Gwynneth D. Offner, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine

PhD, Boston University

Gwynneth D. Offner, Ph.D. is the Director of the M.A. in Medical Sciences Program and an Associate Professor in the Department of Medicine. While her primary focus is teaching, advising and mentoring students, Dr. Offner has also directed an NIH-funded research program for nearly 25 years. Dr. Offner grew up in the Washington, D.C. area and came to Boston to attend Wellesley College where she majored in Chemistry. She subsequently received a Ph.D. in Biochemistry from BU School of Medicine and has been on the faculty here since 1986. She teaches in the Biochemistry courses for both medical and graduate students and is Director of the Biochemistry course for M.A. in Medical Sciences students. Her research focuses on the structure and biological functions of a group of glycoproteins called mucins. These proteins serve as part of the non-immune host defense system and have been linked to many diseases including cancer, cystic fibrosis and inflammatory bowel disease.

Assistant Dean
Boston University School of Medicine

Research Assistant Professor
Boston University School of Medicine

Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences

Boston Medical Center

Mucin and Non-mucin Proteins in Gallstone Pathogenesis
02/01/1992 - 03/31/2003 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R01 DK44619 07

Membrane Bound Mucins in Salivary Glands and Saliva
02/15/2006 - 07/31/2013 (PI)
5R01 DE014080-08

Structure and Function of Human Salivary Mucins
06/01/2006 - 05/31/2013 (PI)
5R01 DE011691-13

Membrane Bound Mucins
08/01/2002 - 02/14/2006 (PI)
5 R01 DE14080-03A

Yr Title Project-Sub Proj Pubs
2010 Membrane Bound Mucins in Salivary Glands and Saliva 5R01DE014080-08 9
2009 Membrane Bound Mucins in Salivary Glands and Saliva 5R01DE014080-07 9
2009 Structure and Function of Human Salivary Mucins 5R01DE011691-13 30
2008 Membrane Bound Mucins in Salivary Glands and Saliva 5R01DE014080-06 9
2008 Structure and Function of Human Salivary Mucins 5R01DE011691-12 30
2007 Membrane Bound Mucins in Salivary Glands and Saliva 5R01DE014080-05 9
2007 Structure and Function of Human Salivary Mucins 5R01DE011691-11 30
2006 Membrane Bound Mucins in Salivary Glands and Saliva 2R01DE014080-04A1 9
2006 Structure and Function of Human Salivary Mucins 7R01DE011691-10 30
2005 Structure and Function of Human Salivary Mucins 2R01DE011691-09A1 30
Showing 10 of 26 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Gallan AJ, Offner GD, Symes K. Vertical integration of biochemistry and clinical medicine using a near-peer learning model. Biochem Mol Biol Educ. 2016 Nov 12; 44(6):507-516.View Related Profiles. PMID: 27123831; DOI: 10.1002/bmb.20972;.
  2. Oppenheim FG, Helmerhorst EJ, Lendenmann U, Offner GD. Anti-candidal activity of genetically engineered histatin variants with multiple functional domains. PLoS One. 2012; 7(12):e51479.View Related Profiles. PMID: 23251551; PMCID: PMC3520795; DOI: 10.1371/journal.pone.0051479;.
  3. Soares RV, Offner GD, Assis MA, Silva KC, Zenóbio EG. An unusual glycoform of human salivary mucin MG2. Clin Oral Investig. 2012 Jun; 16(3):761-6. PMID: 21538073; DOI: 10.1007/s00784-011-0556-5;.
  4. Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55.View Related Profiles. PMID: 21080726; PMCID: PMC3033980; DOI: 10.1021/pr100861k;.
  5. Nunes D, Fleming C, Offner G, Craven D, Fix O, Heeren T, Koziel MJ, Graham C, Tumilty S, Skolnik P, Stuver S, Horsburgh CR, Cotton D. Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infection. Am J Gastroenterol. 2010 Jun; 105(6):1346-53.View Related Profiles. PMID: 20179698; DOI: 10.1038/ajg.2009.746;.
  6. Nunes D, Fleming C, Offner G, O'Brien M, Tumilty S, Fix O, Heeren T, Koziel M, Graham C, Craven DE, Stuver S, Horsburgh CR. HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):538-44.View Related Profiles. PMID: 16284529.
  7. Chen ZY, Wang X, Zhou Y, Offner G, Tseng CC. Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway. Cancer Res. 2005 Nov 15; 65(22):10394-400. PMID: 16288030.
  8. Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD. Two-hybrid analysis of human salivary mucin MUC7 interactions. Biochim Biophys Acta. 2005 Oct 30; 1746(1):65-72.View Related Profiles. PMID: 16203048.
  9. Li X, Wang L, Nunes DP, Troxler RF, Offner GD. Suppression of MUC1 synthesis downregulates expression of the epidermal growth factor receptor. Cancer Biol Ther. 2005 Sep; 4(9):968-73.View Related Profiles. PMID: 16082192.
  10. Soares RV, Lin T, Siqueira CC, Bruno LS, Li X, Oppenheim FG, Offner G, Troxler RF. Salivary micelles: identification of complexes containing MG2, sIgA, lactoferrin, amylase, glycosylated proline-rich protein and lysozyme. Arch Oral Biol. 2004 May; 49(5):337-43.View Related Profiles. PMID: 15041480.
Showing 10 of 72 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 70 publications over 29 distinct years, with a maximum of 7 publications in 1990

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

medical sciences
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72 E. Concord St Instructional (L)
Boston MA 02118
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