Gerald Denis | Profiles RNS

Gerald V. Denis, PhD

Associate Professor

Boston University School of Medicine

Dept of Medicine

Hematology & Medical Oncology

PhD, University of California, Berkeley
MSc, University of Tokyo

Websites

	Pharmacology & Experimental Therapeutics Faculty
	Leukemia and Lymphoma Laboratory
	Denis Laboratory - Cancer Research Center
	Immunology Training Program Faculty

ORCID : 0000-0001-9886-0401

I am a molecular oncologist with experience in chromatin control of transcription in cancer. I pioneered studies of the BET bromodomains proteins, a family comprised of BRD2 (originally named RING3), BRD3 and BRD4 in somatic cells, which are important as transcriptional co-regulators. I was the first to report a function for a BET protein, and to link these co-regulators to human cancer. The BET protein field has grown from sixteen papers, when I first published my work, to over 1,300 to date; they have since been implicated in several cancer types. Our recent data have established that BET bromodomain proteins provide a functional link between abnormal metabolism, inflammation and breast cancer progression in post-menopausal African American women. We are now realizing that BET proteins regulate cytokine/chemokine production in the immune cells that infiltrate the breast cancer microenvironment, which are important for immune exhaustion, chemoresistance and metastasis.

More detailed study of these pathways, in African American women in particular, is essential. Risks for breast cancer incidence and progression are not distributed evenly in the population, and are likely stratified by abnormal metabolism such as is found in Type 2 diabetes; yet, the current standard of care in breast oncology does not fully consider the role of diabetes and obesity-associated inflammation as drivers of progression and metastasis. African American women bear a disproportionate burden of poor-prognosis triple negative breast cancer, as well as higher prevalence of obesity, obesity-driven Type 2 diabetes and chronic inflammation, compared to white women. Deeper mechanistic and clinical studies must focus on these more vulnerable patients.

Molecular models and population studies also now suggest that metabolic disease and its associated imbalances in cytokines are more important for breast cancer initiation and progression than obesity per se. My intensive involvement over the last eight years with collaborators in population science, immunology, endocrinology and molecular oncology have prompted me to investigate a new area of high public health significance: breast cancer in non-obese women with metabolic disease and chronic inflammation. New thinking must consider drivers of metastasis, and the role the BET bromodomain proteins play in regulating metastasis potential. We hypothesize the BET proteins are equally important for breast cancer progression in lean women with metabolic disease and its associated chronic inflammation.

Recently, we have also explored the role of the BET bromodomain proteins in advanced prostate cancer, particularly in men with similar co-morbid conditions such as obesity and Type 2 diabetes. These inflammatory conditions also promote tumor progression in androgen-independent prostate cancer, eliciting greater cell migration and invasion, and raising the risk of metastasis. Advanced prostate cancer is a complex, heterogenous disease, with varying functional states of the androgen receptor and expression patterns across individual tumor cells. As the disease progresses, prostate tumor cells can become less reliant on androgen receptor signaling and use alternative signaling mechanisms to sustain growth and dissemination. Several of the pathways of progression are also relevant to triple negative breast cancer. Work in our lab is identifying ‘druggable’ BET protein targets to block prostate cancer progression in tumors that are either reliant on, or independent of, androgen receptor signaling. The research will benefit men with advancing prostate cancer, for whom initial therapeutic regimens have lost efficacy.

Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics

Co-Director
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Full Member
Boston University Medical Center
Boston Nutrition Obesity Research Center

Member
Boston University
Family Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Mechanisms of BET bromodomain metabolic reprogramming in triple negative breast cancer
08/07/2018 - 07/31/2023 (PI)
NIH/National Cancer Institute
5R01CA222170-02

Uncoupling obesity from breast cancer in African American women
09/01/2016 - 08/31/2020 (Multi-PI)
PI: Gerald V. Denis, PhD
NIH/National Cancer Institute
5U01CA182898-05

Uncoupling Obesity from Breast Cancer in African American Women
09/24/2013 - 08/31/2016 (Multi-PI)
PI: Gerald V. Denis, PhD
NIH/National Cancer Institute
5U01CA182898-03

Mechanisms of Brd2 Immunoprotection for Insulin Resistance
09/30/2011 - 08/31/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R56DK090455-01A1

Mechanisms of Brd2 Immunoprotection for Insulin Resistance
09/30/2011 - 08/31/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R56DK090455-01A1

