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PhD, University of London
BS, Loughborough University of Technology

Websites

	Dental Medicine Periodontology Faculty
	Biochemistry Highlights Dr. Erdjan Salih
	Dr. Erdjan Salih Uncovers Missing Link
	ResearchGate

ORCID : 0000-0003-3322-2323

Research
Publications

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj	Pubs
2009	Phosphoproteomics of Oral Fluids	5R21DE018448-02	10
2008	Phosphoproteomics of Oral Fluids	1R21DE018448-01A2	10
2003	POSTTRANSLATIONAL MODIFICATION/STRUCTURE-FUNCTION OF BON	5R01AG017969-04	12
2002	POSTTRANSLATIONAL MODIFICATION/STRUCTURE-FUNCTION OF BON	5R01AG017969-03	12
2001	POSTTRANSLATIONAL MODIFICATION/STRUCTURE-FUNCTION OF BON	5R01AG017969-02	12
2000	POSTTRANSLATIONAL MODIFICATION/STRUCTURE-FUNCTION OF BON	1R01AG017969-01	12

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Salih E. Ex-Vivo Model Systems of Cancer-Bone Cell Interactions. Methods Mol Biol. 2019; 1914:217-240. PMID: 30729467

Wang Z, Salih E, Igwebuike C, Mulhern R, Bonegio RG, Havasi A, Borkan SC. Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI. J Am Soc Nephrol. 2019 01; 30(1):50-62.View Related Profiles.

Havasi, Andrea
Salih, Erdjan
Bonegio, Ramon
Borkan, Steven
Wang, Zhiyong

PMID: 30573638; PMCID: PMC6317607; DOI: 10.1681/ASN.2018040401;

Sok-Ja Janket, Martha E. Nunn, Erdjan Salih, and Alison E. Baird. Translational Oral Health Research (J. H. Meurman (ed.)). Evidence-Based Approach in Translational Dental Research. Springer International Publishing AG, part of Springer Nature 2018. 2018; Chapter 8:81-101.

Tang X, Alasiri M, Bamashmous A, Aljahdali B, Cao F, Dibart S, Salih E. The involvement of Kav001 in inhibition of LPS/P. gingivalis-induced. J Cell Biochem. 2018 07; 119(7):6072-6079.View Related Profiles.

Salih, Erdjan
Dibart, Serge

PMID: 29637600

Tang X, Aljahdali B, Alasiri M, Bamashmous A, Cao F, Dibart S, Salih E. A method for high transfection efficiency in THP-1 suspension cells without PMA treatment. Anal Biochem. 2018 03 01; 544:93-97.View Related Profiles.

Salih, Erdjan
Dibart, Serge
Tang, Xiaoren

PMID: 29305095

Salih E. Qualitative and Quantitative Proteome Analysis of Oral Fluids in Health and Periodontal Disease by Mass Spectrometry. Methods Mol Biol. 2017; 1537:37-60. PMID: 27924587

Alasmari A, Lin SC, Dibart S, Salih E. Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells. Clin Exp Metastasis. 2016 Aug; 33(6):563-88.View Related Profiles.

Salih, Erdjan
Dibart, Serge

PMID: 27155840; DOI: 10.1007/s10585-016-9798-6;

Dibart S, Alasmari A, Zanni O, Salih E. Effect of Corticotomies with Different Instruments on Cranial Bone Biology Using an Ex Vivo Calvarial Bone Organ Culture Model System. Int J Periodontics Restorative Dent. 2016; 36 Suppl:s123-36.View Related Profiles.

Salih, Erdjan
Dibart, Serge

PMID: 27031627; DOI: 10.11607/prd.2701;

Carneiro LG, Nouh H, Salih E. Quantitative gingival crevicular fluid proteome in health and periodontal disease using stable isotope chemistries and mass spectrometry. J Clin Periodontol. 2014 Aug; 41(8):733-47.View Related Profiles.

Salih, Erdjan
Nouh, Hesham
Carneiro, Leandro

PMID: 24738839; PMCID: PMC4128226; DOI: 10.1111/jcpe.12262;

Liu J, Czernick D, Lin SC, Alasmari A, Serge D, Salih E. Novel bioactivity of phosvitin in connective tissue and bone organogenesis revealed by live calvarial bone organ culture models. Dev Biol. 2013 Sep 1; 381(1):256-75.View Related Profiles.

