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MD, University of Rome
PhD, University of Rome
BS, University of Rome

BU Research

The Role of EBV in Monocyte Activation in Scleroderma Vasculopathy and Fibrosis
04/01/2018 - 09/30/2020 (PI)
Scleroderma Foundation

Neuroimmune Molecules in Scleroderma lung fibrosis
04/01/2016 - 03/31/2020 (Subcontract PI)
Yale University NIH NHLBI
5R01HL125850-04

Innate Immune Modulation in Scleroderma Fibroblasts by EBV Infection
01/15/2014 - 07/15/2016 (PI)
Scleroderma Foundation

Interplay between Type I IFN and TGF-beta signaling in systematic sclerosis
04/01/2012 - 03/31/2015 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R03AR062721-03

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Farina A, Rosato E, York M, Gewurz BE, Trojanowska M, Farina GA. Innate Immune Modulation Induced by EBV Lytic Infection Promotes Endothelial Cell Inflammation and Vascular Injury in Scleroderma. Front Immunol. 2021; 12:651013.View Related Profiles.

Farina, Giuseppina
Trojanowska, Maria
York, Michael

PMID: 33953718; PMCID: PMC8089375; DOI: 10.3389/fimmu.2021.651013;

Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2020 11; 72(11):1905-1915. PMID: 32602227; PMCID: PMC8081728; DOI: 10.1002/art.41418;

Gonnella R, Dimarco M, Farina GA, Santarelli R, Valia S, Faggioni A, Angeloni A, Cirone M, Farina A. BFRF1 protein is involved in EBV-mediated autophagy manipulation. Microbes Infect. 2020 Nov - Dec; 22(10):585-591. PMID: 32882412

Dreyfus DH, Farina A, Farina GA. Correction to: Molecular mimicry, genetic homology, and gene sharing proteomic "molecular fingerprints" using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease. Immunol Res. 2019 Oct; 67(4-5):460. PMID: 31773489

Dreyfus DH, Farina A, Farina GA. Molecular mimicry, genetic homology, and gene sharing proteomic "molecular fingerprints" using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease. Immunol Res. 2018 12; 66(6):686-695. PMID: 30552620

Farina A, Peruzzi G, Lacconi V, Lenna S, Quarta S, Rosato E, Vestri AR, York M, Dreyfus DH, Faggioni A, Morrone S, Trojanowska M, Farina GA. Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes. Arthritis Res Ther. 2017 Feb 28; 19(1):39.View Related Profiles.

Farina, Giuseppina
Trojanowska, Maria
York, Michael
Lenna, Stefania

PMID: 28245863; PMCID: PMC5331713; DOI: 10.1186/s13075-017-1237-9;

Yadav S, Libotte F, Buono E, Valia S, Farina GA, Faggioni A, Farina A. EBV early lytic protein BFRF1 alters emerin distribution and post-translational modification. Virus Res. 2017 03 15; 232:113-122. PMID: 28238874

Farina A, Farina GA. Fresh Insights into Disease Etiology and the Role of Microbial Pathogens. Curr Rheumatol Rep. 2016 Jan; 18(1):1. PMID: 26700911; DOI: 10.1007/s11926-015-0552-x;

Lenna S, Assassi S, Farina GA, Mantero JC, Scorza R, Lafyatis R, Farber HW, Trojanowska M. The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients. Arthritis Res Ther. 2015; 17:363.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Trojanowska, Maria
Lafyatis, Robert

PMID: 26669670; PMCID: PMC4704539; DOI: 10.1186/s13075-015-0881-1;

Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest. 2015 Jul 1; 125(7):2795-807.View Related Profiles.

Farina, Giuseppina
Weinberg, Janice
Rice, Lisa
York, Michael
Lafyatis, Robert
Simms, Robert
Nakerakanti, Sashidhar

PMID: 26098215; PMCID: PMC4563675; DOI: 10.1172/JCI77958;

Showing 10 of 30 results. Show More

van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30; 370(5):433-43.View Related Profiles.

Farina, Giuseppina
Stifano, Giuseppina
Stawski, Lukasz
Trojanowska, Maria
York, Michael
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 24350901; PMCID: PMC4040466; DOI: 10.1056/NEJMoa1114576;

Farina A, Cirone M, York M, Lenna S, Padilla C, McLaughlin S, Faggioni A, Lafyatis R, Trojanowska M, Farina GA. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Invest Dermatol. 2014 Apr; 134(4):954-64.View Related Profiles.

Farina, Giuseppina
Trojanowska, Maria
York, Michael
Lafyatis, Robert
Lenna, Stefania

PMID: 24129067; PMCID: PMC3961515; DOI: 10.1038/jid.2013.423;

Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R. Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin. Ann Rheum Dis. 2014 Oct; 73(10):1864-72.View Related Profiles.

Farina, Giuseppina
Stifano, Giuseppina
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 23873879; PMCID: PMC4076390; DOI: 10.1136/annrheumdis-2012-202814;

Lenna S, Chrobak I, Farina GA, Rodriguez-Pascual F, Lamas S, Lafyatis R, Scorza R, Trojanowska M. HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One. 2013; 8(2):e56123.View Related Profiles.

