Haiyan Gong, MD, PhD
Boston University School of Medicine
Dept of Ophthalmology

MD, Jiangxi University of Traditional Chinese Medicine
PhD, Boston University School of Medicine
MS, Peking Union Medical College

Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Boston University School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 08/31/2018 (PI)
NIH/National Eye Institute

Cell-cell interactions in giant vacuole/pore formation
07/01/2016 - 06/30/2018 (PI)
Bright Focus Foundation

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2018 (PI)
Northwestern University NIH NEI

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2018 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, I

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2017 - 05/31/2018 (PI)
Duke University NIH NEI

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2016 - 08/31/2017 (PI)
NIH/National Eye Institute

Cellular Physiology of the Aqueous Outflow Pathway
09/30/2012 - 08/31/2016 (PI)
NIH/National Eye Institute

A Mouse Giaucoma Model and Stem Cell-Based Therapy for Glaucoma
07/01/2014 - 06/30/2016 (PI)
University of Pittsburgh Bright Focus Fdn

Evaluation of the effect of an Aerie drug (AR-13324) on aqueous flow pattern and morphology in enucleated human eyes
10/15/2014 - 12/30/2015 (PI)
Aerie Pharmaceuticals, Inc.

The Mechanical Basis of Primary Open Angle Glaucoma
09/30/2009 - 09/29/2015 (PI)
Northwestern University NIH NEI

Showing 10 of 20 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Raghunathan V, Eaton JS, Christian BJ, Morgan JT, Ver Hoeve JN, Yang CC, Gong H, Rasmussen CA, Miller PE, Russell P, Nork TM, Murphy CJ. Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. Sci Rep. 2017 Oct 30; 7(1):14329. PMID: 29085025.
  2. Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209.View Related Profiles. PMID: 27842161; DOI: 10.1167/iovs.16-20189;.
  3. Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60.View Related Profiles. PMID: 26775054; PMCID: PMC4893924; DOI: 10.1016/j.exer.2016.01.008;.
  4. Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.
  5. Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760; PMCID: PMC4787989; DOI: 10.1016/j.cvsm.2015.06.005;.
  6. Swain DL, Ho J, Lai J, Gong H. Shorter scleral spur in eyes with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1638-48.View Related Profiles. PMID: 25670488; PMCID: PMC4351652; DOI: 10.1167/iovs.14-15593;.
  7. Vargas-Pinto R, Lai J, Gong H, Ethier CR, Johnson M. Finite element analysis of the pressure-induced deformation of Schlemm''s canal endothelial cells. Biomech Model Mechanobiol. 2015 Aug; 14(4):851-63. PMID: 25516410; PMCID: PMC4470892; DOI: 10.1007/s10237-014-0640-2;.
  8. Yang CY, Huynh T, Johnson M, Gong H. Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes. Exp Eye Res. 2014 Nov; 128:27-33. PMID: 25217864; PMCID: PMC4254369; DOI: 10.1016/j.exer.2014.08.015;.
  9. Gong H, Yang CY. Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632. J Ocul Pharmacol Ther. 2014 Mar-Apr; 30(2-3):143-53. PMID: 24460021; PMCID: PMC3991982; DOI: 10.1089/jop.2013.0192;.
  10. Gong H and Francis A. Surgical Innovations in Glaucoma. Schlemm’s Canal and Collector Channels as Therapeutic Targets. Springer. New York. 2014; 3-25.
Showing 10 of 64 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 64 publications over 27 distinct years, with a maximum of 6 publications in 2013

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Ocular perfusion
Trabecular meshwork

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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