk Prediction Project (DRPP). Int J Epidemiol. 2024 Feb 01; 53(1).View Related Profiles.

Satizabal, Claudia
Lloyd-Jones, Donald
Himali, Jayandra
Seshadri, Sudha

PMID: 38339864; PMCID: PMC10858348; DOI: 10.1093/ije/dyae012;

Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 38290090; PMCID: PMC11383876; DOI: 10.1212/WNL.0000000000208075;

Zhao A, Balcer LJ, Himali JJ, O'Donnell A, Rahimpour Y, DeCarli C, Gonzales MM, Aparicio HJ, Ramos-Cejudo J, Kenney R, Beiser A, Seshadri S, Salinas J. Association of Loneliness with Functional Connectivity MRI, Amyloid-ß PET, and Tau PET Neuroimaging Markers of Vulnerability for Alzheimer's Disease. J Alzheimers Dis. 2024; 99(4):1473-1484.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 38820017; PMCID: PMC11191473; DOI: 10.3233/JAD-231425;

Baril AA, Kojis DJ, Himali JJ, Decarli CS, Sanchez E, Johnson KA, El Fakhri G, Thibault E, Yiallourou SR, Himali D, Cavuoto MG, Pase MP, Beiser AS, Seshadri S. Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology. Neurology. 2024 Jan 09; 102(1):e207807.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 38165370; PMCID: PMC10834132; DOI: 10.1212/WNL.0000000000207807;

Himali JJ, Baril AA, Cavuoto MG, Yiallourou S, Wiedner CD, Himali D, DeCarli C, Redline S, Beiser AS, Seshadri S, Pase MP. Association Between Slow-Wave Sleep Loss and Incident Dementia. JAMA Neurol. 2023 Dec 01; 80(12):1326-1333.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 37902739; PMCID: PMC10616771; DOI: 10.1001/jamaneurol.2023.3889;

Melo van Lent D, Mesa HG, Short MI, Gonzales MM, Aparicio HJ, Salinas J, Yuan C, Jacques PF, Beiser A, Seshadri S, Jacob ME, Himali JJ. Association between dietary inflammatory index score and incident dementia: results from the Framingham heart Study offspring cohort. medRxiv. 2023 Aug 22.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 37662354; PMCID: PMC10473791; DOI: 10.1101/2023.08.21.23294374;

Fongang B, Satizabal C, Kautz TF, Wadop YN, Muhammad JAS, Vasquez E, Mathews J, Gireud-Goss M, Saklad AR, Himali J, Beiser A, Cavazos JE, Mahaney MC, Maestre G, DeCarli C, Shipp EL, Vasan RS, Seshadri S. Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study. Sci Rep. 2023 Aug 21; 13(1):13622.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 37604954; PMCID: PMC10442369; DOI: 10.1038/s41598-023-40872-5;

Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril AA, Yiallourou S, Bisson A, Himali D, Leng Y, Yang Q, Seshadri S, Beiser A, Gottesman RF, Redline S, Lopez O, Lutsey PL, Yaffe K, Stone KL, Purcell SM, Himali JJ. Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults. JAMA Netw Open. 2023 Jul 03; 6(7):e2325152.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 37462968; PMCID: PMC10354680; DOI: 10.1001/jamanetworkopen.2023.25152;

Duperron MG, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Trégouët DA, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bülow R, Carrera C, Chen C, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Muñoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdés Hernández MC, Vernooij MW, Völker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023 Apr; 29(4):950-962.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Romero, Jose
Parva, Pedram
Yang, Qiong
Seshadri, Sudha

PMID: 37069360; PMCID: PMC10115645; DOI: 10.1038/s41591-023-02268-w;

Nichols E, Merrick R, Hay SI, Himali D, Himali JJ, Hunter S, Keage HAD, Latimer CS, Scott MR, Steinmetz JD, Walker JM, Wharton SB, Wiedner CD, Crane PK, Keene CD, Launer LJ, Matthews FE, Schneider J, Seshadri S, White L, Brayne C, Vos T. The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. Lancet Healthy Longev. 2023 Mar; 4(3):e115-e125.View Related Profiles.

Himali, Jayandra
Seshadri, Sudha

PMID: 36870337; PMCID: PMC9977689; DOI: 10.1016/S2666-7568(23)00019-3;

DeCarli C, Pase M, Beiser A, Kojis D, Satizabal C, Himali J, Aparicio H, Flether E, Maillard P, Seshadri S. Secular Trends in Head Size and Cerebral Volumes In the Framingham Heart Study for Birth Years 1902-1985. Res Sq. 2023 Jan 30.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 36778357; PMCID: PMC9915799; DOI: 10.21203/rs.3.rs-2524684/v1;

Satizabal CL, Himali JJ, Beiser AS, Ramachandran V, Melo van Lent D, Himali D, Aparicio HJ, Maillard P, DeCarli CS, Harris WS, Seshadri S. Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife: The Framingham Heart Study. Neurology. 2022 Dec 05; 99(23):e2572-e2582.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 36198518; PMCID: PMC9754651; DOI: 10.1212/WNL.0000000000201296;

Baril AA, Pinheiro AA, Himali JJ, Beiser A, Sanchez E, Pase MP, Seshadri S, Demissie S, Romero JR. Lighter sleep is associated with higher enlarged perivascular spaces burden in middle-aged and elderly individuals. Sleep Med. 2022 Dec; 100:558-564.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Romero, Jose
Demissie, Serkalem
Seshadri, Sudha

PMID: 36308914; PMCID: PMC9815141; DOI: 10.1016/j.sleep.2022.10.006;

Baril AA, Beiser AS, DeCarli C, Himali D, Sanchez E, Cavuoto M, Redline S, Gottlieb DJ, Seshadri S, Pase MP, Himali JJ. Self-reported sleepiness associates with greater brain and cortical volume and lower prevalence of ischemic covert brain infarcts in a community sample. Sleep. 2022 Oct 10; 45(10).View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 35917199; PMCID: PMC9548673; DOI: 10.1093/sleep/zsac185;

Gonzales MM, Wiedner C, Wang CP, Liu Q, Bis JC, Li Z, Himali JJ, Ghosh S, Thomas EA, Parent DM, Kautz TF, Pase MP, Aparicio HJ, Djoussé L, Mukamal KJ, Psaty BM, Longstreth WT, Mosley TH, Gudnason V, Mbangdadji D, Lopez OL, Yaffe K, Sidney S, Bryan RN, Nasrallah IM, DeCarli CS, Beiser AS, Launer LJ, Fornage M, Tracy RP, Seshadri S, Satizabal CL. A population-based meta-analysis of circulating GFAP for cognition and dementia risk. Ann Clin Transl Neurol. 2022 Oct; 9(10):1574-1585.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 36056631; PMCID: PMC9539381; DOI: 10.1002/acn3.51652;

Lara FR, Scruton AL, Pinheiro A, Demissie S, Parva P, Charidimou A, Francis M, Himali JJ, DeCarli C, Beiser A, Seshadri S, Romero JR. Aging, prevalence and risk factors of MRI-visible enlarged perivascular spaces. Aging (Albany NY). 2022 Jul 15; 14(17):6844-6858.View Related Profiles.

