Frederick L. Ruberg, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

MD, University of Pennsylvania School of Medicine
BA, Haverford College

Pronouns: he/him/his



Dr. Ruberg's clinical and research expertise is in the field of cardiac imaging including echocardiography and cardiovascular magnetic resonance imaging (CMR). Dr. Ruberg applies imaging in research designed to facilitate improved diagnosis and management of the infiltrative cardiomyopathy cardiac amyloidosis.

Diversity, Equity, Inclusion and Accessibility

I am deeply committed to developing an equitable and supportive clinical and research environment at BU/BMC. Through my nearly 2 decades of experience and leadership at BU/BMC, I have been focused on increasing representation of women and under-represented minority groups in medicine (URiM) in the clinical workforce while working to ensure that such populations are appropriately represented in research programs. Under my leadership as Program Director of the clinical fellowship training program and now Chief of Cardiovascular Medicine, the cardiovascular medicine fellowship has achieved an approximate 50% women trainee census, and presently exceeds national census means for trainees who identify as URiM in cardiovascular medicine. I also serve as the Section lead of the BUMG campus-wide Commitment to Operationalize Racial Equity (CORE) program (to define and meet racial equity goals) and served as a member of the Department of Medicine Faculty Development and Diversity Committee before transitioning to my current position on the BUMG Gender Equity Advisory Council. My current clinical research team reflects this commitment, composed nearly entirely of women and/or URiM trainees. My primary research focus, hereditary transthyretin cardiac amyloidosis (ATTR), is a heart disease that disproportionately affects patients identifying as Black. I have served as PI on two awards from NIH that specifically focus on ATTR cardiac amyloidosis (most notably the ongoing Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations, or SCAN-MP study). Finally, since 2016, I have also meaningfully contributed to development of a diverse scientific workforce at BU by facilitating the careers of early investigators through my role as Director of Pilot Grant Award Program and now Workforce Development Lead at the BU Clinical and Translational Science Institute.

Professor
Boston University Chobanian & Avedisian School of Medicine
Radiology


Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Amyloidosis Center


Program Director
Boston University Chobanian & Avedisian School of Medicine
Clinical and Translational Science Institute
Pilot Translational & Clinical Studies Program



The Boston University Clinical and Transitional Science Institute
04/15/2020 - 03/31/2025 (Key Person)
PI: Megan H. Bair-Merritt, MD, MSCE
NIH/National Center for Advancing Translational Sciences
3UL1TR001430-08S1

Molecular Imaging of Primary Amyloid Cardiomyopathy
04/01/2017 - 03/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL130563-04


A Multi-Center Study of an ECG-AI Software as a Medical Device to Detect Cardiac Amyloidosis
03/11/2024 - 03/31/2025 (PI)
Anumana, Inc.

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
06/01/2023 - 02/28/2025 (PI)
Trustees of Columbia University National Institute o
1R01AG081582-01

Scan-MP (Screening fro cardiac amyloidosis with nuclear imaging in minority…
05/01/2019 - 02/28/2025 (PI)
The Trustees of Colombia University in the City of New York dba Colombia University National Heart, Lung

Boston University/Boston Medical Center Research Fellowship in Cardiac Amyloidosis
07/01/2023 - 06/30/2024 (PI)
Pfizer, Inc

Gadolinium-Free Myocardial Scar and Fibrosis Imaging with Cardiac MRI
07/01/2020 - 06/30/2024 (PI)
Beth Israel Deaconess Medical Center National Heart, Lung
1R01HL154744-01

Screening for ATTR Amyloidosis among patients undergoing lumbar spinal stenosis decompression…
02/11/2020 - 11/30/2023 (PI)
Akcea Therapeutics,Inc

2021 Transthyretin Cardiac Amyloidosis Fellowship
10/14/2021 - 10/25/2023 (PI)
Pfizer, Inc

Cardiac Amyloidosis Fellowship
01/01/2020 - 02/14/2023 (PI)
Pfizer, Inc

2020 RD L – Cardiac Amyloidosis Fellowship U.S
10/26/2020 - 10/25/2022 (PI)
Pfizer, Inc

Longitudinal strain in ATTR cardiac amyloidosis
09/25/2017 - 09/25/2022 (PI)
Eidos Therapeutics Inc.

Showing 10 of 20 results. Show All Results

Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Datar Y, Clerc OF, Cuddy SAM, Kim S, Taylor A, Neri JC, Benz DC, Bianchi G, Yee AJ, Sanchorawala V, Ruberg FL, Landau H, Liao R, Kijewski MF, Jerosch-Herold M, Kwong RY, Di Carli MF, Falk RH, Dorbala S. Quantification of right ventricular amyloid burden with 18F-florbetapir positron emission tomography/computed tomography and its association with right ventricular dysfunction and outcomes in light-chain amyloidosis. Eur Heart J Cardiovasc Imaging. 2024 Apr 30; 25(5):687-697.View Related Profiles. PMID: 38193678; PMCID: PMC11057921; DOI: 10.1093/ehjci/jead350;
     
  2. Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Bawa PS, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. bioRxiv. 2024 Mar 16.View Related Profiles. PMID: 38558967; PMCID: PMC10980073; DOI: 10.1101/2024.03.14.584987;
     
