Haiyan Gong | Profiles RNS

Haiyan Gong, MD, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Ophthalmology

MD, Nanchang University
PhD, Boston University School of Medicine
MS, Peking Union Medical College

Websites

	Ophthalmology Faculty
	New England College of Optometry Profile
	5 Questions With Haiyan Gong, MD, PhD
	LinkedIn
	ResearchGate

ORCID : 0000-0002-7204-5019

Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2025 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Investigations of segmental uveal aqueous outflow
07/01/2022 - 06/30/2025 (PI)
BrightFocus Foundation

The Role of Giant Vacuoles and Pores of Schlemm's Canal Endothelial Cells in Regulating Aqueous Outflow
01/01/2020 - 03/14/2024 (Key Person / Mentor)
PI: David L. Swain
NIH/National Eye Institute
5F30EY030318-04

Function of Glycocalyx in the Trabecular Outflow Pathway
06/01/2020 - 05/31/2023 (PI)
NIH/National Eye Institute
5R21EY028674-02

Small molecular compounds for glaucoma therapy
01/01/2023 - 03/31/2023 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health BrightFocus Fdn

Testing Effect of Sustained Release vs. Cyclic Exposure of Bimatoprost on MMP/TIMP/ECM Expression by Outflow Cells
05/21/2019 - 12/31/2022 (Subcontract PI)
Duke University Allergan Sales Inc

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 12/31/2022 (PI)
NIH/National Eye Institute
5R01EY022634-09

The Role of Thrombospondin-1 in Regulating IOP
07/01/2019 - 07/30/2022 (PI)
Bright Focus Foundation

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2019 - 05/31/2022 (Subcontract PI)
Duke University NIH NEI
5R01EY027733-04

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2021 (Subcontract PI)
Northwestern University NIH NEI
5R01EY019696-10

Showing 10 of 31 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2021	Function of Glycocalyx in the Trabecular Outflow Pathway	5R21EY028674-02
2020	Transmission Electron Microscope	1S10OD028571-01
2020	Function of Glycocalyx in the Trabecular Outflow Pathway	1R21EY028674-01A1
2020	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-09	16
2019	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-08	16
2018	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-07	16
2017	Cellular Physiology of the Aqueous Outflow Pathway	2R01EY022634-06	16
2016	Cellular Physiology of the Aqueous Outflow Pathway	4R01EY022634-05	16
2015	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-04	16
2014	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-03	16

Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Acott TS, Fautsch MP, Mao W, Ethier CR, Huang AS, Kelley MJ, Aga M, Bhattacharya SK, Borras T, Bovenkamp D, Chowdhury UR, Clark AF, Dibas MI, Du Y, Elliott MH, Faralli JA, Gong H, Herberg S, Johnstone MA, Kaufman PL, Keller KE, Kelly RA, Krizaj D, Kuehn MH, Li HL, Lieberman R, Lin SC, Liu Y, McDonnell FS, McDowell CM, McLellan GJ, Mzyk P, Nair KS, Overby DR, Peters DM, Raghunathan V, Rao PV, Roddy GW, Sharif NA, Shim MS, Sun Y, Thomson BR, Toris CB, Willoughby CE, Zhang HF, Freddo TF, Fuchshofer R, Hill KR, Karimi A, Kizhatil K, Kopcyznski CC, Liton P, Patel G, Peng M, Pattabiraman PP, Prasanna G, Reina-Torres E, Samples EG, Samples JR, Steel CL, Strohmaier CA, Subramanian P, Sugali CK, van Batenburg-Sherwood J, Wong C, Youngblood H, Zode GS, White E, Stamer WD. Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Invest Ophthalmol Vis Sci. 2024 Dec 02; 65(14):32.View Related Profiles.