Beiser, Alexa
Charidimou , Antreas
Himali, Jayandra
Romero, Jose
Parva, Pedram
Demissie, Serkalem
Seshadri, Sudha

PMID: 35852852; PMCID: PMC9512514; DOI: 10.18632/aging.204181;

McGrath ER, Beiser AS, O'Donnell A, Himali JJ, Pase MP, Satizabal CL, Seshadri S. Determining Vascular Risk Factors for Dementia and Dementia Risk Prediction Across Mid- to Later Life: The Framingham Heart Study. Neurology. 2022 Jul 11; 99(2):e142-e153.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 35584926; PMCID: PMC9280997; DOI: 10.1212/WNL.0000000000200521;

Melo Van Lent D, Gokingco H, Short MI, Yuan C, Jacques PF, Romero JR, DeCarli CS, Beiser AS, Seshadri S, Himali JJ, Jacob ME. Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort. Alzheimers Dement. 2023 Feb; 19(2):621-631.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 35522830; PMCID: PMC9637238; DOI: 10.1002/alz.12685;

Lin H, Himali JJ, Satizabal CL, Beiser AS, Levy D, Benjamin EJ, Gonzales MM, Ghosh S, Vasan RS, Seshadri S, McGrath ER. Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study. Cells. 2022 Apr 30; 11(9).View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Benjamin, Emelia
Lin, Honghuang
Himali, Jayandra
Seshadri, Sudha

PMID: 35563811; PMCID: PMC9100323; DOI: 10.3390/cells11091506;

Angoff R, Himali JJ, Maillard P, Aparicio HJ, Vasan RS, Seshadri S, Beiser AS, Tsao CW. Relations of Metabolic Health and Obesity to Brain Aging in Young to Middle-Aged Adults. J Am Heart Assoc. 2022 03 15; 11(6):e022107.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 35229662; PMCID: PMC9075324; DOI: 10.1161/JAHA.121.022107;

Wittfeld K, Raman MR, Conner SC, Aslam A, Teumer A, Nauck M, Hosten N, Habes M, DeCarli C, Vasan RS, Beiser AS, Himali JJ, Seshadri S, Grabe HJ, Satizabal CL. Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults. J Alzheimers Dis. 2022; 88(1):311-322.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 35599493; PMCID: PMC9472289; DOI: 10.3233/JAD-220356;

McGrath ER, Beiser AS, O'Donnell A, Yang Q, Ghosh S, Gonzales MM, Himali JJ, Satizabal CL, Johnson KA, Tracy RP, Seshadri S. Blood Phosphorylated Tau 181 as a Biomarker for Amyloid Burden on Brain PET in Cognitively Healthy Adults. J Alzheimers Dis. 2022; 87(4):1517-1526.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 35491781; DOI: 10.3233/JAD-215639;

McGrath ER, Himali JJ, Levy D, Yang Q, DeCarli CS, Courchesne P, Satizabal CL, Finney R, Vasan RS, Beiser AS, Seshadri S. Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study. J Alzheimers Dis. 2022; 85(4):1657-1666.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 34958018; DOI: 10.3233/JAD-215053;

Spartano NL, Himali JJ, Trinquart L, Yang Q, Weinstein G, Satizabal CL, Dukes KA, Beiser AS, Murabito JM, Vasan RS, Seshadri S. Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study. J Alzheimers Dis. 2022; 85(2):805-814.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Weinstein, Galit
Himali, Jayandra
Murabito, Joanne
Dukes, Kimberly Ann
Trinquart, Ludovic
Spartano, Nicole
Yang, Qiong
Seshadri, Sudha

PMID: 34864673; DOI: 10.3233/JAD-215109;

Stefanidou M, Himali JJ, Devinsky O, Romero JR, Ikram MA, Beiser AS, Seshadri S, Friedman D. Vascular risk factors as predictors of epilepsy in older age: The Framingham Heart Study. Epilepsia. 2022 01; 63(1):237-243.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Romero, Jose
Stefanidou, Maria
Seshadri, Sudha

PMID: 34786697; DOI: 10.1111/epi.17108;

Stefanidou M, O'Donnell A, Himali JJ, DeCarli C, Satizabal C, Beiser AS, Seshadri S, Zaldy T. Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function: The Framingham Offspring Cohort. Alzheimer Dis Assoc Disord. 2021 Oct-Dec 01; 35(4):291-297.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Stefanidou, Maria
Seshadri, Sudha

PMID: 33973881; PMCID: PMC8608007; DOI: 10.1097/WAD.0000000000000453;

Baril AA, Beiser AS, Sanchez E, Mysliwiec V, Redline S, Gottlieb DJ, O'Connor GT, Gonzales MM, Himali D, Seshadri S, Himali JJ, Pase MP. Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype. Alzheimers Dement. 2022 03; 18(3):408-421.View Related Profiles.

Beiser, Alexa
O'Connor, George
Himali, Jayandra
Seshadri, Sudha

PMID: 34310026; PMCID: PMC8802306; DOI: 10.1002/alz.12405;

Walker ME, O'Donnell AA, Himali JJ, Rajendran I, Melo van Lent D, Ataklte F, Jacques PF, Beiser AS, Seshadri S, Vasan RS, Xanthakis V. Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study. Br J Nutr. 2021 12 28; 126(12):1888-1896.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Walker, Maura
Seshadri, Sudha
Xanthakis, Vanessa

PMID: 33618785; PMCID: PMC8380746; DOI: 10.1017/S0007114521000660;

Baril AA, Beiser AS, Redline S, McGrath ER, Aparicio HJ, Gottlieb DJ, Seshadri S, Pase MP, Himali JJ. Systemic inflammation as a moderator between sleep and incident dementia. Sleep. 2021 02 12; 44(2).View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 32860698; PMCID: PMC7879417; DOI: 10.1093/sleep/zsaa164;

Lioutas VA, Ivan CS, Himali JJ, Aparicio HJ, Leveille T, Romero JR, Beiser AS, Seshadri S. Incidence of Transient Ischemic Attack and Association With Long-term Risk of Stroke. JAMA. 2021 01 26; 325(4):373-381.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 33496774; PMCID: PMC7838926; DOI: 10.1001/jama.2020.25071;