Salih, Erdjan
Liu, Jess

PMID: 23791550; DOI: 10.1016/j.ydbio.2013.06.005;

Showing 10 of 95 results. Show More

Czernick D, Liu J, Serge D, Salih E. Topographical distribution of phosphorylation sites of phosvitins by mass spectrometry. J Proteomics. 2013 May 27; 83:76-98.View Related Profiles.

Salih, Erdjan
Liu, Jess

PMID: 23474079; DOI: 10.1016/j.jprot.2013.02.016;

Curtin P, Youm H, Salih E. Three-dimensional cancer-bone metastasis model using ex-vivo co-cultures of live calvarial bones and cancer cells. Biomaterials. 2012 Feb; 33(4):1065-78. PMID: 22071100; PMCID: PMC3221840; DOI: 10.1016/j.biomaterials.2011.10.046;

Carneiro LG, Venuleo C, Oppenheim FG, Salih E. Proteome data set of human gingival crevicular fluid from healthy periodontium sites by multidimensional protein separation and mass spectrometry. J Periodontal Res. 2012 Apr; 47(2):248-62.View Related Profiles.

Salih, Erdjan
Oppenheim, Frank
Carneiro, Leandro

PMID: 22029670; PMCID: PMC3272151; DOI: 10.1111/j.1600-0765.2011.01429.x;

Wang Z, Salih E, Burke PA. Quantitative analysis of cytokine-induced hepatocyte nuclear factor-4a phosphorylation by mass spectrometry. Biochemistry. 2011 Jun 14; 50(23):5292-300.View Related Profiles.

Salih, Erdjan
Burke, Peter
Wang, Zhongyan

PMID: 21598922; PMCID: PMC3115757; DOI: 10.1021/bi200540w;

Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank
Offner, Gwynneth

PMID: 21080726; PMCID: PMC3033980; DOI: 10.1021/pr100861k;

Helmerhorst EJ, Traboulsi G, Salih E, Oppenheim FG. Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains. J Proteome Res. 2010 Oct 1; 9(10):5413-21.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 20731414; PMCID: PMC2948583; DOI: 10.1021/pr100653r;

Zhou HY, Salih E, Glimcher MJ. The isolation and characterization of glycosylated phosphoproteins from herring fish bones. J Biol Chem. 2010 Nov 12; 285(46):36170-8. PMID: 20833721; PMCID: PMC2975239; DOI: 10.1074/jbc.M110.146910;

Salih E, Siqueira WL, Helmerhorst EJ, Oppenheim FG. Large-scale phosphoproteome of human whole saliva using disulfide-thiol interchange covalent chromatography and mass spectrometry. Anal Biochem. 2010 Dec 1; 407(1):19-33.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 20659418; PMCID: PMC2954488; DOI: 10.1016/j.ab.2010.07.012;

Vora SR, Guo Y, Stephens DN, Salih E, Vu ED, Kirsch KH, Sonenshein GE, Trackman PC. Characterization of recombinant lysyl oxidase propeptide. Biochemistry. 2010 Apr 6; 49(13):2962-72.View Related Profiles.

Salih, Erdjan
Sonenshein, Gail
Kirsch, Kathrin
Trackman, Philip

PMID: 20192271; PMCID: PMC2847845; DOI: 10.1021/bi902218p;

Curtin P, McHugh KP, Zhou HY, Flückiger R, Goldhaber P, Oppenheim FG, Salih E. Modulation of bone resorption by phosphorylation state of bone sialoprotein. Biochemistry. 2009 Jul 28; 48(29):6876-86.View Related Profiles.

