Dr. Klings is an Associate Professor in the Department of Medicine. She is the Director of the Center for Excellence in Sickle Cell Disease and the Director of the Pulmonary Hypertension at BUSM/Boston Medical Center. She has an outpatient clinical practice focused on patients with pulmonary hypertension and those with pulmonary complications of sickle cell disease. She attends in the Medical Intensive Care Unit and on the Pulmonary Hypertension Consultation Service at Boston Medical Center. As Director of the largest sickle cell center in New England, Dr. Klings has created numerous new clinical programs for our patients and has expanded the clinical trials program.
Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with numerous other investigators across the medical campus. She has phenotypically screened over 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and currently investigating the roles of disease modulators including sleep-disordered breathing and venous thromboembolism in the endothelial and vascular dysfunction these patients experience. Known internationally as a leader in the care and treatment of patients with sickle cell disease, she was first author of the American Thoracic Society sponsored clinical guidelines for Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease. She recently chaired an ATS sponsored workshop to define clinical and research priorities in sickle cell lung disease and serves on the NHLBI Sickle Cell Disease Advisory Committee.
Diversity, Equity, Inclusion and Accessibility
My commitment to diversity, equity and inclusion dates back to medical school. I came to BU for Internal Medicine Residency training at the then Boston City Hospital to work specifically with an underserved population and was excited by resources that existed here over 20 years ago to improve the healthcare of these patients. During my pulmonary/critical care fellowship, I began to study the pulmonary vascular complications of sickle cell disease. As I joined the faculty in 2000, I began to understand that my work in sickle cell disease coupled exciting science with a population riddled by profound healthcare disparities. I have remained committed to this work since that time. As Director of the Center for Excellence in Sickle Cell Disease, I oversee a diverse group of physicians, advanced practice providers, social workers, patient navigators and research staff dedicated to improving care for our patients.
One of my passions is mentoring trainees and junior faculty, particularly in research. I have over 30 prior and current research mentees, many of whom identify as female or members of under-represented groups. As a member of the LGBTQ+ community, I understand the importance of not only recruiting a diverse group of trainees but assisting them in overcoming barriers to their development.
Within the Pulmonary Center, I serve in two important, and partiaily overlapping, roles. I am the co-chair of our Diversity and Inclusion Faculty Recruitment Committee which has as its goal the identification and recruitment of diverse faculty candidates. Since 2021, I have been the chair of our Racial Equity committee which is leading our division's monthly education sessions on topics of race, health equity, career development and related issues.
Center of Excellence in Sickle Cell Disease
Evans Center for Interdisciplinary Biomedical Research
Role of Regional Left Ventricular Strain Patterns in Systemic Sclerosis-related Pulmonary Hypertension
07/01/2023 - 06/30/2026 (Key Person / Mentor)
PI: Justin K. Lui, MD, MSAmerican Heart Association
Cardiac Strain Phenotyping of Systemic Sclerosis-related Pulmonary Hypertension
04/01/2023 - 03/31/2026 (Key Person / Mentor)
PI: Justin K. Lui, MD, MSScleroderma Foundation
Protocol 21427/BAY0903201: ROAR: Riociguat Users Registry
07/13/2021 - 02/28/2024 (PI)Bayer HealthCare Pharmaceuticals
A StuDy eVAluatiNg the EfficaCy and Safety of RalinEpag To Improve Treatment OUTCOMES in PAH Patients
11/30/2018 - 12/31/2023 (PI)United Therapeutics Corporation
Protocol # STERIO-SCD, A Phase lib Randomized, Double-Blind, Placebo-Controlled Multi-Center Study to Assess the Safety, Tolerability, and Efficacy of Riociguat in Patients with Sickle Cell Diseases
03/20/2018 - 09/19/2023 (Subcontract PI)University of Pittsburgh Bayer HealthCare
Biomarkers of Left Ventricular Strain in Systemic Sclerosis-related Pulmonary Hypertension
07/27/2022 - 07/27/2023 (Key Person / Mentor)
PI: Justin K. Lui, MD, MSUnited Therapeutics Corporation
Protocol #APD811-303: A Study Evaluating the Long-Term Efficacy and Safety of RalinEpag in Subjects with PAH via an Open-Label EXTENSION
02/06/2019 - 02/06/2023 (PI)United Therapeutics Corporation
Protocol # 402-C-1602, An Extended Access Program to Assess Long-Term Safety of Bardoxolone Methyl in Patients with Pulmonary Hypertension.
07/27/2017 - 07/26/2022 (PI)Reata Pharmaceuticals, Inc.
Left Ventricular Strain in Systemic Sclerosis-related Pulmonary Hypertension
07/01/2021 - 06/30/2022 (Key Person / Mentor)
PI: Justin K. Lui, MD, MSNIH/National Heart, Lung, and Blood Institute1F32HL156614-01
A Dose-Ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients with Pulmonary Arterial Hypertension
05/30/2014 - 05/31/2022 (PI)Reata Pharmaceuticals, Inc.
