Francesca Seta | Profiles RNS

Francesca Seta, PhD

Assistant Professor

Boston University School of Medicine

Dept of Medicine

Vascular Biology

PhD, New York Medical College
MSc, Università degli Studi "G. d'Annunzio" Chieti-Pescara

Websites

	Evans Center for Interdisciplinary Biomedical Research
	Seta Lab
	ResearchGate
	LinkedIn

ORCID : 0000-0001-7985-5615

Francesca Seta, PhD, is an Assistant Professor of Vascular Biology at the Boston University School of Medicine. Although she teaches Vascular Biology she has been trained in Pharmacology and Cardiovascular Physiology as well. Her current research is on genetic and molecular mechanisms of vascular smooth muscle function and stiffening and novel therapeutic targets for aortic aneurysms and dissections. Her research interests are Arterial Stiffness, Aortic Aneurysm/Dissection, Cardiovascular Physiology, Cardiovascular Disease Related to Metabolic Syndrome, Hypertension, Oxidative Stress, Pulmonary Hypertension, Vascular Biology, and Vascular Diseases.

2014-2016 BUMC- Evans Center: Evans Center Fellow Award

BU Sponsored Research

Role of Vascular Smooth Muscle Bcl11b in Arterial Stiffness
04/01/2018 - 01/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL136311-01A1

Preclinical study to test the efficacy of sirtuin1 against the vascular complications of Marfan's and related disorders
07/01/2017 - 06/30/2019 (PI)
National Marfan Foundation

Boston Nutrition Obesity Research Center
04/01/2017 - 03/31/2018 (PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-25

Sirtuin1 in Aortic Remodeling and Dissection
07/01/2014 - 06/30/2016 (PI)
National Marfan Foundation

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 04; 22:101150.View Related Profiles.
Costello, Catherine
Yao, Chunxiang
Shao, Di
Seta, Francesca
Fry, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
PMID: 30877853.
Yu X, Turcotte R, Seta F, Zhang Y. Micromechanics of elastic lamellae: unravelling the role of structural inhomogeneity in multi-scale arterial mechanics. J R Soc Interface. 2018 Oct 17; 15(147). PMID: 30333250.
Kohn JC, Azar J, Seta F, Reinhart-King CA. High-Fat, High-Sugar Diet-Induced Subendothelial Matrix Stiffening is Mitigated by Exercise. Cardiovasc Eng Technol. 2018 03; 9(1):84-93. PMID: 29159794.
Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 11 10; 121(11):1216-1218.View Related Profiles.
Seta, Francesca
Ruiz-Opazo, Nelson
Cohen, Richard
PMID: 29122942.
Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405.View Related Profiles.
Coleman, David
Center, David
Seta, Francesca
Ravid, Katya
PMID: 28445220.
Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles.
Shao, Di
Seta, Francesca
Roy, Hemant
Behring, Jessica
Fry, Jessica
Han, Jingyan
Bachschmid, Markus
Long, Michelle
Matsui, Reiko
Cohen, Richard
PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KSS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta Mol Basis Dis. 2017 06; 1863(6):1382-1391.View Related Profiles.
Seta, Francesca
Cohen, Richard
PMID: 28185955; DOI: 10.1016/j.bbadis.2017.02.004;.
Grzegorzewska AP, Seta F, Han R, Czajka CA, Makino K, Stawski L, Isenberg JS, Browning JL, Trojanowska M. Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways. Sci Rep. 2017 02 02; 7:41605.View Related Profiles.
Seta, Francesca
Browning, Jeffrey
Stawski, Lukasz
Trojanowska, Maria
PMID: 28150703; DOI: 10.1038/srep41605;.
Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles.
Shao, Di
Seta, Francesca
Han, Jingyan
Bachschmid, Markus
Hamburg, Naomi
Matsui, Reiko
Cohen, Richard
PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;.
Nicholson CJ, Seta F, Lee S, Morgan KG. MicroRNA-203 mimics age-related aortic smooth muscle dysfunction of cytoskeletal pathways. J Cell Mol Med. 2017 Jan; 21(1):81-95.View Related Profiles.
Seta, Francesca
Morgan, Kathleen
PMID: 27502584; DOI: 10.1111/jcmm.12940;.