Salih, Erdjan
Oppenheim, Frank

PMID: 19518132; PMCID: PMC2748923; DOI: 10.1021/bi900066b;

Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Activity-based mass spectrometric characterization of proteases and inhibitors in human saliva. Proteomics Clin Appl. 2009 Jul 01; 3(7):810-820.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 20011683; PMCID: PMC2790210; DOI: 10.1002/prca.200800242;

Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties. FASEB J. 2009 Aug; 23(8):2691-701.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 19339663; PMCID: PMC2717783; DOI: 10.1096/fj.09-131045;

Helmerhorst EJ, Sun X, Salih E, Oppenheim FG. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. J Biol Chem. 2008 Jul 18; 283(29):19957-66.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 18463091; PMCID: PMC2459269; DOI: 10.1074/jbc.M708282200;

Siqueira WL, Salih E, Wan DL, Helmerhorst EJ, Oppenheim FG. Proteome of human minor salivary gland secretion. J Dent Res. 2008 May; 87(5):445-50.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 18434574; PMCID: PMC2857507; DOI: 10.1177/154405910808700508;

Saad FA, Salih E, Glimcher MJ. Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification. J Cell Biochem. 2008 Feb 15; 103(3):852-6. PMID: 17615552; PMCID: PMC2744143

Siqueira WL, Helmerhorst EJ, Zhang W, Salih E, Oppenheim FG. Acquired enamel pellicle and its potential role in oral diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:504-9.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 17435160

Oppenheim FG, Salih E, Siqueira WL, Zhang W, Helmerhorst EJ. Salivary proteome and its genetic polymorphisms. Ann N Y Acad Sci. 2007 Mar; 1098:22-50.View Related Profiles.

Salih, Erdjan
Helmerhorst, Eva
Oppenheim, Frank

PMID: 17303824

Wang J, Zhou HY, Salih E, Xu L, Wunderlich L, Gu X, Hofstaetter JG, Torres M, Glimcher MJ. Site-specific in vivo calcification and osteogenesis stimulated by bone sialoprotein. Calcif Tissue Int. 2006 Sep; 79(3):179-89. PMID: 16969594

Salih E. Phosphoproteomics by mass spectrometry and classical protein chemistry approaches. Mass Spectrom Rev. 2005 Nov-Dec; 24(6):828-46. PMID: 15538747

Saad FA, Salih E, Wunderlich L, Flückiger R, Glimcher MJ. Prokaryotic expression of bone sialoprotein and identification of casein kinase II phosphorylation sites. Biochem Biophys Res Commun. 2005 Jul 29; 333(2):443-7. PMID: 15950178

Mah J, Hung J, Wang J, Salih E. The efficacy of various alloplastic bone grafts on the healing of rat calvarial defects. Eur J Orthod. 2004 Oct; 26(5):475-82. PMID: 15536835

O'Toole GC, Salih E, Gallagher C, FitzPatrick D, O'Higgins N, O'Rourke SK. Bone sialoprotein-coated femoral implants are osteoinductive but mechanically compromised. J Orthop Res. 2004 May; 22(3):641-6. PMID: 15099646

Salih E, Flückiger R. Complete topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein and their biological implications. J Biol Chem. 2004 May 7; 279(19):19808-15. PMID: 15004024

Tartaix PH, Doulaverakis M, George A, Fisher LW, Butler WT, Qin C, Salih E, Tan M, Fujimoto Y, Spevak L, Boskey AL. In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem. 2004 Apr 30; 279(18):18115-20. PMID: 14769788

Goldhaber, P., Rabadjija, L., Fluckiger, R., Salih, E., Bernard, G. Effects of ascorbic acid on formation and differentiation of bone cell aggregates and their ability to heal bone resorption defects by new osteoid formation in neonatal mouse calvaria grown in serum-free organ cultures. Biological mechanisms of tooth eruption, resorption, and implants. Birmingham AL: EBSCO Media. 2004; 179-195.
Wang J. Zhou, H-Y, Salih, E., Xu, L., Hofstaetter, J.G. and Glimcher MJ. Bone sialoprotein elicits biomineralization and ossification in a bone defect model. The chemistry and biology of mineralized tissues University of Toronto Press. 2004; 139-142.
Curtin, P.; McHugh, K.; Goldhaber, P.; Flückiger, R.; Salih, E. Role of bone sialoprotein phosphorylation in bone resorption using calvarial organ and osteoclast cultures. The chemistry and biology of mineralized tissues. University of Toronto Press. 2004; 73-76.
Salih, E. . Emergence of phosphoproteomics through combination of mass spectrometry and classical protein chemistry approaches. he chemistry and biology of mineralized tissues University of Toronto Pres. 2004; 208-211.

