Huiping Zhang | Profiles RNS

Huiping Zhang, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Psychiatry

PhD, Queen's University
MS, Tongji Medical University
BS, Central China Normal University

Websites

	Biomedical Genetics Faculty
	ResearchGate
	LinkedIn

ORCID : 0000-0002-4902-0104

Huiping Zhang, PhD is a Professor in the Department of Psychiatry and the Department of Medicine (Section of Biomedical Genetics) at the Boston University Chobanian & Avedisian School of Medicine. He previously held academic appointments at Yale University School of Medicine, where he completed his postdoctoral training and advanced through roles as Research Associate Scientist (equivalent to Research Assistant Professor), Assistant Professor (tenure-track), and Research Scientist (equivalent to Research Associate Professor) before joining Boston University as an Associate Professor in 2017. Dr. Zhang’s research investigates the genetic and epigenetic mechanisms underlying substance use disorders (SUDs) and related psychiatric conditions. His work has been supported by multiple NIH awards, including a K99/R00, an R21, and two R01 grants from the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). He has also served as a subcontract Principal Investigator on two R01 projects funded by the National Institute of Child Health and Human Development (NICHD). In addition to his research, Dr. Zhang is actively engaged in academic publishing. He serves on the editorial boards of several peer-reviewed journals, including PLOS ONE, Frontiers in Genetics, Frontiers in Psychiatry, Frontiers in Cell and Developmental Biology, and Complex Psychiatry.

Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Biomedical Genetics

Member
Boston University
Genome Science Institute

Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder
03/01/2022 - 12/31/2026 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R01AA029758-05

Association of maternal, fetal, and placental biomarkers with neonatal neuroimaging and development following in-utero opioid exposure
09/01/2023 - 08/31/2026 (Subcontract PI)
Boston Medical Center Corporation NIH NICHD
1R01HD113143-01

Safety, pharmacokinetics and efficacy of extended-release naltrexone in pregnant women with opioid use disorder
10/01/2018 - 05/31/2023 (Subcontract PI)
Boston Medical Center Corporation NIH NICHD
5R01HD096798-05

Brain microRNA-mRNA regulatory networks and alcohol use disorders
08/01/2017 - 07/31/2022 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R01AA025080-05

Salivary MicroRNAs as Biomarkers for Alcohol Dependence
08/01/2017 - 04/30/2019 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
7R21AA023068-03

Association of maternal, fetal and placental biomarkers with neonatal neuroimaging and development following in-utero opioid exposure
09/01/2023 - 08/31/2026 (Subcontract PI)
Boston Medical Center - NIH/National Institute of Child Health and Human Development
1R01HD113143-01

Effects of prenatal opioid exposure on placental DNA methylation and gene expression
03/01/2022 - 02/28/2024 (Subcontract PI)
Boston Medical Center - March of Dimes

Title

Adverse childhood experiences and alcohol misuse in Latino adolescents: Testing biopsychosocial and cultural mechanisms
02/01/2022 - 01/01/2027 (Co-Mentor)
Massachusetts General Hospital - NIH/National Institute on Alcohol Abuse and Alcoholism
K08AA029150-03

Utilization of BioDot Omnia Automated Liquid Dispensing/Handling System to Enhance the Efficiency and Accuracy of High-Throughput Biological Assays
05/01/2025 - 05/01/2026 (Co-Investigator)
PI: Naomi M. Hamburg, MD, MS
NIH NIH
1S10OD038188-01

Single-Nucleus RNA Sequencing Analysis of Transcriptome Changes in the Postmortem Ventral Tegmental Area of Individuals with Alcohol Use Disorder
06/15/2024 - 06/14/2025 (PI)
Boston University Genome Science Institute

Functional validation of 22q11.2 deletion syndrome-associated missense mutation in MRPL40 using CRISPR-Cas9 gene editing
01/01/2022 - 12/31/2022 (PI)
Wing Tat Lee Research Award

Transmission Electron Microscope
06/15/2020 - 06/14/2021 (Co-Investigator)
NIH NIH
1S10OD028571-01

Epigenetic study of cocaine use disorder using a rat model
07/01/2018 - 08/31/2019 (PI)
Boston University CTSI Pilot Award