Farina, Giuseppina
Chrobak, Izabela
Trojanowska, Maria
Lafyatis, Robert

PMID: 23441162; PMCID: PMC3575387; DOI: 10.1371/journal.pone.0056123;

Ghosh AK, Bhattacharyya S, Lafyatis R, Farina G, Yu J, Thimmapaya B, Wei J, Varga J. p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-ß: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol. 2013 May; 133(5):1302-10.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 23303459; PMCID: PMC3626729; DOI: 10.1038/jid.2012.479;

Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO. Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol. 2012 Mar; 180(3):1080-94.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 22245215; PMCID: PMC3349888; DOI: 10.1016/j.ajpath.2011.11.024;

Dimarzio M, Farina G, Lafyatis R. Modeling innate immunity in murine skin: utilization of subcutaneous osmotic pumps for inflammatory and fibrotic skin disease. Methods Mol Biol. 2012; 900:317-26.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 22933076; DOI: 10.1007/978-1-60761-720-4_15;

Christmann RB, Hayes E, Pendergrass S, Padilla C, Farina G, Affandi AJ, Whitfield ML, Farber HW, Lafyatis R. Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum. 2011 Jun; 63(6):1718-28.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Lafyatis, Robert
Christmann de Souza, Romy

PMID: 21425123; PMCID: PMC4030759; DOI: 10.1002/art.30318;

Farina G, York M, Collins C, Lafyatis R. dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts. Ann Rheum Dis. 2011 Mar; 70(3):544-50.View Related Profiles.

Farina, Giuseppina
York, Michael
Lafyatis, Robert

PMID: 21068089; PMCID: PMC3086552; DOI: 10.1136/ard.2010.132464;

Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R. Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One. 2010; 5(8):e12106.View Related Profiles.

Farina, Giuseppina
Farber, Harrison
Lafyatis, Robert

PMID: 20808962; PMCID: PMC2923145; DOI: 10.1371/journal.pone.0012106;

Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93.View Related Profiles.

Marshak-Rothstein, Ann
Farina, Giuseppina
Rifkin, Ian
York, Michael
Lafyatis, Robert

PMID: 20613770; PMCID: PMC3086558; DOI: 10.1038/jid.2010.200;

Lemaire R, Farina G, Bayle J, Dimarzio M, Pendergrass SA, Milano A, Perbal B, Whitfield ML, Lafyatis R. Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest Dermatol. 2010 Jun; 130(6):1514-23.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 20182440; PMCID: PMC3071475; DOI: 10.1038/jid.2010.15;

Farina G, Lafyatis D, Lemaire R, Lafyatis R. A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2010 Feb; 62(2):580-8.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 20112379; PMCID: PMC3018285; DOI: 10.1002/art.27220;

Lafyatis R, Kissin E, York M, Farina G, Viger K, Fritzler MJ, Merkel PA, Simms RW. B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2009 Feb; 60(2):578-83.View Related Profiles.

Kissin, Eugene
Farina, Giuseppina
York, Michael
Merkel, Peter
Lafyatis, Robert
Simms, Robert
Amar, Salomon

PMID: 19180481; PMCID: PMC2637937; DOI: 10.1002/art.24249;

Farina G, Lemaire R, Pancari P, Bayle J, Widom RL, Lafyatis R. Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor beta. Ann Rheum Dis. 2009 Mar; 68(3):435-41.View Related Profiles.

Farina, Giuseppina
Lafyatis, Robert

PMID: 18408251; DOI: 10.1136/ard.2007.086850;

Farina G, Lemaire R, Korn JH, Widom RL. Cartilage oligomeric matrix protein is overexpressed by scleroderma dermal fibroblasts. Matrix Biol. 2006 May; 25(4):213-22. PMID: 16520029

Merla A, Di Donato L, Di Luzio S, Farina G, Pisarri S, Proietti M, Salsano F, Romani GL. Infrared functional imaging applied to Raynaud's phenomenon. IEEE Eng Med Biol Mag. 2002 Nov-Dec; 21(6):73-9. PMID: 12613214

Giacomelli R, Valentini G, Salsano F, Cipriani P, Sambo P, Conforti ML, Fulminis A, De Luca A, Farina G, Candela M, Generini S, De Francisci A, Tirri E, Proietti M, Bombardieri S, Gabrielli A, Tonietti G, Cerinic MM. Cyclophosphamide pulse regimen in the treatment of alveolitis in systemic sclerosis. J Rheumatol. 2002 Apr; 29(4):731-6. PMID: 11950014

Farina G, Rosato E, Francia C, Proietti M, Donato G, Ammendolea C, Pisarri S, Salsano F. High incidence of Helicobacter pylori infection in patients with systemic sclerosis: association with Sicca Syndrome. Int J Immunopathol Pharmacol. 2001; 14(2):81-85. PMID: 12604022

Danieli MG, Fraticelli P, Franceschini F, Cattaneo R, Farsi A, Passaleva A, Pietrogrande M, Invernizzi F, Vanoli M, Scorza R, Sabbadini MG, Gerli R, Corvetta A, Farina G, Salsano F, Priori R, Valesini G, Danieli G. Five-year follow-up of 165 Italian patients with undifferentiated connective tissue diseases. Clin Exp Rheumatol. 1999 Sep-Oct; 17(5):585-91. PMID: 10544842

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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