Salih E. Synthesis of a radioactive thiol reagent, 1-S-[3H]carboxymethyl-dithiothreitol: identification of the phosphorylation sites by N-terminal peptide sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2003 Aug 1; 319(1):143-58. PMID: 12842118

Choi EK, Miller JS, Zaidi NF, Salih E, Buxbaum JD, Wasco W. Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3. Mol Cell Neurosci. 2003 Jul; 23(3):495-506. PMID: 12837631

Carvalho RS, Kostenuik PJ, Salih E, Bumann A, Gerstenfeld LC. Selective adhesion of osteoblastic cells to different integrin ligands induces osteopontin gene expression. Matrix Biol. 2003 May; 22(3):241-9.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 12853034

Goldberg M, Six N, Decup F, Lasfargues JJ, Salih E, Tompkins K, Veis A. Bioactive molecules and the future of pulp therapy. Am J Dent. 2003 Feb; 16(1):66-76. PMID: 12744417

Salih E. In vivo and in vitro phosphorylation regions of bone sialoprotein. Connect Tissue Res. 2003; 44 Suppl 1:223-9. PMID: 12952202

Salih E, Wang J, Mah J, Fluckiger R. Natural variation in the extent of phosphorylation of bone phosphoproteins as a function of in vivo new bone formation induced by demineralized bone matrix in soft tissue and bony environments. Biochem J. 2002 Jun 1; 364(Pt 2):465-74. PMID: 12023890; PMCID: PMC1222592

Goldberg M, Six N, Decup F, Bourd K, Palmier K, Salih E, Veis A, Lasfargues JJ. [Mineralization of the dental pulp: contributions of tissue engineering to tomorrow's therapeutics in odontology]. Pathol Biol (Paris). 2002 Apr; 50(3):194-203. PMID: 11980334

Six N, Decup F, Lasfargues JJ, Salih E, Goldberg M. Osteogenic proteins (bone sialoprotein and bone morphogenetic protein-7) and dental pulp mineralization. J Mater Sci Mater Med. 2002 Feb; 13(2):225-32. PMID: 15348647

Goldberg M, Six N, Decup F, Buch D, Soheili Majd E, Lasfargues JJ, Salih E, Stanislawski L. Application of bioactive molecules in pulp-capping situations. Adv Dent Res. 2001 Aug; 15:91-5. PMID: 12640750

Kim Y, Takanori T, Elovic A, Shintani S, Mihara M, Salih E, Kohno Y, Chin B-R, Patel V, Wong D, Todd R. Murin doc-1 cDNA cloning, sequencing and expression in normal adult tissues. Int. J. Oral Biol. 2001; 87-91.

Decup F, Six N, Palmier B, Buch D, Lasfargues JJ, Salih E, Goldberg M. Bone sialoprotein-induced reparative dentinogenesis in the pulp of rat's molar. Clin Oral Investig. 2000 Jun; 4(2):110-9. PMID: 11218498

Kennedy JG, O'Grady P, McCarthy DR, Johnson SJ, Hynes D, Walsh M, McManus FM, Salih E, Gouverneur M, Fitzpatrick J. An investigation into the role of oxygen free radical scavengers in preventing polymethylmethacrylate-induced necrosis in an osteoblast cell culture. Orthopedics. 2000 May; 23(5):481-5. PMID: 10825116

Kennedy J, Harty JA, Gouverneur M, Salih E, Walsh MG, McManus F, and Fitzpatrick J. The role of collagen type IV angiogenic factor in reversing osteonecrosis in rabbit femoral head model. J.Orthopedic Surg. & Traum. 2000; 5(1):1-10.
Zhou H-Y,Wang J, Glimcher MJ, *Salih E. Osteometrin. The chemistry and biology of mineralized tissues: Rosemont, IL: Amer Acad Orthopaedic Surg Press. 2000; 185-188.
Salih E, Huang J, Gouverneur M, Glimcher M. Novel phosphoproteins and protein kinases of tooth enamel: Novel methods of determining covalently-bound phosphates in phosphoproteins. The chemistry and biology of mineralized tissues: Rosemont, IL: Amer Acad Orthopaedic Surg Press. 2000; 191-198.

