Haiyan Gong, MD, PhD
Professor
Boston University School of Medicine
Dept of Ophthalmology

MD, Nanchang University
PhD, Boston University School of Medicine
MS, Peking Union Medical College




Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Professor
Boston University School of Medicine
Anatomy & Neurobiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2019 Association For Research in Vision and Ophthalmology: Gold Fellow of ARVO
2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO
1978 Lhasa City Hospital: Physician of the Year


The Role of Thrombospondin-1 in Regulating IOP
07/01/2019 - 06/30/2022 (PI)
Bright Focus Foundation


Function of Glycocalyx in the Trabecular Outflow Pathway
06/01/2020 - 05/31/2022 (PI)
NIH/National Eye Institute
5R21EY028674-02

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2019 - 05/31/2022 (Subcontract PI)
Duke University NIH NEI
5R01EY027733-04

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 08/31/2021 (PI)
NIH/National Eye Institute
5R01EY022634-09

Testing Effect of Sustained Release vs. Cyclic Exposure of Bimatoprost on MMP/TIMP/ECM Expression by Outflow Cells
05/21/2019 - 06/30/2021 (Subcontract PI)
Duke University Allergan Sales Inc


The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2021 (Subcontract PI)
Northwestern University NIH NEI
5R01EY019696-10

Transmission Electron Microscope
06/15/2020 - 06/14/2021 (PI)
NIH/Office of the Director
1S10OD028571-01

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 05/31/2021 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Effect of Netarsudil and AR-12286 on Effective Filtration Area and Morphology of the Trabecular Outflow Pathway
10/15/2018 - 10/15/2019 (PI)
Aerie Pharmaceuticals, Inc.


Glycocalyx in the pores of the inner wall endothelial cells of Schlemms canal
06/01/2018 - 05/31/2019 (PI)
Western Glaucoma Foundation


Showing 10 of 28 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Function of Glycocalyx in the Trabecular Outflow Pathway 5R21EY028674-02
2020 Transmission Electron Microscope 1S10OD028571-01
2020 Function of Glycocalyx in the Trabecular Outflow Pathway 1R21EY028674-01A1
2020 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-09 16
2019 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-08 16
2018 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-07 16
2017 Cellular Physiology of the Aqueous Outflow Pathway 2R01EY022634-06 16
2016 Cellular Physiology of the Aqueous Outflow Pathway 4R01EY022634-05 16
2015 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-04 16
2014 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-03 16
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21; 13(28):32823-32836. PMID: 34232612
     
  2. Swain DL, Le TD, Yasmin S, Fernandes B, Lamaj G, Dasgupta I, Gao Y, Gong H. Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study. Exp Eye Res. 2021 04; 205:108488.View Related Profiles. PMID: 33571532; PMCID: PMC8044056; DOI: 10.1016/j.exer.2021.108488;
     
  3. Freddo TF, Civan M and Gong H. Albert and Jakobiec's Principles and Practices of Ophthalmology. Aqueous humor and the dynamics of its flow: Mechanisms and routes of aqueous humor drainage. Springer. 2021.
  4. Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma. J Clin Med. 2020 Dec 28; 10(1). PMID: 33379277; PMCID: PMC7795952; DOI: 10.3390/jcm10010078;
     
  5. Gong H and Swain DL. Current Developments in Glaucoma Surgery and MIGS. Anatomy of the conventional aqueous outflow pathway. Kugler. 2020; 1-37.
  6. Vahabikashi A, Gelman A, Dong B, Gong L, Cha EDK, Schimmel M, Tamm ER, Perkumas K, Stamer WD, Sun C, Zhang HF, Gong H, Johnson M. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc Natl Acad Sci U S A. 2019 Dec 05.View Related Profiles. PMID: 31806762; PMCID: PMC6936716; DOI: 10.1073/pnas.1911837116;
     
  7. Fini ME, Jeong S, Gong H, Martinez-Carrasco R, Laver NMV, Hijikata M, Keicho N, Argüeso P. Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse. Prog Retin Eye Res. 2020 03; 75:100777. PMID: 31493487
     
  8. Lai J, Su Y, Swain DL, Huang D, Getchevski D, Gong H. The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1630-1643.View Related Profiles. PMID: 30995299; PMCID: PMC6736380; DOI: 10.1167/iovs.18-26011;
     
  9. Wang Y, Osakue D, Yang E, Zhou Y, Gong H, Xia X, Du Y. Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):265-273. PMID: 30654386; PMCID: PMC6340162; DOI: 10.1167/iovs.18-25477;
     
  10. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. PMID: 29526795; PMCID: PMC6042513; DOI: 10.1016/j.exer.2018.03.001;
     
Showing 10 of 74 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 74 publications over 31 distinct years, with a maximum of 6 publications in 2013

YearPublications
19851
19861
19892
19921
19931
19941
19951
19962
19975
19981
19991
20002
20011
20025
20031
20062
20073
20083
20094
20102
20113
20124
20136
20144
20152
20163
20172
20181
20194
20202
20213

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Glaucoma
Ocular perfusion
Trabecular meshwork

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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