Herbert T. Cohen, MD

Dr. Cohen’s laboratory is addressing the molecular basis of renal cancer, renal cystic disease and renal development and offers special expertise in gene expression mechanisms, signal transduction, protein-protein interactions, transcription factors, and renal epithelial cell biology. The laboratory has identified the first member of new protein family, the Jade family of proteins, on the basis of its interaction with the von Hippel-Lindau tumor suppressor pVHL. pVHL protein is a key component of the cellular oxygen-sensing system. VHL is also the major renal cancer gene in adults. Jade-1 is a novel, growth suppressive plant homeodomain transcription factor that is the first protein found to be stabilized by pVHL. Jade-1 is also a ubiquitin ligase and key component of histone acetylation complexes. Interestingly, Jade-1 is stabilized by VHL protein in a manner that correlates with risk of renal manifestations in von Hippel-Lindau disease, which includes a cystic renal disease phenotype. A wider role for Jade-1 in renal cyst formation was therefore sought. Jade-1 is regulated by the product of the major gene for autosomal dominant polycystic kidney disease (ADPKD), polycystin-1, in a manner that is also disease relevant and physiologic. Importantly, Jade-1 serves as a critical ubiquitin ligase for the oncoprotein beta-catenin, which also plays critical roles in renal cancer, renal cyst formation and renal development. In part by controlling transcription and beta-catenin ubiquitination, Jade-1 and related family members are likely to be particularly important in many contexts. .

Techniques:
Cancer biology and epithelial cell biology approaches, advanced molecular biology approaches, protein-protein interactions, yeast 2-hybrid screening, protein ubiquitination assays, protein-DNA interactions, transcription assays, gene expression mechanisms including microarrays, confocal microscopy, transgenic and knockout mice.

Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Associate Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Active Staff Privileges
Boston Medical Center
Medicine
Nephrology




The pVHL/Jade-1/beta-catenin axis in renal cancer
12/15/2009 - 11/30/2015 (PI)
NIH-NCI

JADE - 1 in Cystic Renal Disease
04/01/2004 - 03/31/2010 (PI)
NIH-NIDDK

VHL Jade-1 + Protein Stability in Renal Cancer
07/15/2003 - 04/30/2009 (PI)
NIH-NCI

Vegf Transcriptional Regulatio
04/01/1999 - 03/31/2003 (PI)
NIH-NCI

Career Enhancement Award
01/01/1999 - 12/31/2002 (PI)
Amer Soc Nephrology

R410 K08Dk022805 3/31/98
10/01/1999 - 09/30/2000 (PI)
NIH

Transcriptional Repression
07/01/1998 - 06/30/2000 (PI)
National Kidney Fdtn

Regulation Of Wilms Tumor - 1
05/13/1998 - 03/31/2000 (PI)
NIH-NIDDK



Yr Title Project-Sub Proj Pubs
2014 The pVHL/Jade-1/beta-catenin axis in renal cancer 5R01CA079830-13 10
2014 The pVHL/Jade-1/beta-catenin axis in renal cancer 3R01CA079830-13S1 10
2013 The pVHL/Jade-1/beta-catenin axis in renal cancer 5R01CA079830-12 10
2013 The pVHL/Jade-1/beta-catenin axis in renal cancer 3R01CA079830-12S1 10
2012 The pVHL/Jade-1/beta-catenin axis in renal cancer 5R01CA079830-11 10
2012 The pVHL/Jade-1/beta-catenin axis in renal cancer 3R01CA079830-11S1 10
2011 The pVHL/Jade-1/beta-catenin axis in renal cancer 5R01CA079830-10 10
2011 The pVHL/Jade-1/beta-catenin axis in renal cancer 5R01CA079830-10 10
2010 The pVHL/Jade-1/beta-catenin axis in renal cancer 2R01CA079830-09A1 10
2008 Jade-1 in cystic renal disease 5R01DK067569-05 6
Showing 10 of 29 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Havasi A, Lu W, Cohen HT, Beck L, Wang Z, Igwebuike C, Borkan SC. Blocking peptides and molecular mimicry as treatment for kidney disease. Am J Physiol Renal Physiol. 2017 Jun 01; 312(6):F1016-F1025.View Related Profiles. PMID: 27654896; DOI: 10.1152/ajprenal.00601.2015;.
     
  2. Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, Thiagalingam S. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):638-43.View Related Profiles. PMID: 26739564; PMCID: PMC4725521; DOI: 10.1073/pnas.1514663113;.
     
  3. Fu Y, Rope R, Fargue S, Cohen HT, Holmes RP, Cohen DM. A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5''UTR causing primary hyperoxaluria type II. Clin Genet. 2015 Nov; 88(5):494-8. PMID: 25410531; PMCID: PMC4437915.
     
  4. Komers R, Xu B, Fu Y, McClelland A, Kantharidis P, Mittal A, Cohen HT, Cohen DM. Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment. PLoS One. 2014; 9(5):e96987. PMID: 24827579; PMCID: PMC4020814; DOI: 10.1371/journal.pone.0096987;.
     
  5. Zeng L, Bai M, Mittal AK, El-Jouni W, Zhou J, Cohen DM, Zhou MI, Cohen HT. Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. Cancer Res. 2013 Sep 1; 73(17):5371-80. PMID: 23824745; PMCID: PMC3766477; DOI: 10.1158/0008-5472.CAN-12-4707;.
     
  6. Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71.View Related Profiles. PMID: 23001567; PMCID: PMC3516131; DOI: 10.1093/hmg/dds391;.
     
  7. Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16.View Related Profiles. PMID: 18806787; PMCID: PMC2830866; DOI: 10.1038/ncb1781;.
     
  8. Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, Vaziri C, Côté J, Panchenko MV. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem. 2008 Oct 24; 283(43):28817-26.View Related Profiles. PMID: 18684714; PMCID: PMC2570895; DOI: 10.1074/jbc.M801407200;.
     
  9. Basu A, Contreras AG, Datta D, Flynn E, Zeng L, Cohen HT, Briscoe DM, Pal S. Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer. Cancer Res. 2008 Jul 15; 68(14):5689-98. PMID: 18632621; PMCID: PMC2630878; DOI: 10.1158/0008-5472.CAN-07-6603;.
     
  10. Nolan VG, Ma Q, Cohen HT, Adewoye A, Rybicki AC, Baldwin C, Mahabir RN, Homan EP, Wyszynski DF, Fabry ME, Nagel RL, Farrer LA, Steinberg MH. Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B. Am J Hematol. 2007 Mar; 82(3):179-84.View Related Profiles. PMID: 17034027.
     
Showing 10 of 39 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 39 publications over 18 distinct years, with a maximum of 5 publications in 1992

YearPublications
19881
19913
19925
19934
19973
19982
19993
20001
20021
20031
20043
20052
20071
20083
20121
20131
20142
20162
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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