Ultrasound-Directed Delivery of Cancer Chemotherapeutic Drugs
01/01/2009 - 12/31/2009 (PI)
Massachusetts General Hospital DOD Army Med Resrch

Proteomic Biomarkers for Lymphoma
06/01/2007 - 05/31/2009 (PI)
NIH/National Cancer Institute
5 R03 CA128006 02

The Role of Brd2 in Energy Homeostasis
04/01/2007 - 03/31/2009 (PI)
Massachusetts General Hospital Boston Diab Endo Res

Molecular Analysis of BRD2 Signaling and B Cell Function
01/01/2005 - 12/31/2008 (PI)
American Cancer Society

Biomarkers for Lymphoma in a New Transgenic Mouse Model
03/01/2004 - 02/28/2006 (PI)
NIH/National Cancer Institute
5 R03 CA102889 02

Showing 10 of 11 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2019	Mechanisms of BET bromodomain metabolic reprogramming in triple negative breast cancer	5R01CA222170-02	2
2018	Mechanisms of BET bromodomain metabolic reprogramming in triple negative breast cancer	1R01CA222170-01A1	2
2017	Uncoupling obesity from breast cancer in African American women	5U01CA182898-05	47
2016	Uncoupling obesity from breast cancer in African American women	4U01CA182898-04	47
2015	Uncoupling obesity from breast cancer in African American women	5U01CA182898-03	47
2015	Uncoupling obesity from breast cancer in African American women	3U01CA182898-02S1	47
2014	Uncoupling obesity from breast cancer in African American women	5U01CA182898-02	47
2013	Uncoupling obesity from breast cancer in African American women	1U01CA182898-01	47
2011	Mechanisms of Brd2 immunoprotection from insulin resistance	1R56DK090455-01A1	19
2010	BRD2-MULTIPROTEIN COMPLEXES IN MAMMALIAN CELL CYCLE TRANSCRIPTIONAL CONTROL	5P41RR010888-14-6783	259

Showing 10 of 29 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Lombardi FL, Jafari N, Bertrand KA, Oshry LJ, Cassidy MR, Ko NY, Denis GV. Novel semi-automated algorithm for high-throughput quantification of adipocyte size in breast adipose tissue, with applications for breast cancer microenvironment. Adipocyte. 2020 Dec; 9(1):313-325.View Related Profiles.

Denis, Gerald
Bertrand, Kimberly
Oshry, Lauren
Cassidy, Michael
Ko, Naomi
Jafari, Naser

PMID: 32633194

Shafran JS, Jafari N, Casey AN, Gyorffy B, Denis GV. BRD4 regulates key transcription factors that drive epithelial-mesenchymal transition in castration-resistant prostate cancer. Prostate Cancer Prostatic Dis. 2020 Jul 21.View Related Profiles.

Denis, Gerald
Jafari, Naser

PMID: 32690869

Andrieu GP, Shafran JS, Smith CL, Belkina AC, Casey AN, Jafari N, Denis GV. BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response. Cancer Lett. 2019 11 28; 465:45-58.View Related Profiles.

Belkina, Anna
Denis, Gerald
Jafari, Naser

PMID: 31473251

Dean LT, Ransome Y, Frasso-Jaramillo L, Moss SL, Zhang Y, Ashing K, Denis GV, Frick KD, Visvanathan K, Schmitz KH. Drivers of cost differences between US breast cancer survivors with or without lymphedema. J Cancer Surviv. 2019 Oct; 13(5):804-814. PMID: 31446591

Shafran JS, Andrieu GP, Györffy B, Denis GV. BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK. Mol Cancer Res. 2019 08; 17(8):1627-1638. PMID: 31110158

Denis GV, Sebastiani P, Bertrand KA, Strissel KJ, Tran AH, Slama J, Medina ND, Andrieu G, Palmer JR. Inflammatory signatures distinguish metabolic health in African American women with obesity. PLoS One. 2018; 13(5):e0196755.View Related Profiles.

Denis, Gerald
Slama, Jaromir
Palmer, Julie
Bertrand, Kimberly
Medina, Nilton
Sebastiani, Paola

PMID: 29738558

Andrieu GP, Shafran JS, Deeney JT, Bharadwaj KR, Rangarajan A, Denis GV. BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment. J Leukoc Biol. 2018 08; 104(2):265-274.View Related Profiles.

