Honghuang Lin, PhD
Adjunct Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Computational Biomedicine

PhD, National University of Singapore (NUS)



I am a bioinformatician with training in mathematics, machine learning, genetics, and digital medicine. I am also an investigator of the Framingham Heart Study. Our lab is mainly focused on the development and application of computational tools to study complex diseases.

1. Identification of genetic causes of complex diseases. We have been involved in multiple large-scale genetic consortiums, such as the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Trans-Omics for Precision Medicine (TOPMed) program, and Alzheimer's Disease Sequencing Project (ADSP). These studies have identified hundreds of genetic loci associated with atrial fibrillation, heart failure, hypertension, and Alzheimer’s disease.

2. Integration of multi-omics data to understand disease molecular mechanisms. Complex diseases are usually caused by the interplay of genetic and environmental factors. We have identified numerous molecular signatures from gene expression, protein expression, and DNA methylation that are related to aging and cardiovascular disease. We are also developing computational methods to integrate different molecular signatures and build gene interaction networks to study potential disease regulation networks.

3. Development of machine learning models for early disease diagnosis. We have built multiple machine learning models to predict dementia risk from midlife risk factors and neuropsychological tests. In combination with neuroimaging and blood-based measures, we are also developing multimodal machine learning methods to identify new biomarkers that are predictive of future cognitive impairment.

4. Exploration of digital and wearable devices for health monitoring. We have deployed thousands of wearable devices and mobile apps to monitor cardiovascular health and cognitive health. We are integrating active engagement with passive engagement technologies from the habitual environment to make sustained monitoring feasible. Novel analytic strategies are also being developed to analyze big unstructured data to identify potential digital biomarkers that are predictive of future health outcomes.

Member
Boston University
BU-BMC Cancer Center


Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Integrated Digital Technology Platform for Optimization of Precision Brain Health
07/01/2020 - 06/30/2024 (Multi-PI)
PI: Honghuang Lin, PhD
American Heart Association


Identification of digital biomarkers for Alzheimer's disease
03/01/2020 - 02/28/2023 (PI)
Alzheimer's Association


Assessing Alzheimer disease risk and heterogeneity using multimodal machine learning approaches
09/15/2021 - 12/31/2021 (Multi-PI)
PI: Honghuang Lin, PhD
NIH/National Institute on Aging
1U01AG068221-01A1



Title

Biostatistical analysis of TOPMed genetics data
06/01/2019 - 05/31/2020 (PI)
University of Connecticut Health Center

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Pirruccello JP, Lin H, Khurshid S, Nekoui M, Weng LC, Ramachandran VS, Isselbacher EM, Benjamin EJ, Lubitz SA, Lindsay ME, Ellinor PT. Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals. JAMA. 2022 11 15; 328(19):1935-1944. PMID: 36378208
     