Wang J, Glimcher MJ, Mah J, Zhou HY, Salih E. Expression of bone microsomal casein kinase II, bone sialoprotein, and osteopontin during the repair of calvarial defects. Bone. 1998 Jun; 22(6):621-8. PMID: 9626400

Zhou HY, Salih E, Glimcher MJ. Isolation of a novel bone glycosylated phosphoprotein with disulphide cross-links to osteonectin. Biochem J. 1998 Mar 15; 330 ( Pt 3):1423-31. PMID: 9494116; PMCID: PMC1219292

Salih E, Huang JC, Strawich E, Gouverneur M, Glimcher MJ. Enamel specific protein kinases and state of phosphorylation of purified amelogenins. Connect Tissue Res. 1998; 38(1-4):225-35; discussion 241-6. PMID: 11063030

Salih E, Huang J, Gouverneur M, Ly D, Mah J, Glimcher MJ. . Protein kinases that phosphorylated extracellular matrix phosphoproteins of mineralizing tissues: Novel enamel protein kinase. Biological mechanisms of tooth eruption, resorption, and implants. 1998; 133-147.
Wang J, Mah J, Glimcher MJ, Salih E. Biochemical changes during new bone formation in the calvarial and subcutaneous tissue environments. Biological mechanisms of tooth eruption, resorption, and implants. Birmingham AL: EBSCO Media. 1998; 123-132.

Salih E, Ashkar S, Gerstenfeld LC, Glimcher MJ. Identification of the phosphorylated sites of metabolically 32P-labeled osteopontin from cultured chicken osteoblasts. J Biol Chem. 1997 May 23; 272(21):13966-73.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 9153260

Salih E, Ashkar S, Gerstenfeld LC, Glimcher MJ. Protein kinases of cultured osteoblasts: selectivity for the extracellular matrix proteins of bone and their catalytic competence for osteopontin. J Bone Miner Res. 1996 Oct; 11(10):1461-73.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 8889846

Salih E, Zhou HY, Glimcher MJ. Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases. J Biol Chem. 1996 Jul 12; 271(28):16897-905. PMID: 8663267

Salih E. . Rate enhancement in acetylcholinesterase catalyzed reactions through coupling of increased collision density and correct orientation. Proc Chem Defence Biosc. 1996; (1):245-258.

Salih E, Ashkar S, Zhou HY, Gerstenfeld L, Glimcher MJ. Protein kinases of cultured chicken osteoblasts that phosphorylate extracellular bone proteins. Connect Tissue Res. 1996; 35(1-4):207-13.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 9084659

Salih E, Chishti B, Vicedomine P, Cohen SG, Chiara DC, Cohen JB. . Inactivation and labeling by [14C] Phenocyl Bromide of Acetylcoholinesterase, from E. Electricus at His-550 in a peripheral site and from T.Nobiliana at Cys-231 and Ser-226 in the active site and His-550. Proc Chem Defence. 1996; (1):259-271.

Gerstenfeld LC, Uporova T, Ashkar S, Salih E, Gotoh Y, McKee MD, Nanci A, Glimcher MJ. Regulation of avian osteopontin pre- and posttranscriptional expression in skeletal tissues. Ann N Y Acad Sci. 1995 Apr 21; 760:67-82.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 7785927

Salih E, Ashkar S, Gerstenfeld LC, Glimcher MJ. Identification of the in vivo phosphorylated sites of secreted osteopontin from cultured chicken osteoblasts. Ann N Y Acad Sci. 1995 Apr 21; 760:357-60.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 7785916

Ashkar S, Schaffer JL, Salih E, Gerstenfeld LC, Glimcher MJ. Phosphorylation of osteopontin by Golgi kinases. Ann N Y Acad Sci. 1995 Apr 21; 760:296-8.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 7785903

Gotoh Y, Salih E, Glimcher MJ, Gerstenfeld LC. Characterization of the major non-collagenous proteins of chicken bone: identification of a novel 60 kDa non-collagenous phosphoprotein. Biochem Biophys Res Commun. 1995 Mar 17; 208(2):863-70.View Related Profiles.

