Haiyan Gong | Profiles RNS

Haiyan Gong, MD, PhD

Professor

Boston University School of Medicine

Dept of Ophthalmology

MD, Jiangxi University of Traditional Chinese Medicine
PhD, Boston University School of Medicine
MS, Peking Union Medical College

Websites

Ophthalmology Faculty

ORCID : 0000-0002-7204-5019

Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Professor
Boston University School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO

BU Sponsored Research
NIH RePORTER Sponsored Research

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 08/31/2021 (PI)
NIH/National Eye Institute
2R01EY022634-06

Cell-cell interactions in giant vacuole/pore formation
07/01/2016 - 06/30/2018 (PI)
Bright Focus Foundation

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2018 (PI)
Northwestern University NIH NEI
R01EY019696

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2018 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2017 - 05/31/2018 (PI)
Duke University NIH NEI
1R01EY027733-01

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2016 - 08/31/2017 (PI)
NIH/National Eye Institute
4R01EY022634-05

Cellular Physiology of the Aqueous Outflow Pathway
09/30/2012 - 08/31/2016 (PI)
NIH/National Eye Institute
5R01EY022634-04

A Mouse Giaucoma Model and Stem Cell-Based Therapy for Glaucoma
07/01/2014 - 06/30/2016 (PI)
University of Pittsburgh Bright Focus Fdn

Evaluation of the effect of an Aerie drug (AR-13324) on aqueous flow pattern and morphology in enucleated human eyes
10/15/2014 - 12/30/2015 (PI)
Aerie Pharmaceuticals, Inc.

The Mechanical Basis of Primary Open Angle Glaucoma
09/30/2009 - 09/29/2015 (PI)
Northwestern University NIH NEI
R01EY019696

Showing 10 of 20 results. Show All Results

Yr	Title	Project-Sub Proj	Pubs
2017	Cellular Physiology of the Aqueous Outflow Pathway	2R01EY022634-06	8
2016	Cellular Physiology of the Aqueous Outflow Pathway	4R01EY022634-05	8
2015	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-04	8
2014	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-03	8
2013	Cellular Physiology of the Aqueous Outflow Pathway	5R01EY022634-02	8
2012	Cellular Physiology of the Aqueous Outflow Pathway	1R01EY022634-01	8
2010	A Previously Unrecognized Site of Resistance in POAG	5R21EY018712-02	8
2009	A Previously Unrecognized Site of Resistance in POAG	1R21EY018712-01A2	8

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Keller KE, Bhattacharya SK, Borrás T, Brunner TM, Chansangpetch S, Clark AF, Dismuke WM, Du Y, Elliott MH, Ethier CR, Faralli JA, Freddo TF, Fuchshofer R, Giovingo M, Gong H, Gonzalez P, Huang A, Johnstone MA, Kaufman PL, Kelley MJ, Knepper PA, Kopczynski CC, Kuchtey JG, Kuchtey RW, Kuehn MH, Lieberman RL, Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Mao W, Masis-Solano M, McDonnell F, McDowell CM, Overby DR, Pattabiraman PP, Raghunathan VK, Rao PV, Rhee DJ, Chowdhury UR, Russell P, Samples JR, Schwartz D, Stubbs EB, Tamm ER, Tan JC, Toris CB, Torrejon KY, Vranka JA, Wirtz MK, Yorio T, Zhang J, Zode GS, Fautsch MP, Peters DM, Acott TS, Stamer WD. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 2018 Mar 08. PMID: 29526795.

Tripon RG, Oláh J, Nasir T, Csincsik L, Li CL, Szunyogh S, Gong H, Flinn JM, Ovádi J, Lengyel I. Localization of the zinc binding tubulin polymerization promoting protein in the mice and human eye. J Trace Elem Med Biol. 2017 Dec 27. PMID: 29317136; DOI: 10.1016/j.jtemb.2017.12.009;.

Raghunathan V, Eaton JS, Christian BJ, Morgan JT, Ver Hoeve JN, Yang CC, Gong H, Rasmussen CA, Miller PE, Russell P, Nork TM, Murphy CJ. Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model. Sci Rep. 2017 Oct 30; 7(1):14329. PMID: 29085025.

Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 27842161; DOI: 10.1167/iovs.16-20189;.

Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60.View Related Profiles.

Cha, Elliot
Gong, Haiyan

PMID: 26775054; PMCID: PMC4893924; DOI: 10.1016/j.exer.2016.01.008;.

Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.

Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760; PMCID: PMC4787989; DOI: 10.1016/j.cvsm.2015.06.005;.

