Hengye Man | Profiles RNS

Hengye Man, MD, PhD

Professor

Boston University College of Arts and Sciences

Biology

MD, Taishan Medical University
PhD, University of Toronto
MSc, Shandong Medical University

Websites

Biology Faculty

ORCID : 0000-0002-3530-3066

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Professor
Boston University College of Arts and Sciences
Neuroscience

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

BU Research
NIH RePORTER Research

Molecular Mechanisms of Homeostatic Synaptic Plasticity
02/06/2023 - 01/31/2028 (PI)
NIH/National Institute of Mental Health
5R01MH130600-02

Study of NEXMIF mosaic expression on neuronal development and connectivity in female mice
02/06/2023 - 01/31/2025 (PI)
NIH/National Institute of Mental Health
5R21MH133014-02

Joint estimation of motion model, model parameters, and particle trajectories in single particle tracking
09/20/2017 - 08/31/2023 (Multi-PI)
PI: Hengye Man, MD, PhD
NIH/National Institute of General Medical Sciences
5R01GM117039-05

Dysregulated N-Cadherin trafficking in autism and intellectual disability
07/01/2020 - 09/30/2022 (PI)
President and Fellows of Harvard College

SBIR Phase II: High resolution micro-magnetometer based on novel nano-junction oxide SQUIDs
09/30/2018 - 08/31/2021 (Subcontract PI)
Tristan Technologies NIH NIBIB
5R44EB023147-03

Molecular Mechanisms of Homeostatic Synaptic Plasticity
09/15/2014 - 06/30/2020 (PI)
NIH/National Institute of Mental Health
5R01MH079407-10

HOMEOSTATIC REGULATION AND TRAFFICKING OF AMPA RECEPTORS AT SINGLE SYNAPSES
08/01/2008 - 09/14/2014 (PI)
NIH/National Institute of Mental Health
5R01MH079407-05

2010 YOUNG INVESTIGATOR AWARD: REGULATION OF AMPAR DISTRIBUTION BY N EURONAL GLUTAMATE TRANSPORTERS
07/15/2011 - 07/14/2013 (PI)
National Alliance for Research on Schizophrenia and Depressi

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Exploring the Rescue Strategy for Female NEXMIF Haploinsufficiency via X Chromosome Reactivation	1R21MH134174-01A1
2024	Study of NEXMIF mosaic expression on neuronal development and connectivity in female mice	5R21MH133014-02
2024	Molecular mechanisms of homeostatic synaptic plasticity	5R01MH130600-02
2023	Study of NEXMIF mosaic expression on neuronal development and connectivity in female mice	1R21MH133014-01
2023	Molecular mechanisms of homeostatic synaptic plasticity	1R01MH130600-01A1
2018	Molecular Mechanisms of Homeostatic Synaptic Plasticity	5R01MH079407-10	29
2017	Molecular Mechanisms of Homeostatic Synaptic Plasticity	5R01MH079407-09	29
2016	Molecular Mechanisms of Homeostatic Synaptic Plasticity	5R01MH079407-08	29
2015	Molecular Mechanisms of Homeostatic Synaptic Plasticity	5R01MH079407-07	29
2014	Molecular Mechanisms of Homeostatic Synaptic Plasticity	2R01MH079407-06A1	29

Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Hou Q, Hu W, Peterson L, Gilbert J, Liu R, Man HY. SIK1 Downregulates Synaptic AMPA Receptors and Contributes to Cognitive Defects in Alzheimer's Disease. Mol Neurobiol. 2024 May 10. PMID: 38727976

Tian Y, Qiao H, Zhu LQ, Man HY. Sexually dimorphic phenotypes and the role of androgen receptors in UBE3A-dependent autism spectrum disorder. bioRxiv. 2024 May 04. PMID: 38746146; PMCID: PMC11092617; DOI: 10.1101/2024.05.02.592248;

Gardner Z, Holbrook O, Tian Y, Odamah K, Man HY. The role of glia in the dysregulation of neuronal spinogenesis in Ube3a-dependent ASD. Exp Neurol. 2024 Jun; 376:114756. PMID: 38508482; PMCID: PMC11058030; DOI: 10.1016/j.expneurol.2024.114756;

Tian Y, Yu F, Yun E, Lin JW, Man HY. mRNA nuclear retention reduces AMPAR expression and promotes autistic behavior in UBE3A-overexpressing mice. EMBO Rep. 2024 Mar; 25(3):1282-1309. PMID: 38316900; PMCID: PMC10933332; DOI: 10.1038/s44319-024-00073-1;

O'Connor M, Qiao H, Odamah K, Cerdeira PC, Man HY. Heterozygous Nexmif female mice demonstrate mosaic NEXMIF expression, autism-like behaviors, and abnormalities in dendritic arborization and synaptogenesis. Heliyon. 2024 Feb 15; 10(3):e24703. PMID: 38322873; PMCID: PMC10844029; DOI: 10.1016/j.heliyon.2024.e24703;

Qiao H, Tian Y, Huo Y, Man HY. Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice. iScience. 2022 Jul 15; 25(7):104595. PMID: 35800757; PMCID: PMC9253496; DOI: 10.1016/j.isci.2022.104595;

Huo Y, Lu W, Tian Y, Hou Q, Man HY. Prkn knockout mice show autistic-like behaviors and aberrant synapse formation. iScience. 2022 Jul 15; 25(7):104573. PMID: 35789851; PMCID: PMC9249611; DOI: 10.1016/j.isci.2022.104573;

Xiao S, Lowet E, Gritton HJ, Fabris P, Wang Y, Sherman J, Mount RA, Tseng HA, Man HY, Straub C, Piatkevich KD, Boyden ES, Mertz J, Han X. Large-scale voltage imaging in behaving mice using targeted illumination. iScience. 2021 Nov 19; 24(11):103263.View Related Profiles.