Yr	Title	Project-Sub Proj	Pubs
2026	Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder	5R01AA029758-05
2025	Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder	5R01AA029758-04
2024	Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder	5R01AA029758-03
2023	Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder	5R01AA029758-02
2022	Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder	1R01AA029758-01
2020	Brain microRNA-mRNA regulatory networks and alcohol use disorders	5R01AA025080-05	13
2019	Brain microRNA-mRNA regulatory networks and alcohol use disorders	5R01AA025080-04	13
2018	Brain microRNA-mRNA regulatory networks and alcohol use disorders	5R01AA025080-03	13
2017	Brain microRNA-mRNA regulatory networks and alcohol use disorders	7R01AA025080-02	13
2016	Brain microRNA-mRNA regulatory networks and alcohol use disorders	1R01AA025080-01	13

Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Koo JS, Zhan Q, Zhang H. m6A RNA methylation regulatory gene expression in response to ethanol and acetaldehyde exposure and withdrawal. Environ Epigenet. 2026; 12(1):dvag011. PMID: 41970606; PMCID: PMC13069560; DOI: 10.1093/eep/dvag011;

Wang LC, Lu AK, Zhu ZH, Hou WL, Yin X, Yang Q, Man LJ, Chen J, Zhu HL, Yu X, Zhang H, Hui L. Association between reduced plasma dopamine ß-hydroxylase levels and immediate memory impairment in first-episode drug-naïve schizophrenia. Schizophr Res. 2026 Mar; 289:94-99. PMID: 41576833; DOI: 10.1016/j.schres.2026.01.011;

Zhu ZH, Wu YM, Wang JJ, Zhang LW, Yin XY, Jia NN, Zhu HH, Cai Y, Hou WL, Yu X, Zhang H, Hui L. Prevalence and cognitive correlates of sleep problems in Chinese patients with first-episode drug-naïve schizophrenia. BMC Psychiatry. 2026 Jan 08; 26(1):127. PMID: 41507882; PMCID: PMC12882125; DOI: 10.1186/s12888-026-07791-x;

Ye G, Hou WL, Li J, Man LJ, Zhu ZH, Yin XY, Yu X, Zhang H, Hui L. Association between increased serum TNF-a levels and immediate memory impairment in patients with major depressive disorder: pilot study. BJPsych Open. 2025 Dec 15; 12(1):e16. PMID: 41392773; PMCID: PMC12724106; DOI: 10.1192/bjo.2025.10908;

Ngo AL, Nguyen L, Gharavi Alkhansari N, Zhang H. m6A RNA Methylation in Psychiatric Disorders: An Emerging Epitranscriptomic Axis. Epigenomes. 2025 Sep 19; 9(3). PMID: 40981072; PMCID: PMC12452703; DOI: 10.3390/epigenomes9030036;

Yin XY, Wu YM, Yang Q, Zhu ZH, Hou WL, Wang M, Lv J, Yu X, Zhang H, Hui L. Increased plasma TRANK1 levels in first-episode drug-naïve schizophrenia: Association with delayed memory decline. Asian J Psychiatr. 2025 Nov; 113:104700. PMID: 40972056; DOI: 10.1016/j.ajp.2025.104700;

Koo JS, Zhang H. Decoding the role of m6A RNA methylation regulators in psychiatric and substance use disorders. Neurochem Int. 2025 Nov; 190:106035. PMID: 40876784; PMCID: PMC12450308; DOI: 10.1016/j.neuint.2025.106035;

Jia N, Yin X, Zhu Z, Hou W, Yang Q, Zhu H, Zhang H, Yu X, Yu Q, Hui L. Comprehensive transcriptome analysis and lncRNA-miRNA-mRNA establishment of schizophrenia based on induced pluripotent stem cells. Schizophr Res. 2025 Jul; 281:22-29. PMID: 40311511; DOI: 10.1016/j.schres.2025.04.027;

Koo JS, Zhan Q, Zhang H. Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes. Epigenetics. 2025 Dec; 20(1):2493865. PMID: 40252050; PMCID: PMC12013419; DOI: 10.1080/15592294.2025.2493865;

Cakir B, Tanaka Y, Choe MS, Chu PY, Xiang Y, Kim KY, Zhong M, Gelernter J, Zhang H, Krystal J, Park IH. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. Int J Stem Cells. 2025 Aug 30; 18(3):263-274. PMID: 40205763; PMCID: PMC12394083; DOI: 10.15283/ijsc24123;

Showing 10 of 96 results. Show More

Ngo AL, Ahmad CM, Gharavi Alkhansari N, Nguyen L, Zhang H. Epigenetic Insights into Substance Use Disorder and Associated Psychiatric Conditions. Complex Psychiatry. 2025; 11(1):12-36. PMID: 40201238; PMCID: PMC11975344; DOI: 10.1159/000544912;

Sousa A, Besong OTO, Wachman EM, Taglauer ES, Beane JE, Kefella Y, Koo JS, Saia K, Jones HE, Zhang H. Placental transcriptome analysis in opioid-exposed versus non-opioid exposed pregnancies. Placenta. 2025 Mar 25; 162:27-34.View Related Profiles.