  2. Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, Yin X, Chen SH, Ferreira T, Highland HH, Ji Y, Karaderi T, Lin K, Lüll K, Malden DE, Medina-Gomez C, Machado M, Moore A, Rüeger S, Sim X, Vrieze S, Ahluwalia TS, Akiyama M, Allison MA, Alvarez M, Andersen MK, Ani A, Appadurai V, Arbeeva L, Bhaskar S, Bielak LF, Bollepalli S, Bonnycastle LL, Bork-Jensen J, Bradfield JP, Bradford Y, Braund PS, Brody JA, Burgdorf KS, Cade BE, Cai H, Cai Q, Campbell A, Cañadas-Garre M, Catamo E, Chai JF, Chai X, Chang LC, Chang YC, Chen CH, Chesi A, Choi SH, Chung RH, Cocca M, Concas MP, Couture C, Cuellar-Partida G, Danning R, Daw EW, Degenhard F, Delgado GE, Delitala A, Demirkan A, Deng X, Devineni P, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Ekici AB, Engmann JE, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Francescatto M, Freitag-Wolf S, Fuchsberger C, Galesloot TE, Gao Y, Gao Z, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, He J, Heard-Costa N, Hebbar P, Hindy G, Ho YA, Hofer E, Holliday E, Horn K, Hornsby WE, Hottenga JJ, Huang H, Huang J, Huerta-Chagoya A, Huffman JE, Hung YJ, Huo S, Hwang MY, Iha H, Ikeda DD, Isono M, Jackson AU, Jäger S, Jansen IE, Johansson I, Jonas JB, Jonsson A, Jørgensen T, Kalafati IP, Kanai M, Kanoni S, Kårhus LL, Kasturiratne A, Katsuya T, Kawaguchi T, Kember RL, Kentistou KA, Kim HN, Kim YJ, Kleber ME, Knol MJ, Kurbasic A, Lauzon M, Le P, Lea R, Lee JY, Leonard HL, Li SA, Li X, Li X, Liang J, Lin H, Lin SY, Liu J, Liu X, Lo KS, Long J, Lores-Motta L, Luan J, Lyssenko V, Lyytikäinen LP, Mahajan A, Mamakou V, Mangino M, Manichaikul A, Marten J, Mattheisen M, Mavarani L, McDaid AF, Meidtner K, Melendez TL, Mercader JM, Milaneschi Y, Miller JE, Millwood IY, Mishra PP, Mitchell RE, Møllehave LT, Morgan A, Mucha S, Munz M, Nakatochi M, Nelson CP, Nethander M, Nho CW, Nielsen AA, Nolte IM, Nongmaithem SS, Noordam R, Ntalla I, Nutile T, Pandit A, Christofidou P, Pärna K, Pauper M, Petersen ERB, Petersen LV, Pitkänen N, Polašek O, Poveda A, Preuss MH, Pyarajan S, Raffield LM, Rakugi H, Ramirez J, Rasheed A, Raven D, Rayner NW, Riveros C, Rohde R, Ruggiero D, Ruotsalainen SE, Ryan KA, Sabater-Lleal M, Saxena R, Scholz M, Sendamarai A, Shen B, Shi J, Shin JH, Sidore C, Sitlani CM, Slieker RC, Smit RAJ, Smith AV, Smith JA, Smyth LJ, Southam L, Steinthorsdottir V, Sun L, Takeuchi F, Tallapragada DSP, Taylor KD, Tayo BO, Tcheandjieu C, Terzikhan N, Tesolin P, Teumer A, Theusch E, Thompson DJ, Thorleifsson G, Timmers PRHJ, Trompet S, Turman C, Vaccargiu S, van der Laan SW, van der Most PJ, van Klinken JB, van Setten J, Verma SS, Verweij N, Veturi Y, Wang CA, Wang C, Wang L, Wang Z, Warren HR, Bin Wei W, Wickremasinghe AR, Wielscher M, Wiggins KL, Winsvold BS, Wong A, Wu Y, Wuttke M, Xia R, Xie T, Yamamoto K, Yang J, Yao J, Young H, Yousri NA, Yu L, Zeng L, Zhang W, Zhang X, Zhao JH, Zhao W, Zhou W, Zimmermann ME, Zoledziewska M, Adair LS, Adams HHH, Aguilar-Salinas CA, Al-Mulla F, Arnett DK, Asselbergs FW, Åsvold BO, Attia J, Banas B, Bandinelli S, Bennett DA, Bergler T, Bharadwaj D, Biino G, Bisgaard H, Boerwinkle E, Böger CA, Bønnelykke K, Boomsma DI, Børglum AD, Borja JB, Bouchard C, Bowden DW, Brandslund I, Brumpton B, Buring JE, Caulfield MJ, Chambers JC, Chandak GR, Chanock SJ, Chaturvedi N, Chen YI, Chen Z, Cheng CY, Christophersen IE, Ciullo M, Cole JW, Collins FS, Cooper RS, Cruz M, Cucca F, Cupples LA, Cutler MJ, Damrauer SM, Dantoft TM, de Borst GJ, de Groot LCPGM, De Jager PL, de Kleijn DPV, Janaka de Silva H, Dedoussis GV, den Hollander AI, Du S, Easton DF, Elders PJM, Eliassen AH, Ellinor PT, Elmståhl S, Erdmann J, Evans MK, Fatkin D, Feenstra B, Feitosa MF, Ferrucci L, Ford I, Fornage M, Franke A, Franks PW, Freedman BI, Gasparini P, Gieger C, et al. A saturated View Related Profiles. PMID: 36224396; PMCID: PMC9605867; DOI: 10.1038/s41586-022-05275-y;
     