Gong, Haiyan
Li, Hoi Lam

PMID: 39693082; PMCID: PMC11708870; DOI: 10.1167/iovs.65.14.32;

Karimi A, Razaghi R, Stanik A, Daniel D'costa S, Mirafzal I, Kelley MJ, Acott TS, Gong H. High-resolution modeling of aqueous humor dynamics in the conventional outflow pathway of a normal human donor eye. Comput Methods Programs Biomed. 2025 Mar; 260:108538. PMID: 39644783; PMCID: PMC11805654; DOI: 10.1016/j.cmpb.2024.108538;

Chung YG, Fan S, Gulati V, Li HL, Gong H, Toris CB, Prausnitz MR, Ethier CR. IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space. Transl Vis Sci Technol. 2024 Oct 01; 13(10):14.View Related Profiles.

Gong, Haiyan
Li, Hoi Lam

PMID: 39377753; PMCID: PMC11469220; DOI: 10.1167/tvst.13.10.14;

Karimi A, Aga M, Khan T, D'costa SD, Thaware O, White E, Kelley MJ, Gong H, Acott TS. Comparative analysis of traction forces in normal and glaucomatous trabecular meshwork cells within a 3D, active fluid-structure interaction culture environment. Acta Biomater. 2024 May; 180:206-229. PMID: 38641184; PMCID: PMC11095374; DOI: 10.1016/j.actbio.2024.04.021;

Li HL, Ren R, Gong H. Segmental Unconventional Outflow in Mouse Eyes. Invest Ophthalmol Vis Sci. 2023 Dec 01; 64(15):26.View Related Profiles.

Gong, Haiyan
Li, Hoi Lam

PMID: 38117243; PMCID: PMC10741088; DOI: 10.1167/iovs.64.15.26;

Dixon A, Shim MS, Nettesheim A, Coyne A, Su CC, Gong H, Liton PB. Autophagy deficiency protects against ocular hypertension and glaucoma. Autophagy Rep. 2024; 3(1). PMID: 39726939; PMCID: PMC11671156; DOI: 10.1080/27694127.2023.2285214;

Karimi A, Razaghi R, D'costa SD, Torbati S, Ebrahimi S, Rahmati SM, Kelley MJ, Acott TS, Gong H. Implementing new computational methods for the study of JCT and SC inner wall basement membrane biomechanics and hydrodynamics. Comput Methods Programs Biomed. 2024 Jan; 243:107909. PMID: 37976613; PMCID: PMC10840991; DOI: 10.1016/j.cmpb.2023.107909;

Karimi A, Razaghi R, Kelley MJ, Acott TS, Gong H. Biomechanics of the JCT and SC Inner Wall Endothelial Cells with Their Basement Membrane Using 3D Serial Block-Face Scanning Electron Microscopy. Bioengineering (Basel). 2023 Sep 04; 10(9). PMID: 37760140; PMCID: PMC10525990; DOI: 10.3390/bioengineering10091038;

Dixon A, Shim MS, Nettesheim A, Coyne A, Su CC, Gong H, Liton PB. Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontanous glaucoma mouse models. Cell Death Dis. 2023 Aug 24; 14(8):554. PMID: 37620383; PMCID: PMC10449899; DOI: 10.1038/s41419-023-06086-3;

Ren R, Humphrey AA, Kopczynski C, Gong H. Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes. Invest Ophthalmol Vis Sci. 2023 Feb 01; 64(2):7.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 36734964; PMCID: PMC9907372; DOI: 10.1167/iovs.64.2.7;

Showing 10 of 92 results. Show More

Sosnowik S, Swain DL, Liu N, Fan S, Toris CB, Gong H. Endothelial Glycocalyx Morphology in Different Flow Regions of the Aqueous Outflow Pathway of Normal and Laser-Induced Glaucoma Monkey Eyes. Cells. 2022 Aug 07; 11(15).View Related Profiles.