Denis, Gerald
Deeney, Jude

PMID: 29493812

Andrieu GP, Denis GV. BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition. Mol Cancer Res. 2018 04; 16(4):580-586. PMID: 29437854

Palmer JR, Castro-Webb N, Bertrand K, Bethea TN, Denis GV. Type II Diabetes and Incidence of Estrogen Receptor Negative Breast Cancer in African American Women. Cancer Res. 2017 Nov 15; 77(22):6462-6469.View Related Profiles.

Denis, Gerald
Palmer, Julie
Bertrand, Kimberly
Bethea, Traci

PMID: 29141994; DOI: 10.1158/0008-5472.CAN-17-1903;

Denis GV, Sebastiani P, Andrieu G, Tran AH, Strissel KJ, Lombardi FL, Palmer JR. Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women. Obesity (Silver Spring). 2017 Nov; 25(11):1916-1920.View Related Profiles.

Denis, Gerald
Palmer, Julie
Sebastiani, Paola

PMID: 28840653

Showing 10 of 62 results. Show More

Denis GV, Palmer JR. "Obesity-Associated" Breast Cancer in Lean Women: Metabolism and Inflammation as Critical Modifiers of Risk. Cancer Prev Res (Phila). 2017 May; 10(5):267-269.View Related Profiles.

Denis, Gerald
Palmer, Julie

PMID: 28408379; DOI: 10.1158/1940-6207.CAPR-17-0083;

Charlot M, Castro-Webb N, Bethea TN, Bertrand K, Boggs DA, Denis GV, Adams-Campbell LL, Rosenberg L, Palmer JR. Diabetes and breast cancer mortality in Black women. Cancer Causes Control. 2017 Jan; 28(1):61-67.View Related Profiles.

Boggs, Deborah
Denis, Gerald
Palmer, Julie
Bertrand, Kimberly
Rosenberg, Lynn
Charlot, Marjory
Bethea, Traci

PMID: 27995352; DOI: 10.1007/s10552-016-0837-z;

Andrieu G, Tran AH, Strissel KJ, Denis GV. BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling. Cancer Res. 2016 Nov 15; 76(22):6555-6567. PMID: 27651315; DOI: 10.1158/0008-5472.CAN-16-0559;

Strissel KJ, Nicholas DA, Castagne-Charlotin M, Ko N, Denis GV. Correction to "Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research". Clin Med Insights Womens Health. 2016; 9:35.View Related Profiles.

Denis, Gerald
Ko, Naomi

PMID: 27695380

Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV. BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci. 2017 Jan; 74(2):231-243.View Related Profiles.

Nikolajczyk, Barbara
Denis, Gerald

PMID: 27491296; DOI: 10.1007/s00018-016-2320-0;

Andrieu G, Belkina AC, Denis GV. Clinical trials for BET inhibitors run ahead of the science. Drug Discov Today Technol. 2016 Mar; 19:45-50.View Related Profiles.

Belkina, Anna
Denis, Gerald

PMID: 27769357; DOI: 10.1016/j.ddtec.2016.06.004;

Strissel KJ, Nicholas DA, Castagne-Charlotin M, Ko N, Denis GV. Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research. Clin Med Insights Womens Health. 2016; 9(Suppl 1):57-61.View Related Profiles.

Denis, Gerald
Ko, Naomi

PMID: 27441007; DOI: 10.4137/CMWH.S34698;

Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS One. 2016; 11(3):e0151329.View Related Profiles.

Belkina, Anna
Corkey, Barbara
Denis, Gerald
Deeney, Jude
Shirihai, Orian

PMID: 27008626; PMCID: PMC4805167; DOI: 10.1371/journal.pone.0151329;

Berger SM, Gislason G, Moore LL, Andersson C, Torp-Pedersen C, Denis GV, Schmiegelow MD. Associations between metabolic disorders and risk of cancer in Danish men and women--a nationwide cohort study. BMC Cancer. 2016 Feb 22; 16:133.View Related Profiles.

Denis, Gerald
Moore, Lynn

PMID: 26900131; PMCID: PMC4762170; DOI: 10.1186/s12885-016-2122-7;

Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307.View Related Profiles.

