Hiroshi Tokuo | Profiles RNS

Hiroshi Tokuo, MD

Research Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

MD, Kumamoto University
PhD, Kumamoto University

Websites

	Physiology & Biophysics Faculty
	LinkedIn
	ResearchGate
	Outrun the Sun Profile

ORCID : 0000-0002-7614-7805

Hiroshi Tokuo, PhD is a Research Assistant Professor of Physiology & Biophysics at the Chobanian and Avedisian School of Medicine. Before coming to Massachusetts Dr. Tokuo worked as a dermatologist in Japan, where he is a licensed physician. Now, he trains medical students on Physiology and is a member of the American Society for Cell Biology and the American Biophysical Society. In addition to writing papers and attending conferences, Dr. Tokuo has served as Principal Investigator for two research projects.

BU Research

Identifying New Targets to Prevent Tumor Angiogenesis in Melanoma
06/01/2021 - 05/31/2022 (PI)
Outrun the Sun

Regulation of myosin-X
03/09/2013 - 07/31/2015 (PI)
NIH/National Institute on Deafness & Communication Disorders
5R03DC009887-04

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Tokuo H, Komaba S, Coluccio LM. In pancreatic ß-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi. Mol Biol Cell. 2021 06 01; 32(12):1210-1220.View Related Profiles.

Tokuo, Hiroshi
Coluccio, Lynne

PMID: 33826361; PMCID: PMC8351557; DOI: 10.1091/mbc.E21-03-0094;

Tokuo H. Myosin X. Adv Exp Med Biol. 2020; 1239:391-403. PMID: 32451868

Tokuo H, Bhawan J, Coluccio LM. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11; 8(1):10449.View Related Profiles.

Tokuo, Hiroshi
Bhawan, Jag
Coluccio, Lynne

PMID: 29993000; PMCID: PMC6041326; DOI: 10.1038/s41598-018-28717-y;

Tokuo H, Coluccio LM. Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Sep; 24(18):2820-33.View Related Profiles.

Tokuo, Hiroshi
Coluccio, Lynne

PMID: 23864705; PMCID: PMC3771945; DOI: 10.1091/mbc.E12-12-0884;

Watanabe TM, Tokuo H, Gonda K, Higuchi H, Ikebe M. Myosin-X induces filopodia by multiple elongation mechanism. J Biol Chem. 2010 Jun 18; 285(25):19605-14. PMID: 20392702; PMCID: PMC2885239; DOI: 10.1074/jbc.M109.093864;

Tokuo H, Mabuchi K, Ikebe M. The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation. J Cell Biol. 2007 Oct 22; 179(2):229-38. PMID: 17954606; PMCID: PMC2064759; DOI: 10.1083/jcb.200703178;

Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J Biol Chem. 2005 Nov 25; 280(47):39524-33. PMID: 16169856

Saeki N, Tokuo H, Ikebe M. BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. J Biol Chem. 2005 Mar 18; 280(11):10128-34. PMID: 15644318

Tokuo H, Ikebe M. Myosin X transports Mena/VASP to the tip of filopodia. Biochem Biophys Res Commun. 2004 Jun 18; 319(1):214-20. PMID: 15158464

Feng L, Yunoue S, Tokuo H, Ozawa T, Zhang D, Patrakitkomjorn S, Ichimura T, Saya H, Araki N. PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin. FEBS Lett. 2004 Jan 16; 557(1-3):275-82. PMID: 14741381

Showing 10 of 15 results. Show More

Yunoue S, Tokuo H, Fukunaga K, Feng L, Ozawa T, Nishi T, Kikuchi A, Hattori S, Kuratsu J, Saya H, Araki N. Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras. J Biol Chem. 2003 Jul 18; 278(29):26958-69. PMID: 12730209

Kageshita T, Ishihara T, Tokuo H, Funasaka Y, Ichihashi M, Dong J, Nakajima M, Ono T. Widespread expression of parathyroid hormone-related peptide in melanocytic cells. Br J Dermatol. 2003 Mar; 148(3):533-8. PMID: 12653746

Kageshita T, Funasaka Y, Ichihashi M, Ishihara T, Tokuo H, Ono T. Differential expression of tissue factor and tissue factor pathway inhibitor in metastatic melanoma lesions. Pigment Cell Res. 2002 Jun; 15(3):212-6. PMID: 12028585

Tokuo H, Yunoue S, Feng L, Kimoto M, Tsuji H, Ono T, Saya H, Araki N. Phosphorylation of neurofibromin by cAMP-dependent protein kinase is regulated via a cellular association of N(G),N(G)-dimethylarginine dimethylaminohydrolase. FEBS Lett. 2001 Apr 06; 494(1-2):48-53. PMID: 11297733

Araki N, Morimasa T, Sakai T, Tokuoh H, Yunoue S, Kamo M, Miyazaki K, Abe K, Saya H, Tsugita A. Comparative analysis of brain proteins from p53-deficient mice by two-dimensional electrophoresis. Electrophoresis. 2000 May; 21(9):1880-9. PMID: 10870973; DOI: 10.1002/(SICI)1522-2683(20000501)21:9<1880::AID-ELPS1880>3.0.CO;2-9;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2003 and 2004 and 2005

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2003 and 2004 and 2005

Year	Publications
2000	1
2001	1
2002	1
2003	2
2004	2
2005	2
2007	1
2010	1
2013	1
2018	1
2020	1
2021	1

Contact for Mentoring:

700 Albany Street
Boston MA 02118
Google Map

617.638.4001

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