Identifying New Targets to Prevent Tumor Angiogenesis in Melanoma
06/01/2021 - 05/31/2022 (PI)
Outrun the Sun

Regulation of myosin-X
03/09/2013 - 07/31/2015 (PI)
NIH/National Institute on Deafness & Communication Disorders


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Tokuo H, Komaba S, Coluccio LM. In pancreatic ß-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi. Mol Biol Cell. 2021 06 01; 32(12):1210-1220.View Related Profiles. PMID: 33826361; PMCID: PMC8351557; DOI: 10.1091/mbc.E21-03-0094;
  2. Tokuo H. Myosin X. Adv Exp Med Biol. 2020; 1239:391-403. PMID: 32451868
  3. Tokuo H, Bhawan J, Coluccio LM. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11; 8(1):10449.View Related Profiles. PMID: 29993000; PMCID: PMC6041326; DOI: 10.1038/s41598-018-28717-y;
  4. Tokuo H, Coluccio LM. Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Sep; 24(18):2820-33.View Related Profiles. PMID: 23864705; PMCID: PMC3771945; DOI: 10.1091/mbc.E12-12-0884;
  5. Watanabe TM, Tokuo H, Gonda K, Higuchi H, Ikebe M. Myosin-X induces filopodia by multiple elongation mechanism. J Biol Chem. 2010 Jun 18; 285(25):19605-14. PMID: 20392702; PMCID: PMC2885239; DOI: 10.1074/jbc.M109.093864;
  6. Tokuo H, Mabuchi K, Ikebe M. The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation. J Cell Biol. 2007 Oct 22; 179(2):229-38. PMID: 17954606; PMCID: PMC2064759; DOI: 10.1083/jcb.200703178;
  7. Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J Biol Chem. 2005 Nov 25; 280(47):39524-33. PMID: 16169856
  8. Saeki N, Tokuo H, Ikebe M. BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. J Biol Chem. 2005 Mar 18; 280(11):10128-34. PMID: 15644318
  9. Tokuo H, Ikebe M. Myosin X transports Mena/VASP to the tip of filopodia. Biochem Biophys Res Commun. 2004 Jun 18; 319(1):214-20. PMID: 15158464
  10. Feng L, Yunoue S, Tokuo H, Ozawa T, Zhang D, Patrakitkomjorn S, Ichimura T, Saya H, Araki N. PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin. FEBS Lett. 2004 Jan 16; 557(1-3):275-82. PMID: 14741381
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