Swain, David
Gong, Haiyan
Sosnowik, Shayna

PMID: 35954296; PMCID: PMC9367875; DOI: 10.3390/cells11152452;

Sosnowik S, Swain DL, Liu N, Fan S, Toris CB, Gong H. Endothelial Glycocalyx Morphology in Different Flow Regions of the Aqueous Outflow Pathway of Normal and Laser-Induced Glaucoma Monkey Eyes,. Cells. 2022; 15(11):2452. View Publication

Gupta M, Heo JY, Gong H, Cha E, Latina M, Rhee DJ. Morphologic and Cellular Changes Induced by Selective Laser Trabeculoplasty. Clin Ophthalmol. 2022; 16:1383-1390.View Related Profiles.

Cha, Elliot
Gong, Haiyan

PMID: 35520109; PMCID: PMC9064177; DOI: 10.2147/OPTH.S342787;

Swain DL, Yasmin S, Fernandes B, Lamaj G, Su Y, Gong H. Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole and Pore Formation in Different Flow-type Areas: A Serial Block-Face Scanning Electron Microscopy Study. Front Cell Dev Biol. 2022; 10:867376.View Related Profiles.

Swain, David
Gong, Haiyan

PMID: 35493087; PMCID: PMC9043561; DOI: 10.3389/fcell.2022.867376;

Sosnowik S, Swain DL, Fan S, Toris CB, Gong H. Morphological changes to Schlemm's canal and the distal aqueous outflow pathway in monkey eyes with laser-induced ocular hypertension. Exp Eye Res. 2022 Jun; 219:109030.View Related Profiles.

Swain, David
Gong, Haiyan
Sosnowik, Shayna

PMID: 35283108; PMCID: PMC9133064; DOI: 10.1016/j.exer.2022.109030;

McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. PMID: 35129590; PMCID: PMC8842499; DOI: 10.1167/iovs.63.2.12;

Ren R, Humphrey AA, Swain DL, Gong H. Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes. Int J Mol Sci. 2022 Jan 13; 23(2).View Related Profiles.

Swain, David
Gong, Haiyan
Ren, Ruiyi

PMID: 35055036; PMCID: PMC8775853; DOI: 10.3390/ijms23020854;

Freddo TF, Civan M and Gong H. Albert and Jakobiec's Principles and Practices of Ophthalmology. Aqueous humor and the dynamics of its flow: Mechanisms and routes of aqueous humor drainage. Springer. 2022; 1989-2032.

Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21; 13(28):32823-32836. PMID: 34232612; PMCID: PMC9131393; DOI: 10.1021/acsami.1c09294;

Swain DL, Le TD, Yasmin S, Fernandes B, Lamaj G, Dasgupta I, Gao Y, Gong H. Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study. Exp Eye Res. 2021 04; 205:108488.View Related Profiles.

Swain, David
Gong, Haiyan

PMID: 33571532; PMCID: PMC8044056; DOI: 10.1016/j.exer.2021.108488;

Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma. J Clin Med. 2020 Dec 28; 10(1). PMID: 33379277; PMCID: PMC7795952; DOI: 10.3390/jcm10010078;

Gong H and Swain DL. Current Developments in Glaucoma Surgery and MIGS. Anatomy of the conventional aqueous outflow pathway. Kugler. 2020; 1-37.

Vahabikashi A, Gelman A, Dong B, Gong L, Cha EDK, Schimmel M, Tamm ER, Perkumas K, Stamer WD, Sun C, Zhang HF, Gong H, Johnson M. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26555-26563.View Related Profiles.

Cha, Elliot
Gong, Haiyan

PMID: 31806762; PMCID: PMC6936716; DOI: 10.1073/pnas.1911837116;

Fini ME, Jeong S, Gong H, Martinez-Carrasco R, Laver NMV, Hijikata M, Keicho N, Argüeso P. Membrane-associated mucins of the ocular surface: New genes, new protein functions and new biological roles in human and mouse. Prog Retin Eye Res. 2020 03; 75:100777. PMID: 31493487; PMCID: PMC10276350; DOI: 10.1016/j.preteyeres.2019.100777;

Lai J, Su Y, Swain DL, Huang D, Getchevski D, Gong H. The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1630-1643.View Related Profiles.