Shoamanesh A, Akoudad S, Himali JJ, Beiser AS, DeCarli C, Seshadri S, Arfan Ikram M, Romero JR, Vernooij MW. Cortical superficial siderosis in the general population: The Framingham Heart and Rotterdam studies. Int J Stroke. 2021 10; 16(7):798-808.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 33478376; PMCID: PMC9822782; DOI: 10.1177/1747493020984559;

Romero JR, Himali JJ, Beiser A, Pase MP, Davis-Plourde KL, Parva P, Seshadri S, Mitchell GF. Aortic stiffness and cerebral microbleeds: The Framingham Heart Study. Vasc Med. 2021 06; 26(3):312-314.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Romero, Jose
Parva, Pedram
Seshadri, Sudha

PMID: 33393444

Melo van Lent D, O'Donnell A, Beiser AS, Vasan RS, DeCarli CS, Scarmeas N, Wagner M, Jacques PF, Seshadri S, Himali JJ, Pase MP. Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study. J Alzheimers Dis. 2021; 82(2):827-839.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 34092629; DOI: 10.3233/JAD-201238;

Baril AA, Beiser AS, Redline S, McGrath ER, Gottlieb DJ, Aparicio H, Seshadri S, Himali JJ, Pase MP. Interleukin-6 Interacts with Sleep Apnea Severity when Predicting Incident Alzheimer's Disease Dementia. J Alzheimers Dis. 2021; 79(4):1451-1457.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 33459710; PMCID: PMC8803404; DOI: 10.3233/JAD-200545;

Baril AA, Beiser AS, Mysliwiec V, Sanchez E, DeCarli CS, Redline S, Gottlieb DJ, Maillard P, Romero JR, Satizabal CL, Zucker JM, Seshadri S, Pase MP, Himali JJ. Slow-Wave Sleep and MRI Markers of Brain Aging in a Community-Based Sample. Neurology. 2021 03 09; 96(10):e1462-e1469.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 33361258; PMCID: PMC8055313; DOI: 10.1212/WNL.0000000000011377;

Stefanidou M, Beiser AS, Himali JJ, Peng TJ, Devinsky O, Seshadri S, Friedman D. Bi-directional association between epilepsy and dementia: The Framingham Heart Study. Neurology. 2020 12 15; 95(24):e3241-e3247.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Stefanidou, Maria
Seshadri, Sudha

PMID: 33097599; PMCID: PMC7836659; DOI: 10.1212/WNL.0000000000011077;

Lioutas VA, Beiser AS, Aparicio HJ, Himali JJ, Selim MH, Romero JR, Seshadri S. Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016. JAMA Neurol. 2020 10 01; 77(10):1252-1260.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 32511690; PMCID: PMC7281354; DOI: 10.1001/jamaneurol.2020.1512;

Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, DeCarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Veronica Witte A, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Bruce Pike G, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT, Fornage M, Paus T, Debette S, Arfan Ikram M, Schmidt H, Schmidt R, Seshadri S. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun. 2020 09 22; 11(1):4796.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Lin, Honghuang
Himali, Jayandra
Logue, Mark
Yang, Qiong
Seshadri, Sudha

PMID: 32963231; PMCID: PMC7508833; DOI: 10.1038/s41467-020-18367-y;

McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli C, Pase MP, Ninomiya T, Ohara T, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia. J Am Heart Assoc. 2020 10 20; 9(19):e014659.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 32921207; PMCID: PMC7792414; DOI: 10.1161/JAHA.119.014659;

Knol MJ, Lu D, Traylor M, Adams HHH, Romero JRJ, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, Trompet S, Giese AK, Hilal S, van den Akker EB, Vojinovic D, Li S, Sigurdsson S, van der Lee SJ, Jack CR, Wilson D, Yilmaz P, Satizabal CL, Liewald DCM, van der Grond J, Chen C, Saba Y, van der Lugt A, Bastin ME, Windham BG, Cheng CY, Pirpamer L, Kantarci K, Himali JJ, Yang Q, Morris Z, Beiser AS, Tozer DJ, Vernooij MW, Amin N, Beekman M, Koh JY, Stott DJ, Houlden H, Schmidt R, Gottesman RF, MacKinnon AD, DeCarli C, Gudnason V, Deary IJ, van Duijn CM, Slagboom PE, Wong TY, Rost NS, Jukema JW, Mosley TH, Werring DJ, Schmidt H, Wardlaw JM, Ikram MA, Seshadri S, Launer LJ, Markus HS. Association of common genetic variants with brain microbleeds: A genome-wide association study. Neurology. 2020 12 15; 95(24):e3331-e3343.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Romero, Jose
Yang, Qiong
Seshadri, Sudha

PMID: 32913026; PMCID: PMC7836652; DOI: 10.1212/WNL.0000000000010852;

Romero JR, Demissie S, Beiser A, Himali JJ, DeCarli C, Levy D, Seshadri S. Relation of plasma ß-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study. Ann Clin Transl Neurol. 2020 07; 7(7):1083-1091.View Related Profiles.

Beiser, Alexa
Levy, Daniel
Himali, Jayandra
Romero, Jose
Demissie, Serkalem
Seshadri, Sudha

PMID: 32588552; PMCID: PMC7359126; DOI: 10.1002/acn3.51066;

Baradaran H, Demissie S, Himali JJ, Beiser A, Gupta A, Polak JF, DeCarli C, Seshadri S, Romero JR. The progression of carotid atherosclerosis and imaging markers of dementia. Alzheimers Dement (N Y). 2020; 6(1):e12015.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Romero, Jose
Polak, Joseph
Demissie, Serkalem
Seshadri, Sudha

PMID: 32296732; PMCID: PMC7154591; DOI: 10.1002/trc2.12015;

McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating ceramide ratios and risk of vascular brain aging and dementia. Ann Clin Transl Neurol. 2020 02; 7(2):160-168.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Xanthakis, Vanessa

PMID: 31950603; PMCID: PMC7034495; DOI: 10.1002/acn3.50973;

Pase MP, Himali JJ, Beiser AS, DeCarli C, McGrath ER, Satizabal CL, Aparicio HJ, Adams HHH, Reiner AP, Longstreth WT, Fornage M, Tracy RP, Lopez O, Psaty BM, Levy D, Seshadri S, Bis JC. Association of CD14 with incident dementia and markers of brain aging and injury. Neurology. 2020 01 21; 94(3):e254-e266.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Levy, Daniel
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 31818907; PMCID: PMC7108812; DOI: 10.1212/WNL.0000000000008682;

Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Gwen Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. Lancet Neurol. 2020 01; 19(1):61-70.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 31706889; PMCID: PMC7391421; DOI: 10.1016/S1474-4422(19)30393-X;

Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Ann Clin Transl Neurol. 2019 12; 6(12):2403-2412.View Related Profiles.

