Herbert Cohen | Profiles RNS

Herbert T. Cohen, MD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Nephrology

MD, Thomas Jefferson University
BS, Pennsylvania State University

Websites

	Pathology & Laboratory Medicine Faculty
	Boston Medical Center Provider Profile
	American Society for Clinical Investigation Research Profile

ORCID : 0000-0003-1900-8718

Dr. Cohen’s laboratory is addressing the molecular basis of renal cancer, renal cystic disease and renal development and offers special expertise in gene expression mechanisms, signal transduction, protein-protein interactions, transcription factors, and renal epithelial cell biology. The laboratory has identified the first member of new protein family, the Jade family of proteins, on the basis of its interaction with the von Hippel-Lindau tumor suppressor pVHL. pVHL protein is a key component of the cellular oxygen-sensing system. VHL is also the major renal cancer gene in adults. Jade-1 is a novel, growth suppressive plant homeodomain transcription factor that is the first protein found to be stabilized by pVHL. Jade-1 is also a ubiquitin ligase and key component of histone acetylation complexes. Interestingly, Jade-1 is stabilized by VHL protein in a manner that correlates with risk of renal manifestations in von Hippel-Lindau disease, which includes a cystic renal disease phenotype. A wider role for Jade-1 in renal cyst formation was therefore sought. Jade-1 is regulated by the product of the major gene for autosomal dominant polycystic kidney disease (ADPKD), polycystin-1, in a manner that is also disease relevant and physiologic. Importantly, Jade-1 serves as a critical ubiquitin ligase for the oncoprotein beta-catenin, which also plays critical roles in renal cancer, renal cyst formation and renal development. In part by controlling transcription and beta-catenin ubiquitination, Jade-1 and related family members are likely to be particularly important in many contexts. .

Techniques:
Cancer biology and epithelial cell biology approaches, advanced molecular biology approaches, protein-protein interactions, yeast 2-hybrid screening, protein ubiquitination assays, protein-DNA interactions, transcription assays, gene expression mechanisms including microarrays, confocal microscopy, transgenic and knockout mice.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BMC Research
NIH RePORTER Research

The pVHL/Jade-1/beta-catenin axis in renal cancer
12/15/2009 - 11/30/2015 (PI)
NIH-NCI
3R01 CA079830-13S1

JADE - 1 in Cystic Renal Disease
04/01/2004 - 03/31/2010 (PI)
NIH-NIDDK
5 R01 DK067569-05

VHL Jade-1 + Protein Stability in Renal Cancer
07/15/2003 - 04/30/2009 (PI)
NIH-NCI
5R01CA079830-08 (B)

Vegf Transcriptional Regulatio
04/01/1999 - 03/31/2003 (PI)
NIH-NCI
5 R01 CA79830-03 (A)

Career Enhancement Award
01/01/1999 - 12/31/2002 (PI)
Amer Soc Nephrology

R410 K08Dk022805 3/31/98
10/01/1999 - 09/30/2000 (PI)
NIH

Transcriptional Repression
07/01/1998 - 06/30/2000 (PI)
National Kidney Fdtn

Regulation Of Wilms Tumor - 1
05/13/1998 - 03/31/2000 (PI)
NIH-NIDDK
5 K08 DK02280-06

Title

Yr	Title	Project-Sub Proj	Pubs
2014	The pVHL/Jade-1/beta-catenin axis in renal cancer	3R01CA079830-13S1	15
2014	The pVHL/Jade-1/beta-catenin axis in renal cancer	5R01CA079830-13	15
2013	The pVHL/Jade-1/beta-catenin axis in renal cancer	3R01CA079830-12S1	15
2013	The pVHL/Jade-1/beta-catenin axis in renal cancer	5R01CA079830-12	15
2012	The pVHL/Jade-1/beta-catenin axis in renal cancer	3R01CA079830-11S1	15
2012	The pVHL/Jade-1/beta-catenin axis in renal cancer	5R01CA079830-11	15
2011	The pVHL/Jade-1/beta-catenin axis in renal cancer	5R01CA079830-10	15
2010	The pVHL/Jade-1/beta-catenin axis in renal cancer	2R01CA079830-09A1	15
2008	Jade-1 in cystic renal disease	5R01DK067569-05	11
2007	Jade-1 in cystic renal disease	5R01DK067569-04	11

Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 01; 143(1):33-53.View Related Profiles.

McKee, Ann
Cohen, Herbert
Cherry, Jonathan
Stein, Thor

PMID: 34719765; PMCID: PMC8786260; DOI: 10.1007/s00401-021-02379-z;

Havasi A, Lu W, Cohen HT, Beck L, Wang Z, Igwebuike C, Borkan SC. Blocking peptides and molecular mimicry as treatment for kidney disease. Am J Physiol Renal Physiol. 2017 Jun 01; 312(6):F1016-F1025.View Related Profiles.

Havasi, Andrea
Cohen, Herbert
Beck, Laurence
Borkan, Steven
Lu, Weining
Wang, Zhiyong

PMID: 27654896; PMCID: PMC5495884; DOI: 10.1152/ajprenal.00601.2015;

Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, Thiagalingam S. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):638-43.View Related Profiles.