Belkina, Anna
Bragdon, Beth
Denis, Gerald
Schlezinger, Jennifer
Gerstenfeld, Louis

PMID: 24962433; PMCID: PMC4317374; DOI: 10.1002/jcp.24705;

Strissel KJ, Denis GV, Nikolajczyk BS. Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease. Curr Opin Endocrinol Diabetes Obes. 2014 Oct; 21(5):330-8.View Related Profiles.

Nikolajczyk, Barbara
Denis, Gerald

PMID: 25106001; PMCID: PMC4251956; DOI: 10.1097/MED.0000000000000085;

LeBrasseur NK, Huffman DM, Denis GV. Impact of Energy Balance on Cancer Disparities. In "Energy Balance and Cancer". D.J. Bowen, G. V. Denis, N. A. Berger, Eds. The biology of aging: Role in cancer, metabolic dysfunction and health disparities. Springer. New York. 2014; 91-118. View Publication

Moore LL, Chadid S, Singer MR, Kreger BE, Denis GV. Metabolic health reduces risk of obesity-related cancer in framingham study adults. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2057-65.View Related Profiles.

Kreger, Bernard
Denis, Gerald
Moore, Lynn
Chadid, Susan

PMID: 25012997; PMCID: PMC4184957; DOI: 10.1158/1055-9965.EPI-14-0240;

Goodson JM, Kantarci A, Hartman ML, Denis GV, Stephens D, Hasturk H, Yaskell T, Vargas J, Wang X, Cugini M, Barake R, Alsmadi O, Al-Mutawa S, Ariga J, Soparkar P, Behbehani J, Behbehani K, Welty F. Metabolic disease risk in children by salivary biomarker analysis. PLoS One. 2014; 9(6):e98799. PMID: 24915044; PMCID: PMC4051609; DOI: 10.1371/journal.pone.0098799;

Belkina AC, Blanton WP, Nikolajczyk BS, Denis GV. The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis. J Leukoc Biol. 2014 Mar; 95(3):451-60.View Related Profiles.

Belkina, Anna
Nikolajczyk, Barbara
Denis, Gerald

PMID: 24319289; PMCID: PMC3923082; DOI: 10.1189/jlb.1112588;

Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers LW, Agostinelli C, Pileri S, Denis GV, Baiocchi RA, Sif S. Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing. J Biol Chem. 2013 Dec 6; 288(49):35534-47. PMID: 24189068; PMCID: PMC3853299; DOI: 10.1074/jbc.M113.510669;

Denis GV, Hamilton JA. Healthy obese persons: how can they be identified and do metabolic profiles stratify risk? Curr Opin Endocrinol Diabetes Obes. 2013 Oct; 20(5):369-76.View Related Profiles.

Denis, Gerald
Hamilton, James

PMID: 23974763; PMCID: PMC3934493; DOI: 10.1097/01.med.0000433058.78485.b3;

Gerald V. Denis, Deborah J. Bowen. Energy Balance and Cancer. A. J. Dannenberg, N. A. Berger, Eds. Uncoupling obesity from cancer: bromodomain co-regulators that control inflammatory networks. Springer. New York. 2013; 7:61-82. View Publication

DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):5133-8.View Related Profiles.

Watkins, Amanda
Belkina, Anna
Nikolajczyk, Barbara
Apovian, Caroline
Markham, Douglas
Denis, Gerald
Toraldo, Gianluca
Defuria, Jason
Snyder-Cappione , Jennifer
Ritter, Jessica
McDonnell, Marie

PMID: 23479618; PMCID: PMC3612635; DOI: 10.1073/pnas.1215840110;

Belkina AC, Nikolajczyk BS, Denis GV. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J Immunol. 2013 Apr 1; 190(7):3670-8.View Related Profiles.

Belkina, Anna
Nikolajczyk, Barbara
Denis, Gerald

PMID: 23420887; PMCID: PMC3608815; DOI: 10.4049/jimmunol.1202838;

Wang F, Deeney JT, Denis GV. Brd2 gene disruption causes "metabolically healthy" obesity: epigenetic and chromatin-based mechanisms that uncouple obesity from type 2 diabetes. Vitam Horm. 2013; 91:49-75.View Related Profiles.