Swain DL, Ho J, Lai J, Gong H. Shorter scleral spur in eyes with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1638-48.View Related Profiles.

Swain, David
Gong, Haiyan

PMID: 25670488; PMCID: PMC4351652; DOI: 10.1167/iovs.14-15593;.

Vargas-Pinto R, Lai J, Gong H, Ethier CR, Johnson M. Finite element analysis of the pressure-induced deformation of Schlemm''s canal endothelial cells. Biomech Model Mechanobiol. 2015 Aug; 14(4):851-63. PMID: 25516410; PMCID: PMC4470892; DOI: 10.1007/s10237-014-0640-2;.

Yang CY, Huynh T, Johnson M, Gong H. Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes. Exp Eye Res. 2014 Nov; 128:27-33. PMID: 25217864; PMCID: PMC4254369; DOI: 10.1016/j.exer.2014.08.015;.

Showing 10 of 66 results. Show More

Gong H, Yang CY. Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632. J Ocul Pharmacol Ther. 2014 Mar-Apr; 30(2-3):143-53. PMID: 24460021; PMCID: PMC3991982; DOI: 10.1089/jop.2013.0192;.

Gong H and Francis A. Surgical Innovations in Glaucoma. Schlemm’s Canal and Collector Channels as Therapeutic Targets. Springer. New York. 2014; 3-25.

Yang CY, Liu Y, Lu Z, Ren R, Gong H. Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013; 54(8):5859-70.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 23920374; PMCID: PMC3757907; DOI: 10.1167/iovs.12-10930;.

Vargas-Pinto R, Gong H, Vahabikashi A, Johnson M. The effect of the endothelial cell cortex on atomic force microscopy measurements. Biophys J. 2013 Jul 16; 105(2):300-9. PMID: 23870251; PMCID: PMC3714930; DOI: 10.1016/j.bpj.2013.05.034;.

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte'' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. Ann Neurosci. 2013 Apr; 20(2):65-6.View Related Profiles.

Gong, Haiyan
Ren, Ruiyi

PMID: 25206015; DOI: 10.5214/ans.0972.7531.200207;.

Swaminathan SS, Oh DJ, Kang MH, Ren R, Jin R, Gong H, Rhee DJ. Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow. Invest Ophthalmol Vis Sci. 2013 Mar; 54(3):2035-47. PMID: 23422826; PMCID: PMC3621502; DOI: 10.1167/iovs.12-10950;.

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156. PMID: 23527308; PMCID: PMC3603933; DOI: 10.1371/journal.pone.0060156;.

Zhu JY, Ye W, Wang T, Gong HY. Reversible changes in aqueous outflow facility, hydrodynamics, and morphology following acute intraocular pressure variation in bovine eyes. Chin Med J (Engl). 2013; 126(8):1451-7. PMID: 23595376; PMCID: PMC3771502.

Freddo TF, Neville N, Gong H. Pilocarpine-induced flare is physiological rather than pathological. Exp Eye Res. 2013 Feb; 107:37-43. PMID: 23187102; PMCID: PMC3556229; DOI: 10.1016/j.exer.2012.11.003;.

Haddadin RI, Oh DJ, Kang MH, Villarreal G, Kang JH, Jin R, Gong H, Rhee DJ. Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures. Invest Ophthalmol Vis Sci. 2012; 53(10):6708-17. PMID: 22930728; PMCID: PMC3462480.

Diskin S, Chen WS, Cao Z, Gyawali S, Gong H, Soza A, González A, Panjwani N. Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling. PLoS One. 2012; 7(9):e44400. PMID: 22973445; PMCID: PMC3433423; DOI: 10.1371/journal.pone.0044400;.

Francis AW, Gyasi ME, Deng L, Gong H. Comparison of moderate and advanced glaucoma patients in Ghana. Clin Ophthalmol. 2012; 6:297-304. PMID: 22393281; PMCID: PMC3292413; DOI: 10.2147/OPTH.S28288;.

Lu Z, Zhang Y, Freddo TF, Gong H. Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes. Exp Eye Res. 2011 Oct; 93(4):397-404. PMID: 21669200; PMCID: PMC3197945; DOI: 10.1016/j.exer.2011.05.012;.

Kagemann L, Wollstein G, Ishikawa H, Sigal IA, Folio LS, Xu J, Gong H, Schuman JS. 3D visualization of aqueous humor outflow structures in-situ in humans. Exp Eye Res. 2011 Sep; 93(3):308-15. PMID: 21514296; PMCID: PMC3196779; DOI: 10.1016/j.exer.2011.03.019;.