  3. Soni A, Herbert C, Filippaios A, Broach J, Colubri A, Fahey N, Woods K, Nanavati J, Wright C, Orwig T, Gilliam K, Kheterpal V, Suvarna T, Nowak C, Schrader S, Lin H, O'Connor L, Pretz C, Ayturk D, Orvek E, Flahive J, Lazar P, Shi Q, Achenbach C, Murphy R, Robinson M, Gibson L, Stamegna P, Hafer N, Luzuriaga K, Barton B, Heetderks W, Manabe YC, McManus D. Comparison of Rapid Antigen Tests' Performance Between Delta and Omicron Variants of SARS-CoV-2 : A Secondary Analysis From a Serial Home Self-testing Study. Ann Intern Med. 2022 Oct 11. PMID: 36215709; PMCID: PMC9578286; DOI: 10.7326/M22-0760;
     
  4. Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins JW, Haessler J, Lyytikäinen LP, Repetto L, Concas MP, van den Berg ME, Weiss S, Baldassari AR, Bartz TM, Cook JP, Evans DS, Freudling R, Hines O, Isaksen JL, Lin H, Mei H, Moscati A, Müller-Nurasyid M, Nursyifa C, Qian Y, Richmond A, Roselli C, Ryan KA, Tarazona-Santos E, Thériault S, van Duijvenboden S, Warren HR, Yao J, Raza D, Aeschbacher S, Ahlberg G, Alonso A, Andreasen L, Bis JC, Boerwinkle E, Campbell A, Catamo E, Cocca M, Cutler MJ, Darbar D, De Grandi A, De Luca A, Ding J, Ellervik C, Ellinor PT, Felix SB, Froguel P, Fuchsberger C, Gögele M, Graff C, Graff M, Guo X, Hansen T, Heckbert SR, Huang PL, Huikuri HV, Hutri-Kähönen N, Ikram MA, Jackson RD, Junttila J, Kavousi M, Kors JA, Leal TP, Lemaitre RN, Lin HJ, Lind L, Linneberg A, Liu S, MacFarlane PW, Mangino M, Meitinger T, Mezzavilla M, Mishra PP, Mitchell RN, Mononen N, Montasser ME, Morrison AC, Nauck M, Nauffal V, Navarro P, Nikus K, Pare G, Patton KK, Pelliccione G, Pittman A, Porteous DJ, Pramstaller PP, Preuss MH, Raitakari OT, Reiner AP, Ribeiro ALP, Rice KM, Risch L, Schlessinger D, Schotten U, Schurmann C, Shen X, Shoemaker MB, Sinagra G, Sinner MF, Soliman EZ, Stoll M, Strauch K, Tarasov K, Taylor KD, Tinker A, Trompet S, Uitterlinden A, Völker U, Völzke H, Waldenberger M, Weng LC, Whitsel EA, Wilson JG, Avery CL, Conen D, Correa A, Cucca F, Dörr M, Gharib SA, Girotto G, Grarup N, Hayward C, Jamshidi Y, Järvelin MR, Jukema JW, Kääb S, Kähönen M, Kanters JK, Kooperberg C, Lehtimäki T, Lima-Costa MF, Liu Y, Loos RJF, Lubitz SA, Mook-Kanamori DO, Morris AP, O'Connell JR, Olesen MS, Orini M, Padmanabhan S, Pattaro C, Peters A, Psaty BM, Rotter JI, Stricker B, van der Harst P, van Duijn CM, Verweij N, Wilson JF, Arking DE, Ramirez J, Lambiase PD, Sotoodehnia N, Mifsud B, Newton-Cheh C, Munroe PB. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nat Commun. 2022 Sep 01; 13(1):5144. PMID: 36050321; PMCID: PMC9436946; DOI: 10.1038/s41467-022-32821-z;
     
  5. Soni A, Herbert C, Lin H, Pretz C, Stamegna P, Orwig T, Wright C, Tarrant S, Behar S, Suvarna T, Schrader S, Harman E, Nowak C, Kheterpal V, Rao LV, Cashman L, Orvek E, Ayturk D, Lazar P, Wang Z, Barton B, Achenbach CJ, Murphy RL, Robinson M, Manabe Y, Wang B, Pandey S, Colubri A, Oâ Connor L, Lemon SC, Fahey N, Luzuriaga KL, Hafer N, Heetderks W, Broach J, McManus DD. Performance of Screening for SARS-CoV-2 using Rapid Antigen Tests to Detect Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infection: findings from the Test Us at Home prospective cohort study. medRxiv. 2022 Aug 06. PMID: 35982680; PMCID: PMC9387089; DOI: 10.1101/2022.08.05.22278466;
     