Denis, Gerald
Deeney, Jude

PMID: 23374712; DOI: 10.1016/B978-0-12-407766-9.00003-1;

Denis GV, Obin MS. 'Metabolically healthy obesity': origins and implications. Mol Aspects Med. 2013 Feb; 34(1):59-70. PMID: 23068072; PMCID: PMC3583231; DOI: 10.1016/j.mam.2012.10.004;

Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV. The outliers become a stampede as immunometabolism reaches a tipping point. Immunol Rev. 2012 Sep; 249(1):253-75.View Related Profiles.

Nikolajczyk, Barbara
Denis, Gerald

PMID: 22889227; PMCID: PMC3419483; DOI: 10.1111/j.1600-065X.2012.01142.x;

Banerjee C, Archin N, Michaels D, Belkina AC, Denis GV, Bradner J, Sebastiani P, Margolis DM, Montano M. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec; 92(6):1147-54.View Related Profiles.

Belkina, Anna
Banerjee, Camellia
Denis, Gerald
Montano, Monty
Sebastiani, Paola

PMID: 22802445; PMCID: PMC3501896; DOI: 10.1189/jlb.0312165;

Belkina AC, Denis GV. BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer. 2012 Jul; 12(7):465-77.View Related Profiles.

Belkina, Anna
Denis, Gerald

PMID: 22722403; DOI: 10.1038/nrc3256;

Ehrlich DJ, McKenna BK, Evans JG, Belkina AC, Denis GV, Sherr DH, Cheung MC. Parallel imaging microfluidic cytometer. Methods Cell Biol. 2011; 102:49-75.View Related Profiles.

Belkina, Anna
Sherr, David
Denis, Gerald

PMID: 21704835; PMCID: PMC3139515; DOI: 10.1016/B978-0-12-374912-3.00003-1;

Denis GV. Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation. Discov Med. 2010 Dec; 10(55):489-99. PMID: 21189220; PMCID: PMC3025494

Belkina AC, Denis GV. Obesity genes and insulin resistance. Curr Opin Endocrinol Diabetes Obes. 2010 Oct; 17(5):472-7.View Related Profiles.

Belkina, Anna
Denis, Gerald

PMID: 20585247; PMCID: PMC3079383; DOI: 10.1097/MED.0b013e32833c5c48;

Denis GV, Nikolajczyk BS, Schnitzler GR. An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Lett. 2010 Aug 4; 584(15):3260-8.View Related Profiles.

Nikolajczyk, Barbara
Denis, Gerald

PMID: 20493850; PMCID: PMC2914217; DOI: 10.1016/j.febslet.2010.05.030;

Wang F, Liu H, Blanton WP, Belkina A, Lebrasseur NK, Denis GV. Brd2 disruption in mice causes severe obesity without Type 2 diabetes. Biochem J. 2010 Jan 1; 425(1):71-83.View Related Profiles.

Belkina, Anna
Denis, Gerald
Liu, Hongsheng
Blanton, Wanda

PMID: 19883376; PMCID: PMC2819394; DOI: 10.1042/BJ20090928;

Romesser PB, Perlman DH, Faller DV, Costello CE, McComb ME, Denis GV. Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma. Am J Pathol. 2009 Jul; 175(1):25-35.View Related Profiles.

Costello, Catherine
Faller, Douglas
Denis, Gerald
McComb, Mark

PMID: 19498000; PMCID: PMC2708791; DOI: 10.2353/ajpath.2009.080707;

Longe HO, Romesser PB, Rankin AM, Faller DV, Eller MS, Gilchrest BA, Denis GV. Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential. Int J Cancer. 2009 Jan 15; 124(2):473-82.View Related Profiles.

Gilchrest, Barbara
Faller, Douglas
Denis, Gerald

PMID: 19003960; PMCID: PMC2888476; DOI: 10.1002/ijc.23946;

Denis GV. Imatinib Mesylate (Gleevec®) and the Emergence of Chemotherapeutic Drug-Resistant Mutations. 2008. View Publication

Lenburg ME, Sinha A, Faller DV, Denis GV. Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J Biol Chem. 2007 Feb 16; 282(7):4803-11.View Related Profiles.

Faller, Douglas
Denis, Gerald
Lenburg, Marc

PMID: 17166848; PMCID: PMC2819333

You J, Srinivasan V, Denis GV, Harrington WJ, Ballestas ME, Kaye KM, Howley PM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep; 80(18):8909-19. PMID: 16940503; PMCID: PMC1563901

Denis GV, McComb ME, Faller DV, Sinha A, Romesser PB, Costello CE. Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res. 2006 Mar; 5(3):502-11.View Related Profiles.