Beiser, Alexa
McKee, Ann
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Stein, Thor
Alvarez, Victor

PMID: 31691546; PMCID: PMC6917310; DOI: 10.1002/acn3.50936;

Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, Luciano M, Hofer E, Teumer A, van der Lee SJ, Yang J, Yanek LR, Lee TV, Li S, Hu Y, Koh JY, Eicher JD, Desrivières S, Arias-Vasquez A, Chauhan G, Athanasiu L, Rentería ME, Kim S, Hoehn D, Armstrong NJ, Chen Q, Holmes AJ, den Braber A, Kloszewska I, Andersson M, Espeseth T, Grimm O, Abramovic L, Alhusaini S, Milaneschi Y, Papmeyer M, Axelsson T, Ehrlich S, Roiz-Santiañez R, Kraemer B, Håberg AK, Jones HJ, Pike GB, Stein DJ, Stevens A, Bralten J, Vernooij MW, Harris TB, Filippi I, Witte AV, Guadalupe T, Wittfeld K, Mosley TH, Becker JT, Doan NT, Hagenaars SP, Saba Y, Cuellar-Partida G, Amin N, Hilal S, Nho K, Mirza-Schreiber N, Arfanakis K, Becker DM, Ames D, Goldman AL, Lee PH, Boomsma DI, Lovestone S, Giddaluru S, Le Hellard S, Mattheisen M, Bohlken MM, Kasperaviciute D, Schmaal L, Lawrie SM, Agartz I, Walton E, Tordesillas-Gutierrez D, Davies GE, Shin J, Ipser JC, Vinke LN, Hoogman M, Jia T, Burkhardt R, Klein M, Crivello F, Janowitz D, Carmichael O, Haukvik UK, Aribisala BS, Schmidt H, Strike LT, Cheng CY, Risacher SL, Pütz B, Fleischman DA, Assareh AA, Mattay VS, Buckner RL, Mecocci P, Dale AM, Cichon S, Boks MP, Matarin M, Penninx BWJH, Calhoun VD, Chakravarty MM, Marquand AF, Macare C, Kharabian Masouleh S, Oosterlaan J, Amouyel P, Hegenscheid K, Rotter JI, Schork AJ, Liewald DCM, de Zubicaray GI, Wong TY, Shen L, Sämann PG, Brodaty H, Roffman JL, de Geus EJC, Tsolaki M, Erk S, van Eijk KR, Cavalleri GL, van der Wee NJA, McIntosh AM, Gollub RL, Bulayeva KB, Bernard M, Richards JS, Himali JJ, Loeffler M, Rommelse N, Hoffmann W, Westlye LT, Valdés Hernández MC, Hansell NK, van Erp TGM, Wolf C, Kwok JBJ, Vellas B, Heinz A, Olde Loohuis LM, Delanty N, Ho BC, Ching CRK, Shumskaya E, Singh B, Hofman A, van der Meer D, Homuth G, Psaty BM, Bastin ME, Montgomery GW, Foroud TM, Reppermund S, Hottenga JJ, Simmons A, Meyer-Lindenberg A, Cahn W, Whelan CD, van Donkelaar MMJ, Yang Q, Hosten N, Green RC, Thalamuthu A, Mohnke S, Hulshoff Pol HE, Lin H, Jack CR, Schofield PR, Mühleisen TW, Maillard P, Potkin SG, Wen W, Fletcher E, Toga AW, Gruber O, Huentelman M, Davey Smith G, Launer LJ, Nyberg L, Jönsson EG, Crespo-Facorro B, Koen N, Greve DN, Uitterlinden AG, Weinberger DR, Steen VM, Fedko IO, Groenewold NA, Niessen WJ, Toro R, Tzourio C, Longstreth WT, Ikram MK, Smoller JW, van Tol MJ, Sussmann JE, Paus T, Lemaître H, Schroeter ML, Mazoyer B, Andreassen OA, Holsboer F, Depondt C, Veltman DJ, Turner JA, Pausova Z, Schumann G, van Rooij D, Djurovic S, Deary IJ, McMahon KL, Müller-Myhsok B, Brouwer RM, Soininen H, Pandolfo M, Wassink TH, Cheung JW, Wolfers T, Martinot JL, Zwiers MP, Nauck M, Melle I, Martin NG, Kanai R, Westman E, Kahn RS, Sisodiya SM, White T, Saremi A, van Bokhoven H, Brunner HG, Völzke H, Wright MJ, van 't Ent D, Nöthen MM, Ophoff RA, Buitelaar JK, Fernández G, Sachdev PS, Rietschel M, van Haren NEM, Fisher SE, Beiser AS, Francks C, Saykin AJ, Mather KA, Romanczuk-Seiferth N, Hartman CA, DeStefano AL, Heslenfeld DJ, Weiner MW, Walter H, Hoekstra PJ, Nyquist PA, Franke B, Bennett DA, Grabe HJ, Johnson AD, Chen C, van Duijn CM, Lopez OL, Fornage M, Wardlaw JM, Schmidt R, DeCarli C, De Jager PL, Villringer A, Debette S, Gudnason V, Medland SE, Shulman JM, Thompson PM, Seshadri S, Ikram MA. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019 11; 51(11):1624-1636.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Satizabal, Claudia
Lin, Honghuang
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 31636452; PMCID: PMC7055269; DOI: 10.1038/s41588-019-0511-y;

Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimers Dement (N Y). 2019; 5:618-626.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Dukes, Kimberly Ann
Spartano, Nicole
Demissie, Serkalem
Seshadri, Sudha

PMID: 31660424; PMCID: PMC6807299; DOI: 10.1016/j.trci.2019.08.007;

Echouffo-Tcheugui J, Conner SC, Himali JJ, Beiser AS, Seshadri S. Author response: Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study. Neurology. 2019 10 08; 93(15):685-686.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 31591178

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. Author CoView Related Profiles.

Beiser, Alexa
DeStefano, Anita
McKee, Ann
Sarnowski, Chloe
Jun, Gyungah
Himali, Jayandra
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha

PMID: 31417202; PMCID: PMC7265117; DOI: 10.1038/s41588-019-0495-7;

Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S. Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study. PLoS One. 2019; 14(8):e0219261.View Related Profiles.