Showing 10 of 33 results. Show More

Fry JL, Al Sayah L, Weisbrod RM, Van Roy I, Weng X, Cohen RA, Bachschmid MM, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. Hypertension. 2016 Sep; 68(3):775-84.View Related Profiles.
Seta, Francesca
Fry, Jessica
Bachschmid, Markus
Cohen, Richard
PMID: 27432859; PMCID: PMC4982825; DOI: 10.1161/HYPERTENSIONAHA.116.07622;.
Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016 Mar; 92:30-40.View Related Profiles.
Seta, Francesca
Cohen, Richard
PMID: 26812119; PMCID: PMC5008453; DOI: 10.1016/j.yjmcc.2016.01.020;.
Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles.
Sverdlov, Aaron
Elezaby, Aly
Costello, Catherine
Yao, Chunxiang
Siwik, Deborah
Shao, Di
Seta, Francesca
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Whelan, Stephen
Colucci, Wilson
Yin, Xiaoyan
PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;.
Fry JL, Shiraishi Y, Turcotte R, Yu X, Gao YZ, Akiki R, Bachschmid M, Zhang Y, Morgan KG, Cohen RA, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc. 2015 Sep; 4(9):e002384.View Related Profiles.
Seta, Francesca
Fry, Jessica
Morgan, Kathleen
Bachschmid, Markus
Cohen, Richard
PMID: 26376991; PMCID: PMC4599512; DOI: 10.1161/JAHA.115.002384;.
Seta F, Cohen RA. The endothelium: paracrine mediator of aortic dissection. Circulation. 2014 Jun 24; 129(25):2629-32.View Related Profiles.
Seta, Francesca
Cohen, Richard
PMID: 24807873; PMCID: PMC4100940; DOI: 10.1161/CIRCULATIONAHA.114.010609;.
Qin Z, Hou X, Weisbrod RM, Seta F, Cohen RA, Tong X. Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells. J Mol Cell Cardiol. 2014 Jul; 72:56-63.View Related Profiles.
Seta, Francesca
Cohen, Richard
Tong, XiaoYong
PMID: 24631774; PMCID: PMC4037381; DOI: 10.1016/j.yjmcc.2014.02.019;.
Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F. Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension. 2013 Dec; 62(6):1105-10.View Related Profiles.
Seta, Francesca
Fry, Jessica
Cohen, Richard
PMID: 24060894; PMCID: PMC3951434; DOI: 10.1161/HYPERTENSIONAHA.113.01744;.
Ghatnekar A, Chrobak I, Reese C, Stawski L, Seta F, Wirrig E, Paez-Cortez J, Markiewicz M, Asano Y, Harley R, Silver R, Feghali-Bostwick C, Trojanowska M. Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol. 2013 Jun; 182(6):2391-406.View Related Profiles.
Seta, Francesca
Chrobak, Izabela
Paez-Cortez, Jesus
Stawski, Lukasz
Trojanowska, Maria
PMID: 23583651; PMCID: PMC3668018; DOI: 10.1016/j.ajpath.2013.02.039;.
Seta F, Rahmani M, Turner PV, Funk CD. Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline. PLoS One. 2011; 6(8):e23439. PMID: 21850273; PMCID: PMC3151294; DOI: 10.1371/journal.pone.0023439;.
Seta F, Chung AD, Turner PV, Mewburn JD, Yu Y, Funk CD. Renal and cardiovascular characterization of COX-2 knockdown mice. Am J Physiol Regul Integr Comp Physiol. 2009 Jun; 296(6):R1751-60. PMID: 19357295; DOI: 10.1152/ajpregu.90985.2008;.
Di Francesco L, Totani L, Dovizio M, Piccoli A, Di Francesco A, Salvatore T, Pandolfi A, Evangelista V, Dercho RA, Seta F, Patrignani P. Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. Circ Res. 2009 Feb 27; 104(4):506-13. PMID: 19122175; DOI: 10.1161/CIRCRESAHA.108.191114;.
Seta F, Patil K, Bellner L, Mezentsev A, Kemp R, Dunn MW, Schwartzman ML. Inhibition of VEGF expression and corneal neovascularization by siRNA targeting cytochrome P450 4B1. Prostaglandins Other Lipid Mediat. 2007 Nov; 84(3-4):116-27. PMID: 17991614; PMCID: PMC2128778; DOI: 10.1016/j.prostaglandins.2007.05.001;.
Biteman B, Hassan IR, Walker E, Leedom AJ, Dunn M, Seta F, Laniado-Schwartzman M, Gronert K. Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing. FASEB J. 2007 Jul; 21(9):2257-66. PMID: 17384141; DOI: 10.1096/fj.06-7918com;.