Freddo TF, Gong H and Civan M. Duane’s Clinical Ophthalmology. Anatomy of the Ciliary Body and Outflow Pathways. Lippincott, Williams & Wilkins. Philadelphia. 2011.

Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82.View Related Profiles.

Costello, Catherine
Seldin, David
Gong, Haiyan
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery
Hong, Zhenning

PMID: 20870723; PMCID: PMC2988372; DOI: 10.1074/jbc.M110.149575;.

Zhu JY, Ye W, Gong HY. Development of a novel two color tracer perfusion technique for the hydrodynamic study of aqueous outflow in bovine eyes. Chin Med J (Engl). 2010 Mar 5; 123(5):599-605. PMID: 20367989; PMCID: PMC2905231.

Scott PA, Lu Z, Liu Y, Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp Eye Res. 2009 Dec; 89(6):942-9.View Related Profiles.

Gong, Haiyan
Lu, Zhaohua

PMID: 19679123; DOI: 10.1016/j.exer.2009.08.002;.

Zhang Y, Toris CB, Liu Y, Ye W, Gong H. Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma. Exp Eye Res. 2009 Nov; 89(5):748-56. PMID: 19591828; DOI: 10.1016/j.exer.2009.06.015;.

Freddo TF, Gong H. ETIOLOGY OF IOP ELEVATION IN PRIMARY OPEN ANGLE GLAUCOMA. Optom Glaucoma Soc E J. 2009 Jul; 4(1). PMID: 22957318.

Gong H, Freddo TF. The washout phenomenon in aqueous outflow--why does it matter? Exp Eye Res. 2009 Apr; 88(4):729-37. PMID: 19385044; PMCID: PMC2775510.

Sieminski AL, Semino CE, Gong H, Kamm RD. Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. J Biomed Mater Res A. 2008 Nov; 87(2):494-504. PMID: 18186067; DOI: 10.1002/jbm.a.31785;.

Battista SA, Lu Z, Hofmann S, Freddo T, Overby DR, Gong H. Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5346-52. PMID: 18515571; DOI: 10.1167/iovs.08-1707;.

Freddo TF, Civan M and Gong H. Principles and Practice of Ophthalmology. Aqueous humor and the dynamics of its flow: mechanisms and routes of aqueous humor drainage. Saunders. 2008.

Lu Z, Overby DR, Scott PA, Freddo TF, Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res. 2008 Feb; 86(2):271-81. PMID: 18155193; PMCID: PMC2441864.

Dimicco MA, Kisiday JD, Gong H, Grodzinsky AJ. Structure of pericellular matrix around agarose-embedded chondrocytes. Osteoarthritis Cartilage. 2007 Oct; 15(10):1207-16. PMID: 17524677; DOI: 10.1016/j.joca.2007.03.023;.

Sieminski AL, Was AS, Kim G, Gong H, Kamm RD. The stiffness of three-dimensional ionic self-assembling peptide gels affects the extent of capillary-like network formation. Cell Biochem Biophys. 2007; 49(2):73-83. PMID: 17906362.

Scott PA, Overby DR, Freddo TF, Gong H. Comparative studies between species that do and do not exhibit the washout effect. Exp Eye Res. 2007 Mar; 84(3):435-43. PMID: 17173894; PMCID: PMC1850108.

Zaman MH, Trapani LM, Sieminski AL, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10889-94.View Related Profiles.

Gong, Haiyan
Zaman, Muhammad

PMID: 16832052; PMCID: PMC1544144.

Song QH, Gong H, Trinkaus-Randall V. Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit beta4. Cell Tissue Res. 2003 May; 312(2):203-20.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 12715147.

Overby D, Gong H, Qiu G, Freddo TF, Johnson M. The mechanism of increasing outflow facility during washout in the bovine eye. Invest Ophthalmol Vis Sci. 2002 Nov; 43(11):3455-64. PMID: 12407156.

Gong H, Ruberti J, Overby D, Johnson M, Freddo TF. A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy. Exp Eye Res. 2002 Sep; 75(3):347-58. PMID: 12384097.

Vauthey S, Santoso S, Gong H, Watson N, Zhang S. Molecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5355-60. PMID: 11929973; PMCID: PMC122773.

Sonsino J, Gong H, Wu P, Freddo TF. Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actin. Exp Eye Res. 2002 Jan; 74(1):123-9. PMID: 11878825.