Swain, David
Gong, Haiyan

PMID: 30995299; PMCID: PMC6736380; DOI: 10.1167/iovs.18-26011;

Wang Y, Osakue D, Yang E, Zhou Y, Gong H, Xia X, Du Y. Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):265-273. PMID: 30654386; PMCID: PMC6340162; DOI: 10.1167/iovs.18-25477;

Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. PMID: 29526795; PMCID: PMC6042513; DOI: 10.1016/j.exer.2018.03.001;

Tripon RG, Oláh J, Nasir T, Csincsik L, Li CL, Szunyogh S, Gong H, Flinn JM, Ovádi J, Lengyel I. Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye. J Trace Elem Med Biol. 2018 Sep; 49:222-230. PMID: 29317136; DOI: 10.1016/j.jtemb.2017.12.009;

Raghunathan V, Eaton JS, Christian BJ, Morgan JT, Ver Hoeve JN, Yang CC, Gong H, Rasmussen CA, Miller PE, Russell P, Nork TM, Murphy CJ. Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. Sci Rep. 2017 10 30; 7(1):14329. PMID: 29085025; PMCID: PMC5662689; DOI: 10.1038/s41598-017-14720-2;

Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 27842161; PMCID: PMC5114035; DOI: 10.1167/iovs.16-20189;

Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60.View Related Profiles.

Cha, Elliot
Gong, Haiyan
Xu, Jia

PMID: 26775054; PMCID: PMC4893924; DOI: 10.1016/j.exer.2016.01.008;

Gong H, Swain DL. Glaucoma Research and Clinical Advances 2016-2018, Knepper P, Samples J, editors. The Histopathological Changes in the Trabecular Outflow Pathway and Their Possible Effects on Aqueous Outflow in Eyes with Primary Open-Angle Glaucoma. Kugler. Amsterdam, The Netherlands. 2016; 17-40.

Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760; PMCID: PMC4787989; DOI: 10.1016/j.cvsm.2015.06.005;

Swain DL, Ho J, Lai J, Gong H. Shorter scleral spur in eyes with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1638-48.View Related Profiles.

Swain, David
Gong, Haiyan

PMID: 25670488; PMCID: PMC4351652; DOI: 10.1167/iovs.14-15593;

Vargas-Pinto R, Lai J, Gong H, Ethier CR, Johnson M. Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells. Biomech Model Mechanobiol. 2015 Aug; 14(4):851-63. PMID: 25516410; PMCID: PMC4470892; DOI: 10.1007/s10237-014-0640-2;

Yang CY, Huynh T, Johnson M, Gong H. Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes. Exp Eye Res. 2014 Nov; 128:27-33. PMID: 25217864; PMCID: PMC4254369; DOI: 10.1016/j.exer.2014.08.015;

Gong H, Yang CY. Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632. J Ocul Pharmacol Ther. 2014 Mar-Apr; 30(2-3):143-53. PMID: 24460021; PMCID: PMC3991982; DOI: 10.1089/jop.2013.0192;

Gong H and Francis A. Surgical Innovations in Glaucoma. Schlemm’s Canal and Collector Channels as Therapeutic Targets. Springer. New York. 2014; 3-25.

Yang CY, Liu Y, Lu Z, Ren R, Gong H. Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013; 54(8):5859-70.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 23920374; PMCID: PMC3757907; DOI: 10.1167/iovs.12-10930;

Vargas-Pinto R, Gong H, Vahabikashi A, Johnson M. The effect of the endothelial cell cortex on atomic force microscopy measurements. Biophys J. 2013 Jul 16; 105(2):300-9. PMID: 23870251; PMCID: PMC3714930; DOI: 10.1016/j.bpj.2013.05.034;

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. Ann Neurosci. 2013 Apr; 20(2):65-6.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 25206015; PMCID: PMC4117107; DOI: 10.5214/ans.0972.7531.200207;

Swaminathan SS, Oh DJ, Kang MH, Ren R, Jin R, Gong H, Rhee DJ. Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow. Invest Ophthalmol Vis Sci. 2013 Mar; 54(3):2035-47. PMID: 23422826; PMCID: PMC3621502; DOI: 10.1167/iovs.12-10950;

