Erdjan Salih, PhD
Research Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Periodontology

PhD, University of London

Dr. Salih’s research expertise and interests are in several areas of biomedical sciences. These include regulation of biomineralization and modulation of bone remodeling stages such as bone resorption and formation utilizing both cell culture and mouse calvarial bone organ culture systems. Such studies are coupled with extensive protein structure-function analysis of bone extracellular matrix (ECM) components specifically the phosphoproteins and protein kinases that phosphorylate them. Development and use of novel chemistries for qualitative and quantitative determination of the precise phosphorylation sites and their topographical distribution on phosphoproteins using both N-terminal automated amino-acid sequencing and mass spectrometric (MS) technologies. Application of the state-of-the-art MS instrumentations such as MALDI-TOF-MS/MS and LTQ-LC-ESI-MS/MS for large-scale proteome and phosphoproteome studies in general cell biology and bone biology. These MS based approaches have been utilized in conjunction with specific new chemistries for quantitative proteomics and phosphoproteomics in both general cell biology and clinical samples, saliva and gingival crevicular fluid from patients with periodontal disease for diagnostic/predictive biomarker discovery. Further extensive studies have been carried out in the field of tissue engineering by design and use of bioactive composites of bone ECM phosphoproteins and native collagen as a carrier in in vivo models of bone regeneration and reparative dentinogenesis studies. Additional major interests and research areas are development and use of novel three-dimensional cancer-bone metastasis model using ex-vivo mouse calvarial bone organ cultures. This novel model developed by Dr Salih has been more recently utilized to evaluate effects of clinically used bisphosphonates on cancer-bone interactions as well as establish why and how patients who are treated with bisphosphonates for osteoporosis and cancer treatment are at high risk for “bisphosphonate induced-osteonecrosis of jaw bone”.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Salih E. Ex-Vivo Model Systems of Cancer-Bone Cell Interactions. Methods Mol Biol. 2019; 1914:217-240. PMID: 30729467.
  2. Wang Z, Salih E, Igwebuike C, Mulhern R, Bonegio RG, Havasi A, Borkan SC. Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI. J Am Soc Nephrol. 2019 Jan; 30(1):50-62.View Related Profiles. PMID: 30573638.
  3. Sok-Ja Janket, Martha E. Nunn, Erdjan Salih, and Alison E. Baird. Translational Oral Health Research (J. H. Meurman (ed.)). Evidence-Based Approach in Translational Dental Research. Springer International Publishing AG, part of Springer Nature 2018. 2018; Chapter 8:81-101.
  4. Tang X, Alasiri M, Bamashmous A, Aljahdali B, Cao F, Dibart S, Salih E. The involvement of Kav001 in inhibition of LPS/P. gingivalis-induced. J Cell Biochem. 2018 07; 119(7):6072-6079.View Related Profiles. PMID: 29637600.
  5. Tang X, Aljahdali B, Alasiri M, Bamashmous A, Cao F, Dibart S, Salih E. A method for high transfection efficiency in THP-1 suspension cells without PMA treatment. Anal Biochem. 2018 03 01; 544:93-97.View Related Profiles. PMID: 29305095.
  6. Salih E. Qualitative and Quantitative Proteome Analysis of Oral Fluids in Health and Periodontal Disease by Mass Spectrometry. Methods Mol Biol. 2017; 1537:37-60. PMID: 27924587.
  7. Alasmari A, Lin SC, Dibart S, Salih E. Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells. Clin Exp Metastasis. 2016 Aug; 33(6):563-88.View Related Profiles. PMID: 27155840; DOI: 10.1007/s10585-016-9798-6;.
  8. Dibart S, Alasmari A, Zanni O, Salih E. Effect of Corticotomies with Different Instruments on Cranial Bone Biology Using an Ex Vivo Calvarial Bone Organ Culture Model System. Int J Periodontics Restorative Dent. 2016; 36 Suppl:s123-36.View Related Profiles. PMID: 27031627; DOI: 10.11607/prd.2701;.
  9. Carneiro LG, Nouh H, Salih E. Quantitative gingival crevicular fluid proteome in health and periodontal disease using stable isotope chemistries and mass spectrometry. J Clin Periodontol. 2014 Aug; 41(8):733-47.View Related Profiles. PMID: 24738839; PMCID: PMC4128226; DOI: 10.1111/jcpe.12262;.
  10. Liu J, Czernick D, Lin SC, Alasmari A, Serge D, Salih E. Novel bioactivity of phosvitin in connective tissue and bone organogenesis revealed by live calvarial bone organ culture models. Dev Biol. 2013 Sep 1; 381(1):256-75.View Related Profiles. PMID: 23791550; DOI: 10.1016/j.ydbio.2013.06.005;.
Showing 10 of 95 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 95 publications over 35 distinct years, with a maximum of 8 publications in 2004

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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