Haiyan Gong, MD, PhD
Boston University School of Medicine
Dept of Ophthalmology

MD, Jiangxi University of Traditional Chinese Medicine
PhD, Boston University School of Medicine
MS, Peking Union Medical College

Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Boston University School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2019 Association For Research in Vision and Ophthalmology: Gold Fellow of ARVO
2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO
1978 Lhasa City Hospital: Physician of the Year

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 08/31/2021 (PI)
NIH/National Eye Institute

The Role of Thrombospondin-1 in Regulating IOP
07/01/2019 - 06/30/2021 (PI)
Bright Focus Foundation

Testing Effect of Sustained Release vs. Cyclic Exposure of Bimatoprost on MMP/TIMP/ECM Expression by Outflow Cells
05/21/2019 - 09/21/2020 (Subcontract PI)
Duke University Allergan Sales Inc

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2020 (Subcontract PI)
Northwestern University NIH NEI

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2020 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Effect of Netarsudil and AR-12286 on Effective Filtration Area and Morphology of the Trabecular Outflow Pathway
10/15/2018 - 10/15/2019 (PI)
Aerie Pharmaceuticals, Inc.

Glycocalyx in the pores of the inner wall endothelial cells of Schlemms canal
06/01/2018 - 05/31/2019 (PI)
Western Glaucoma Foundation

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2018 - 05/31/2019 (Subcontract PI)
Duke University NIH NEI

Cell-cell interactions in giant vacuole/pore formation
07/01/2016 - 06/30/2018 (PI)
Bright Focus Foundation

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2017 - 05/31/2018 (Subcontract PI)
Duke University NIH NEI

Showing 10 of 25 results. Show All Results


Yr Title Project-Sub Proj Pubs
2020 Transmission Electron Microscope 1S10OD028571-01
2020 Function of Glycocalyx in the Trabecular Outflow Pathway 1R21EY028674-01A1
2020 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-09 16
2019 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-08 16
2018 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-07 16
2017 Cellular Physiology of the Aqueous Outflow Pathway 2R01EY022634-06 16
2016 Cellular Physiology of the Aqueous Outflow Pathway 4R01EY022634-05 16
2015 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-04 16
2014 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-03 16
2013 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-02 16
Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Vahabikashi A, Gelman A, Dong B, Gong L, Cha EDK, Schimmel M, Tamm ER, Perkumas K, Stamer WD, Sun C, Zhang HF, Gong H, Johnson M. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc Natl Acad Sci U S A. 2019 Dec 05.View Related Profiles. PMID: 31806762
  2. Fini ME, Jeong S, Gong H, Martinez-Carrasco R, Laver NMV, Hijikata M, Keicho N, Argüeso P. Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse. Prog Retin Eye Res. 2020 03; 75:100777. PMID: 31493487
  3. Lai J, Su Y, Swain DL, Huang D, Getchevski D, Gong H. The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1630-1643.View Related Profiles. PMID: 30995299; DOI: 10.1167/iovs.18-26011;
  4. Wang Y, Osakue D, Yang E, Zhou Y, Gong H, Xia X, Du Y. Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):265-273. PMID: 30654386
  5. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. PMID: 29526795
  6. Tripon RG, Oláh J, Nasir T, Csincsik L, Li CL, Szunyogh S, Gong H, Flinn JM, Ovádi J, Lengyel I. Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye. J Trace Elem Med Biol. 2018 Sep; 49:222-230. PMID: 29317136; DOI: 10.1016/j.jtemb.2017.12.009;
  7. Raghunathan V, Eaton JS, Christian BJ, Morgan JT, Ver Hoeve JN, Yang CC, Gong H, Rasmussen CA, Miller PE, Russell P, Nork TM, Murphy CJ. Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. Sci Rep. 2017 10 30; 7(1):14329. PMID: 29085025
  8. Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209.View Related Profiles. PMID: 27842161; DOI: 10.1167/iovs.16-20189;
  9. Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60.View Related Profiles. PMID: 26775054; PMCID: PMC4893924; DOI: 10.1016/j.exer.2016.01.008;
  10. Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.
Showing 10 of 71 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 71 publications over 29 distinct years, with a maximum of 6 publications in 2013


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Ocular perfusion
Trabecular meshwork

Available to Mentor as: (Review Mentor Role Definitions):
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  • Education Mentor
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Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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