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156. PMID: 23527308; PMCID: PMC3603933; DOI: 10.1371/journal.pone.0060156;

Bhattacharya SK, Lee RK, Grus FH. Molecular biomarkers in glaucoma. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):121-31. PMID: 23297392; PMCID: PMC3544416; DOI: 10.1167/iovs.12-11067;

Zhu JY, Ye W, Wang T, Gong HY. Reversible changes in aqueous outflow facility, hydrodynamics, and morphology following acute intraocular pressure variation in bovine eyes. Chin Med J (Engl). 2013; 126(8):1451-7. PMID: 23595376; PMCID: PMC3771502

Freddo TF, Neville N, Gong H. Pilocarpine-induced flare is physiological rather than pathological. Exp Eye Res. 2013 Feb; 107:37-43. PMID: 23187102; PMCID: PMC3556229; DOI: 10.1016/j.exer.2012.11.003;

Haddadin RI, Oh DJ, Kang MH, Villarreal G, Kang JH, Jin R, Gong H, Rhee DJ. Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures. Invest Ophthalmol Vis Sci. 2012; 53(10):6708-17. PMID: 22930728; PMCID: PMC3462480; DOI: 10.1167/iovs.11-9013;

Diskin S, Chen WS, Cao Z, Gyawali S, Gong H, Soza A, González A, Panjwani N. Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling. PLoS One. 2012; 7(9):e44400. PMID: 22973445; PMCID: PMC3433423; DOI: 10.1371/journal.pone.0044400;

Francis AW, Gyasi ME, Deng L, Gong H. Comparison of moderate and advanced glaucoma patients in Ghana. Clin Ophthalmol. 2012; 6:297-304. PMID: 22393281; PMCID: PMC3292413; DOI: 10.2147/OPTH.S28288;

Lu Z, Zhang Y, Freddo TF, Gong H. Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes. Exp Eye Res. 2011 Oct; 93(4):397-404. PMID: 21669200; PMCID: PMC3197945; DOI: 10.1016/j.exer.2011.05.012;

Kagemann L, Wollstein G, Ishikawa H, Sigal IA, Folio LS, Xu J, Gong H, Schuman JS. 3D visualization of aqueous humor outflow structures in-situ in humans. Exp Eye Res. 2011 Sep; 93(3):308-15. PMID: 21514296; PMCID: PMC3196779; DOI: 10.1016/j.exer.2011.03.019;

Freddo TF, Gong H and Civan M. Duane’s Clinical Ophthalmology. Anatomy of the Ciliary Body and Outflow Pathways. Lippincott, Williams & Wilkins. Philadelphia. 2011.

Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82.View Related Profiles.

Costello, Catherine
Seldin, David
Gong, Haiyan
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery
Hong, Zhenning

PMID: 20870723; PMCID: PMC2988372; DOI: 10.1074/jbc.M110.149575;

Zhu JY, Ye W, Gong HY. Development of a novel two color tracer perfusion technique for the hydrodynamic study of aqueous outflow in bovine eyes. Chin Med J (Engl). 2010 Mar 5; 123(5):599-605. PMID: 20367989; PMCID: PMC2905231

Scott PA, Lu Z, Liu Y, Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp Eye Res. 2009 Dec; 89(6):942-9.View Related Profiles.

Gong, Haiyan
Lu, Zhaohua

PMID: 19679123; DOI: 10.1016/j.exer.2009.08.002;

Zhang Y, Toris CB, Liu Y, Ye W, Gong H. Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma. Exp Eye Res. 2009 Nov; 89(5):748-56. PMID: 19591828; DOI: 10.1016/j.exer.2009.06.015;

Freddo TF, Gong H. ETIOLOGY OF IOP ELEVATION IN PRIMARY OPEN ANGLE GLAUCOMA. Optom Glaucoma Soc E J. 2009 Jul; 4(1). PMID: 22957318; PMCID: PMC3432647

