Francisco J. Naya
Associate Professor
Boston University Arts & Sciences
Biology

PhD, Baylor College of Medicine
BA, Boston University



Our lab focuses on gene regulatory networks in muscle development and disease. Defining these networks in differentiation and homeostasis can yield insight into the molecular mechanisms that drive pathological gene expression in cardiac and skeletal muscle diseases. Our lab has addressed this problem using a systems-level approach to dissect the intricate gene regulatory function of the mammalian MEF2 transcription factors, an evolutionarily conserved transcription factor family and core regulator of muscle gene programs. Detailed investigation of MEF2-dependent gene programs led to the identification of an imprinted noncoding RNA locus (Dlk1-Dio3). This locus encodes numerous long (lncRNAs) and small (miRNAs, snoRNAs) noncoding RNAs which are involved in skeletal muscle differentiation and regeneration, and in cardiomyocyte proliferation. We have also shown that expression of the Dlk1-Dio3 noncoding RNA locus is dysregulated in cardiac and skeletal myopathies. Understanding how this transcription factor-noncoding RNA regulatory network functions in muscle may ultimately lead to the development of novel treatments for cardiac and skeletal myopathies.

Director of Graduate Studies
Boston University Arts & Sciences
Biology
Cell and Molecular Biology Program

Member
Boston University Arts & Sciences
Genome Science Institute




Utility of the DyW mouse model biology for proof of concept studies in the development of a bispecific antibody for DMD
07/01/2020 - 06/30/2023 (PI)
Pfizer, Inc.


MEF2 Function in Cardiac Muscle Development
07/20/2009 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL073304-09

Characterizing the function of long noncoding RNA Gtl2-Dio3 in cardiac muscle cells
05/14/2015 - 08/31/2015 (PI)
American Heart Association - Founders Affiliate


Molecular Characterization of the BMP2-MEF2A regulatory circuit in cardiac myocyte structural integrity
05/14/2014 - 08/31/2014 (PI)
American Heart Association - Founders Affiliate


Functional Characterization of a Novel Co-Regulator for MEF2-Dependent Transcription in Cardiac Muscle
06/01/2013 - 08/31/2013 (PI)
American Heart Association




Title


Yr Title Project-Sub Proj Pubs
2013 MEF2 Function in Cardiac Muscle Development 5R01HL073304-09 15
2012 MEF2 Function in Cardiac Muscle Development 5R01HL073304-08 15
2011 MEF2 Function in Cardiac Muscle Development 5R01HL073304-07 15
2010 MEF2 Function in Cardiac Muscle Development 3R01HL073304-06S1 15
2010 MEF2 Function in Cardiac Muscle Development 5R01HL073304-06 15
2009 MEF2 Function in Cardiac Muscle Development 2R01HL073304-05A2 15
2006 MEF2 Function in Cardiac Muscle Development 5R01HL073304-04 15
2005 MEF2 Function in Cardiac Muscle Development 5R01HL073304-03 15
2004 MEF2 Function in Cardiac Muscle Development 5R01HL073304-02 15
2003 MEF2 Function in Cardiac Muscle Development 1R01HL073304-01A1 15
Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.


This graph shows the total number of publications by year, by first, middle/unknown, or last author.




2022 Boston University: Nominated for 2023 Metcalf Teaching Award
1997-2000 NIH Postdoctoral Fellowship: National Research Service Award
Contact for Mentoring:

24 Cummington Mall
Boston MA 02215
Google Map


Same Department