Elena Losina, PhD
Adjunct Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MSc, Odessa I. I. Mechnikov National University




For nearly two decades I have been dedicated to bringing rigorous research methods to bear on pressing clinical and policy questions. I enjoy working closely with clinical investigators in two spheres – rheumatology and orthopaedics. I serve as the principal investigator on several NIH-funded projects and
as the collaborating methodologist on several others. My work focuses on: application of decision analytic models to the analysis of long-term clinical and economic implications of treatment or prevention strategies; statistical analysis of data collected longitudinally or via complex hierarchical surveys; design
and conduct of non-pharmacologic clinical trials.

I am the principal investigator of a multidisciplinary team that has developed the Osteoarthritis (OA) Policy Model, a computer simulation model of prevention, natural history and treatment for knee OA. This model is supported by an RO1 from NIAMS. I am also the Analytic Core Director of a multidisciplinary, international project assessing the prognostic value of serum and imaging biomarkers in knee OA.

Studies of surgery raise especially challenging methodologic problems. I serve as the principal statistician of a NIAMS-funded multicenter RCT of the efficacy of arthroscopic partial meniscectomy in persons with meniscal tear and knee osteoarthritis; principal investigator of an RCT that investigates the efficacy of a patient navigator intervention to enhance recovery following total knee replacement; and principal statistician on a multidimensional population-based study examining the association of hospital volume and outcomes of total hip and knee replacement.

I am a passionate, dedicated educator. Since 2007 I have served as a Core faculty member of EPI 208, the keystone course of the Harvard School of Public Health Program in Clinical Effectiveness. As a core faculty member I lead workshops and seminars and help students to shape research ideas into feasible
research projects. I am also a co-Director of a T32 funded training program in musculoskeletal clinical research based at Brigham and Women’s Hospital.

For more than a decade I have served as Principal Investigator of the Methodology Core of the NIAMSfunded P60 Multidisciplinary Clinical Research Center at Brigham and Women’s Hospital. The core provides direction and support for study design, data management, programming, statistical analysis, psychometric testing, training and education of post-doctoral fellows and other trainees.

In recent years I became interested in implementing methods of behavior economics into workplace wellness programs and to increase physical activity in persons with arthritis. I led the R21 supported pilot RCT and currently work on planning a multicenter RCT to examine the efficacy of two interventions –
financial incentives and telephonic coaching to improve physical activity post total knee replacements.

I spend about a quarter of my time providing methodological mentorship to fellows, medical and doctoral students, and junior faculty. This work is funded in part by a NIAMS K24 Mentoring award. I co-founded and co-directed a short course “Essentials of Clinical Research in Orthopaedics” for orthopaedic fellows. I lead monthly research seminars and co-direct the PRIDE (Pilot Research Incubation and Development) Program in the Department of Orthopedic Surgery at Brigham and Women’s Hospital. This innovative program creates collaborations between clinical investigators and our methodology team to move the clinicians’ research ideas toward feasible projects and publications. I also serve as a Deputy Editor for Methodology and Biostatistics for the premier orthopaedic journal, the Journal of Bone and Joint Surgery.

The breadth of clinical and methodological topics encompassed in my research and mentoring has enabled me to translate methods and concepts across disciplines and cultures.

2016 Osteoarthritis Research Society International: Clinical Research Award
2012 Association for Rheumatology Health Professionals, Division of American College of Rheumatology: Distinguished Scholar Award
2011 Harvard Medical School: Young Mentor Award
2010-Pres National Institute of Arthritis, Musculoskeletal and Skin Diseases: Midcareer Mentoring Award
2008 Arthritis Foundation: Innovative Research Grant
2002 American College of Rheumatology (ACR): Arthritis Health Professional Investigator Award
2001 National Institutes of Health (NIH): Mentored Quantitative Research Career Development Award

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Huizinga JL, Stanley EE, Sullivan JK, Song S, Hunter DJ, Paltiel AD, Neogi T, Edwards RR, Katz JN, Losina E. Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States. Arthritis Care Res (Hoboken). 2021 Feb 24.View Related Profiles. PMID: 33629485
     