Beiser, Alexa
Liu, Chunyu
Lin, Honghuang
Himali, Jayandra
Larson, Martin
Seshadri, Sudha

PMID: 31393881; PMCID: PMC6687152; DOI: 10.1371/journal.pone.0219261;

McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli CS, Pase MP, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating IGFBP-2: a novel biomarker for incident dementia. Ann Clin Transl Neurol. 2019 09; 6(9):1659-1670.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 31373442; PMCID: PMC6764739; DOI: 10.1002/acn3.50854;

Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S. Plasma total-tau as a biomarker of stroke risk in the community. Ann Neurol. 2019 09; 86(3):463-467.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 31271449; PMCID: PMC7297542; DOI: 10.1002/ana.25542;

Weinstein G, Davis-Plourde K, Himali JJ, Zelber-Sagi S, Beiser AS, Seshadri S. Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study. Liver Int. 2019 09; 39(9):1713-1721.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
Himali, Jayandra
Seshadri, Sudha

PMID: 31155826; PMCID: PMC6736704; DOI: 10.1111/liv.14161;

Aparicio HJ, Himali JJ, Satizabal CL, Pase MP, Romero JR, Kase CS, Beiser AS, Seshadri S. Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study. Stroke. 2019 06; 50(6):1558-1560.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 31084341; PMCID: PMC6538454; DOI: 10.1161/STROKEAHA.119.025171;

Pase MP, Beiser AS, Himali JJ, Satizabal CL, Aparicio HJ, DeCarli C, Chêne G, Dufouil C, Seshadri S. Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes. JAMA Neurol. 2019 05 01; 76(5):598-606.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 30830207; PMCID: PMC6515589; DOI: 10.1001/jamaneurol.2018.4666;

Spartano NL, Davis-Plourde KL, Himali JJ, Andersson C, Pase MP, Maillard P, DeCarli C, Murabito JM, Beiser AS, Vasan RS, Seshadri S. Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study. JAMA Netw Open. 2019 04 05; 2(4):e192745.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Spartano, Nicole
Seshadri, Sudha

PMID: 31002329; PMCID: PMC6481600; DOI: 10.1001/jamanetworkopen.2019.2745;

McGrath ER, Himali JJ, Levy D, Conner SC, Pase MP, Abraham CR, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study. PLoS One. 2019; 14(3):e0213321.View Related Profiles.

Beiser, Alexa
Abraham, Carmela
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 30830941; PMCID: PMC6398923; DOI: 10.1371/journal.pone.0213321;

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. GenetView Related Profiles.

Beiser, Alexa
DeStefano, Anita
McKee, Ann
Sarnowski, Chloe
Jun, Gyungah
Lin, Honghuang
Himali, Jayandra
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha

PMID: 30820047; PMCID: PMC6463297; DOI: 10.1038/s41588-019-0358-2;

Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts. PLoS One. 2019; 14(2):e0212293.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
Himali, Jayandra
Seshadri, Sudha

PMID: 30768625; PMCID: PMC6377188; DOI: 10.1371/journal.pone.0212293;

Spartano NL, Davis-Plourde KL, Himali JJ, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study. J Diabetes Res. 2019; 2019:2718465.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Spartano, Nicole
Seshadri, Sudha

PMID: 30729134; PMCID: PMC6343169; DOI: 10.1155/2019/2718465;

Conner SC, Benayoun L, Himali JJ, Adams SL, Yang Q, DeCarli C, Blusztajn JK, Beiser A, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts. J Alzheimers Dis. 2019; 68(1):357-365.View Related Profiles.

Beiser, Alexa
Delalle, Ivana
Blusztajn, Jan
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 30775993; PMCID: PMC6481535; DOI: 10.3233/JAD-180977;

Echouffo-Tcheugui JB, Conner SC, Himali JJ, Maillard P, DeCarli CS, Beiser AS, Vasan RS, Seshadri S. Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study. Neurology. 2018 11 20; 91(21):e1961-e1970.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 30355700; PMCID: PMC6260201; DOI: 10.1212/WNL.0000000000006549;

Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S, Beiser AS, DeCarli C. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology. 2018 10 16; 91(16):e1479-e1486.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 30232248; PMCID: PMC6202941; DOI: 10.1212/WNL.0000000000006360;

Raman MR, Himali JJ, Conner SC, DeCarli C, Vasan RS, Beiser AS, Seshadri S, Maillard P, Satizabal CL. Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. Stroke. 2018 09; 49(9):2227-2229.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 30354979; PMCID: PMC6101979; DOI: 10.1161/STROKEAHA.118.022613;

Story Jovanova O, Nedeljkovic I, Spieler D, Walker RM, Liu C, Luciano M, Bressler J, Brody J, Drake AJ, Evans KL, Gondalia R, Kunze S, Kuhnel B, Lahti J, Lemaitre RN, Marioni RE, Swenson B, Himali JJ, Wu H, Li Y, McRae AF, Russ TC, Stewart J, Wang Z, Zhang G, Ladwig KH, Uitterlinden AG, Guo X, Peters A, Räikkönen K, Starr JM, Waldenberger M, Wray NR, Whitsel EA, Sotoodehnia N, Seshadri S, Porteous DJ, van Meurs J, Mosley TH, McIntosh AM, Mendelson MM, Levy D, Hou L, Eriksson JG, Fornage M, Deary IJ, Baccarelli A, Tiemeier H, Amin N. DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies. JAMA Psychiatry. 2018 09 01; 75(9):949-959.View Related Profiles.

Liu, Chunyu
Himali, Jayandra
Seshadri, Sudha

PMID: 29998287; PMCID: PMC6142917; DOI: 10.1001/jamapsychiatry.2018.1725;

Seiler S, Fletcher E, Hassan-Ali K, Weinstein M, Beiser A, Himali JJ, Satizabal CL, Seshadri S, DeCarli C, Maillard P. Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition. Neurobiol Aging. 2018 12; 72:14-22.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha

PMID: 30172922; PMCID: PMC6242702; DOI: 10.1016/j.neurobiolaging.2018.08.005;

Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Author response: Sleep architecture and the risk of incident dementia in the community. Neurology. 2018 03 06; 90(10):487.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 29507137

Charidimou A, Shams S, Romero JR, Ding J, Veltkamp R, Horstmann S, Eiriksdottir G, van Buchem MA, Gudnason V, Himali JJ, Gurol ME, Viswanathan A, Imaizumi T, Vernooij MW, Seshadri S, Greenberg SM, Benavente OR, Launer LJ, Shoamanesh A. Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1). Int J Stroke. 2018 07; 13(5):454-468.View Related Profiles.