Gong H, Freddo TF. The washout phenomenon in aqueous outflow--why does it matter? Exp Eye Res. 2009 Apr; 88(4):729-37. PMID: 19385044; PMCID: PMC2775510; DOI: 10.1016/j.exer.2009.01.015;

Sieminski AL, Semino CE, Gong H, Kamm RD. Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. J Biomed Mater Res A. 2008 Nov; 87(2):494-504. PMID: 18186067; DOI: 10.1002/jbm.a.31785;

Battista SA, Lu Z, Hofmann S, Freddo T, Overby DR, Gong H. Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5346-52. PMID: 18515571; PMCID: PMC4788035; DOI: 10.1167/iovs.08-1707;

Freddo TF, Civan M and Gong H. Principles and Practice of Ophthalmology. Aqueous humor and the dynamics of its flow: mechanisms and routes of aqueous humor drainage. Saunders. 2008.

Lu Z, Overby DR, Scott PA, Freddo TF, Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res. 2008 Feb; 86(2):271-81. PMID: 18155193; PMCID: PMC2441864; DOI: 10.1016/j.exer.2007.10.018;

Dimicco MA, Kisiday JD, Gong H, Grodzinsky AJ. Structure of pericellular matrix around agarose-embedded chondrocytes. Osteoarthritis Cartilage. 2007 Oct; 15(10):1207-16. PMID: 17524677; DOI: 10.1016/j.joca.2007.03.023;

Sieminski AL, Was AS, Kim G, Gong H, Kamm RD. The stiffness of three-dimensional ionic self-assembling peptide gels affects the extent of capillary-like network formation. Cell Biochem Biophys. 2007; 49(2):73-83. PMID: 17906362

Scott PA, Overby DR, Freddo TF, Gong H. Comparative studies between species that do and do not exhibit the washout effect. Exp Eye Res. 2007 Mar; 84(3):435-43. PMID: 17173894; PMCID: PMC1850108; DOI: 10.1016/j.exer.2006.10.015;

Zaman MH, Trapani LM, Sieminski AL, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10889-94.View Related Profiles.

Gong, Haiyan
Zaman, Muhammad

PMID: 16832052; PMCID: PMC1544144; DOI: 10.1073/pnas.0604460103;

Song QH, Gong H, Trinkaus-Randall V. Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit beta4. Cell Tissue Res. 2003 May; 312(2):203-20.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 12715147

Overby D, Gong H, Qiu G, Freddo TF, Johnson M. The mechanism of increasing outflow facility during washout in the bovine eye. Invest Ophthalmol Vis Sci. 2002 Nov; 43(11):3455-64. PMID: 12407156

Gong H, Ruberti J, Overby D, Johnson M, Freddo TF. A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy. Exp Eye Res. 2002 Sep; 75(3):347-58. PMID: 12384097

Vauthey S, Santoso S, Gong H, Watson N, Zhang S. Molecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5355-60. PMID: 11929973; PMCID: PMC122773

Freddo TF and Gong H. Duane’s Clinical Ophthalmology. Anatomy of the Ciliary Body and Outflow Pathways. Lippincott, Williams & Wilkins. Philadelphia. 2002.

Sonsino J, Gong H, Wu P, Freddo TF. Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actin. Exp Eye Res. 2002 Jan; 74(1):123-9. PMID: 11878825

Overby D, Ruberti J, Gong H, Freddo TF, Johnson M. Specific hydraulic conductivity of corneal stroma as seen by quick-freeze/deep-etch. J Biomech Eng. 2001 Apr; 123(2):154-61. PMID: 11340876

Wu P, Gong H, Richman R, Freddo TF. Localization of occludin, ZO-1, and pan-cadherin in rabbit ciliary epithelium and iris vascular endothelium. Histochem Cell Biol. 2000 Oct; 114(4):303-10. PMID: 11131095

Payne J, Gong H, Trinkaus-Randall V. Tyrosine phosphorylation: a critical component in the formation of hemidesmosomes. Cell Tissue Res. 2000 Jun; 300(3):401-11.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 10928271

Al-Aswad LA, Gong H, Lee D, O'Donnell ME, Brandt JD, Ryan WJ, Schroeder A, Erickson KA. Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro. Invest Ophthalmol Vis Sci. 1999 Jul; 40(8):1695-701.View Related Profiles.