Showing 10 of 35 results.
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SEG101 (STAND): A phase III, Multicenter, Randomized, Double-blind Study to Assess Efficacy and …
01/23/2020 - 03/01/2028 (PI)Novartis Pharma Corp
1/2 Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCDCARRE Trial)
05/01/2020 - 04/30/2026 (PI)University of Pittsburgh National Heart, Lung4UH3HL143192-02
2 U1EMC27864-08-00; Sickle Cell Treatment Demonstration Program
09/01/2021 - 08/31/2024 (PI)Johns Hopkins University Health Resources and
ASH Research Collaborative-Data Hub Agreement
09/01/2021 - 06/30/2024 (PI)American Society of Hematology
Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE)
08/01/2022 - 04/30/2024 (PI)University of Maryland National Heart, Lung7UH3HL143192-05
4202-HEM-301: An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Activator in Patients with Sickle Cell Disease (PRAISE).
03/24/2021 - 03/23/2024 (PI)Forma Therapeutics, Inc.
Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE)
05/01/2020 - 07/31/2022 (PI)University of Pittsburgh National Heart, Lung4UH3HL143192-02
Showing 10 of 17 results.
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 84 results.
Vakhshoorzadeh J, Lui JK, Sangani RA, Trojanowski MA, Bujor AM, LaValley MP, Klings ES. Emphysema and interstitial lung disease in systemic sclerosis-related pulmonary hypertension. Respir Med. 2023 Sep; 216:107333.View Related Profiles. PMID: 37336329; DOI: 10.1016/j.rmed.2023.107333;
Lui JK, Sangani RA, Gillmeyer KR, Vakhshoorzadeh J, Trojanowski MA, Bujor AM, Gopal DM, Wiener RS, LaValley MP, Klings ES. Correction to: Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension. Cardiovasc Drugs Ther. 2023 Jan 20.View Related Profiles. PMID: 36662449
Lui JK, Gillmeyer KR, Sangani RA, Smyth RJ, Gopal DM, Trojanowski MA, Bujor AM, Soylemez Wiener R, LaValley MP, Klings ES. A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis. Arthritis Care Res (Hoboken). 2023 Jul; 75(7):1462-1468.View Related Profiles. PMID: 35678779; PMCID: PMC9732142; DOI: 10.1002/acr.24969;
Lui JK, Sangani RA, Gillmeyer KR, Vakhshoorzadeh J, Trojanowski MA, Bujor AM, Gopal DM, Wiener RS, LaValley MP, Klings ES. Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension. Cardiovasc Drugs Ther. 2023 Jan 06.View Related Profiles. PMID: 36607535; DOI: 10.1007/s10557-022-07420-1;
Sangani RA, Lui JK, Gillmeyer KR, Trojanowski MA, Bujor AM, LaValley MP, Klings ES. Clinical characteristics and outcomes in pulmonary manifestations of systemic sclerosis: Contribution from pulmonary hypertension and interstitial lung disease severity. Pulm Circ. 2022 Oct; 12(4):e12117.View Related Profiles. PMID: 36238967; PMCID: PMC9535436; DOI: 10.1002/pul2.12117;
Gillmeyer KR, Rinne ST, Qian SX, Maron BA, Johnson SW, Klings ES, Wiener RS. Socioeconomically disadvantaged veterans experience treatment delays for pulmonary arterial hypertension. Pulm Circ. 2022 Oct; 12(4):e12171.View Related Profiles. PMID: 36568691; PMCID: PMC9768567; DOI: 10.1002/pul2.12171;
Johnson SW, Gillmeyer KR, Bolton RE, McCullough MB, Qian SX, Maron BA, Klings ES, Wiener RS. Variable Monitoring of Veterans with Group 3 Pulmonary Hypertension Treated with Off-Label Pulmonary Vasodilator Therapy. Ann Am Thorac Soc. 2022 Jul; 19(7):1236-1239.View Related Profiles. PMID: 35312466; PMCID: PMC9278628; DOI: 10.1513/AnnalsATS.202110-1168RL;
Nakagawa A, Cooper MK, Kost-Alimova M, Berstler J, Yu B, Berra L, Klings ES, Huang MS, Heeney MM, Bloch DB, Zapol WM. High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells. ACS Omega. 2022 Apr 26; 7(16):14009-14016. PMID: 35559170; PMCID: PMC9089379; DOI: 10.1021/acsomega.2c00541;
Lui JK, Sangani RA, Chen CA, Bujor AM, Trojanowski MA, Gopal DM, LaValley MP, Soylemez Wiener R, Klings ES. Prognostic Value of Cardiac Axis Deviation in Systemic Sclerosis-Related Pulmonary Hypertension. Arthritis Care Res (Hoboken). 2022 Jul; 74(7):1219-1226.View Related Profiles. PMID: 34085410; PMCID: PMC8639831; DOI: 10.1002/acr.24724;
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