Salih, Erdjan
Gerstenfeld, Louis

PMID: 7695644

Salih E, Chishti SB, Vicedomine P, Cohen SG, Chiara DC, Cohen JB. Active-site peptides of acetylcholinesterase of Electrophorus electricus: labelling of His-440 by 1-bromo-[2-14C]pinacolone and Ser-200 by tritiated diisopropyl fluorophosphate. Biochim Biophys Acta. 1994 Oct 19; 1208(2):324-31. PMID: 7947965

Salih E, Howard S, Chishti SB, Cohen SG, Liu WS, Cohen JB. Labeling of cysteine 231 in acetylcholinesterase from Torpedo nobiliana by the active-site directed reagent, 1-bromo-2-[14C] pinacolone. Effects of 2,2'-dipyridyl disulfide and other sulfhydryl reagents. J Biol Chem. 1993 Jan 5; 268(1):245-51. PMID: 8416933

Salih E, Chishti SB, Vicedomine P, Cohen SG, Liu WS, Cohen JB. Labelling by l-bromo-2-[14C] pinacolone of His-440 and Trp-435 in acetylcholinesterase from Electrophorus electricus. Proc Chem Defence Biosc. 1993; (2):759-767.

Salih E. Catalysis by acetylcholinesterase in two-hydronic-reactive states. Integrity of deuterium oxide effects and hydron inventories. Biochem J. 1992 Jul 15; 285 ( Pt 2):451-60. PMID: 1322133; PMCID: PMC1132809

Topham CM, Salih E, Frazao C, Kowlessur D, Overington JP, Thomas M, Brocklehurst SM, Patel M, Thomas EW, Brocklehurst K. Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis. Biochem J. 1991 Nov 15; 280 ( Pt 1):79-92. PMID: 1741760; PMCID: PMC1130603

Salih E. Two-hydronic-reactive states of acetylcholinesterase, mechanistically relevant acid-base catalyst of pKa 6.5 and a modulatory group of pKa 5.5. Biochim Biophys Acta. 1991 Jan 23; 1073(1):183-94. PMID: 1991134

Cohen SG, Chishti SB, Bell DA, Howard SI, Salih E, Cohen JB. General occurrence of binding to acetylcholinesterase-substrate complex in noncompetitive inhibition and in inhibition by substrate. Biochim Biophys Acta. 1991 Jan 8; 1076(1):112-22. PMID: 1986784

Salih E, Howard S, Chishti SB, Cohen SG, Liu WS, Cohen JB. . Labelling of cysteine-231 by l-bromo-2-14C pinacolone in the active site of acetylcholinesterase from torpedo nobiliana. Proc Chem Defence Biosc. 1991; (1):603-606.

Topham CM, Overington J, O'driscoll M, Salih E, Thomas M, Thomas EW, Brocklehurst K. Three-dimensional structure of a B-type chymopapain. Biochem Soc Trans. 1990 Oct; 18(5):933-4. PMID: 2083745

French H, Williams R, Salih E, Kowlessur D, Brocklehurst K. Studies on streptococcal proteinase. Biochem Soc Trans. 1990 Aug; 18(4):593-4. PMID: 2276454

Cohen SG, Salih E, Solomon M, Howard S, Chishti SB, Cohen JB. Reactions of 1-bromo-2-[14C]pinacolone with acetylcholinesterase from Torpedo nobiliana. Effects of 5-trimethylammonio-2-pentanone and diisopropyl fluorophosphate. Biochim Biophys Acta. 1989 Aug 31; 997(3):167-75. PMID: 2765553

Cohen SG, Salih E, Solomon M, Howard S, Chishti SB, Cohen JB, Broomfield C. . Reaction of 1-bromo-2-14C-pinacolone with acetylcholinesterase from torpedo nobiliana. Effects of 5-trimethyl ammonio-2-pentanone, diisopropyl fluorophosphate and soman. Proc Chem Defence Biosc. 1989; (1):497-500.