Man, Hengye
Mertz, Jerome
Han, Xue

PMID: 34761183; PMCID: PMC8567393; DOI: 10.1016/j.isci.2021.103263;

Shi L, Jiang Y, Fernandez FR, Chen G, Lan L, Man HY, White JA, Cheng JX, Yang C. Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter. Light Sci Appl. 2021 Jul 14; 10(1):143.View Related Profiles.

Fernandez, Fernando
Man, Hengye
Cheng, Ji-Xin
White, John

PMID: 34257273; PMCID: PMC8277806; DOI: 10.1038/s41377-021-00580-z;

O'Connor M, Shentu YP, Wang G, Hu WT, Xu ZD, Wang XC, Liu R, Man HY. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. 2020 Sep 25; 23(9):101465. PMID: 32861999; PMCID: PMC7476873; DOI: 10.1016/j.isci.2020.101465;

Showing 10 of 37 results. Show More

Bensussen S, Shankar S, Ching KH, Zemel D, Ta TL, Mount RA, Shroff SN, Gritton HJ, Fabris P, Vanbenschoten H, Beck C, Man HY, Han X. A Viral Toolbox of Genetically Encoded Fluorescent Synaptic Tags. iScience. 2020 Jul 24; 23(7):101330.View Related Profiles.

Man, Hengye
Han, Xue

PMID: 32674057; PMCID: PMC7363701; DOI: 10.1016/j.isci.2020.101330;

Hastings MH, Gauthier JM, Mabry K, Tran A, Man HY, Kantak KM. Facilitative effects of environmental enrichment for cocaine relapse prevention are dependent on extinction training context and involve increased TrkB signaling in dorsal hippocampus and ventromedial prefrontal cortex. Behav Brain Res. 2020 05 27; 386:112596.View Related Profiles.

Tran, Audrey
Man, Hengye
Kantak, Kathleen

PMID: 32194188; PMCID: PMC7430990; DOI: 10.1016/j.bbr.2020.112596;

Jiang Y, Lee HJ, Lan L, Tseng HA, Yang C, Man HY, Han X, Cheng JX. Optoacoustic brain stimulation at submillimeter spatial precision. Nat Commun. 2020 02 14; 11(1):881.View Related Profiles.

Man, Hengye
Cheng, Ji-Xin
Han, Xue

PMID: 32060282; PMCID: PMC7021819; DOI: 10.1038/s41467-020-14706-1;

Wang G, Zhong J, Guttieres D, Man HY. Non-scaling regulation of AMPA receptors in homeostatic synaptic plasticity. Neuropharmacology. 2019 11 01; 158:107700. PMID: 31283924; PMCID: PMC6745258; DOI: 10.1016/j.neuropharm.2019.107700;

Khatri N, Man HY. The Autism and Angelman Syndrome Protein Ube3A/E6AP: The Gene, E3 Ligase Ubiquitination Targets and Neurobiological Functions. Front Mol Neurosci. 2019; 12:109.View Related Profiles.

Man, Hengye
Khatri, Natasha

PMID: 31114479; PMCID: PMC6502993; DOI: 10.3389/fnmol.2019.00109;

Keaveney MK, Tseng HA, Ta TL, Gritton HJ, Man HY, Han X. A MicroRNA-Based Gene-Targeting Tool for Virally Labeling Interneurons in the Rodent Cortex. Cell Rep. 2018 07 10; 24(2):294-303.View Related Profiles.

Man, Hengye
Han, Xue

PMID: 29996091; PMCID: PMC6095194; DOI: 10.1016/j.celrep.2018.06.049;

Hastings MH, Man HY. Synaptic Capture of Laterally Diffusing AMPA Receptors - An Idea That Stuck. Trends Neurosci. 2018 06; 41(6):330-332. PMID: 29801525

Khatri N, Gilbert JP, Huo Y, Sharaflari R, Nee M, Qiao H, Man HY. The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization. J Neurosci. 2018 01 10; 38(2):363-378.View Related Profiles.

Man, Hengye
Khatri, Natasha

PMID: 29175955; PMCID: PMC5761614; DOI: 10.1523/JNEUROSCI.1511-17.2017;

Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017 08 08; 20(6):1335-1347.View Related Profiles.

