Giuseppina Farina, MD, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Medicine
Rheumatology (Arthritis)

MD, University of Rome
PhD, University of Rome

I have a broad background in clinical and research activities, with specific training and expertise in key research areas for this application. As a postdoctoral fellow I have focused my attention on translational studies, bridging clinical problems in scleroderma with molecular pathogenesis of skin, pulmonary hypertension and pulmonary fibrosis

The Role of EBV in Monocyte Activation in Scleroderma Vasculopathy and Fibrosis
04/01/2018 - 03/31/2020 (PI)
Scleroderma Foundation

Neuroimmune Molecules in Scleroderma lung fibrosis
04/01/2016 - 03/31/2020 (PI)
Yale University NIH NHLBI

Innate Immune Modulation in Scleroderma Fibroblasts by EBV Infection
01/15/2014 - 07/15/2016 (PI)
Scleroderma Foundation

Interplay between Type I IFN and TGF-beta signaling in systematic sclerosis
04/01/2012 - 03/31/2015 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Dreyfus DH, Farina A, Farina GA. Molecular mimicry, genetic homology, and gene sharing proteomic "molecular fingerprints" using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease. Immunol Res. 2018 12; 66(6):686-695. PMID: 30552620.
  2. Farina A, Peruzzi G, Lacconi V, Lenna S, Quarta S, Rosato E, Vestri AR, York M, Dreyfus DH, Faggioni A, Morrone S, Trojanowska M, Farina GA. Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes. Arthritis Res Ther. 2017 Feb 28; 19(1):39.View Related Profiles. PMID: 28245863; DOI: 10.1186/s13075-017-1237-9;.
  3. Yadav S, Libotte F, Buono E, Valia S, Farina GA, Faggioni A, Farina A. EBV early lytic protein BFRF1 alters emerin distribution and post-translational modification. Virus Res. 2017 03 15; 232:113-122. PMID: 28238874.
  4. Farina A, Farina GA. Fresh Insights into Disease Etiology and the Role of Microbial Pathogens. Curr Rheumatol Rep. 2016 Jan; 18(1):1. PMID: 26700911; DOI: 10.1007/s11926-015-0552-x;.
  5. Lenna S, Assassi S, Farina GA, Mantero JC, Scorza R, Lafyatis R, Farber HW, Trojanowska M. The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients. Arthritis Res Ther. 2015; 17:363.View Related Profiles. PMID: 26669670; PMCID: PMC4704539; DOI: 10.1186/s13075-015-0881-1;.
  6. Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest. 2015 Jul 1; 125(7):2795-807.View Related Profiles. PMID: 26098215; PMCID: PMC4563675; DOI: 10.1172/JCI77958;.
  7. van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30; 370(5):433-43.View Related Profiles. PMID: 24350901; PMCID: PMC4040466; DOI: 10.1056/NEJMoa1114576;.
  8. Farina A, Cirone M, York M, Lenna S, Padilla C, McLaughlin S, Faggioni A, Lafyatis R, Trojanowska M, Farina GA. Epstein-Barr virus infection induces aberrant TLR activation pathway and fibroblast-myofibroblast conversion in scleroderma. J Invest Dermatol. 2014 Apr; 134(4):954-64.View Related Profiles. PMID: 24129067; PMCID: PMC3961515; DOI: 10.1038/jid.2013.423;.
  9. Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R. Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin. Ann Rheum Dis. 2014 Oct; 73(10):1864-72.View Related Profiles. PMID: 23873879; PMCID: PMC4076390; DOI: 10.1136/annrheumdis-2012-202814;.
  10. Lenna S, Chrobak I, Farina GA, Rodriguez-Pascual F, Lamas S, Lafyatis R, Scorza R, Trojanowska M. HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One. 2013; 8(2):e56123.View Related Profiles. PMID: 23441162; PMCID: PMC3575387; DOI: 10.1371/journal.pone.0056123;.
Showing 10 of 22 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 22 publications over 11 distinct years, with a maximum of 5 publications in 2013

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

innate immunity

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

75 E. Newton St Evans Building
Boston MA 02118
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