Francesca Seta, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Vascular Biology

PhD, New York Medical College
MSc, Università degli Studi "G. d'Annunzio" Chieti-Pescara

Francesca Seta, PhD, is an Assistant Professor of Vascular Biology at the Boston University School of Medicine. Although she teaches Vascular Biology she has been trained in Pharmacology and Cardiovascular Physiology as well. Her current research is on genetic and molecular mechanisms of vascular smooth muscle function and stiffening and novel therapeutic targets for aortic aneurysms and dissections. Her research interests are Arterial Stiffness, Aortic Aneurysm/Dissection, Cardiovascular Physiology, Cardiovascular Disease Related to Metabolic Syndrome, Hypertension, Oxidative Stress, Pulmonary Hypertension, Vascular Biology, and Vascular Diseases.

2014-2016 BUMC- Evans Center: Evans Center Fellow Award

Role of Vascular Smooth Muscle Bcl11b in Arterial Stiffness
04/01/2018 - 01/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute

Preclinical study to test the efficacy of sirtuin1 against the vascular complications of Marfan's and related disorders
07/01/2017 - 06/30/2019 (PI)
National Marfan Foundation

Boston Nutrition Obesity Research Center
04/01/2017 - 03/31/2018 (PI)
Boston Medical Center Corporation NIH NIDDK

Sirtuin1 in Aortic Remodeling and Dissection
07/01/2014 - 06/30/2016 (PI)
National Marfan Foundation

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 04; 22:101150.View Related Profiles. PMID: 30877853.
  2. Yu X, Turcotte R, Seta F, Zhang Y. Micromechanics of elastic lamellae: unravelling the role of structural inhomogeneity in multi-scale arterial mechanics. J R Soc Interface. 2018 Oct 17; 15(147). PMID: 30333250.
  3. Kohn JC, Azar J, Seta F, Reinhart-King CA. High-Fat, High-Sugar Diet-Induced Subendothelial Matrix Stiffening is Mitigated by Exercise. Cardiovasc Eng Technol. 2018 03; 9(1):84-93. PMID: 29159794.
  4. Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 11 10; 121(11):1216-1218.View Related Profiles. PMID: 29122942.
  5. Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405.View Related Profiles. PMID: 28445220.
  6. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles. PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
  7. Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KSS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1382-1391.View Related Profiles. PMID: 28185955; DOI: 10.1016/j.bbadis.2017.02.004;.
  8. Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways. Sci Rep. 2017 02 02; 7:41605.View Related Profiles. PMID: 28150703; DOI: 10.1038/srep41605;.
  9. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;.
  10. Nicholson CJ, Seta F, Lee S, Morgan KG. MicroRNA-203 mimics age-related aortic smooth muscle dysfunction of cytoskeletal pathways. J Cell Mol Med. 2017 Jan; 21(1):81-95.View Related Profiles. PMID: 27502584; DOI: 10.1111/jcmm.12940;.
Showing 10 of 33 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 6 publications in 2017


I am a research scientist with expertise in vascular surgery and hemodynamic measurements in small animals. My research interest is vascular biology with a focus on diseases of large arteries, such as arterial stiffness and aortic aneurysm/dissection, and hypertension. I have mentored, as direct supervisor, more than 15 undergraduate, graduate and medical students, mainly during their laboratory training. I am available as peer mentor to early stage investigators and as research mentor to students and post-docs to share my technical and knowledge expertise as well as science culture.

Available to Mentor as: (Review Mentor Role Definitions):
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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