Elizabeth S. Klings, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, New York University School of Medicine



Dr. Klings is an Associate Professor in the Department of Medicine. She is the Director of the Center for Excellence in Sickle Cell Disease and the Director of the Pulmonary Hypertension at BUSM/Boston Medical Center. She has an outpatient clinical practice focused on patients with pulmonary hypertension and those with pulmonary complications of sickle cell disease. She attends in the Medical Intensive Care Unit and on the Pulmonary Hypertension Consultation Service at Boston Medical Center. As Director of the largest sickle cell center in New England, Dr. Klings has created numerous new clinical programs for our patients and has expanded the clinical trials program.

Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with numerous other investigators across the medical campus. She has phenotypically screened over 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and currently investigating the roles of disease modulators including sleep-disordered breathing and venous thromboembolism in the endothelial and vascular dysfunction these patients experience. Known internationally as a leader in the care and treatment of patients with sickle cell disease, she was first author of the American Thoracic Society sponsored clinical guidelines for Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease. She recently chaired an ATS sponsored workshop to define clinical and research priorities in sickle cell lung disease and serves on the NHLBI Sickle Cell Disease Advisory Committee.

Active Staff Privileges
Boston Medical Center
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine



A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP, PLACEBO-CONTROLLED PHASE 2 TRIAL OF APD811, AN ORAL IP RECEPTOR AGONIST, IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION
12/12/2014 - 12/31/2020 (PI)
Arena Pharmaceuticals Inc.

HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR YOUNG ADULTS WITH SICKLE CELL DISEASE
09/01/2015 - 07/31/2020 (PI)
Emory University NIH NHLBI
5U01HL128566-03

PROTOCOL AC-055-512 RETRO: A RETROSPECTIVE, MULTICENTER CHART REVIEW TO COLLECT DOSING INFORMATION OF PAH BACKGROUND MEDICATION IN SUBJECT WHO PARTICIPATED IN THE AC-055-302 (SERAPHIN) DOUBLE-BLIND
07/26/2018 - 05/31/2020 (PI)
Actelion Pharmaceuticals, Ltd.

A DOSE-RANGING STUDY OF THE EFFICACY AND SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION
05/30/2014 - 05/31/2020 (PI)
Reata Pharmaceuticals, Inc.

PFIZER CONSULTANT AGREEMENT- RIVIPANSEL
03/17/2014 - 12/31/2019 (PI)
Pfizer, Inc.

PROTOCOL INCB59872-102, A PHASE 1 OPEN-LABEL, DOSE-ESCALATION/DOSE-EXPANSION SAFETY AND TOLERABILITY STUDY OF INCB059872 IN SUBJECTS WITH SICKLE CELL DISEASE
12/06/2017 - 12/05/2019 (PI)
Incyte Corporation

A STUDY OF THE EFFICACY AND SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION
10/12/2016 - 10/11/2019 (PI)
Reata Pharmaceuticals, Inc.

PROTOCOL STERIO-SCD, A PHASE LIB RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED MULTI-CENTER STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND EFFICACY OF RIOCIGUAT IN PATIENTS WITH SICKLE CELL DISEASES
03/20/2018 - 09/19/2019 (PI)
University of Pittsburgh Bayer HealthCare

A PHASE 2, OPEN-LABEL, EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND EFFICACY OF UBENIMEX IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION (WHO GROUP 1)
08/24/2016 - 08/23/2019 (PI)
Eiger BioPharmaceuticals, Inc.

PROTOCOL 402-C-1602, AN EXTENDED ACCESS PROGRAM TO ASSESS LONG-TERM SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH PULMONARY HYPERTENSION.
07/27/2017 - 07/26/2019 (PI)
Reata Pharmaceuticals, Inc.