Wachman, Elisha
Taglauer, Elizabeth
Zhang, Huiping
Beane-Ebel, Jennifer
Saia, Kelley

PMID: 39983471; PMCID: PMC11908891; DOI: 10.1016/j.placenta.2025.02.012;

Jia N, Zhu Z, Liu Y, Yin X, Man L, Hou W, Zhang H, Yu Q, Hui L. From single nucleotide variations to genes: identifying the genetic links between sleep and psychiatric disorders. Sleep. 2025 Jan 13; 48(1). PMID: 39243390; DOI: 10.1093/sleep/zsae209;

Besong OTO, Koo JS, Zhang H. Brain lncRNA-mRNA co-expression regulatory networks and alcohol use disorder. Genomics. 2024 Sep; 116(5):110928. PMID: 39197730; PMCID: PMC11531342; DOI: 10.1016/j.ygeno.2024.110928;

Cai Y, Zhu ZH, Qi Q, Yin XY, Jia NN, Hou WL, Chen P, Man LJ, Wang PJ, Qian S, Wang WX, Zhang TH, Wang JJ, Zhang H, Hui L. The negative association of serum complement 3 and 4 levels with visuospatial/constructional function in first-episode patients with schizophrenia. Schizophr Res. 2024 Feb; 264:404-406. PMID: 38237363; DOI: 10.1016/j.schres.2024.01.017;

Liu Y, Koo JS, Zhang H. Chronic intermittent ethanol exposure-induced m6A modifications around mRNA stop codons of opioid receptor genes. Epigenetics. 2024 Dec; 19(1):2294515. PMID: 38118075; PMCID: PMC10761033; DOI: 10.1080/15592294.2023.2294515;

Borrelli KN, Wingfield KK, Yao EJ, Zamorano CA, Sena KD, Beierle JA, Roos MA, Zhang H, Wachman EM, Bryant CD. Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice. Neuropharmacology. 2023 Dec 01; 240:109732.View Related Profiles.

Bryant, Camron
Wachman, Elisha
Zhang, Huiping
Beierle, Jacob
Borrelli, Kristyn

PMID: 37774943; PMCID: PMC10598517; DOI: 10.1016/j.neuropharm.2023.109732;

Kumaresan V, Lim Y, Juneja P, Tipton AE, de Guglielmo G, Carrette LLG, Kallupi M, Maturin L, Liu Y, George O, Zhang H. Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway. Biomedicines. 2023 May 05; 11(5).View Related Profiles.

Zhang, Huiping
Kumaresan, Vidhya

PMID: 37239038; PMCID: PMC10216163; DOI: 10.3390/biomedicines11051368;

Cai Y, Zhu ZH, Li RH, Yin XY, Chen RF, Man LJ, Hou WL, Zhu HL, Wang J, Zhang H, Jia QF, Hui L. Association between increased serum interleukin-8 levels and improved cognition in major depressive patients with SSRIs. BMC Psychiatry. 2023 Feb 23; 23(1):122. PMID: 36823619; PMCID: PMC9948487; DOI: 10.1186/s12888-023-04616-z;

Chen RF, Cai Y, Zhu ZH, Hou WL, Chen P, Wang J, Jia YM, Zhu ZB, Zhang YH, Tao LY, Wu JW, Zhang J, Zhang H, Wang ZX, Jia QF, Hui L. Sleep disorder as a clinical risk factor of major depression: associated with cognitive impairment. Asian J Psychiatr. 2022 Oct; 76:103228. PMID: 35973338; DOI: 10.1016/j.ajp.2022.103228;

Liu Y, Zhang H. RNA m6A Modification Changes in Postmortem Nucleus Accumbens of Subjects with Alcohol Use Disorder: A Pilot Study. Genes (Basel). 2022 May 27; 13(6). PMID: 35741720; PMCID: PMC9222907; DOI: 10.3390/genes13060958;

Borrelli KN, Wachman EM, Beierle JA, Taglauer ES, Jain M, Bryant CD, Zhang H. Effect of Prenatal Opioid Exposure on the Human Placental Methylome. Biomedicines. 2022 May 17; 10(5).View Related Profiles.

Bryant, Camron
Wachman, Elisha
Taglauer, Elizabeth
Zhang, Huiping
Beierle, Jacob
Borrelli, Kristyn

PMID: 35625888; PMCID: PMC9138340; DOI: 10.3390/biomedicines10051150;

Lim Y, Beane-Ebel JE, Tanaka Y, Ning B, Husted CR, Henderson DC, Xiang Y, Park IH, Farrer LA, Zhang H. Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks. Transl Psychiatry. 2021 10 02; 11(1):504.View Related Profiles.

