Haiyan Gong, MD, PhD
Boston University School of Medicine
Dept of Ophthalmology

MD, Jiangxi University of Traditional Chinese Medicine
PhD, Boston University School of Medicine
MS, Peking Union Medical College

Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Boston University School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO
1978 Lhasa City Hospital: Physician of the Year

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 08/31/2021 (PI)
NIH/National Eye Institute

Effect of Netarsudil and AR-12286 on Effective Filtration Area and Morphology of the Trabecular Outflow Pathway
10/15/2018 - 10/15/2019 (PI)
Aerie Pharmaceuticals, Inc.

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2019 (PI)
Northwestern University NIH NEI

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2019 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Glycocalyx in the pores of the inner wall endothelial cells of Schlemms canal
06/01/2018 - 05/31/2019 (PI)
Western Glaucoma Foundation

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2018 - 05/31/2019 (PI)
Duke University NIH NEI

Cell-cell interactions in giant vacuole/pore formation
07/01/2016 - 06/30/2018 (PI)
Bright Focus Foundation

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2017 - 05/31/2018 (PI)
Duke University NIH NEI

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2016 - 08/31/2017 (PI)
NIH/National Eye Institute

Cellular Physiology of the Aqueous Outflow Pathway
09/30/2012 - 08/31/2016 (PI)
NIH/National Eye Institute

Showing 10 of 23 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lai J, Su Y, Swain DL, Huang D, Getchevski D, Gong H. The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study. Invest Ophthalmol Vis Sci. 2019 Apr 01; 60(5):1630-1643.View Related Profiles. PMID: 30995299; DOI: 10.1167/iovs.18-26011;.
  2. Wang Y, Osakue D, Yang E, Zhou Y, Gong H, Xia X, Du Y. Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):265-273. PMID: 30654386.
  3. Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 06; 171:164-173. PMID: 29526795.
  4. Tripon RG, Oláh J, Nasir T, Csincsik L, Li CL, Szunyogh S, Gong H, Flinn JM, Ovádi J, Lengyel I. Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye. J Trace Elem Med Biol. 2018 Sep; 49:222-230. PMID: 29317136; DOI: 10.1016/j.jtemb.2017.12.009;.
  5. Raghunathan V, Eaton JS, Christian BJ, Morgan JT, Ver Hoeve JN, Yang CC, Gong H, Rasmussen CA, Miller PE, Russell P, Nork TM, Murphy CJ. Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. Sci Rep. 2017 10 30; 7(1):14329. PMID: 29085025.
  6. Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209.View Related Profiles. PMID: 27842161; DOI: 10.1167/iovs.16-20189;.
  7. Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60.View Related Profiles. PMID: 26775054; PMCID: PMC4893924; DOI: 10.1016/j.exer.2016.01.008;.
  8. Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.
  9. Gong H, Swain DL. Glaucoma Research and Clinical Advances 2016-2018, Knepper P, Samples J, editors. The Histopathological Changes in the Trabecular Outflow Pathway and Their Possible Effects on Aqueous Outflow in Eyes with Primary Open-Angle Glaucoma. Kugler. Amsterdam, The Netherlands. 2016; 17-40.
  10. Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760; PMCID: PMC4787989; DOI: 10.1016/j.cvsm.2015.06.005;.
Showing 10 of 69 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 69 publications over 29 distinct years, with a maximum of 6 publications in 2013

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Ocular perfusion
Trabecular meshwork

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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