Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

MD, University of Pennsylvania School of Medicine
BA, Haverford College

Pronouns: he/him/his



Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.

Professor
Boston University Chobanian & Avedisian School of Medicine
Radiology


Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Amyloidosis Center


Program Director
Boston University Chobanian & Avedisian School of Medicine
Clinical and Translational Science Institute
Pilot Translational & Clinical Studies Program



The Boston University Clinical and Transitional Science Institute
04/15/2020 - 03/31/2025 (Key Person)
PI: Megan H. Bair-Merritt, MD, MSCE
NIH/National Center for Advancing Translational Sciences
5UL1TR001430-09

Molecular Imaging of Primary Amyloid Cardiomyopathy
04/01/2017 - 03/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL130563-04


A Multi-Center Study of an ECG-AI Software as a Medical Device to Detect Cardiac Amyloidosis
03/11/2024 - 03/31/2027 (PI)
Anumana, Inc.


AG10-501: A Phase 3, Randomized, Multicenter, Double-Blind, Placebo Controlled Study of Acoramidis for Transthyretin Amyloidosis Prevention in the Young (ACT-EARLY Trial
03/05/2025 - 03/05/2027 (PI)
Eidos Therapeutics Inc.

ATTR Database Pilot
10/01/2024 - 12/31/2026 (Subcontract PI)
PI: Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine
TriNetX, LLC Astrazeneca Pharm

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
06/01/2023 - 02/28/2026 (Subcontract PI)
PI: Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine
Trustees of Columbia University NIH NIA
1R01AG081582-01

Boston University/Boston Medical Center Research Fellowship in Cardiac Amyloidosis
07/01/2023 - 06/30/2025 (PI)
Pfizer, Inc


Scan-MP (Screening fro cardiac amyloidosis with nuclear imaging in minority…
05/01/2019 - 02/28/2025 (Subcontract PI)
PI: Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine
The Trustees of Colombia University in the City of New York dba Colombia University NIH NHLBI


Gadolinium-Free Myocardial Scar and Fibrosis Imaging with Cardiac MRI
07/01/2020 - 06/30/2024 (Subcontract PI)
PI: Frederick L. Ruberg, MD - Chief, Cardiovascular Medicine
Beth Israel Deaconess Medical Center NIH NHLBI
1R01HL154744-01

Screening for ATTR Amyloidosis among patients undergoing lumbar spinal stenosis decompression…
02/11/2020 - 11/30/2023 (PI)
Akcea Therapeutics,Inc


2021 Transthyretin Cardiac Amyloidosis Fellowship
10/14/2021 - 10/25/2023 (PI)
Pfizer, Inc


Cardiac Amyloidosis Fellowship
01/01/2020 - 02/14/2023 (PI)
Pfizer, Inc


Showing 10 of 22 results. Show All Results

Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Regan JA, Kittleson MM, Khouri MG, Ruberg FL, Selvaraj S. Serum Transthyretin as a Biomarker of Treatment Response in ATTR Cardiomyopathy. J Am Coll Cardiol. 2025 May 27; 85(20):1924-1926. PMID: 40398972
     
  2. Siddiqi OK, Ruberg FL, Gopal DM. Impact of Vutrisiran on Functional Capacity and Quality of Life in ATTR Cardiomyopathy: HELIOS-B Analysis. J Am Coll Cardiol. 2025 May 27; 85(20):1956-1958.View Related Profiles. PMID: 40398974
     
  3. Griffin JM, Grodin JL, Ruberg FL, Masri A, Hanna M, Maurer MS. Current Landscape of Therapies for Transthyretin Amyloid Cardiomyopathy. JACC Heart Fail. 2025 May; 13(5):685-694. PMID: 40335224
     
  4. Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Singh Bawa P, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. Amyloid. 2025 Jun; 32(2):179-192.View Related Profiles. PMID: 40134188; DOI: 10.1080/13506129.2025.2478397;
     
  5. Dorbala S, Adigun R, Alexander KM, Brambatti M, Cuddy SAM, Dispenzieri A, Dunnmon P, Emdin M, Abou Ezzeddine OF, Falk RH, Fontana M, Grodin JL, Guthrie S, Jerosch-Herold M, Hofling AA, Hsu K, Lin G, Masri A, Maurer MS, Mittmann C, Prasad K, Quarta CC, Race JM, Rajendran JG, Ruberg FL, Sachdev V, Sanchorawala V, Signorovitch J, Sirac C, Soman P, Sorensen J, Sperry BW, Stephens AW, Stockbridge NL, Vest J, Wall JS, Wechalekar A, Welsh C, Lousada I. Development of Imaging Endpoints for Clinical Trials in AL and ATTR Amyloidosis: Proceedings of the Amyloidosis Forum. JACC Cardiovasc Imaging. 2025 May; 18(5):602-617.View Related Profiles. PMID: 39985507
     