Charidimou , Antreas
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 29338604; PMCID: PMC6123529; DOI: 10.1177/1747493017751931;

Adams S, Conner S, Himali JJ, Beiser A, Vasan RS, Seshadri S, Pase MP. Vascular risk factor burden and new-onset depression in the community. Prev Med. 2018 06; 111:348-350.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 29197532; PMCID: PMC5930122; DOI: 10.1016/j.ypmed.2017.11.022;

Pase MP, Westwood AJ, Beiser A, Jain N, DeCarli C, Himali JJ, Auerbach SH, Seshadri S. Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017 10 03; 89(14):1533.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 28972111

Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, McManus DD, Benjamin EJ, Au R. Atrial fibrillation and cognitive decline in the Framingham Heart Study. Heart Rhythm. 2018 02; 15(2):166-172.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Au, Rhoda

PMID: 28943482; PMCID: PMC5881912; DOI: 10.1016/j.hrthm.2017.09.036;

Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Sleep architecture and the risk of incident dementia in the community. Neurology. 2017 Sep 19; 89(12):1244-1250.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 28835407; PMCID: PMC5606917; DOI: 10.1212/WNL.0000000000004373;

Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, Mitchell GF. Inter-Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults. J Am Heart Assoc. 2017 Aug 17; 6(8).View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Hamburg, Naomi
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28862943; PMCID: PMC5586458; DOI: 10.1161/JAHA.117.006206;

Pase MP, Himali JJ, Seshadri S, Jacques PF. Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia". Stroke. 2017 09; 48(9):e269.View Related Profiles.

Himali, Jayandra
Seshadri, Sudha

PMID: 28784919; PMCID: PMC5575961; DOI: 10.1161/STROKEAHA.117.018603;

Pase MP, Himali JJ, Beiser A, Seshadri S, Jacques PF. Response by Pase et al to Letters Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study". Stroke. 2017 Jul 18.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 28720657; PMCID: PMC5773417; DOI: 10.1161/STROKEAHA.117.018067;

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, et al. RarView Related Profiles.

Beiser, Alexa
DeStefano, Anita
McKee, Ann
O'Donnell, Christopher
Satizabal, Claudia
Jun, Gyungah
Lin, Honghuang
Himali, Jayandra
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Choi, Seung Hoan
Seshadri, Sudha

PMID: 28714976; PMCID: PMC5669039; DOI: 10.1038/ng.3916;

Aparicio HJ, Himali JJ, Beiser AS, Davis-Plourde KL, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. J Am Heart Assoc. 2017 Jun 24; 6(6).View Related Profiles.

Beiser, Alexa
Kase, Carlos
Aparicio, Hugo
Himali, Jayandra
Wolf, Philip
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28647687; PMCID: PMC5669145; DOI: 10.1161/JAHA.116.004721;

Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. Stroke. 2017 Jul; 48(7):1760-1765.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Romero, Jose
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28596451; PMCID: PMC5505338; DOI: 10.1161/STROKEAHA.116.016563;

Maillard P, Mitchell GF, Himali JJ, Beiser A, Fletcher E, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury. Stroke. 2017 Jun; 48(6):1567-1573.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28473633; PMCID: PMC5502744; DOI: 10.1161/STROKEAHA.116.016321;

Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. 2017 May; 48(5):1139-1146.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28428346; PMCID: PMC5405737; DOI: 10.1161/STROKEAHA.116.016027;

Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017 Jun; 3(2):229-237.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Weinstein, Galit
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 29067329; PMCID: PMC5651441; DOI: 10.1016/j.trci.2017.03.001;

Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimers Dement. 2017 Sep; 13(9):955-964.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28274718; PMCID: PMC6820519; DOI: 10.1016/j.jalz.2017.01.024;

Romero JR, Beiser A, Himali JJ, Shoamanesh A, DeCarli C, Seshadri S. Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study. Neurobiol Aging. 2017 Jun; 54:94-99.View Related Profiles.

Beiser, Alexa
Shoamanesh, Ashkan
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 28347929; PMCID: PMC5401784; DOI: 10.1016/j.neurobiolaging.2017.02.018;

Westwood AJ, Beiser A, Jain N, Himali JJ, DeCarli C, Auerbach SH, Pase MP, Seshadri S. Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017 Mar 21; 88(12):1172-1179.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 28228567; PMCID: PMC5373785; DOI: 10.1212/WNL.0000000000003732;

Dufouil C, Beiser A, McLure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan L, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, D'Agostino RB, Samieri C, Vasan RS, Chêne G, Howard G, Seshadri S. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. 2017 Mar 21; 135(12):1145-1159.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28159800; PMCID: PMC5504355; DOI: 10.1161/CIRCULATIONAHA.115.021275;

Romero JR, Preis SR, Beiser A, Himali JJ, Shoamanesh A, Wolf PA, Kase CS, Vasan RS, DeCarli C, Seshadri S. Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study. Stroke. 2017 Mar; 48(3):781-783.View Related Profiles.

Beiser, Alexa
Shoamanesh, Ashkan
Kase, Carlos
Himali, Jayandra
Romero, Jose
Wolf, Philip
Preis, Sarah
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28143923; PMCID: PMC5330856; DOI: 10.1161/STROKEAHA.116.015354;

Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients. J Alzheimers Dis. 2017; 60(1):43-56.View Related Profiles.

Delalle, Ivana
Blusztajn, Jan
Himali, Jayandra
Chavez, Olivia
Seshadri, Sudha

PMID: 28777754; PMCID: PMC5922439; DOI: 10.3233/JAD-170459;

Lioutas VA, Beiser A, Himali J, Aparicio H, Romero JR, DeCarli C, Seshadri S. Lacunar Infarcts and Intracerebral Hemorrhage Differences: A Nested Case-Control Analysis in the FHS (Framingham Heart Study). Stroke. 2017 Feb; 48(2):486-489.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 28008091; PMCID: PMC5288009; DOI: 10.1161/STROKEAHA.116.014839;

Rahman F, Himali JJ, Yin X, Beiser AS, Ellinor PT, Lubitz SA, Vasan RS, Magnani JW, McManus DD, Seshadri S, Benjamin EJ. Serum brain-derived neurotrophic factor and risk of atrial fibrillation. Am Heart J. 2017 Jan; 183:69-73.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 27979044; PMCID: PMC5166602; DOI: 10.1016/j.ahj.2016.07.027;

Pase MP, Beiser A, Himali JJ, Tsao C, Satizabal CL, Vasan RS, Seshadri S, Mitchell GF. Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia. Stroke. 2016 Sep; 47(9):2256-61.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 27491735; PMCID: PMC4995162; DOI: 10.1161/STROKEAHA.116.013508;

Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology. J Alzheimers Dis. 2016 07 06; 53(4):1553-62.View Related Profiles.