Costello, Catherine
Faller, Douglas
Denis, Gerald
McComb, Mark

PMID: 16512664; PMCID: PMC2823066

Sinha A, Faller DV, Denis GV. Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem J. 2005 Apr 1; 387(Pt 1):257-69.View Related Profiles.

Faller, Douglas
Denis, Gerald

PMID: 15548137; PMCID: PMC1134954

Greenwald RJ, Tumang JR, Sinha A, Currier N, Cardiff RD, Rothstein TL, Faller DV, Denis GV. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Blood. 2004 Feb 15; 103(4):1475-84.View Related Profiles.

Faller, Douglas
Denis, Gerald

PMID: 14563639; PMCID: PMC2825482

Denis GV, Yu Q, Ma P, Deeds L, Faller DV, Chen CY. Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras. J Biol Chem. 2003 Feb 21; 278(8):5775-85.View Related Profiles.

Faller, Douglas
Denis, Gerald

PMID: 12477721

Peulen O, Denis G, Defresne MP, Dandrifosse G. Spermine-Induced alteration of small intestine in suckling rat: involvement of apoptosis or Zn2+ enzymes? Dig Dis Sci. 2001 Nov; 46(11):2490-8. PMID: 11713959

Denis GV. Bromodomain motifs and "scaffolding"? Front Biosci. 2001 Sep 1; 6:D1065-8. PMID: 11532602; PMCID: PMC3042883

Denis GV. Duality in bromodomain-containing protein complexes. Front Biosci. 2001 Aug 1; 6:D849-52. PMID: 11487463; PMCID: PMC3034383

Verlaet M, Deregowski V, Denis G, Humblet C, Stalmans MT, Bours V, Castronovo V, Boniver J, Defresne MP. Genetic imbalances in preleukemic thymuses. Biochem Biophys Res Commun. 2001 Apr 27; 283(1):12-8. PMID: 11322760

Guo N, Faller DV, Denis GV. Activation-induced nuclear translocation of RING3. J Cell Sci. 2000 Sep; 113 ( Pt 17):3085-91.View Related Profiles.

Faller, Douglas
Denis, Gerald

PMID: 10934046

Denis GV, Vaziri C, Guo N, Faller DV. RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ. 2000 Aug; 11(8):417-24.View Related Profiles.

Vaziri, Cyrus
Faller, Douglas
Denis, Gerald

PMID: 10965846

Humblet C, Denis G, Greimers R, Boniver J, Defresne MP. Apoptosis during the development of radiogenic thymic lymphomas: effects of treatments inhibiting lymphoma development. Anticancer Res. 1998 Sep-Oct; 18(5A):3469-74. PMID: 9858926

Ostrowski J, Florio SK, Denis GV, Suzuki H, Bomsztyk K. Stimulation of p85/RING3 kinase in multiple organs after systemic administration of mitogens into mice. Oncogene. 1998 Mar 5; 16(9):1223-7. PMID: 9528865

Denis GV, Green MR. A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev. 1996 Feb 1; 10(3):261-71. PMID: 8595877

Tegge W, Denis GV, Ballou CE. Synthesis and Ca(2+)-release activity of D- and L-myo-inositol 2,4,5-trisphosphate and D- and L-chiro-inositol 1,3,4-trisphosphate. Carbohydr Res. 1991 Sep 18; 217:107-16. PMID: 1797394

Denis GV, Ballou CE. The Ca2+ release activities of D-myo-inositol 1,4,5-trisphosphate analogs are quantized. Cell Calcium. 1991 Jun; 12(6):395-401. PMID: 1884394

Denis GV, Toyoshima S, Osawa T. Concanavalin A- and calcium-dependent phosphorylation of a protein of 80 kDa in mouse lymphocytes rendered permeable to exogenously added [gamma-32P]ATP. Biochim Biophys Acta. 1986 Feb 21; 885(2):136-45. PMID: 3947677

Goodman MS, Denis GV, Hall M, Karpovsky A, Wilson R. IEEE Transactions on Nuclear Science. Liquid argon as an electron/photon detector in the energy range of 50 MeV to 2 GeV :A Monte Carlo investigation. 1981; 28(1):524-527.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 62 publications over 24 distinct years, with a maximum of 8 publications in 2016