Gong, Haiyan
Al-Aswad, Lina

PMID: 10393038

Svoboda KKH, Gong H, Rrinkaus-Randall V. Collagen expression and orientation in ocular tissue. Prog Polym Sci. 1998; 23:329-374.

Gong H, Johnson M, Ye W, Kamm RD, Freddo TF. The non-uniform distribution of albumin in human and bovine cornea. Exp Eye Res. 1997 Dec; 65(6):747-56. PMID: 9441698

Ye W, Gong H, Sit A, Johnson M, Freddo TF. Interendothelial junctions in normal human Schlemm's canal respond to changes in pressure. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2460-8. PMID: 9375563

Hubbard WC, Johnson M, Gong H, Gabelt BT, Peterson JA, Sawhney R, Freddo T, Kaufman PL. Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys. Exp Eye Res. 1997 Aug; 65(2):177-90. PMID: 9268586

Sit AJ, Gong H, Ritter N, Freddo TF, Kamm R, Johnson M. The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye. Exp Eye Res. 1997 May; 64(5):813-21. PMID: 9245912

Gong H, Ye W, Freddo TF, Hernandez MR. Hyaluronic acid in the normal and glaucomatous optic nerve. Exp Eye Res. 1997 Apr; 64(4):587-95. PMID: 9227277

Gong H, Tripathi RC, Tripathi BJ. Morphology of the aqueous outflow pathway. Microsc Res Tech. 1996 Mar 1; 33(4):336-67. PMID: 8652890

Hernandez MR and Gong H. The Glaucomas. Extracellular matrix of the trabecular meshwork and optic nerve head. Mosby. 1996.

Bhatt K, Gong H, Freddo TF. Freeze-fracture studies of interendothelial junctions in the angle of the human eye. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1379-89. PMID: 7775116

Gong H, Underhill CB, Freddo TF. Hyaluronan in the bovine ocular anterior segment, with emphasis on the outflow pathways. Invest Ophthalmol Vis Sci. 1994 Dec; 35(13):4328-32. PMID: 7528182

Johnson M, Gong H, Freddo TF, Ritter N, Kamm R. Serum proteins and aqueous outflow resistance in bovine eyes. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3549-57. PMID: 8258512

Gong H, Freddo TF, Johnson M. Age-related changes of sulfated proteoglycans in the normal human trabecular meshwork. Exp Eye Res. 1992 Nov; 55(5):691-709. PMID: 1478279

Gong HY, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989 Oct; 8(10):1071-82.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 2612196

Jabbour NM, McCormick SA, Gong HY. Transscleral and transconjunctival diathermy. Retina. 1989; 9(2):127-30. PMID: 2772420

Gong HY. [Serous detachment of the retinal pigment epithelium. Long-term follow-up studies]. Zhonghua Yan Ke Za Zhi. 1986 Nov; 22(6):339-42. PMID: 3100250

Zhang CF. [Acute multiple ischemic choroidopathy]. Zhonghua Yan Ke Za Zhi. 1985 Nov; 21(6):331-4. PMID: 3939203

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 92 publications over 34 distinct years, with a maximum of 8 publications in 2022

Bar chart showing 92 publications over 34 distinct years, with a maximum of 8 publications in 2022

Year	Publications
1985	1
1986	1
1989	2
1992	1
1993	1
1994	1
1995	1
1996	2
1997	5
1998	1
1999	1
2000	2
2001	1
2002	5
2003	1
2006	2
2007	3
2008	3
2009	4
2010	2
2011	3
2012	4
2013	7
2014	4
2015	2
2016	3
2017	2
2018	1
2019	4
2020	2
2021	2
2022	8
2023	6
2024	4