Henderson, David
Zhang, Huiping
Beane-Ebel, Jennifer
Farrer, Lindsay

PMID: 34601489; PMCID: PMC8487426; DOI: 10.1038/s41398-021-01635-w;

Moazzam M, Yim T, Kumaresan V, Henderson DC, Farrer LA, Zhang H. Analysis of telomere length variation and Shelterin complex subunit gene expression changes in ethanol-exposed human embryonic stem cells. J Psychiatr Res. 2021 11; 143:543-549.View Related Profiles.

Henderson, David
Zhang, Huiping
Farrer, Lindsay
Kumaresan, Vidhya

PMID: 33243459; PMCID: PMC8126580; DOI: 10.1016/j.jpsychires.2020.11.027;

Wachman EM, Wang A, Isley BC, Boateng J, Beierle JA, Hansbury A, Shrestha H, Bryant C, Zhang H. Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study. Explor Med. 2020 Jun; 1(3):124-135.View Related Profiles.

Bryant, Camron
Wachman, Elisha
Zhang, Huiping
Beierle, Jacob

PMID: 33763662; PMCID: PMC7985727; DOI: 10.37349/emed.2020.00009;

Lin H, Wang F, Rosato AJ, Farrer LA, Henderson DC, Zhang H. Prefrontal cortex eQTLs/mQTLs enriched in genetic variants associated with alcohol use disorder and other diseases. Epigenomics. 2020 05; 12(9):789-800.View Related Profiles.

Henderson, David
Lin, Honghuang
Zhang, Huiping
Farrer, Lindsay

PMID: 32496132; PMCID: PMC7607393; DOI: 10.2217/epi-2019-0270;

Dai Y, Hu R, Pei G, Zhang H, Zhao Z, Jia P. Diverse types of genomic evidence converge on alcohol use disorder risk genes. J Med Genet. 2020 11; 57(11):733-743. PMID: 32170004; PMCID: PMC7487038; DOI: 10.1136/jmedgenet-2019-106490;

Lin Y, Kranzler HR, Farrer LA, Xu H, Henderson DC, Zhang H. An analysis of the effect of mu-opioid receptor gene (OPRM1) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence. Pharmacogenomics J. 2020 10; 20(5):672-680.View Related Profiles.

Henderson, David
Zhang, Huiping
Farrer, Lindsay

PMID: 32029903; PMCID: PMC7415483; DOI: 10.1038/s41397-020-0158-1;

Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women. Sci Rep. 2019 Dec 05; 9(1):18774. PMID: 31801960; PMCID: PMC6892860; DOI: 10.1038/s41598-019-55022-z;

Fu Y, Zhou N, Yu Y, Zhang H, Sun Y, Zhang M, Chen X, Wang Y, Yu Q. Profiling of schizophrenia-associated serum peptides by MALDI-TOF-MS. J Neural Transm (Vienna). 2020 01; 127(1):95-101. PMID: 31786691; DOI: 10.1007/s00702-019-02108-7;

Yang M, Zhou N, Zhang H, Kang G, Cao B, Kang Q, Li R, Zhu X, Rao W, Yu Q. Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses. PeerJ. 2019; 7:e7327. PMID: 31346501; PMCID: PMC6642793; DOI: 10.7717/peerj.7327;

Rosato AJ, Chen X, Tanaka Y, Farrer LA, Kranzler HR, Nunez YZ, Henderson DC, Gelernter J, Zhang H. Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence. Epigenomics. 2019 05; 11(7):739-749.View Related Profiles.

Henderson, David
Zhang, Huiping
Farrer, Lindsay

PMID: 31140863; PMCID: PMC6595542; DOI: 10.2217/epi-2018-0177;

Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women. Sci Rep. 2019 03 15; 9(1):4660. PMID: 30874594; PMCID: PMC6420601; DOI: 10.1038/s41598-019-41110-7;

Zhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test. Am J Med Genet B Neuropsychiatr Genet. 2018 07; 177(5):511-519.View Related Profiles.

Zhang, Huiping
Farrer, Lindsay

PMID: 30134085; PMCID: PMC6110090; DOI: 10.1002/ajmg.b.32642;

Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. Int J Neuropsychopharmacol. 2018 01 01; 21(1):12-20.View Related Profiles.