  6. Cheng RK, Leedy D, Ruberg FL. Can Outpatient Worsening Heart Failure Serve as an Endpoint in Clinical Trials of Transthyretin Amyloidosis? J Am Coll Cardiol. 2025 Feb 25; 85(7):762-765. PMID: 39846939; DOI: 10.1016/j.jacc.2024.10.126;
     
  7. Madhani A, Kotturu N, Fine D, Alreshq R, Saade A, Tannoury T, Tannoury C, Ruberg FL. Spinal amyloid deposits are common among older patients undergoing spinal stenosis decompression surgery. J Gen Fam Med. 2025 May; 26(3):222-230.View Related Profiles. PMID: 40291058; PMCID: PMC12022420; DOI: 10.1002/jgf2.766;
     
  8. Fontana M, Ioannou A, Cuddy S, Dorbala S, Masri A, Moon JC, Singh V, Clerc O, Hanna M, Ruberg F, Grogan M, Emdin M, Gillmore J. The Last Decade in Cardiac Amyloidosis: Advances in Understanding Pathophysiology, Diagnosis and Quantification, Prognosis, Treatment Strategies, and Monitoring Response. JACC Cardiovasc Imaging. 2025 Apr; 18(4):478-499. PMID: 39797879; DOI: 10.1016/j.jcmg.2024.10.011;
     
  9. Chan N, Einstein AJ, Teruya S, Rodriguez C, Helmke S, Cuomo M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, de Freitas C, Kattan CG, Miller EJ, Maurer MS, Ruberg FL. The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations Study. Am J Cardiol. 2025 Feb 15; 237:60-64. PMID: 39581521; PMCID: PMC11761373; DOI: 10.1016/j.amjcard.2024.11.019;
     
  10. Clerc OF, Vijayakumar S, Cuddy SAM, Bianchi G, Canseco Neri J, Taylor A, Benz DC, Datar Y, Kijewski MF, Yee AJ, Ruberg FL, Liao R, Falk RH, Sanchorawala V, Dorbala S. Functional Status and Quality of Life in Light-Chain Amyloidosis: Advanced Imaging, Longitudinal Changes, and Outcomes. JACC Heart Fail. 2024 Dec; 12(12):1994-2006.View Related Profiles. PMID: 39243245; PMCID: PMC12042710; DOI: 10.1016/j.jchf.2024.07.007;
     
Showing 10 of 154 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 154 publications over 26 distinct years, with a maximum of 15 publications in 2023 and 2024

YearPublications
19961
19981
20011
20022
20041
20052
20063
20073
20083
20092
20104
20115
20124
20133
20143
20155
20166
201711
20189
201911
20209
202114
202213
202315
202415
20258
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

amyloidosis
Cardiac-Gated Imaging Techniques
echocardiography
MRI

Dr. Ruberg is Chief, Section of Cardiovascular Medicine and Workforce Development Co-Lead, BU Clinical and Translational Science Institute (CTSI). He is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University Chobanian & Avedisian School of Medicine. An active clinical cardiologist and clinical investigator, Dr. Ruberg’s commitment to interdisciplinary research and team science is exemplified by his various responsibilities at BUMC. His clinical interest is in infiltrative cardiomyopathy and he is a participating clinician and researcher in the multi-disciplinary BU/BMC Amyloidosis Center. He is an internationally recognized expert in cardiac amyloidosis. His clinical and research expertise is in the field of cardiac imaging with interest in refining quantitative techniques for application in the clinical care of infiltrative cardiomyopathies. His research has been funded by the American Heart Association (AHA), foundations, industry, and NIH. Research collaboration include investigators in Boston, elsewhere in the US, and world-wide. Dr. Ruberg has servs as Senior Associate Editor of Circulation: Cardiovascular Imaging. He is a fellow of the American College of Cardiology and the American Heart Association. Dr. Ruberg is an active mentor of Internal Medicine residents and Cardiovascular Medicine fellows, having been awarding the 2017 Research Mentor of the year award from the IM residency and the 2022 Citizenship Award from the Department of Medicine. He serves on the Executive Committee of the NIH/NHLBI R38 award designed to facilitate research experiences for MD-trained IM residents.



Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')
  • Assistant
         Name: Denise Phillips
         Email: denise.phillips@bmc.org
         Phone: 617-638-8706

75 E. Newton St Collamore Building
Boston MA 02118
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