Lambert, Arthur
Wong, Chen Khuan
Cohen, Herbert
Thiagalingam, Sam

PMID: 26739564; PMCID: PMC4725521; DOI: 10.1073/pnas.1514663113;

Fu Y, Rope R, Fargue S, Cohen HT, Holmes RP, Cohen DM. A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5'UTR causing primary hyperoxaluria type II. Clin Genet. 2015 Nov; 88(5):494-8. PMID: 25410531; PMCID: PMC4437915; DOI: 10.1111/cge.12541;

Komers R, Xu B, Fu Y, McClelland A, Kantharidis P, Mittal A, Cohen HT, Cohen DM. Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment. PLoS One. 2014; 9(5):e96987. PMID: 24827579; PMCID: PMC4020814; DOI: 10.1371/journal.pone.0096987;

Zeng L, Bai M, Mittal AK, El-Jouni W, Zhou J, Cohen DM, Zhou MI, Cohen HT. Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. Cancer Res. 2013 Sep 1; 73(17):5371-80. PMID: 23824745; PMCID: PMC3766477; DOI: 10.1158/0008-5472.CAN-12-4707;

Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71.View Related Profiles.

Lopez, Delia
Cohen, Herbert
Panchenko, Maria
Chitalia, Vipul

PMID: 23001567; PMCID: PMC3516131; DOI: 10.1093/hmg/dds391;

Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16.View Related Profiles.

Bharti, Ajit
Seldin, David
Cohen, Herbert
Dominguez, Maria
Panchenko, Maria
Bachschmid, Markus
Zhou, Mina
Chitalia, Vipul

PMID: 18806787; PMCID: PMC2830866; DOI: 10.1038/ncb1781;

Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, Vaziri C, Côté J, Panchenko MV. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem. 2008 Oct 24; 283(43):28817-26.View Related Profiles.

Vaziri, Cyrus
Cohen, Herbert
Panchenko, Maria
Chitalia, Vipul

PMID: 18684714; PMCID: PMC2570895; DOI: 10.1074/jbc.M801407200;

Basu A, Contreras AG, Datta D, Flynn E, Zeng L, Cohen HT, Briscoe DM, Pal S. Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer. Cancer Res. 2008 Jul 15; 68(14):5689-98. PMID: 18632621; PMCID: PMC2630878; DOI: 10.1158/0008-5472.CAN-07-6603;

Showing 10 of 40 results. Show More

Nolan VG, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C, Mahabir RN, Homan EP, Wyszynski DF, Fabry ME, Nagel RL, Farrer LA, Steinberg MH. Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Am J Hematol. 2007 Mar; 82(3):179-84.View Related Profiles.

Baldwin, Clinton
Cohen, Herbert
Farrer, Lindsay
Steinberg, Martin

PMID: 17034027

Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med. 2005 Dec 8; 353(23):2477-90. PMID: 16339096

Zhou MI, Foy RL, Chitalia VC, Zhao J, Panchenko MV, Wang H, Cohen HT. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. Proc Natl Acad Sci U S A. 2005 Aug 2; 102(31):11035-40.View Related Profiles.

Cohen, Herbert
Panchenko, Maria
Zhou, Mina
Chitalia, Vipul

PMID: 16046545; PMCID: PMC1182408; DOI: 10.1073/pnas.0500757102;

Xu H, Tian W, Lindsley JN, Oyama TT, Capasso JM, Rivard CJ, Cohen HT, Bagnasco SM, Anderson S, Cohen DM. EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo. Am J Physiol Renal Physiol. 2005 Apr; 288(4):F855-66. PMID: 15561974

Panchenko MV, Zhou MI, Cohen HT. von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity. J Biol Chem. 2004 Dec 31; 279(53):56032-41.View Related Profiles.

Cohen, Herbert
Panchenko, Maria
Zhou, Mina

PMID: 15502158

Zhou MI, Wang H, Foy RL, Ross JJ, Cohen HT. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer Res. 2004 Feb 15; 64(4):1278-86.View Related Profiles.

Cohen, Herbert
Zhou, Mina

PMID: 14973063

Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 2003 Nov 27; 3:31.View Related Profiles.

Cohen, Herbert
Lenburg, Marc

PMID: 14641932; PMCID: PMC317310

Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem. 2002 Oct 18; 277(42):39887-98. PMID: 12169691

Datta K, Nambudripad R, Pal S, Zhou M, Cohen HT, Mukhopadhyay D. Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer. J Biol Chem. 2000 Jul 7; 275(27):20700-6. PMID: 10748176; DOI: 10.1074/jbc.M909970199;

Cohen HT, Zhou M, Welsh AM, Zarghamee S, Scholz H, Mukhopadhyay D, Kishida T, Zbar B, Knebelmann B, Sukhatme VP. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association. Biochem Biophys Res Commun. 1999 Dec 9; 266(1):43-50. PMID: 10581162

