Elena Losina, PhD
Adjunct Associate Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MSc, Odessa I. I. Mechnikov National University

For nearly two decades I have been dedicated to bringing rigorous research methods to bear on pressing clinical and policy questions. I enjoy working closely with clinical investigators in two spheres – rheumatology and orthopaedics. I serve as the principal investigator on several NIH-funded projects and
as the collaborating methodologist on several others. My work focuses on: application of decision analytic models to the analysis of long-term clinical and economic implications of treatment or prevention strategies; statistical analysis of data collected longitudinally or via complex hierarchical surveys; design
and conduct of non-pharmacologic clinical trials.

I am the principal investigator of a multidisciplinary team that has developed the Osteoarthritis (OA) Policy Model, a computer simulation model of prevention, natural history and treatment for knee OA. This model is supported by an RO1 from NIAMS. I am also the Analytic Core Director of a multidisciplinary, international project assessing the prognostic value of serum and imaging biomarkers in knee OA.

Studies of surgery raise especially challenging methodologic problems. I serve as the principal statistician of a NIAMS-funded multicenter RCT of the efficacy of arthroscopic partial meniscectomy in persons with meniscal tear and knee osteoarthritis; principal investigator of an RCT that investigates the efficacy of a patient navigator intervention to enhance recovery following total knee replacement; and principal statistician on a multidimensional population-based study examining the association of hospital volume and outcomes of total hip and knee replacement.

I am a passionate, dedicated educator. Since 2007 I have served as a Core faculty member of EPI 208, the keystone course of the Harvard School of Public Health Program in Clinical Effectiveness. As a core faculty member I lead workshops and seminars and help students to shape research ideas into feasible
research projects. I am also a co-Director of a T32 funded training program in musculoskeletal clinical research based at Brigham and Women’s Hospital.

For more than a decade I have served as Principal Investigator of the Methodology Core of the NIAMSfunded P60 Multidisciplinary Clinical Research Center at Brigham and Women’s Hospital. The core provides direction and support for study design, data management, programming, statistical analysis, psychometric testing, training and education of post-doctoral fellows and other trainees.

In recent years I became interested in implementing methods of behavior economics into workplace wellness programs and to increase physical activity in persons with arthritis. I led the R21 supported pilot RCT and currently work on planning a multicenter RCT to examine the efficacy of two interventions –
financial incentives and telephonic coaching to improve physical activity post total knee replacements.

I spend about a quarter of my time providing methodological mentorship to fellows, medical and doctoral students, and junior faculty. This work is funded in part by a NIAMS K24 Mentoring award. I co-founded and co-directed a short course “Essentials of Clinical Research in Orthopaedics” for orthopaedic fellows. I lead monthly research seminars and co-direct the PRIDE (Pilot Research Incubation and Development) Program in the Department of Orthopedic Surgery at Brigham and Women’s Hospital. This innovative program creates collaborations between clinical investigators and our methodology team to move the clinicians’ research ideas toward feasible projects and publications. I also serve as a Deputy Editor for Methodology and Biostatistics for the premier orthopaedic journal, the Journal of Bone and Joint Surgery.

The breadth of clinical and methodological topics encompassed in my research and mentoring has enabled me to translate methods and concepts across disciplines and cultures.

2016 Osteoarthritis Research Society International: Clinical Research Award
2012 Association for Rheumatology Health Professionals, Division of American College of Rheumatology: Distinguished Scholar Award
2011 Harvard Medical School: Young Mentor Award
2010-Pres National Institute of Arthritis, Musculoskeletal and Skin Diseases: Midcareer Mentoring Award
2008 Arthritis Foundation: Innovative Research Grant
2002 American College of Rheumatology (ACR): Arthritis Health Professional Investigator Award
2001 National Institutes of Health (NIH): Mentored Quantitative Research Career Development Award
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Wolf LL, Ejiofor JI, Wang Y, Hunink MG, Losina E, Haider AH, Smink DS. Management of Reducible Ventral Hernias: Clinical Outcomes and Cost-effectiveness of Repair at Diagnosis Versus Watchful Waiting. Ann Surg. 2019 Feb; 269(2):358-366. PMID: 29194083; DOI: 10.1097/SLA.0000000000002507;.
  2. Cleveland RJ, Alvarez C, Schwartz TA, Losina E, Renner JB, Jordan JM, Callahan LF. The impact of painful knee osteoarthritis on mortality: a community-based cohort study with over 24 years of follow-up. Osteoarthritis Cartilage. 2018 Dec 22. PMID: 30583096.
  3. MacFarlane LA, Yang H, Collins JE, Jarraya M, Guermazi A, Mandl LA, Martin SD, Wright J, Losina E, Katz JN. Association of Changes in Effusion-Synovitis With Progression of Cartilage Damage Over Eighteen Months in Patients With Osteoarthritis and Meniscal Tear. Arthritis Rheumatol. 2019 Jan; 71(1):73-81.View Related Profiles. PMID: 30133187.
  4. Rajan PV, Qudsi RA, Dyer GSM, Losina E. Cost-utility studies in upper limb orthopaedic surgery. Bone Joint J. 2018 Nov; 100-B(11):1416-1423. PMID: 30418054.
  5. Smith SR, Katz JN, Losina E. Cost-effectiveness of alternative anticoagulation strategies for postoperative management of total knee arthroplasty patients. Arthritis Care Res (Hoboken). 2018 Oct 28. PMID: 30369093.
  6. Solomon DH, Lu B, Yu Z, Corrigan C, Harrold LR, Smolen JS, Fraenkel L, Katz JN, Losina E. Benefits and Sustainability of a Learning Collaborative for Implementation of Treat-to-Target in Rheumatoid Arthritis: Results of a Cluster-Randomized Controlled Phase II Clinical Trial. Arthritis Care Res (Hoboken). 2018 Oct; 70(10):1551-1556. PMID: 29316341; DOI: 10.1002/acr.23508;.
  7. Gong Y, Trentadue TP, Shrestha S, Losina E, Collins JE. Financial incentives for objectively-measured physical activity or weight loss in adults with chronic health conditions: A meta-analysis. PLoS One. 2018; 13(9):e0203939. PMID: 30252864.
  8. Losina E. Why past research successes do not translate to clinical reality: gaps in evidence on exercise program efficacy. Osteoarthritis Cartilage. 2019 Jan; 27(1):1-2. PMID: 30248501.
  9. Solomon DH, Yu Z, Katz JN, Bitton A, Corrigan C, Fraenkel L, Harrold LR, Smolen JS, Losina E, Lu B. Adverse Events and Resource Use Before and After Treat to Target in Rheumatoid Arthritis:A Post-Hoc Analysis of a Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2018 Sep 17. PMID: 30221841.
  10. Kerman HM, Smith SR, Smith KC, Collins JE, Suter LG, Katz JN, Losina E. Disparities in Total Knee Replacement: Population Losses in Quality-Adjusted Life-Years Due to Differential Offer, Acceptance, and Complication Rates for African Americans. Arthritis Care Res (Hoboken). 2018 Sep; 70(9):1326-1334. PMID: 29363280; DOI: 10.1002/acr.23484;.
Showing 10 of 404 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 404 publications over 23 distinct years, with a maximum of 40 publications in 2011

Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
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