Freddo TF and Gong H. Duane’s Clinical Ophthalmology. Anatomy of the Ciliary Body and Outflow Pathways. Lippincott, Williams & Wilkins. Philadelphia. 2002.

Overby D, Ruberti J, Gong H, Freddo TF, Johnson M. Specific hydraulic conductivity of corneal stroma as seen by quick-freeze/deep-etch. J Biomech Eng. 2001 Apr; 123(2):154-61. PMID: 11340876.

Wu P, Gong H, Richman R, Freddo TF. Localization of occludin, ZO-1, and pan-cadherin in rabbit ciliary epithelium and iris vascular endothelium. Histochem Cell Biol. 2000 Oct; 114(4):303-10. PMID: 11131095.

Payne J, Gong H, Trinkaus-Randall V. Tyrosine phosphorylation: a critical component in the formation of hemidesmosomes. Cell Tissue Res. 2000 Jun; 300(3):401-11.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 10928271.

Al-Aswad LA, Gong H, Lee D, O'Donnell ME, Brandt JD, Ryan WJ, Schroeder A, Erickson KA. Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro. Invest Ophthalmol Vis Sci. 1999 Jul; 40(8):1695-701.View Related Profiles.

Gong, Haiyan
Al-Aswad, Lina

PMID: 10393038.

Svoboda KKH, Gong H, Rrinkaus-Randall V. Collagen expression and orientation in ocular tissue. Prog Polym Sci. 1998; 23:329-374.

Gong H, Johnson M, Ye W, Kamm RD, Freddo TF. The non-uniform distribution of albumin in human and bovine cornea. Exp Eye Res. 1997 Dec; 65(6):747-56. PMID: 9441698.

Ye W, Gong H, Sit A, Johnson M, Freddo TF. Interendothelial junctions in normal human Schlemm's canal respond to changes in pressure. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2460-8. PMID: 9375563.

Hubbard WC, Johnson M, Gong H, Gabelt BT, Peterson JA, Sawhney R, Freddo T, Kaufman PL. Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys. Exp Eye Res. 1997 Aug; 65(2):177-90. PMID: 9268586.

Sit AJ, Gong H, Ritter N, Freddo TF, Kamm R, Johnson M. The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye. Exp Eye Res. 1997 May; 64(5):813-21. PMID: 9245912.

Gong H, Ye W, Freddo TF, Hernandez MR. Hyaluronic acid in the normal and glaucomatous optic nerve. Exp Eye Res. 1997 Apr; 64(4):587-95. PMID: 9227277.

Gong H, Tripathi RC, Tripathi BJ. Morphology of the aqueous outflow pathway. Microsc Res Tech. 1996 Mar 1; 33(4):336-67. PMID: 8652890.

Hernandez MR and Gong H. The Glaucomas. Extracellular matrix of the trabecular meshwork and optic nerve head. Mosby. 1996.

Bhatt K, Gong H, Freddo TF. Freeze-fracture studies of interendothelial junctions in the angle of the human eye. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1379-89. PMID: 7775116.

Gong H, Underhill CB, Freddo TF. Hyaluronan in the bovine ocular anterior segment, with emphasis on the outflow pathways. Invest Ophthalmol Vis Sci. 1994 Dec; 35(13):4328-32. PMID: 7528182.

Johnson M, Gong H, Freddo TF, Ritter N, Kamm R. Serum proteins and aqueous outflow resistance in bovine eyes. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3549-57. PMID: 8258512.

Gong H, Freddo TF, Johnson M. Age-related changes of sulfated proteoglycans in the normal human trabecular meshwork. Exp Eye Res. 1992 Nov; 55(5):691-709. PMID: 1478279.

Gong HY, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989 Oct; 8(10):1071-82.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 2612196.

Jabbour NM, McCormick SA, Gong HY. Transscleral and transconjunctival diathermy. Retina. 1989; 9(2):127-30. PMID: 2772420.

Gong H, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989; 8(10):1071-1081.View Related Profiles.

Gong, Haiyan
Trinkaus-Randall, Vickery

PMID: 28692813.

Gong HY. [Serous detachment of the retinal pigment epithelium. Long-term follow-up studies]. Zhonghua Yan Ke Za Zhi. 1986 Nov; 22(6):339-42. PMID: 3100250.

Zhang CF. [Acute multiple ischemic choroidopathy]. Zhonghua Yan Ke Za Zhi. 1985 Nov; 21(6):331-4. PMID: 3939203.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 66 publications over 28 distinct years, with a maximum of 6 publications in 2013