Liu, Chunyu
Zhang, Huiping

PMID: 29106553; PMCID: PMC5789263; DOI: 10.1093/ijnp/pyx087;

Parade SH, Parent J, Rabemananjara K, Seifer R, Marsit CJ, Yang BZ, Zhang H, Tyrka AR. Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity. Dev Psychopathol. 2017 12; 29(5):1627-1634. PMID: 29162173; PMCID: PMC5720139; DOI: 10.1017/S0954579417001286;

Mei S, Gao T, Li J, Zhang Y, Chai J, Wang L, Zhang Z, Zhang H. Internet addiction in college students and its relationship with cigarette smoking and alcohol use in Northeast China. Asia Pac Psychiatry. 2017 Dec; 9(4). PMID: 29193712; PMCID: PMC6003817; DOI: 10.1111/appy.12281;

DeVito EE, Herman AI, Konkus NS, Zhang H, Sofuoglu M. Atomoxetine in abstinent cocaine users: Sex differences. Data Brief. 2017 Oct; 14:566-572. PMID: 28861456; PMCID: PMC5568877; DOI: 10.1016/j.dib.2017.08.011;

DeVito EE, Herman AI, Konkus NS, Zhang H, Sofuoglu M. Atomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects. Pharmacol Biochem Behav. 2017 Aug; 159:55-61. PMID: 28716656; PMCID: PMC5573182; DOI: 10.1016/j.pbb.2017.07.002;

Liu R, Ning L, Liu X, Zhang H, Yu Y, Zhang S, Rao W, Shi J, Sun H, Yu Q. Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. Oncotarget. 2017 Feb 28; 8(9):15838-15845. PMID: 28178662; PMCID: PMC5362527; DOI: 10.18632/oncotarget.15028;

Xu H, Wang F, Kranzler HR, Gelernter J, Zhang H. Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes. Sci Rep. 2017 02 06; 7:41816. PMID: 28165486; PMCID: PMC5292964; DOI: 10.1038/srep41816;

Rao W, Zhou N, Zhang H, Liu R, Zhang S, Su Y, Yang G, Ma Y, Shi J, Yu Y, Yu Q. A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia. Dis Markers. 2017; 2017:3104180. PMID: 28203040; PMCID: PMC5288525; DOI: 10.1155/2017/3104180;

Zhang H, Gelernter J. Review: DNA methylation and alcohol use disorders: Progress and challenges. Am J Addict. 2017 Aug; 26(5):502-515. PMID: 27759945; PMCID: PMC6003819; DOI: 10.1111/ajad.12465;

Yang G, Xu H, Zhang H, Yu Q, Wu Y, Shi J, Rao W, You Y, Kou C, Yu Y. Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China. PLoS One. 2016; 11(7):e0159584. PMID: 27434078; PMCID: PMC4951095; DOI: 10.1371/journal.pone.0159584;

He H, Zhen Q, Li Y, Kou CG, Tao YC, Wang C, Kanu JS, Lu YP, Yu MX, Zhang HP, Yu YQ, Li B, Liu YW. Prevalence of High Non-high-density Lipoprotein Cholesterol and Associated Risk Factors in Patients with Diabetes Mellitus in Jilin Province, China: A Cross-sectional Study. Biomed Environ Sci. 2016 07; 29(7):534-8. PMID: 27554125; DOI: 10.3967/bes2016.071;

Wang J, Liu Y, Liu F, Huang C, Han S, Lv Y, Liu CJ, Zhang S, Qin Y, Ling L, Gao M, Yu S, Li C, Huang M, Liao S, Hu X, Lu Z, Liu X, Jiang T, Tang Z, Zhang H, Guo AY, Liu M. Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. Sci Rep. 2016 Apr 07; 6:24226. PMID: 27052676; PMCID: PMC4823745; DOI: 10.1038/srep24226;

Li R, Li W, Lun Z, Zhang H, Sun Z, Kanu JS, Qiu S, Cheng Y, Liu Y. Prevalence of metabolic syndrome in Mainland China: a meta-analysis of published studies. BMC Public Health. 2016 Apr 01; 16:296. PMID: 27039079; PMCID: PMC4818385; DOI: 10.1186/s12889-016-2870-y;

Wang F, Xu H, Zhao H, Gelernter J, Zhang H. DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Sci Rep. 2016 Jan 14; 6:19430. PMID: 26763658; PMCID: PMC4725922; DOI: 10.1038/srep19430;

Yu M, Liu Y, Li Yong, Zhang H, Lu Y, Kanu JS, Qiao Y, Tang Y, Zhen Q, Cheng Y. Endothelial lipase gene polymorphisms are associated with serum HDL-C levels but not coronary heart disease. Int J Clin Exp Pathol. 2016; 9(2):2181-2191.