Beiser, Alexa
McKee, Ann
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 27392855; PMCID: PMC5494258; DOI: 10.3233/JAD-160163;

Pase MP, Beiser A, Enserro D, Xanthakis V, Aparicio H, Satizabal CL, Himali JJ, Kase CS, Vasan RS, DeCarli C, Seshadri S. Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. Stroke. 2016 May; 47(5):1201-6.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha
Xanthakis, Vanessa
Ramachandran, Vasan

PMID: 27073239; PMCID: PMC5006676; DOI: 10.1161/STROKEAHA.115.012608;

Salinas J, Beiser A, Himali JJ, Rosand J, Seshadri S, Dunn EC. Factors Associated With New-Onset Depression After Stroke. J Neuropsychiatry Clin Neurosci. 2016; 28(4):286-291.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 27056020; PMCID: PMC5474200; DOI: 10.1176/appi.neuropsych.15110388;

Qiu WQ, Himali JJ, Wolf PA, DeCarli DC, Beiser A, Au R. Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study. Int J Geriatr Psychiatry. 2017 Feb; 32(2):214-221.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Qiu, Wendy

PMID: 27059548; PMCID: PMC5052093; DOI: 10.1002/gps.4469;

Maillard P, Mitchell GF, Himali JJ, Beiser A, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study. Stroke. 2016 Apr; 47(4):1030-6.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26965846; PMCID: PMC4811686; DOI: 10.1161/STROKEAHA.116.012949;

Spartano NL, Himali JJ, Beiser AS, Lewis GD, DeCarli C, Vasan RS, Seshadri S. Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later. Neurology. 2016 Apr 5; 86(14):1313-9.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Spartano, Nicole
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26865519; PMCID: PMC4826343; DOI: 10.1212/WNL.0000000000002415;

Tsao CW, Himali JJ, Beiser AS, Larson MG, DeCarli C, Vasan RS, Mitchell GF, Seshadri S. Association of arterial stiffness with progression of subclinical brain and cognitive disease. Neurology. 2016 Feb 16; 86(7):619-26.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Larson, Martin
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26791155; PMCID: PMC4762417; DOI: 10.1212/WNL.0000000000002368;

Pase MP, Himali JJ, Mitchell GF, Beiser A, Maillard P, Tsao C, Larson MG, DeCarli C, Vasan RS, Seshadri S. Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study. Hypertension. 2016 Mar; 67(3):513-9.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Larson, Martin
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26754644; PMCID: PMC4752398; DOI: 10.1161/HYPERTENSIONAHA.115.06610;

Karakis I, Pase MP, Beiser A, Booth SL, Jacques PF, Rogers G, DeCarli C, Vasan RS, Wang TJ, Himali JJ, Annweiler C, Seshadri S. Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study. J Alzheimers Dis. 2016; 51(2):451-61.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26890771; PMCID: PMC4911705; DOI: 10.3233/JAD-150991;

Martinez-Ramirez S, Romero JR, Shoamanesh A, McKee AC, Van Etten E, Pontes-Neto O, Macklin EA, Ayres A, Auriel E, Himali JJ, Beiser AS, DeCarli C, Stein TD, Alvarez VE, Frosch MP, Rosand J, Greenberg SM, Gurol ME, Seshadri S, Viswanathan A. Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage. Alzheimers Dement. 2015 Dec; 11(12):1480-8.View Related Profiles.

Beiser, Alexa
McKee, Ann
Shoamanesh, Ashkan
Himali, Jayandra
Romero, Jose
Martinez-Ramirez, Sergi
Seshadri, Sudha
Stein, Thor
Alvarez, Victor

PMID: 26079413; PMCID: PMC4677060; DOI: 10.1016/j.jalz.2015.04.009;

Saber H, Himali JJ, Shoamanesh A, Beiser A, Pikula A, Harris TB, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Leptin Levels and the Risk of Stroke: The Framingham Study. Stroke. 2015 Oct; 46(10):2881-5.View Related Profiles.

Beiser, Alexa
Shoamanesh, Ashkan
Kase, Carlos
Himali, Jayandra
Romero, Jose
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26337973; PMCID: PMC4589501; DOI: 10.1161/STROKEAHA.115.009463;

Weinstein G, Maillard P, Himali JJ, Beiser AS, Au R, Wolf PA, Seshadri S, DeCarli C. Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology. 2015 Jun 9; 84(23):2329-37.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 25948725; PMCID: PMC4464744; DOI: 10.1212/WNL.0000000000001655;

Jefferson AL, Beiser AS, Himali JJ, Seshadri S, O'Donnell CJ, Manning WJ, Wolf PA, Au R, Benjamin EJ. Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation. 2015 Apr 14; 131(15):1333-9.View Related Profiles.

Beiser, Alexa
O'Donnell, Christopher
Benjamin, Emelia
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 25700178; PMCID: PMC4398627; DOI: 10.1161/CIRCULATIONAHA.114.012438;

Pikula A, Beiser AS, Wang J, Himali JJ, Kelly-Hayes M, Kase CS, Yang Q, Seshadri S, Wolf PA. Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study. Neurology. 2015 Feb 3; 84(5):472-9.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip
Yang, Qiong
Seshadri, Sudha

PMID: 25568296; PMCID: PMC4336066; DOI: 10.1212/WNL.0000000000001202;

Nishtala A, Himali JJ, Beiser A, Murabito JM, Seshadri S, Wolf PA, Au R. Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study. J Alzheimers Dis. 2015; 47(1):197-204.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 26402768; PMCID: PMC4827717; DOI: 10.3233/JAD-141881;

Miller IN, Himali JJ, Beiser AS, Murabito JM, Seshadri S, Wolf PA, Au R. Normative Data for the Cognitively Intact Oldest-Old: The Framingham Heart Study. Exp Aging Res. 2015; 41(4):386-409.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 26214098; PMCID: PMC5621515; DOI: 10.1080/0361073X.2015.1053755;

Jain S, Himali J, Beiser A, Ton TG, Kelly-Hayes M, Biggs ML, Delaney JA, Rosano C, Seshadri S, Frank SA. Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria. Am J Epidemiol. 2015 Feb 1; 181(3):185-90.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Kelly-Hayes, Margaret
Seshadri, Sudha

PMID: 25550359; PMCID: PMC4312428; DOI: 10.1093/aje/kwu326;

Kaur B, Himali JJ, Seshadri S, Beiser AS, Au R, McKee AC, Auerbach S, Wolf PA, DeCarli CS. Association between neuropathology and brain volume in the Framingham Heart Study. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):219-25.View Related Profiles.

