Frederick L. Ruberg, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

MD, University of Pennsylvania School of Medicine

Dr. Ruberg's clinical and research expertise is in the field of cardiac imaging including echocardiography and cardiovascular magnetic resonance imaging (CMR). Dr. Ruberg applies imaging in research designed to facilitate improved diagnosis and management of the infiltrative cardiomyopathy cardiac amyloidosis.

Associate Professor
Boston University School of Medicine

Program Director
Boston University School of Medicine
Clinical and Translational Science Institute
Pilot Translational & Clinical Studies Program

Active Staff Privileges
Boston Medical Center

Molecular Imaging of Primary Amyloid Cardiomyopathy
04/01/2017 - 03/31/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI

Longitudinal strain in ATTR cardiac amyloidosis
09/25/2017 - 09/25/2020 (PI)
Eidos Therapeutics

Serum Biomarker identification of cardiac amyloidosis in elderly African Americans
04/15/2015 - 03/31/2017 (PI)

Cardiac Function as a mechanism for maladaptive brain aging (Supplement)
09/01/2015 - 04/30/2016 (PI)
Vanderbilt University Medical Center NIH-NIA

Cardiac Function as a Mechanism for Maladaptive Brain Aging
07/01/2014 - 04/30/2016 (PI)
Vanderbilt University Medical Center NIH-NIA

Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE)
02/01/2011 - 04/30/2015 (PI)
Duke University NIH-NHLBI

Oxidant stress, Matrix remodeling and stem cell transplant in cardiac amyloidosis
01/01/2010 - 12/31/2014 (PI)
American Heart Assoc

Ventricular Remodeling in Cardiac Amyloidosis Following Stem Cell Transplantation: A Cardiovascular
12/01/2009 - 06/30/2014 (PI)
Amyloidosis Foundation

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jhaveri T, Sarosiek S, Ruberg FL, Siddiqi O, Berk JL, Sanchorawala V. Once AL amyloidosis: not always AL amyloidosis. Amyloid. 2018 Mar 08; 1-2.View Related Profiles. PMID: 29516761.
  2. Phull P, Sanchorawala V, Connors LH, Doros G, Ruberg FL, Berk JL, Sarosiek S. Monoclonal gammopathy of undetermined significance in systemic transthyretin amyloidosis (ATTR). Amyloid. 2018 Feb 09; 1-6.View Related Profiles. PMID: 29424556.
  3. Hanson JLS, Arvanitis M, Koch CM, Berk JL, Ruberg FL, Prokaeva T, Connors LH. Use of Serum Transthyretin as a Prognostic Indicator and Predictor of Outcome in Cardiac Amyloid Disease Associated With Wild-Type Transthyretin. Circ Heart Fail. 2018 Feb; 11(2):e004000.View Related Profiles. PMID: 29449366.
  4. Maurer MS, Ruberg FL, Weinsaft JW. More Than Meets the Eye: Time for a New Imaging Paradigm to Test for Cardiac Amyloidosis. J Card Fail. 2018 Feb; 24(2):87-89. PMID: 29305971.
  5. Arvanitis M, Chan GG, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Prevalence of mutant ATTR cardiac amyloidosis in elderly African Americans with heart failure. Amyloid. 2017 Dec; 24(4):253-255.View Related Profiles. PMID: 29052438.
  6. Salinaro F, Meier-Ewert HK, Miller EJ, Pandey S, Sanchorawala V, Berk JL, Seldin DC, Ruberg FL. Longitudinal systolic strain, cardiac function improvement, and survival following treatment of light-chain (AL) cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. 2017 Sep 01; 18(9):1057-1064.View Related Profiles. PMID: 27965280; DOI: 10.1093/ehjci/jew298;.
  7. Arun M, Brauneis D, Doros G, Shelton AC, Sloan JM, Quillen K, Ruberg FL, Sanchorawala V, Varga C. The incidence of atrial fibrillation among patients with AL amyloidosis undergoing high-dose melphalan and stem cell transplantation: experience at a single institution. Bone Marrow Transplant. 2017 09; 52(9):1349-1351.View Related Profiles. PMID: 28737773.
  8. Siddiqi OK, Ruberg FL. Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med. 2018 Jan; 28(1):10-21.View Related Profiles. PMID: 28739313.
  9. Siddiqi OK, Ruberg FL. Challenging the myths of cardiac amyloidosis. Eur Heart J. 2017 Jun 21; 38(24):1909-1912.View Related Profiles. PMID: 28444296; DOI: 10.1093/eurheartj/ehx210;.
  10. Ruberg FL. Cardiac Amyloidosis: A Zebra Hiding in Plain Sight? Circ Cardiovasc Imaging. 2017 Mar; 10(3):e006186. PMID: 28298289; DOI: 10.1161/CIRCIMAGING.117.006186;.
Showing 10 of 67 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 19 distinct years, with a maximum of 11 publications in 2017

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cardiac-Gated Imaging Techniques

Dr. Ruberg is the Director, Pilot Grants Program, BU CTSI and an Associate Professor of Medicine and Radiology at Boston University School of Medicine. Dr. Ruberg is also the Director of the Cardiovascular Medicine Fellowship Training Program. An active clinical cardiologist and investigator, Dr. Ruberg’s commitment to interdisciplinary research and team science is exemplified by his various responsibilities at BUMC. He is the Director of the Advanced Cardiac Imaging Program at Boston Medical Center – a clinical service involving clinicians and trainees in the Departments of Radiology and Medicine. His clinical interest is in infiltrative cardiomyopathy and he is a participating clinician and researcher in the multi-disciplinary BU Amyloidosis Center and Sarcoidosis Center. He is a nationally recognized expert in cardiac amyloidosis. His clinical and research expertise is in the field of cardiac imaging with interest in refining quantitative MR techniques for application in the clinical care of infiltrative cardiomyopathies. His research has been funded by the American Heart Association (AHA), Amyloidosis Foundation, and NIH. In addition to his own grant awards, Dr. Ruberg is also co-investigator on both BUMC and outside BMC collaborative projects, including the NIH-funded Vanderbilt Memory and Alzheimer’s Center. Dr. Ruberg is a peer reviewer for numerous journals including Circulation, Annals of Internal Medicine, Journal of the American College of Cardiology, and JACC: Cardiovascular Imaging. He has served as an NIH peer reviewer and is a member of the editorial board of Circulation: Cardiovascular Imaging. Dr. Ruberg is a fellow of the American College of Cardiology and the AHA. Dr. Ruberg is an active mentor of Internal Medicine residents and Cardiovascular Medicine fellows. Past projects have involved cardiac imaging and past mentees have reported finding at the major national Cardiology meetings and published reports in the peer reviewed literature.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

75 E. Newton St Collamore Building
Boston MA 02118
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