Li Z, Yao Y, Yu Y, Shi J, Liu Y, Tao Y, Kou C, Zhang H, Han W, Yin Y, Jiang L, Li B. Prevalence and Associated Factors of Passive Smoking among Women in Jilin Province, China: A Cross-Sectional Study. Int J Environ Res Public Health. 2015 Oct 30; 12(11):13970-80. PMID: 26529002; PMCID: PMC4661627; DOI: 10.3390/ijerph121113970;

Yin Y, Han W, Wang Y, Zhang Y, Wu S, Zhang H, Jiang L, Wang R, Zhang P, Yu Y, Li B. Identification of Risk Factors Affecting Impaired Fasting Glucose and Diabetes in Adult Patients from Northeast China. Int J Environ Res Public Health. 2015 Oct 12; 12(10):12662-78. PMID: 26473900; PMCID: PMC4626992; DOI: 10.3390/ijerph121012662;

Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study of body mass index in subjects with alcohol dependence. Addict Biol. 2017 Mar; 22(2):535-549.View Related Profiles.

Zhang, Huiping
Farrer, Lindsay

PMID: 26458734; PMCID: PMC5102811; DOI: 10.1111/adb.12317;

Xiang Y, Kim KY, Gelernter J, Park IH, Zhang H. Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons. PLoS One. 2015; 10(8):e0134907. PMID: 26266540; PMCID: PMC4534442; DOI: 10.1371/journal.pone.0134907;

Li Z, Yao Y, Han W, Yu Y, Liu Y, Tao Y, Kou C, Jiang L, Sun Q, Yin Y, Zhang H, Li B. Smoking Prevalence and Associated Factors as well as Attitudes and Perceptions towards Tobacco Control in Northeast China. Int J Environ Res Public Health. 2015 Jul 22; 12(7):8606-18. PMID: 26206569; PMCID: PMC4515736; DOI: 10.3390/ijerph120708606;

Lu Y, Habtetsion TG, Li Y, Zhang H, Qiao Y, Yu M, Tang Y, Zhen Q, Cheng Y, Liu Y. Association of NCOA2 gene polymorphisms with obesity and dyslipidemia in the Chinese Han population. Int J Clin Exp Pathol. 2015; 8(6):7341-9. PMID: 26261634; PMCID: PMC4525968

Hou J, Seneviratne C, Su X, Taylor J, Johnson B, Wang XQ, Zhang H, Kranzler HR, Kang J, Liu L. Subgroup Identification in Personalized Treatment of Alcohol Dependence. Alcohol Clin Exp Res. 2015 Jul; 39(7):1253-9. PMID: 26031187; PMCID: PMC4491003; DOI: 10.1111/acer.12759;

Song Y, Wang F, Wang B, Tao S, Zhang H, Liu S, Ramirez O, Zeng Q. Time series analyses of hand, foot and mouth disease integrating weather variables. PLoS One. 2015; 10(3):e0117296. PMID: 25729897; PMCID: PMC4346267; DOI: 10.1371/journal.pone.0117296;

Liu J, Wang F, Gao X, Zhang H, Wan X, Yang C. A penalized regression approach for integrative analysis in genome-wide association studies. J Biomet Biostat. 2015; 6(2):1000228.

Zhang H, Wang F, Xu H, Liu Y, Liu J, Zhao H, Gelernter J. Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. Hum Genet. 2014 Nov; 133(11):1383-94. PMID: 25073604; PMCID: PMC4185230; DOI: 10.1007/s00439-014-1473-x;

Zhang H, Wang F, Kranzler HR, Yang C, Xu H, Wang Z, Zhao H, Gelernter J. Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. Hum Genet. 2014 Sep; 133(9):1093-104. PMID: 24889829; PMCID: PMC4127343; DOI: 10.1007/s00439-014-1452-2;

Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, Lipschitz D, Douglas-Palumberi H, Ge M, Perepletchikova F, O'Loughlin K, Hudziak JJ, Gelernter J, Kaufman J. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry. 2014 Apr; 53(4):417-24.e5. PMID: 24655651; PMCID: PMC4126411; DOI: 10.1016/j.jaac.2013.12.025;

Barker JM, Zhang H, Villafane JJ, Wang TL, Torregrossa MM, Taylor JR. Epigenetic and pharmacological regulation of 5HT3 receptors controls compulsive ethanol seeking in mice. Eur J Neurosci. 2014 Mar; 39(6):999-1008. PMID: 24772465; PMCID: PMC4004969