Beiser, Alexa
McKee, Ann
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 24614264; PMCID: PMC4139422; DOI: 10.1097/WAD.0000000000000032;

Pekkala S, Wiener D, Himali JJ, Beiser AS, Obler LK, Liu Y, McKee A, Auerbach S, Seshadri S, Wolf PA, Au R. Lexical retrieval in discourse: an early indicator of Alzheimer's dementia. Clin Linguist Phon. 2013 Dec; 27(12):905-21.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Obler, Loraine
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 23985011; PMCID: PMC4095845; DOI: 10.3109/02699206.2013.815278;

Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, Au R, Himali JJ, Hamburg NM, Vita JA, Levy D, Larson MG, Benjamin EJ, Wolf PA, Vasan RS, Mitchell GF. Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology. 2013 Sep 10; 81(11):984-91.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Vita, Joseph
Larson, Martin
Hamburg, Naomi
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 23935179; PMCID: PMC3888200; DOI: 10.1212/WNL.0b013e3182a43e1c;

Nyborn JA, Himali JJ, Beiser AS, Devine SA, Du Y, Kaplan E, O'Connor MK, Rinn WE, Denison HS, Seshadri S, Wolf PA, Au R. The Framingham Heart Study clock drawing performance: normative data from the offspring cohort. Exp Aging Res. 2013; 39(1):80-108.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
O'Connor, Maureen
Wolf, Philip
Au, Rhoda
Devine, Sherral
Seshadri, Sudha

PMID: 23316738; PMCID: PMC3612583; DOI: 10.1080/0361073X.2013.741996;

Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O, Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol. 2012 Dec; 11(12):1039-47.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 23122892; PMCID: PMC3510663; DOI: 10.1016/S1474-4422(12)70241-7;

Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee AC. The Framingham Brain Donation Program: neuropathology along the cognitive continuum. Curr Alzheimer Res. 2012 Jul; 9(6):673-86.View Related Profiles.

Beiser, Alexa
McKee, Ann
Cabral, Howard
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 22471865; PMCID: PMC3622706

Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation. 2012 May 1; 125(17):2100-7.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 22456473; PMCID: PMC3427730; DOI: 10.1161/CIRCULATIONAHA.110.989145;

Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS, Robins SJ, Seshadri S. Red blood cell ?-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012 Feb 28; 78(9):658-64.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Robins, Sander
Seshadri, Sudha
Ramachandran, Vasan

PMID: 22371413; PMCID: PMC3286229; DOI: 10.1212/WNL.0b013e318249f6a9;

Jefferson AL, Himali JJ, Au R, Seshadri S, Decarli C, O'Donnell CJ, Wolf PA, Manning WJ, Beiser AS, Benjamin EJ. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). Am J Cardiol. 2011 Nov 1; 108(9):1346-51.View Related Profiles.

Beiser, Alexa
O'Donnell, Christopher
Benjamin, Emelia
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 21880293; PMCID: PMC3204899; DOI: 10.1016/j.amjcard.2011.06.056;

Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, Wolf PA, DeCarli C. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology. 2011 Aug 2; 77(5):461-8.View Related Profiles.

Beiser, Alexa
Palumbo, Carole
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 21810696; PMCID: PMC3146307; DOI: 10.1212/WNL.0b013e318227b227;

Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Decarli C, Vasan RS, Wolf PA, Seshadri S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care. 2011 Aug; 34(8):1766-70.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 21680719; PMCID: PMC3142014; DOI: 10.2337/dc11-0308;

Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation. 2010 Aug 17; 122(7):690-7.View Related Profiles.

Beiser, Alexa
Jefferson, Angela
O'Donnell, Christopher
Benjamin, Emelia
Himali, Jayandra
Massaro, Joseph
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20679552; PMCID: PMC2929763; DOI: 10.1161/CIRCULATIONAHA.109.905091;

Debette S, Beiser A, Hoffmann U, Decarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol. 2010 Aug; 68(2):136-44.View Related Profiles.

Beiser, Alexa
O'Donnell, Christopher
Himali, Jayandra
Massaro, Joseph
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20695006; PMCID: PMC2933649; DOI: 10.1002/ana.22062;

Seshadri S, Beiser A, Pikula A, Himali JJ, Kelly-Hayes M, Debette S, DeStefano AL, Romero JR, Kase CS, Wolf PA. Parental occurrence of stroke and risk of stroke in their children: the Framingham study. Circulation. 2010 Mar 23; 121(11):1304-12.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
DeStefano, Anita
Kase, Carlos
Himali, Jayandra
Romero, Jose
Kelly-Hayes, Margaret
Wolf, Philip
Seshadri, Sudha

PMID: 20212282; PMCID: PMC2860311; DOI: 10.1161/CIRCULATIONAHA.109.854240;

Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke. 2010 Apr; 41(4):600-6.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Romero, Jose
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20167919; PMCID: PMC2847685; DOI: 10.1161/STROKEAHA.109.570044;

Debette S, Wolf PA, Beiser A, Au R, Himali JJ, Pikula A, Auerbach S, Decarli C, Seshadri S. Association of parental dementia with cognitive and brain MRI measures in middle-aged adults. Neurology. 2009 Dec 15; 73(24):2071-8.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 20007524; PMCID: PMC2790222; DOI: 10.1212/WNL.0b013e3181c67833;

Djoussé L, Himali JJ, Beiser A, Kelly-Hayes M, Wolf PA. Apolipoprotein e, alcohol consumption, and risk of ischemic stroke: the Framingham Heart Study revisited. J Stroke Cerebrovasc Dis. 2009 Sep-Oct; 18(5):384-8.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip

PMID: 19717024; PMCID: PMC2743951; DOI: 10.1016/j.jstrokecerebrovasdis.2009.01.008;

Pikula A, Böger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, Kelly-Hayes M, Kase CS, Vasan RS, Wolf PA, Seshadri S. Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. Stroke. 2009 Sep; 40(9):2959-64.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 19644064; PMCID: PMC2749945; DOI: 10.1161/STROKEAHA.109.557116;

Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O'Donnell CJ, Yoshita M, D'Agostino RB, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke. 2008 Nov; 39(11):2929-35.View Related Profiles.

Beiser, Alexa
Kase, Carlos
O'Donnell, Christopher
Benjamin, Emelia
Himali, Jayandra
Polak, Joseph
Kelly-Hayes, Margaret
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 18583555; PMCID: PMC2712254; DOI: 10.1161/STROKEAHA.108.516575;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 146 publications over 18 distinct years, with a maximum of 19 publications in 2017 and 2019 and 2024