Elena Losina, PhD
Adjunct Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MSc, Odessa I. I. Mechnikov National University

For nearly two decades I have been dedicated to bringing rigorous research methods to bear on pressing clinical and policy questions. I enjoy working closely with clinical investigators in two spheres – rheumatology and orthopaedics. I serve as the principal investigator on several NIH-funded projects and
as the collaborating methodologist on several others. My work focuses on: application of decision analytic models to the analysis of long-term clinical and economic implications of treatment or prevention strategies; statistical analysis of data collected longitudinally or via complex hierarchical surveys; design
and conduct of non-pharmacologic clinical trials.

I am the principal investigator of a multidisciplinary team that has developed the Osteoarthritis (OA) Policy Model, a computer simulation model of prevention, natural history and treatment for knee OA. This model is supported by an RO1 from NIAMS. I am also the Analytic Core Director of a multidisciplinary, international project assessing the prognostic value of serum and imaging biomarkers in knee OA.

Studies of surgery raise especially challenging methodologic problems. I serve as the principal statistician of a NIAMS-funded multicenter RCT of the efficacy of arthroscopic partial meniscectomy in persons with meniscal tear and knee osteoarthritis; principal investigator of an RCT that investigates the efficacy of a patient navigator intervention to enhance recovery following total knee replacement; and principal statistician on a multidimensional population-based study examining the association of hospital volume and outcomes of total hip and knee replacement.

I am a passionate, dedicated educator. Since 2007 I have served as a Core faculty member of EPI 208, the keystone course of the Harvard School of Public Health Program in Clinical Effectiveness. As a core faculty member I lead workshops and seminars and help students to shape research ideas into feasible
research projects. I am also a co-Director of a T32 funded training program in musculoskeletal clinical research based at Brigham and Women’s Hospital.

For more than a decade I have served as Principal Investigator of the Methodology Core of the NIAMSfunded P60 Multidisciplinary Clinical Research Center at Brigham and Women’s Hospital. The core provides direction and support for study design, data management, programming, statistical analysis, psychometric testing, training and education of post-doctoral fellows and other trainees.

In recent years I became interested in implementing methods of behavior economics into workplace wellness programs and to increase physical activity in persons with arthritis. I led the R21 supported pilot RCT and currently work on planning a multicenter RCT to examine the efficacy of two interventions –
financial incentives and telephonic coaching to improve physical activity post total knee replacements.

I spend about a quarter of my time providing methodological mentorship to fellows, medical and doctoral students, and junior faculty. This work is funded in part by a NIAMS K24 Mentoring award. I co-founded and co-directed a short course “Essentials of Clinical Research in Orthopaedics” for orthopaedic fellows. I lead monthly research seminars and co-direct the PRIDE (Pilot Research Incubation and Development) Program in the Department of Orthopedic Surgery at Brigham and Women’s Hospital. This innovative program creates collaborations between clinical investigators and our methodology team to move the clinicians’ research ideas toward feasible projects and publications. I also serve as a Deputy Editor for Methodology and Biostatistics for the premier orthopaedic journal, the Journal of Bone and Joint Surgery.

The breadth of clinical and methodological topics encompassed in my research and mentoring has enabled me to translate methods and concepts across disciplines and cultures.

2016 Osteoarthritis Research Society International: Clinical Research Award
2012 Association for Rheumatology Health Professionals, Division of American College of Rheumatology: Distinguished Scholar Award
2011 Harvard Medical School: Young Mentor Award
2010-Pres National Institute of Arthritis, Musculoskeletal and Skin Diseases: Midcareer Mentoring Award
2008 Arthritis Foundation: Innovative Research Grant
2002 American College of Rheumatology (ACR): Arthritis Health Professional Investigator Award
2001 National Institutes of Health (NIH): Mentored Quantitative Research Career Development Award

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Arant KR, Zimmerman ZE, Bensen GP, Losina E, Katz JN. Perceptions of Physical Activity and the Use of Activity Monitors to Increase Activity Levels in Patients Undergoing Total Knee Replacement. ACR Open Rheumatol. 2021 Aug 19. PMID: 34411466
  2. Zhang M, Selzer F, Losina E, Collins JE, Katz JN. Impact of Preoperative and Incident Musculoskeletal Problematic Areas on Postoperative Outcomes after Total Knee Replacement. ACR Open Rheumatol. 2021 Jul 28. PMID: 34323387
  3. Collins JE, Neogi T, Losina E. Trajectories of Structural Disease Progression in Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2021 09; 73(9):1354-1362.View Related Profiles. PMID: 32491247; PMCID: PMC7710564; DOI: 10.1002/acr.24340;
  4. Schoenfeld AJ, Bensen GP, Blucher JA, Ferrone ML, Balboni TA, Schwab JH, Harris MB, Katz JN, Losina E. The Cost-Effectiveness of Surgical Intervention for Spinal Metastases: A Model-Based Evaluation. J Bone Joint Surg Am. 2021 Jul 21. PMID: 34288901
  5. Leifer VP, Katz JN, Losina E. The burden of OA-health services and economics. Osteoarthritis Cartilage. 2021 May 20. PMID: 34023527
  6. Johansson FD, Collins JE, Yau V, Guan H, Kim SC, Losina E, Sontag D, Stratton J, Trinh H, Greenberg J, Solomon DH. Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-world Data Analysis Using Machine Learning. J Rheumatol. 2021 Sep; 48(9):1364-1370. PMID: 33934070
  7. Chen AT, Bronsther CI, Stanley EE, Paltiel AD, Sullivan JK, Collins JE, Neogi T, Katz JN, Losina E. The Value of Total Knee Replacement in Patients With Knee Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater : A Cost-Effectiveness Analysis. Ann Intern Med. 2021 06; 174(6):747-757.View Related Profiles. PMID: 33750190; PMCID: PMC8288249; DOI: 10.7326/M20-4722;
  8. MacFarlane LA, Yang H, Collins JE, Brophy RH, Cole BJ, Spindler KP, Guermazi A, Jones MH, Mandl LA, Martin S, Marx RG, Levy BA, Stuart M, Safran-Norton C, Wright J, Wright RW, Losina E, Katz JN. Association Between Baseline "Meniscal symptoms" and Outcomes of Operative and Non-Operative Treatment of Meniscal Tear in Patients with Osteoarthritis. Arthritis Care Res (Hoboken). 2021 Mar 01.View Related Profiles. PMID: 33650303; PMCID: PMC8408275; DOI: 10.1002/acr.24588;
  9. Huizinga JL, Stanley EE, Sullivan JK, Song S, Hunter DJ, Paltiel AD, Neogi T, Edwards RR, Katz JN, Losina E. Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States. Arthritis Care Res (Hoboken). 2021 Feb 24.View Related Profiles. PMID: 33629485; PMCID: PMC8382774; DOI: 10.1002/acr.24581;
  10. Solomon DH, Xu C, Collins J, Kim SC, Losina E, Yau V, Johansson FD. The sequence of disease-modifying anti-rheumatic drugs: pathways to and predictors of tocilizumab monotherapy. Arthritis Res Ther. 2021 01 14; 23(1):26. PMID: 33446261; PMCID: PMC7807904; DOI: 10.1186/s13075-020-02408-4;
Showing 10 of 472 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 472 publications over 25 distinct years, with a maximum of 40 publications in 2011


Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
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