Zhang H. Psychotherapeutic Treatments for Posttraumatic Stress Disorder. J Trauma Treat. 2013; S4(e001). View Publication

Xu H, Wang F, Liu Y, Yu Y, Gelernter J, Zhang H. Sex-biased methylome and transcriptome in human prefrontal cortex. Hum Mol Genet. 2014 Mar 01; 23(5):1260-70. PMID: 24163133; PMCID: PMC3919013; DOI: 10.1093/hmg/ddt516;

Wang F, Gelernter J, Zhang H. Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use Disorders. J Addict Res Ther. 2013 Jul 23; 4(155). PMID: 25383235; PMCID: PMC4221234; DOI: 10.4172/2155-6105.1000155;

Zhang H, Wang F, Kranzler HR, Zhao H, Gelernter J. Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. PLoS One. 2013; 8(6):e65648. PMID: 23799031; PMCID: PMC3683055; DOI: 10.1371/journal.pone.0065648;

Li Z, Zhang H. Analyzing Interaction of µ-, d- and ?-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method. J Addict Res Ther. 2013 May 14; Suppl 7:007. PMID: 24533225; PMCID: PMC3921888

Yang BZ, Zhang H, Ge W, Weder N, Douglas-Palumberi H, Perepletchikova F, Gelernter J, Kaufman J. Child abuse and epigenetic mechanisms of disease risk. Am J Prev Med. 2013 Feb; 44(2):101-7. PMID: 23332324; PMCID: PMC3758252; DOI: 10.1016/j.amepre.2012.10.012;

Wang F, Simen A, Arias A, Lu QW, Zhang H. A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. Hum Genet. 2013 Mar; 132(3):347-58. PMID: 23203481; PMCID: PMC3570676; DOI: 10.1007/s00439-012-1251-6;

Wang F, Gelernter J, Kranzler HR, Zhang H. Identification of POMC exonic variants associated with substance dependence and body mass index. PLoS One. 2012; 7(9):e45300. PMID: 23028917; PMCID: PMC3444488; DOI: 10.1371/journal.pone.0045300;

Zhang H, Herman AI, Kranzler HR, Anton RF, Zhao H, Zheng W, Gelernter J. Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcohol Clin Exp Res. 2013 Jan; 37 Suppl 1:E108-15. PMID: 22924764; PMCID: PMC3511647; DOI: 10.1111/j.1530-0277.2012.01928.x;

Zhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J. Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. J Hum Genet. 2012 Oct; 57(10):670-5. PMID: 22914673; PMCID: PMC3481015; DOI: 10.1038/jhg.2012.98;

Zhang XY, Chen DC, Xiu MH, Hui L, Liu H, Luo X, Zuo L, Zhang H, Kosten TA, Kosten TR. Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. Schizophr Res. 2012 Oct; 141(1):48-53. PMID: 22871345; DOI: 10.1016/j.schres.2012.07.011;

Barker JM, Zhang Y, Wang F, Taylor JR, Zhang H. Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain. Alcohol Clin Exp Res. 2013 Jan; 37 Suppl 1:E101-7. PMID: 22834954; PMCID: PMC3511914; DOI: 10.1111/j.1530-0277.2012.01906.x;

Zhang H, Wang F, Kranzler HR, Anton RF, Gelernter J. Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. Behav Brain Funct. 2012 May 16; 8:23. PMID: 22591552; PMCID: PMC3406967; DOI: 10.1186/1744-9081-8-23;

Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, Kosten TA, Kosten TR. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Hum Genet. 2012 Jul; 131(7):1187-95. PMID: 22362486; PMCID: PMC3671849; DOI: 10.1007/s00439-012-1150-x;

Xie P, Kranzler HR, Zhang H, Oslin D, Anton RF, Farrer LA, Gelernter J. Childhood adversity increases risk for nicotine dependence and interacts with a5 nicotinic acetylcholine receptor genotype specifically in males. Neuropsychopharmacology. 2012 Feb; 37(3):669-76.View Related Profiles.