Man, Hengye
Han, Xue

PMID: 28793258; PMCID: PMC5584878; DOI: 10.1016/j.celrep.2017.07.030;

Gilbert J, Shu S, Yang X, Lu Y, Zhu LQ, Man HY. ß-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity. Acta Neuropathol Commun. 2016 Dec 13; 4(1):131. PMID: 27955702

Gilbert J, Man HY. The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and d-Catenin Signaling. eNeuro. 2016 Sep-Oct; 3(5). PMID: 27822498; PMCID: PMC5083950; DOI: 10.1523/ENEURO.0238-16.2016;

Hou Q, Ruan H, Gilbert J, Wang G, Ma Q, Yao WD, Man HY. MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity. Nat Commun. 2015 Dec 01; 6:10045. PMID: 26620774; PMCID: PMC4686673; DOI: 10.1038/ncomms10045;

Huo Y, Khatri N, Hou Q, Gilbert J, Wang G, Man HY. The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking. J Neurochem. 2015 Sep; 134(6):1067-80.View Related Profiles.

Man, Hengye
Khatri, Natasha

PMID: 26077708; PMCID: PMC4668950; DOI: 10.1111/jnc.13194;

Wang G, Amato S, Gilbert J, Man HY. Resveratrol up-regulates AMPA receptor expression via AMP-activated protein kinase-mediated protein translation. Neuropharmacology. 2015 Aug; 95:144-53. PMID: 25791529; PMCID: PMC4466044; DOI: 10.1016/j.neuropharm.2015.03.003;

Khatri N, Man HY. Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases. Front Neurol. 2013; 4:199.View Related Profiles.

Man, Hengye
Khatri, Natasha

PMID: 24376435; PMCID: PMC3858785; DOI: 10.3389/fneur.2013.00199;

Lin AW, Man HY. Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins. Neural Plast. 2013; 2013:432057. PMID: 23431475; PMCID: PMC3574743; DOI: 10.1155/2013/432057;

Foo K, Blumenthal L, Man HY. Regulation of neuronal bioenergy homeostasis by glutamate. Neurochem Int. 2012 Aug; 61(3):389-96. PMID: 22709672; PMCID: PMC3430810; DOI: 10.1016/j.neuint.2012.06.003;

Wang G, Gilbert J, Man HY. AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades. Neural Plast. 2012; 2012:825364. PMID: 22655210; PMCID: PMC3359728; DOI: 10.1155/2012/825364;

Jarzylo LA, Man HY. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci. 2012 Feb 15; 32(7):2552-63. PMID: 22396428; PMCID: PMC3567454; DOI: 10.1523/JNEUROSCI.3237-11.2012;

Hou Q, Gilbert J, Man HY. Homeostatic regulation of AMPA receptor trafficking and degradation by light-controlled single-synaptic activation. Neuron. 2011 Dec 08; 72(5):806-18. PMID: 22153376; PMCID: PMC3240854; DOI: 10.1016/j.neuron.2011.10.011;

Amato S, Man HY. Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases. Cell Cycle. 2011 Oct 15; 10(20):3452-60. PMID: 22067656; PMCID: PMC3266175; DOI: 10.4161/cc.10.20.17953;

Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY. AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science. 2011 Apr 08; 332(6026):247-51. PMID: 21436401; PMCID: PMC3325765; DOI: 10.1126/science.1201678;

Man HY. GluA2-lacking, calcium-permeable AMPA receptors--inducers of plasticity? Curr Opin Neurobiol. 2011 Apr; 21(2):291-8. PMID: 21295464; PMCID: PMC3092818; DOI: 10.1016/j.conb.2011.01.001;

Zhang D, Hou Q, Wang M, Lin A, Jarzylo L, Navis A, Raissi A, Liu F, Man HY. Na,K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci. 2009 Apr 08; 29(14):4498-511. PMID: 19357275; PMCID: PMC2680442; DOI: 10.1523/JNEUROSCI.6094-08.2009;

Hou Q, Huang Y, Amato S, Snyder SH, Huganir RL, Man HY. Regulation of AMPA receptor localization in lipid rafts. Mol Cell Neurosci. 2008 Jun; 38(2):213-23. PMID: 18411055; PMCID: PMC2734417; DOI: 10.1016/j.mcn.2008.02.010;

Hou Q, Zhang D, Jarzylo L, Huganir RL, Man HY. Homeostatic regulation of AMPA receptor expression at single hippocampal synapses. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):775-80. PMID: 18174334; PMCID: PMC2206612; DOI: 10.1073/pnas.0706447105;

Man HY, Wang Q, Lu WY, Ju W, Ahmadian G, Liu L, D'Souza S, Wong TP, Taghibiglou C, Lu J, Becker LE, Pei L, Liu F, Wymann MP, MacDonald JF, Wang YT. Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron. 2003 May 22; 38(4):611-24. PMID: 12765612

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 15 distinct years, with a maximum of 5 publications in 2024

Bar chart showing 37 publications over 15 distinct years, with a maximum of 5 publications in 2024

Year	Publications
2003	1
2008	2
2009	1
2011	4
2012	3
2013	2
2015	3
2016	2
2017	2
2018	2
2019	2
2020	4
2021	2
2022	2
2024	5

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