Arnould T, Sellin L, Benzing T, Tsiokas L, Cohen HT, Kim E, Walz G. Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol. 1999 May; 19(5):3423-34. PMID: 10207066; PMCID: PMC84135

Cohen HT. Advances in the molecular basis of renal neoplasia. Curr Opin Nephrol Hypertens. 1999 May; 8(3):325-31. PMID: 10456263

Pal S, Claffey KP, Cohen HT, Mukhopadhyay D. Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta. J Biol Chem. 1998 Oct 9; 273(41):26277-80. PMID: 9756852

Knebelmann B, Ananth S, Cohen HT, Sukhatme VP. Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res. 1998 Jan 15; 58(2):226-31. PMID: 9443397

Scholz H, Bossone SA, Cohen HT, Akella U, Strauss WM, Sukhatme VP. A far upstream cis-element is required for Wilms' tumor-1 (WT1) gene expression in renal cell culture. J Biol Chem. 1997 Dec 26; 272(52):32836-46. PMID: 9407061

Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S, Sukhatme VP. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mol Cell Biol. 1997 Sep; 17(9):5629-39. PMID: 9271438; PMCID: PMC232411

Cohen HT, Bossone SA, Zhu G, McDonald GA, Sukhatme VP. Sp1 is a critical regulator of the Wilms' tumor-1 gene. J Biol Chem. 1997 Jan 31; 272(5):2901-13. PMID: 9006935

Satoh T, Cohen HT, Katz AI. Different mechanisms of renal Na-K-ATPase regulation by protein kinases in proximal and distal nephron. Am J Physiol. 1993 Sep; 265(3 Pt 2):F399-405. PMID: 8214099

Satoh T, Cohen HT, Katz AI. Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids. J Clin Invest. 1993 Feb; 91(2):409-15. PMID: 8381820; PMCID: PMC287939; DOI: 10.1172/JCI116215;

Katz AI, Satoh T, Takemoto F, Cohen HT. Novel pathways of Na-K-ATPase regulation in kidney cells. Contrib Nephrol. 1993; 101:7-11. PMID: 8385596

Satoh T, Ominato M, Cohen HT, Katz AI. Role of the phospholipase C-protein kinase C pathway in proximal tubule Na-K-ATPase regulation. Trans Assoc Am Physicians. 1993; 106:196-200. PMID: 8036742

Cohen HT, Sukhatme VP. Molecular biology in nephrology: an overview with emphasis on the study of renal cancer. Semin Nephrol. 1992 Nov; 12(6):495-505. PMID: 1335610

Cohen HT, Takemoto F, Satoh T, Katz AI. Renal adrenergic receptors: localization of [125I]prazosin binding sites along the microdissected rat nephron. Can J Physiol Pharmacol. 1992 Jul; 70(7):1016-20. PMID: 1451023

Takemoto F, Cohen HT, Satoh T, Katz AI. Dopamine inhibits Na/K-ATPase in single tubules and cultured cells from distal nephron. Pflugers Arch. 1992 Jul; 421(4):302-6. PMID: 1357625

Satoh T, Cohen HT, Katz AI. Intracellular signaling in the regulation of renal Na-K-ATPase. I. Role of cyclic AMP and phospholipase A2. J Clin Invest. 1992 May; 89(5):1496-500. PMID: 1349027; PMCID: PMC443020; DOI: 10.1172/JCI115740;

Satoh T, Cohen HT, Katz AI. Regulation of renal Na-K-ATPase by eicosanoids: central role of the cytochrome P450-monooxygenase pathway. Trans Assoc Am Physicians. 1992; 105:86-92. PMID: 1339239

Takemoto F, Satoh T, Cohen HT, Katz AI. Localization of dopamine-1 receptors along the microdissected rat nephron. Pflugers Arch. 1991 Oct; 419(3-4):243-8. PMID: 1660593

Cohen HT, Spiegel DM. Air-exposed urine dipsticks give false-positive results for glucose and false-negative results for blood. Am J Clin Pathol. 1991 Sep; 96(3):398-400. PMID: 1877540

Cohen HT, Katz AI. Adrenergic receptors and catecholamine effects on sodium transport in the mammalian nephron. Semin Nephrol. 1991 Mar; 11(2):110-9. PMID: 1674621

Cohen HT, Singh AK, Kasinath BS, Lewis EJ. Red-cell surface charge in patients with nephrotic syndrome. Lancet. 1988 Jun 25; 1(8600):1459. PMID: 2898609

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 40 publications over 19 distinct years, with a maximum of 5 publications in 1992

Bar chart showing 40 publications over 19 distinct years, with a maximum of 5 publications in 1992

Year	Publications
1988	1
1991	3
1992	5
1993	4
1997	3
1998	2
1999	3
2000	1
2002	1
2003	1
2004	3
2005	2
2007	1
2008	3
2012	1
2013	1
2014	2
2016	2
2021	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cell biology
growth & development
kidney diseases
kidney neoplasms
molecular biology
neoplasms
polycystic kidney diseases
signal transduction
transcription factors

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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617.638.7322

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