  6. Filippaios A, Tran KT, Mehawej J, Ding E, Paul T, Lessard D, Barton B, Lin H, Naeem S, Otabil EM, Noorishirazi K, Dai Q, Sadiq H, Chon KH, Soni A, Saczynski J, McManus DD. Psychosocial measures in relation to smartwatch alerts for atrial fibrillation detection. Cardiovasc Digit Health J. 2022 Oct; 3(5):198-200. PMID: 36310684; PMCID: PMC9596300; DOI: 10.1016/j.cvdhj.2022.07.069;
     
  7. Herbert C, Shi Q, Kheterpal V, Nowak C, Suvarna T, Durnan B, Schrader S, Behar S, Naeem S, Tarrant S, Kalibala B, Singh A, Gerber B, Barton B, Lin H, Cohen-Wolkowiez M, Corbie-Smith G, Kibbe W, Marquez J, Baek J, Hafer N, Gibson L, O'Connor L, Broach J, Heetderks W, McManus D, Soni A. Use of a Digital Assistant to Report COVID-19 Rapid Antigen Self-test Results to Health Departments in 6 US Communities. JAMA Netw Open. 2022 Aug 01; 5(8):e2228885. PMID: 36018589; PMCID: PMC9419013; DOI: 10.1001/jamanetworkopen.2022.28885;
     
  8. Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D, Lip GYH, Løchen ML, Lucassen W, Malaczynska-Rajpold K, Massberg S, Merino JL, Meyer R, Mont L, Myers MC, Neubeck L, Niiranen T, Oeff M, Oldgren J, Potpara TS, Psaroudakis G, Pürerfellner H, Ravens U, Rienstra M, Rivard L, Scherr D, Schotten U, Shah D, Sinner MF, Smolnik R, Steinbeck G, Steven D, Svennberg E, Thomas D, True Hills M, van Gelder IC, Vardar B, Palà E, Wakili R, Wegscheider K, Wieloch M, Willems S, Witt H, Ziegler A, Daniel Zink M, Kirchhof P. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. Europace. 2022 Jul 27. PMID: 35894842; DOI: 10.1093/europace/euac062;
     
  9. Herbert C, Kheterpal V, Suvarna T, Broach J, Marquez JL, Gerber B, Schrader S, Nowak C, Harman E, Heetderks W, Fahey N, Orvek E, Lazar P, Ferranto J, Noorishirazi K, Valpady S, Shi Q, Lin H, Marvel K, Gibson L, Barton B, Lemon S, Hafer N, McManus D, Soni A. Design and Preliminary Findings of Adherence to the Self-Testing for Our Protection From COVID-19 (STOP COVID-19) Risk-Based Testing Protocol: Prospective Digital Study. JMIR Form Res. 2022 Jun 16; 6(6):e38113. PMID: 35649180; PMCID: PMC9205422; DOI: 10.2196/38113;
     
  10. Pirruccello JP, Di Achille P, Nauffal V, Nekoui M, Friedman SF, Klarqvist MDR, Chaffin MD, Weng LC, Cunningham JW, Khurshid S, Roselli C, Lin H, Koyama S, Ito K, Kamatani Y, Komuro I, Jurgens SJ, Benjamin EJ, Batra P, Natarajan P, Ng K, Hoffmann U, Lubitz SA, Ho JE, Lindsay ME, Philippakis AA, Ellinor PT. Genetic analysis of right heart structure and function in 40,000 people. Nat Genet. 2022 Jun; 54(6):792-803.View Related Profiles. PMID: 35697867
     
Showing 10 of 180 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 180 publications over 18 distinct years, with a maximum of 21 publications in 2018 and 2022

YearPublications
20041
20052
20069
20078
20084
20092
20114
20125
20134
201417
20155
201615
201717
201821
201913
202019
202113
202221
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Bioinformatics
Machine learning
Microarray data analysis
Next generation sequencing
Multi-omics data integration

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