Herbert M. Kagan, PhD
Emeritus Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, Tufts University School of Medicine
MS, University of Massachusetts Amherst



I arrived at BUSM as a junior faculty member in the biochemistry department in May, 1969, after four years of predoctoral training at Tufts Medical School and a subsequent three year postdoctoral experience at Harvard Medical School. My training and interests were focused on the chemical mechanisms, structures and specificity determinants of enzymes. The research I conducted during my 40 year career at BUSM was primarily concerned with those aspects of lysyl oxidase (LOX), an enzyme discovered just prior to my arrival at BUSM by investigators at the National Institute for Dental Research. LOX proved to be the critical catalyst that initiated the formation of inter- and intramolecular stabilizing crosslinkages in collagen and elastin. My laboratory established a method for the purification of LOX and subsequently characterized its catalytic mechanism and the electrostatic forces which contributed to its surprisingly broad substrate specificity that we had noted. Highly talented pre- and postdoctoral members of my lab cloned and thereby determined the amino acid sequence of LOX; discovered and analyzed the mechanisms whereby a variety of small organic molecules strongly inhibited this enzyme, one class of which was selected for patent protection as an anti-fibrotic agent; characterized the regulation of LOX by growth factors and other effectors; and found that LOX was a highly potent chemokine, strongly attracting vascular smooth muscle cell and other cell types as it oxidized growth factor receptors on the surface of those cells. The sequence of LOX which we had published proved to be critical to the later discovery by investigators at the Armed Forces Medical School in Bethesda that a newly found gene product that repressed of RAS-mediated carcinogenic transformation of fibroblasts was, surprisingly, lysyl oxidase. All of these studies were generously and continuously supported by several NIH grants, one of which was awarded as a distinguished MERIT award.

While I began my stay at BUSM as an Assistant Research Professor, my status was changed to the Associate Professor level In 1972 and approximately five years later, to full Professor of Biochemistry.

I also served as the Chair of two different Gordon Conferences and as invited speaker at several academic and industrial institutions, nationally and internationally. I am grateful to BUSM and, especially, to the Department of Biochemistry, for the strong support given to me and the many friendships that my experience there provided.


The Role of the Arterial Wall in Atherosclerosis
09/01/1976 - 08/31/2009 (PI)
NIH/National Heart, Lung, and Blood Institute
5 P01 HL13262 34

Multiple Functions of Novel Lysyl Oxidase-like Proteins
04/01/2001 - 02/28/2006 (PI)
University of Hawaii NIH NIAMS

Effects of HMR 4396 on Growth and Proliferation of Non-Hematological Mammalian Cells In-Vitro
11/11/1999 - 10/30/2002 (PI)
Hoechst Marion Roussel Inc




Yr Title Project-Sub Proj Pubs
2007 MECHANISMS OF AORTIC FIBROSIS 5P01HL013262-34-28 162
2006 MECHANISMS OF AORTIC FIBROSIS 5P01HL013262-33-28 162
2006 Administrative 5P01HL013262-33-5553 162
2005 Role of the Arterial Wall in Atherosclerosis 5P01HL013262-32 162
2005 Mechanisms of aortic fibrosis 5P01HL013262-32-28 162
2005 Core A-- Administration Core 5P01HL013262-32-9001 162
2004 Mechanisms of aortic fibrosis 5P01HL013262-31-28 162
2004 Core A-- Administration Core 5P01HL013262-31-9001 162
2004 Role of the Arterial Wall in Atherosclerosis 5P01HL013262-31 162
2003 Mechanisms of Aortic Fibrosis 2P01HL013262-30A1-28 162
Showing 10 of 43 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lucero HA, Mäki JM, Kagan HM. Activation of cellular chemotactic responses to chemokines coupled with oxidation of plasma membrane proteins by lysyl oxidase. J Neural Transm. 2011 Jul; 118(7):1091-9. PMID: 21509606; DOI: 10.1007/s00702-011-0642-5;.
     
  2. Grimsby JL, Lucero HA, Trackman PC, Ravid K, Kagan HM. Role of lysyl oxidase propeptide in secretion and enzyme activity. J Cell Biochem. 2010 Dec 1; 111(5):1231-43.View Related Profiles. PMID: 20717923; DOI: 10.1002/jcb.22845;.
     
  3. Lucero HA, Ravid K, Grimsby JL, Rich CB, DiCamillo SJ, Mäki JM, Myllyharju J, Kagan HM. Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. J Biol Chem. 2008 Aug 29; 283(35):24103-17.View Related Profiles. PMID: 18586678; PMCID: PMC2527118; DOI: 10.1074/jbc.M709897200;.
     
  4. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):792-6.View Related Profiles. PMID: 18184815; PMCID: PMC2206615; DOI: 10.1073/pnas.0705563105;.
     
  5. Lucero HA, Kagan HM. Lysyl oxidase: an oxidative enzyme and effector of cell function. Cell Mol Life Sci. 2006 Oct; 63(19-20):2304-16. PMID: 16909208.
     
  6. Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y, Izhak OB, Neufeld G. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol. 2005 Sep; 43(3):499-507. PMID: 16023247.
     
  7. Gilad GM, Kagan HM, Gilad VH. Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain. Neurosci Lett. 2005 Mar 16; 376(3):210-4. PMID: 15721223.
     
  8. Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem. 2004 Aug 1; 92(5):1034-43.View Related Profiles. PMID: 15258925.
     
  9. Jeay S, Pianetti S, Kagan HM, Sonenshein GE. Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B. Mol Cell Biol. 2003 Apr; 23(7):2251-63.View Related Profiles. PMID: 12640111; PMCID: PMC150722.
     
  10. Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003 Mar 1; 88(4):660-72.View Related Profiles. PMID: 12577300.
     
Showing 10 of 124 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 96 publications over 30 distinct years, with a maximum of 7 publications in 1983 and 1986

YearPublications
19803
19815
19823
19837
19843
19853
19867
19873
19882
19893
19903
19915
19924
19935
19945
19956
19963
19974
19983
19992
20003
20012
20021
20033
20042
20051
20061
20082
20101
20111
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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