Brocklehurst K, Brocklehurst SM, Kowlessur D, O'Driscoll M, Patel G, Salih E, Templeton W, Thomas E, Topham CM, Willenbrock F. Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics. Biochem J. 1988 Dec 1; 256(2):543-58. PMID: 3223929; PMCID: PMC1135444

Salih E, Malthouse JP, Kowlessur D, Jarvis M, O'Driscoll M, Brocklehurst K. Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe studies targeted on the catalytic-site thiol group and its immediate microenvironment. Biochem J. 1987 Oct 1; 247(1):181-93. PMID: 2825655; PMCID: PMC1148386

Brocklehurst K, Kowlessur D, O'Driscoll M, Patel G, Quenby S, Salih E, Templeton W, Thomas EW, Willenbrock F. Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding. Biochem J. 1987 May 15; 244(1):173-81. PMID: 3663111; PMCID: PMC1147969

Brocklehurst K, Willenbrock F, Salih E. Chapter: Cysteine proteinases. In:Neuberger, A. and Brocklehurst K., editors. Hydrolytic Enzymes: New Comprehensive Biochemistry. Elsevier. Amsterdam/New York/Oxford. 1987; 39-158.
Baines BS, Brocklehurst K, McKee R, O’Driscoll M, Salih E, Smith H. . Identification and characterization of chymopapain A and B from dried and fresh latex of carica papaya. Biochem Soc Trans. 1986; (14):1226-1227.

Baines BS, Brocklehurst K, Carey PR, Jarvis M, Salih E, Storer AC. Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity-probe kinetics, steady-state kinetics and resonance Raman spectroscopy of some dithioacyl derivatives. Biochem J. 1986 Jan 1; 233(1):119-29. PMID: 3513753; PMCID: PMC1152993

Brocklehurst K, Salih E, McKee R, Smith H. Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase omega. Biochem J. 1985 Jun 1; 228(2):525-7. PMID: 4015629; PMCID: PMC1145013

Brocklehurst K, McKee R, Salih E, Smith H. . Evidence from two-protonic-state reactivity probe kinetics that chymopapain in fresh non-fruit latex of carica papaya consists of multiple forms of chymopapain A. The value of catalytic site characteristics in the identification, classification and characterization of the papaya cysteine proteinases papain, the chymopapains and papaya proteinase II. J Protein Chem. 1985; (4):103-127.

Brocklehurst K, Carey PR, Lee HH, Salih E, Storer AC. Comparative resonance Raman spectroscopic and kinetic studies of acyl-enzymes involving papain, actinidin and papaya peptidase II. Biochem J. 1984 Nov 1; 223(3):649-57. PMID: 6391467; PMCID: PMC1144348

Brocklehurst K, Baines BS, Salih E, Hatzoulis C. 'Chymopapain S' is chymopapain A. Biochem J. 1984 Jul 15; 221(2):553-4. PMID: 6383349; PMCID: PMC1144074

Brocklehurst K, Salih E, Lodwig TS. Differences between the electric fields of the catalytic sites of papain and actinidin detected by using the thiol-located nitrobenzofurazan label as a spectroscopic reporter group. Biochem J. 1984 Jun 1; 220(2):609-12. PMID: 6378189; PMCID: PMC1153668

Salih E, Brocklehurst K. Investigation of the catalytic site of actinidin by using benzofuroxan as a reactivity probe with selectivity for the thiolate-imidazolium ion-pair systems of cysteine proteinases. Evidence that the reaction of the ion-pair of actinidin (pKI 3.0, pKII 9.6) is modulated by the state of ionization of a group associated with a molecular pKa of 5.5. Biochem J. 1983 Sep 1; 213(3):713-8. PMID: 6311173; PMCID: PMC1152187

Brocklehurst K, Salih E. A re-evaluation of the nomenclature of the cysteine proteinases of Carica papaya and a rational basis for their identification. Biochem J. 1983 Aug 1; 213(2):559-60. PMID: 6351846; PMCID: PMC1152164

Brocklehurst K, Willenbrock SJ, Salih E. Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism. Biochem J. 1983 Jun 1; 211(3):701-8. PMID: 6309137; PMCID: PMC1154417

Salih E, Willenbrock F, Baines BS, Brocklehurst K. Benzofuroxane as a reactivity probe for the study of disposition of nucleophilic and acid-base groups in enzyme active centers. Biochem Soc Trans. 1982; (10):217-218.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 4 publications in 2004

Bar chart showing 20 publications over 13 distinct years, with a maximum of 4 publications in 2004

Year	Publications
1982	1
1985	1
1986	1
1987	1
1989	1
1991	1
1993	1
1996	2
1998	2
2000	3
2001	1
2004	4
2018	1

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