Showing 10 of 28 results. Show All Results



Yr Title Project-Sub Proj Pubs
2013 Protein biomarkers of pulmonary hypertension in sickle cell disease 5R21HL107993-02 1
2012 Protein biomarkers of pulmonary hypertension in sickle cell disease 1R21HL107993-01A1 1
2011 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-15-5116 236
2010 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-14-6816 236
2009 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-13-6167 236
2009 Gene polymorphism in chronic sickle cell lung disease 5K23HL079003-05 6
2008 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-12-5241 236
2008 Gene polymorphism in chronic sickle cell lung disease 5K23HL079003-04 6
2007 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 2P41RR010888-11-8062 236
2007 Gene polymorphism in chronic sickle cell lung disease 5K23HL079003-03 6
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kopel LS, Klings ES, Monuteaux MC, Gaffin JM, Heeney MM, Phipatanakul W. Bronchodilator Use for Acute Chest Syndrome Among Large Pediatric Hospitals in North America. Clin Pediatr (Phila). 2018 Dec; 57(14):1630-1637. PMID: 30173539.
     
  2. Kim D, Lee KM, Freiman MR, Powell WR, Klings ES, Rinne ST, Miller DR, Rose AJ, Wiener RS. Phosphodiesterase-5 Inhibitor Therapy for Pulmonary Hypertension in the United States. Actual versus Recommended Use. Ann Am Thorac Soc. 2018 Jun; 15(6):693-701.View Related Profiles. PMID: 29485908.
     
  3. Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM. A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells. Mol Pharm. 2018 May 07; 15(5):1954-1963. PMID: 29634905.
     
  4. Cohen RT, Klings ES. Commentary: Heterogeneity of respiratory disease in children and young adults with sickle cell disease. Thorax. 2018 Jun; 73(6):503.View Related Profiles. PMID: 29353255.
     
  5. Eckman JR, Hassell KL, Huggins W, Werner EM, Klings ES, Adams RJ, Panepinto JA, Hamilton CM. Standard measures for sickle cell disease research: the PhenX Toolkit sickle cell disease collections. Blood Adv. 2017 Dec 26; 1(27):2703-2711. PMID: 29296922.
     
  6. Worsham CM, Martin ST, Nouraie SM, Cohen RT, Klings ES. Clinical and laboratory findings associated with sleep disordered breathing in sickle cell disease. Am J Hematol. 2017 12; 92(12):E649-E651.View Related Profiles. PMID: 28833466.
     
  7. Weir NA, Saiyed R, Alam S, Conrey A, Desai HD, George MP, Keeley JH, Klings ES, Mehari A, Taylor JG, Minniti CP, Kato GJ. Prostacyclin-analog therapy in sickle cell pulmonary hypertension. Haematologica. 2017 05; 102(5):e163-e165. PMID: 28126964; DOI: 10.3324/haematol.2015.131227;.
     
  8. Whitesell PL, Owoyemi O, Oneal P, Nouraie M, Klings ES, Rock A, Mellman TA, Berihun T, Lavella J, Taylor RE, Perrine SP. Sleep-disordered breathing and nocturnal hypoxemia in young adults with sickle cell disease. Sleep Med. 2016 Jun; 22:47-49.View Related Profiles. PMID: 27544835; PMCID: PMC4994534; DOI: 10.1016/j.sleep.2016.05.006;.
     
  9. Mehari A, Klings ES. Chronic Pulmonary Complications of Sickle Cell Disease. Chest. 2016 May; 149(5):1313-24. PMID: 26836905; DOI: 10.1016/j.chest.2015.11.016;.
     
  10. Cohen RT, Klings ES, Strunk RC. Sickle cell disease: wheeze or asthma? Asthma Res Pract. 2015; 1:14.View Related Profiles. PMID: 27965767.
     
Showing 10 of 52 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 52 publications over 20 distinct years, with a maximum of 6 publications in 2014

YearPublications
19992
20003
20014
20022
20031
20041
20052
20062
20072
20082
20093
20102
20113
20123
20131
20146
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20162
20173
20184
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

anemia, sickle cell
endothelium
pulmonary hypertension

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72 E. Concord St Housman (R)
Boston MA 02118
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