Haiyan Gong, MD, PhD
Professor
Boston University School of Medicine
Dept of Ophthalmology

MD, Nanchang University
PhD, Boston University School of Medicine
MS, Peking Union Medical College




Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Professor
Boston University School of Medicine
Anatomy & Neurobiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




The Role of Giant Vacuoles and Pores of Schlemm's Canal Endothelial Cells in Regulating Aqueous Outflow
01/01/2020 - 03/14/2024 (Key Person / Mentor)
PI: David L. Swain
NIH/National Eye Institute
5F30EY030318-03

Function of Glycocalyx in the Trabecular Outflow Pathway
06/01/2020 - 05/31/2023 (PI)
NIH/National Eye Institute
5R21EY028674-02

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 05/31/2023 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.


Testing Effect of Sustained Release vs. Cyclic Exposure of Bimatoprost on MMP/TIMP/ECM Expression by Outflow Cells
05/21/2019 - 12/31/2022 (Subcontract PI)
Duke University Allergan Sales Inc


Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 08/31/2022 (PI)
NIH/National Eye Institute
5R01EY022634-09

The Role of Thrombospondin-1 in Regulating IOP
07/01/2019 - 06/30/2022 (PI)
Bright Focus Foundation


Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2019 - 05/31/2022 (Subcontract PI)
Duke University NIH NEI
5R01EY027733-04

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2021 (Subcontract PI)
Northwestern University NIH NEI
5R01EY019696-10

Transmission Electron Microscope
06/15/2020 - 06/14/2021 (PI)
NIH/Office of the Director
1S10OD028571-01

Effect of Netarsudil and AR-12286 on Effective Filtration Area and Morphology of the Trabecular Outflow Pathway
10/15/2018 - 10/15/2019 (PI)
Aerie Pharmaceuticals, Inc.


Showing 10 of 29 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Function of Glycocalyx in the Trabecular Outflow Pathway 5R21EY028674-02
2020 Transmission Electron Microscope 1S10OD028571-01
2020 Function of Glycocalyx in the Trabecular Outflow Pathway 1R21EY028674-01A1
2020 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-09 16
2019 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-08 16
2018 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-07 16
2017 Cellular Physiology of the Aqueous Outflow Pathway 2R01EY022634-06 16
2016 Cellular Physiology of the Aqueous Outflow Pathway 4R01EY022634-05 16
2015 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-04 16
2014 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-03 16
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sosnowik S, Swain DL, Liu N, Fan S, Toris CB, Gong H. Endothelial Glycocalyx Morphology in Different Flow Regions of the Aqueous Outflow Pathway of Normal and Laser-Induced Glaucoma Monkey Eyes,. Cells. 2022; 15(11):2452. View Publication
  2. Sosnowik S, Swain DL, Fan S, Toris CB, Gong H. Morphological changes to Schlemm's canal and the distal aqueous outflow pathway in monkey eyes with laser-induced ocular hypertension. Exp Eye Res. 2022 Jun; 219:109030.View Related Profiles. PMID: 35283108; DOI: 10.1016/j.exer.2022.109030;
     
  3. McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. PMID: 35129590; DOI: 10.1167/iovs.63.2.12;
     
  4. Ren R, Humphrey AA, Swain DL, Gong H. Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes. Int J Mol Sci. 2022 Jan 13; 23(2).View Related Profiles. PMID: 35055036; DOI: 10.3390/ijms23020854;
     
  5. Freddo TF, Civan M and Gong H. Albert and Jakobiec's Principles and Practices of Ophthalmology. Aqueous humor and the dynamics of its flow: Mechanisms and routes of aqueous humor drainage. Springer. 2022; 1989-2032.
  6. Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21; 13(28):32823-32836. PMID: 34232612; DOI: 10.1021/acsami.1c09294;
     
  7. Swain DL, Le TD, Yasmin S, Fernandes B, Lamaj G, Dasgupta I, Gao Y, Gong H. Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study. Exp Eye Res. 2021 04; 205:108488.View Related Profiles. PMID: 33571532; DOI: 10.1016/j.exer.2021.108488;
     
  8. Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma. J Clin Med. 2020 Dec 28; 10(1). PMID: 33379277; DOI: 10.3390/jcm10010078;
     
  9. Gong H and Swain DL. Current Developments in Glaucoma Surgery and MIGS. Anatomy of the conventional aqueous outflow pathway. Kugler. 2020; 1-37.
  10. Vahabikashi A, Gelman A, Dong B, Gong L, Cha EDK, Schimmel M, Tamm ER, Perkumas K, Stamer WD, Sun C, Zhang HF, Gong H, Johnson M. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc Natl Acad Sci U S A. 2019 Dec 05.View Related Profiles. PMID: 31806762; DOI: 10.1073/pnas.1911837116;
     
Showing 10 of 79 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 79 publications over 32 distinct years, with a maximum of 7 publications in 2013

YearPublications
19851
19861
19892
19921
19931
19941
19951
19962
19975
19981
19991
20002
20011
20025
20031
20062
20073
20083
20094
20102
20113
20124
20137
20144
20152
20163
20172
20181
20194
20202
20212
20225


Recent (within 3 months)

BU researcher receives BrightFocus award

Ophthalmology 9/12/2022

2019 Association For Research in Vision and Ophthalmology: Gold Fellow of ARVO
2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO
1978 Lhasa City Hospital: Physician of the Year
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Glaucoma
Ocular perfusion
Trabecular meshwork

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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