Haiyan Gong, MD, PhD
Boston University Chobanian & Avedisian School of Medicine

MD, Nanchang University
PhD, Boston University School of Medicine
MS, Peking Union Medical College

Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 08/31/2024 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Investigations of segmental uveal aqueous outflow
07/01/2022 - 06/30/2024 (PI)
BrightFocus Foundation

The Role of Giant Vacuoles and Pores of Schlemm's Canal Endothelial Cells in Regulating Aqueous Outflow
01/01/2020 - 03/14/2024 (Key Person / Mentor)
PI: David L. Swain
NIH/National Eye Institute

Function of Glycocalyx in the Trabecular Outflow Pathway
06/01/2020 - 05/31/2023 (PI)
NIH/National Eye Institute

Small molecular compounds for glaucoma therapy
01/01/2023 - 03/31/2023 (Subcontract PI)
President and Fellows of Harvard College dba Harvard T.H. Chan School of Public Health BrightFocus Fdn

Testing Effect of Sustained Release vs. Cyclic Exposure of Bimatoprost on MMP/TIMP/ECM Expression by Outflow Cells
05/21/2019 - 12/31/2022 (Subcontract PI)
Duke University Allergan Sales Inc

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2017 - 12/31/2022 (PI)
NIH/National Eye Institute

The Role of Thrombospondin-1 in Regulating IOP
07/01/2019 - 07/30/2022 (PI)
Bright Focus Foundation

Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
06/01/2019 - 05/31/2022 (Subcontract PI)
Duke University NIH NEI

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2021 (Subcontract PI)
Northwestern University NIH NEI

Showing 10 of 31 results. Show All Results


Yr Title Project-Sub Proj Pubs
2021 Function of Glycocalyx in the Trabecular Outflow Pathway 5R21EY028674-02
2020 Transmission Electron Microscope 1S10OD028571-01
2020 Function of Glycocalyx in the Trabecular Outflow Pathway 1R21EY028674-01A1
2020 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-09 16
2019 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-08 16
2018 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-07 16
2017 Cellular Physiology of the Aqueous Outflow Pathway 2R01EY022634-06 16
2016 Cellular Physiology of the Aqueous Outflow Pathway 4R01EY022634-05 16
2015 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-04 16
2014 Cellular Physiology of the Aqueous Outflow Pathway 5R01EY022634-03 16
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sosnowik S, Swain DL, Liu N, Fan S, Toris CB, Gong H. Endothelial Glycocalyx Morphology in Different Flow Regions of the Aqueous Outflow Pathway of Normal and Laser-Induced Glaucoma Monkey Eyes,. Cells. 2022; 15(11):2452. View Publication
  2. Sosnowik S, Swain DL, Fan S, Toris CB, Gong H. Morphological changes to Schlemm's canal and the distal aqueous outflow pathway in monkey eyes with laser-induced ocular hypertension. Exp Eye Res. 2022 Jun; 219:109030.View Related Profiles. PMID: 35283108; PMCID: PMC9133064; DOI: 10.1016/j.exer.2022.109030;
  3. McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 02 01; 63(2):12. PMID: 35129590; PMCID: PMC8842499; DOI: 10.1167/iovs.63.2.12;
  4. Ren R, Humphrey AA, Swain DL, Gong H. Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes. Int J Mol Sci. 2022 Jan 13; 23(2).View Related Profiles. PMID: 35055036; PMCID: PMC8775853; DOI: 10.3390/ijms23020854;
  5. Freddo TF, Civan M and Gong H. Albert and Jakobiec's Principles and Practices of Ophthalmology. Aqueous humor and the dynamics of its flow: Mechanisms and routes of aqueous humor drainage. Springer. 2022; 1989-2032.
  6. Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA. Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. ACS Appl Mater Interfaces. 2021 Jul 21; 13(28):32823-32836. PMID: 34232612; PMCID: PMC9131393; DOI: 10.1021/acsami.1c09294;
  7. Swain DL, Le TD, Yasmin S, Fernandes B, Lamaj G, Dasgupta I, Gao Y, Gong H. Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study. Exp Eye Res. 2021 04; 205:108488.View Related Profiles. PMID: 33571532; PMCID: PMC8044056; DOI: 10.1016/j.exer.2021.108488;
  8. Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB. Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma. J Clin Med. 2020 Dec 28; 10(1). PMID: 33379277; PMCID: PMC7795952; DOI: 10.3390/jcm10010078;
  9. Gong H and Swain DL. Current Developments in Glaucoma Surgery and MIGS. Anatomy of the conventional aqueous outflow pathway. Kugler. 2020; 1-37.
  10. Vahabikashi A, Gelman A, Dong B, Gong L, Cha EDK, Schimmel M, Tamm ER, Perkumas K, Stamer WD, Sun C, Zhang HF, Gong H, Johnson M. Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26555-26563.View Related Profiles. PMID: 31806762; PMCID: PMC6936716; DOI: 10.1073/pnas.1911837116;
Showing 10 of 79 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 79 publications over 32 distinct years, with a maximum of 7 publications in 2013


2019 Association For Research in Vision and Ophthalmology: Gold Fellow of ARVO
2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO
1978 Lhasa City Hospital: Physician of the Year
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Ocular perfusion
Trabecular meshwork

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72 E. Concord St Instructional (L)
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