Zhang, Huiping
Farrer, Lindsay

PMID: 22012472; PMCID: PMC3260970; DOI: 10.1038/npp.2011.240;

Cui D, Zhang H, Yang BZ, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. Variation in NGFB is associated with primary affective disorders in women. Am J Med Genet B Neuropsychiatr Genet. 2011 Jun; 156B(4):401-12. PMID: 21294249; PMCID: PMC3108453; DOI: 10.1002/ajmg.b.31175;

Zhang H, Kranzler HR, Poling J, Gelernter J. Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. Neuropsychopharmacology. 2010 Oct; 35(11):2211-24. PMID: 20631687; PMCID: PMC3055317; DOI: 10.1038/npp.2010.95;

Zhang H, Smith GN, Liu X, Holden JJ. Association of MAOA, 5-HTT, and NET promoter polymorphisms with gene expression and protein activity in human placentas. Physiol Genomics. 2010 Jun; 42(1):85-92. PMID: 20332182; PMCID: PMC2888558; DOI: 10.1152/physiolgenomics.00220.2009;

Zhang H, Gelernter J, Gruen JR, Kranzler HR, Herman AI, Simen AA. Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region. J Hum Genet. 2010 May; 55(5):278-84. PMID: 20300121; PMCID: PMC2876206; DOI: 10.1038/jhg.2010.22;

Zuo L, Gelernter J, Kranzler HR, Stein MB, Zhang H, Wei F, Sen S, Poling J, Luo X. ADH1A variation predisposes to personality traits and substance dependence. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 05; 153B(2):376-386. PMID: 19526455; PMCID: PMC2861415; DOI: 10.1002/ajmg.b.30990;

Zhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J. Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use. Neuropsychopharmacology. 2009 Nov; 34(12):2508-16. PMID: 19606085; PMCID: PMC2898508; DOI: 10.1038/npp.2009.80;

Zhang H, Kranzler HR, Weiss RD, Luo X, Brady KT, Anton RF, Farrer LA, Gelernter J. Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies. Biol Psychiatry. 2009 Jul 15; 66(2):128-36.View Related Profiles.

Zhang, Huiping
Farrer, Lindsay

PMID: 19217079; PMCID: PMC2896237; DOI: 10.1016/j.biopsych.2008.12.021;

Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study. J Alzheimers Dis. 2009; 17(4):887-98. PMID: 19542613; PMCID: PMC4084650; DOI: 10.3233/JAD-2009-1106;

Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 05; 147B(7):1028-39. PMID: 18213616; PMCID: PMC3162230; DOI: 10.1002/ajmg.b.30701;

Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 05; 147B(2):179-86. PMID: 17918242; PMCID: PMC3160628; DOI: 10.1002/ajmg.b.30589;

Hernandez-Avila CA, Covault J, Wand G, Zhang H, Gelernter J, Kranzler HR. Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation. Pharmacogenet Genomics. 2007 Dec; 17(12):1031-8. PMID: 18004207; DOI: 10.1097/FPC.0b013e3282f0b99c;

Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol Psychiatry. 2008 May; 13(5):531-43. PMID: 17622222; PMCID: PMC3163084; DOI: 10.1038/sj.mp.4002035;

Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness. Hum Mol Genet. 2007 Jul 01; 16(13):1557-68. PMID: 17468496; DOI: 10.1093/hmg/ddm104;

Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcohol Clin Exp Res. 2007 Apr; 31(4):555-63.View Related Profiles.

Kaplan, Gary
Zhang, Huiping

PMID: 17374034; DOI: 10.1111/j.1530-0277.2007.00339.x;

Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S, Yang BZ, Rasmussen A, Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 05; 141B(4):387-93. PMID: 16649215; PMCID: PMC2567822; DOI: 10.1002/ajmg.b.30332;

Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet. 2006 Mar 15; 15(6):807-19. PMID: 16476706; PMCID: PMC3164878; DOI: 10.1093/hmg/ddl024;

Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 01; 128B(1):94-101. PMID: 15211640; DOI: 10.1002/ajmg.b.30019;

Zhang H, Liu X, Zhang C, Mundo E, Macciardi F, Grayson DR, Guidotti AR, Holden JJ. Reelin gene alleles and susceptibility to autism spectrum disorders. Mol Psychiatry. 2002; 7(9):1012-7. PMID: 12399956; DOI: 10.1038/sj.mp.4001124;

Zhang H, Moldenhauer G, Kipriyanov SM, Braunagel M, Klausse J, Little M. Construction, sequencing and binding properties of an anti-CD5 single-chain antibody. Tumor Targeting. 1996; 2:314-321.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 96 publications over 24 distinct years, with a maximum of 10 publications in 2025

Bar chart showing 96 publications over 24 distinct years, with a maximum of 10 publications in 2025

Year	Publications
1996	1
2002	1
2004	1
2006	2
2007	4
2008	2
2009	3
2010	4
2011	2
2012	8
2013	6
2014	4
2015	9
2016	7
2017	7
2018	2
2019	5
2020	5
2021	1
2022	3
2023	4
2024	2
2025	10
2026	3

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Substance Use Disorders
Psychiatric Genetics
Epigenetics

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