  3. Ruberg FL, Maurer MS. Cardiac Amyloidosis Due to Transthyretin Protein: A Review. JAMA. 2024 Mar 05; 331(9):778-791. PMID: 38441582
     
  4. Datar Y, Cuddy SAM, Ovsak G, Giblin GT, Maurer MS, Ruberg FL, Arnaout R, Dorbala S. Myocardial Texture Analysis of Echocardiograms in Cardiac Transthyretin Amyloidosis. J Am Soc Echocardiogr. 2024 May; 37(5):570-573.View Related Profiles. PMID: 38395112
     
  5. Ruberg FL, Gropler RJ. In This Issue of the Journal. Circ Cardiovasc Imaging. 2024 Feb; 17(2):e016675. PMID: 38377239
     
  6. Chan N, Einstein AJ, Griffin JM, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson LL, Kinkhabwala MP, Leb JS, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith SE, Winburn M, Smiley D, Miller EJ, Ruberg FL, Maurer MS. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. J Nucl Cardiol. 2023 Dec; 30(6):2531-2539.View Related Profiles. PMID: 38245059; DOI: 10.1007/s12350-023-03310-7;
     
  7. Stern LK, Grodin JL, Maurer MS, Ruberg FL, Patel AR, Khouri MG, Roth LR, Aras MA, Bhardwaj A, Bhattacharya P, Brailovsky Y, Drachman BM, Ebong IA, Fine NM, Gaggin H, Gopal D, Griffin J, Judge D, Kim P, Mitchell J, Mitter SS, Mohan RC, Ramos H, Reyentovich A, Sheikh FH, Sperry B, Carter S, Urey M, Vaishnav J, Vest AR, Kittleson MM, Patel JK. The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology. J Card Fail. 2024 May; 30(5):669-678. PMID: 37907148; DOI: 10.1016/j.cardfail.2023.09.016;
     
  8. Gustine JN, Staron A, Mendelson L, Joshi T, Gopal DM, Siddiqi OK, Ruberg FL, Sanchorawala V. Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis. Blood Adv. 2023 Oct 24; 7(20):6080-6091.View Related Profiles. PMID: 37581513; PMCID: PMC10582303; DOI: 10.1182/bloodadvances.2023010324;
     
  9. Clerc OF, Cuddy SAM, Jerosch-Herold M, Benz DC, Katznelson E, Canseco Neri J, Taylor A, Kijewski MF, Bianchi G, Ruberg FL, Di Carli MF, Liao R, Kwong RY, Falk RH, Dorbala S. Myocardial Characterization for Early Diagnosis, Treatment Response Monitoring, and Risk Assessment in Systemic Light-Chain Amyloidosis. medRxiv. 2023 Oct 05. PMID: 37873250; PMCID: PMC10593053; DOI: 10.1101/2023.10.04.23296572;
     
  10. Clerc OF, Datar Y, Cuddy SA, Bianchi G, Taylor A, Benz DC, Robertson M, Kijewski MF, Jerosch-Herold M, Kwong RY, Ruberg FL, Liao R, Di Carli MF, Falk RH, Dorbala S. Prognostic Value of Left Ventricular 18 F-Florbetapir Uptake in Systemic Light-Chain Amyloidosis. medRxiv. 2023 Sep 14.View Related Profiles. PMID: 37745589; PMCID: PMC10516059; DOI: 10.1101/2023.09.13.23295520;
     
Showing 10 of 132 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 132 publications over 25 distinct years, with a maximum of 15 publications in 2023

YearPublications
19961
19981
20011
20022
20041
20052
20063
20073
20083
20092
20104
20115
20124
20133
20143
20155
20166
201711
20189
201911
20209
202110
202213
202315
20245
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

amyloidosis
Cardiac-Gated Imaging Techniques
echocardiography
MRI

Dr. Ruberg is Chief, Section of Cardiovascular Medicine and Workforce Development Lead, BU Clinical and Translational Science Institute (CTSI). He is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University Chobanian & Avedisian School of Medicine. An active clinical cardiologist and clinical investigator, Dr. Ruberg’s commitment to interdisciplinary research and team science is exemplified by his various responsibilities at BUMC. His clinical interest is in infiltrative cardiomyopathy and he is a participating clinician and researcher in the multi-disciplinary BU/BMC Amyloidosis Center. He is an internationally recognized expert in cardiac amyloidosis. His clinical and research expertise is in the field of cardiac imaging with interest in refining quantitative techniques for application in the clinical care of infiltrative cardiomyopathies. His research has been funded by the American Heart Association (AHA), foundations, industry, and NIH. Research collaboration include investigators in Boston, elsewhere in the US, and world-wide. Dr. Ruberg has servs as Senior Associate Editor of Circulation: Cardiovascular Imaging. He is a fellow of the American College of Cardiology and the American Heart Association. Dr. Ruberg is an active mentor of Internal Medicine residents and Cardiovascular Medicine fellows, having been awarding the 2017 Research Mentor of the year award from the IM residency and the 2022 Citizenship Award from the Department of Medicine. He serves on the Executive Committee of the NIH/NHLBI R38 award designed to facilitate research experiences for MD-trained IM residents.



Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

75 E. Newton St Collamore Building
Boston MA 02118
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