Seta F, Bellner L, Rezzani R, Regan RF, Dunn MW, Abraham NG, Gronert K, Laniado-Schwartzman M. Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response. Am J Pathol. 2006 Nov; 169(5):1612-23. PMID: 17071585; PMCID: PMC1780218; DOI: 10.2353/ajpath.2006.060555;.
Mezentsev A, Mastyugin V, Seta F, Ashkar S, Kemp R, Reddy DS, Falck JR, Dunn MW, Laniado-Schwartzman M. Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels. J Pharmacol Exp Ther. 2005 Oct; 315(1):42-50. PMID: 16009741; DOI: 10.1124/jpet.105.088211;.
Minuz P, Patrignani P, Gaino S, Seta F, Capone ML, Tacconelli S, Degan M, Faccini G, Fornasiero A, Talamini G, Tommasoli R, Arosio E, Santonastaso CL, Lechi A, Patrono C. Determinants of platelet activation in human essential hypertension. Hypertension. 2004 Jan; 43(1):64-70. PMID: 14656953.
Sciulli MG, Seta F, Tacconelli S, Capone ML, Ricciotti E, Pistritto G, Patrignani P. Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells. Br J Pharmacol. 2003 Feb; 138(4):634-41. PMID: 12598417; PMCID: PMC1573695; DOI: 10.1038/sj.bjp.0705078;.
Li Volti G, Seta F, Schwartzman ML, Nasjletti A, Abraham NG. Heme oxygenase attenuates angiotensin II-mediated increase in cyclooxygenase-2 activity in human femoral endothelial cells. Hypertension. 2003 Mar; 41(3 Pt 2):715-9. PMID: 12623985.
Minuz P, Patrignani P, Gaino S, Degan M, Menapace L, Tommasoli R, Seta F, Capone ML, Tacconelli S, Palatresi S, Bencini C, Del Vecchio C, Mansueto G, Arosio E, Santonastaso CL, Lechi A, Morganti A, Patrono C. Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. Circulation. 2002 Nov 26; 106(22):2800-5. PMID: 12451006.
Mezentsev A, Seta F, Dunn MW, Ono N, Falck JR, Laniado-Schwartzman M. Eicosanoid regulation of vascular endothelial growth factor expression and angiogenesis in microvessel endothelial cells. J Biol Chem. 2002 May 24; 277(21):18670-6. PMID: 11901160; DOI: 10.1074/jbc.M201143200;.
Santini G, Patrignani P, Sciulli MG, Seta F, Tacconelli S, Panara MR, Ricciotti E, Capone ML, Patrono C. The human pharmacology of monocyte cyclooxygenase 2 inhibition by cortisol and synthetic glucocorticoids. Clin Pharmacol Ther. 2001 Nov; 70(5):475-83. PMID: 11719735.
Patrignani P, Panara MR, Tacconelli S, Seta F, Bucciarelli T, Ciabattoni G, Alessandrini P, Mezzetti A, Santini G, Sciulli MG, Cipollone F, Davì G, Gallina P, Bon GB, Patrono C. Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers. Circulation. 2000 Aug 1; 102(5):539-45. PMID: 10920066.
Panara MR, Renda G, Sciulli MG, Santini G, Di Giamberardino M, Rotondo MT, Tacconelli S, Seta F, Patrono C, Patrignani P. Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects. J Pharmacol Exp Ther. 1999 Jul; 290(1):276-80. PMID: 10381787.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 6 publications in 2017

Bar chart showing 33 publications over 17 distinct years, with a maximum of 6 publications in 2017

Year	Publications
1999	1
2000	1
2001	1
2002	3
2003	2
2005	1
2006	1
2007	2
2009	2
2011	1
2013	2
2014	2
2015	2
2016	4
2017	6
2018	1
2019	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

aortic aneurysm/dissection
arterial stiffness
cardiovascular biology
cardiovascular disease related to metabolic syndrome
hypertension
in vivo hemodynamic measurements
pulmonary hypertension
vascular biology

I am a research scientist with expertise in vascular surgery and hemodynamic measurements in small animals. My research interest is vascular biology with a focus on diseases of large arteries, such as arterial stiffness and aortic aneurysm/dissection, and hypertension. I have mentored, as direct supervisor, more than 15 undergraduate, graduate and medical students, mainly during their laboratory training. I am available as peer mentor to early stage investigators and as research mentor to students and post-docs to share my technical and knowledge expertise as well as science culture.

Available to Mentor as: (Review Mentor Role Definitions):