  2. Solomon DH, Xu C, Collins J, Kim SC, Losina E, Yau V, Johansson FD. The sequence of disease-modifying anti-rheumatic drugs: pathways to and predictors of tocilizumab monotherapy. Arthritis Res Ther. 2021 01 14; 23(1):26. PMID: 33446261
     
  3. Hunter DJ, Deveza LA, Collins JE, Losina E, Nevitt MC, Roemer FW, Guermazi A, Bowes MA, Dam EB, Eckstein F, Lynch JA, Katz JN, Kwoh CK, Hoffmann S, Kraus VB. Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium. Arthritis Care Res (Hoboken). 2021 Jan 09.View Related Profiles. PMID: 33421361
     
  4. Barton LB, Arant KR, Blucher JA, Sarno DL, Redmond KJ, Balboni TA, Colman M, Goodwin CR, Laufer I, Placide R, Shin JH, Sciubba DM, Losina E, Katz JN, Schoenfeld AJ. Clinician Experiences in Treatment Decision-Making for Patients with Spinal Metastases: A Qualitative Study. J Bone Joint Surg Am. 2021 Jan 06; 103(1):e1. PMID: 33136698
     
  5. Wolf LL, Sonderman KA, Kwon NK, Armstrong LB, Weil BR, Koehlmoos TP, Losina E, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Epidemiology of abdominal wall and groin hernia repairs in children. Pediatr Surg Int. 2021 Jan 01. PMID: 33386445
     
  6. Losina E, Leifer V, Millham L, Panella C, Hyle EP, Mohareb AM, Neilan AM, Ciaranello AL, Kazemian P, Freedberg KA. College Campuses and COVID-19 Mitigation: Clinical and Economic Value. Ann Intern Med. 2020 Dec 21. PMID: 33347322
     
  7. Baggett TP, Scott JA, Le MH, Shebl FM, Panella C, Losina E, Flanagan C, Gaeta JM, Neilan A, Hyle EP, Mohareb A, Reddy KP, Siedner MJ, Harling G, Weinstein MC, Ciaranello A, Kazemian P, Freedberg KA. Clinical Outcomes, Costs, and Cost-effectiveness of Strategies for Adults Experiencing Sheltered Homelessness During the COVID-19 Pandemic. JAMA Netw Open. 2020 12 01; 3(12):e2028195.View Related Profiles. PMID: 33351082
     
  8. Lenhard NK, Sullivan JK, Ross EL, Song S, Edwards RR, Hunter DJ, Neogi T, Katz JN, Losina E. Does screening for depressive symptoms help optimize duloxetine use in knee OA patients with moderate pain? A cost-effectiveness analysis. Arthritis Care Res (Hoboken). 2020 Nov 30.View Related Profiles. PMID: 33253496
     
  9. Reyes AM, Katz JN, Schoenfeld AJ, Kang JD, Losina E, Chang Y. National utilization and inpatient safety measures of lumbar spinal fusion methods by race/ethnicity. Spine J. 2020 Nov 20. PMID: 33227551
     
  10. Reddy KP, Shebl FM, Foote JHA, Harling G, Scott JA, Panella C, Fitzmaurice KP, Flanagan C, Hyle EP, Neilan AM, Mohareb AM, Bekker LG, Lessells RJ, Ciaranello AL, Wood R, Losina E, Freedberg KA, Kazemian P, Siedner MJ. Cost-effectiveness of public health strategies for COVID-19 epidemic control in South Africa: a microsimulation modelling study. Lancet Glob Health. 2021 02; 9(2):e120-e129. PMID: 33188729
     
Showing 10 of 465 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 465 publications over 25 distinct years, with a maximum of 40 publications in 2011

YearPublications
19961
19971
19982
19992
20018
20029
20038
20047
200516
200618
200716
200812
200922
201031
201140
201231
201335
201424
201528
201633
201734
201822
201926
202034
20215

Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
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