David Waxman | Profiles RNS

David J. Waxman, PhD

Professor

Boston University

Biology

PhD, Harvard University
AM, Harvard University
BA, Queens College, City University of New York

Websites

	College of Engineering Faculty
	Biology Faculty
	Data Science Initiative Profile
	ResearchGate
	Google Scholar
	Biology Dept Profile

ORCID : 0000-0001-7982-9206

David J. Waxman, PhD is a Biologist with extensive experience in the fields of biochemistry, molecular biology, and enzymology. Over the past 35 years, his lab has made seminal contributions to the research of cancer pharmacology and therapeutics, and steroid-metabolizing enzymes. His current interests include genomic and epigenetic mechanisms controlling liver gene expression, molecular endocrinology and cell signaling through transcriptional networks, role of angiogenesis and innate immune system in cancer therapy and pharmacology, and nuclear receptors and responses to environmental chemicals.

Dr. Waxman has spoken at over 130 conferences and has held appointments at a variety of universities including Harvard Medical School, MIT, and the Weizmann Institute.

Member
Boston University
Genome Science Institute

Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Gastroenterology

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

Hormonal control of NASH development and progression
09/01/2023 - 08/31/2027 (PI)
Department of Veterans Affairs

Probing co-transcriptional gene regulatory logics in human transcriptomes
08/01/2022 - 07/31/2027 (Key Person / Mentor)
NIH/National Institute of General Medical Sciences
5R35GM147254-02

Growth Hormone Regulation of Sex Differences in Liver Metabolism
06/19/2019 - 05/31/2025 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK121998-05

Xenobiotic-responsive hepatic long non-coding RNAs
07/07/2020 - 04/30/2025 (PI)
NIH/National Institute of Environmental Health Sciences
3R01ES024421-10S1

Epigenetic Actions of Environmental Chemicals
08/15/2014 - 07/06/2020 (PI)
NIH/National Institute of Environmental Health Sciences
5R01ES024421-05

Regulation of Sex Differences in Liver Metabolism
09/01/2018 - 09/15/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R56DK033765-35A1

Regulation of Sex Differences in Liver Metabolism
02/01/2016 - 08/31/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK033765-34

Regulation of Sex Differences in Liver Metabolism
02/01/2013 - 01/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK033765-32S1

Combination Therapies for Cancer Treatment
12/07/2009 - 11/30/2015 (PI)
NIH/National Cancer Institute
5R01CA049248-24

IGERT: INTEGRATING COMPUTATIONAL SCIENCE INTO RESEARCH IN BIOLOGICAL NETWORKS
07/01/2007 - 06/30/2014 (Co-Investigator)
National Science Foundation
DGE-0654108

Showing 10 of 12 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Xenobiotic-responsive hepatic long non-coding RNAs	5R01ES024421-10
2024	Xenobiotic-responsive hepatic long non-coding RNAs	3R01ES024421-10S1
2023	Xenobiotic-responsive hepatic long non-coding RNAs	3R01ES024421-08S1
2023	Growth Hormone Regulation of Sex Differences in Liver Metabolism	5R01DK121998-05
2023	Xenobiotic-responsive hepatic long non-coding RNAs	5R01ES024421-09
2023	Xenobiotic-responsive hepatic long non-coding RNAs	3R01ES024421-09S1
2022	Growth Hormone Regulation of Sex Differences in Liver Metabolism	5R01DK121998-04
2022	Xenobiotic-responsive hepatic long non-coding RNAs	5R01ES024421-08
2021	Growth Hormone Regulation of Sex Differences in Liver Metabolism	5R01DK121998-03
2021	Xenobiotic-responsive hepatic long non-coding RNAs	5R01ES024421-07	7

Showing 10 of 104 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Sonkar R, Ma H, Waxman DJ. Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression. Toxicol Sci. 2024 Aug 01; 200(2):324-345. PMID: 38710495; PMCID: PMC11285164; DOI: 10.1093/toxsci/kfae057;

Chang TY, Waxman DJ. HDI-STARR-seq: Condition-specific enhancer discovery in mouse liver in vivo. Res Sq. 2024 Jun 26. PMID: 38978599; PMCID: PMC11230509; DOI: 10.21203/rs.3.rs-4559581/v1;

Chang TY, Waxman DJ. HDI-STARR-seq: Condition-specific enhancer discovery in mouse liver in vivo. bioRxiv. 2024 Jun 12. PMID: 38915578; PMCID: PMC11195054; DOI: 10.1101/2024.06.10.598329;

Rampersaud A, Connerney J, Waxman DJ. Plasma growth hormone pulses induce male-biased pulsatile chromatin opening and epigenetic regulation in adult mouse liver. Elife. 2023 Dec 13; 12. PMID: 38091606; PMCID: PMC10721219; DOI: 10.7554/eLife.91367;

Rampersaud A, Connerney J, Waxman DJ. Plasma Growth Hormone Pulsatility Directly Regulates Male-biased Chromatin Accessibility in Adult Mouse Liver. bioRxiv. 2023 Aug 22. PMID: 37662275; PMCID: PMC10473588; DOI: 10.1101/2023.08.21.554153;

Vázquez-Borrego MC, Del Río-Moreno M, Pyatkov M, Sarmento-Cabral A, Mahmood M, Pelke N, Wnek M, Cordoba-Chacon J, Waxman DJ, Puchowicz MA, McGuinness OP, Kineman RD. Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis. Metabolism. 2023 Jul; 144:155589.View Related Profiles.

Waxman, David
Pyatkov, Maxim

PMID: 37182789; PMCID: PMC10843389; DOI: 10.1016/j.metabol.2023.155589;

Karri K, Waxman DJ. TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule. Toxicol Appl Pharmacol. 2023 Jul 15; 471:116550. PMID: 37172768; PMCID: PMC10330769; DOI: 10.1016/j.taap.2023.116550;

Everton E, Del Rio-Moreno M, Villacorta-Martin C, Singh Bawa P, Lindstrom-Vautrin J, Muramatsu H, Rizvi F, Smith AR, Tam Y, Pardi N, Kineman R, Waxman DJ, Gouon-Evans V. Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury. bioRxiv. 2023 Apr 18.View Related Profiles.

Waxman, David
Rizvi, Fatima
Gouon-Evans, Valerie

PMID: 37131727; PMCID: PMC10153200; DOI: 10.1101/2023.04.17.537197;

Karri K, Waxman DJ. Dysregulation of murine long noncoding single-cell transcriptome in nonalcoholic steatohepatitis and liver fibrosis. RNA. 2023 Jul; 29(7):977-1006. PMID: 37015806; PMCID: PMC10275269; DOI: 10.1261/rna.079580.123;

Karri K, Waxman DJ. TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule. bioRxiv. 2023 Jan 08. PMID: 36711947; PMCID: PMC9881922; DOI: 10.1101/2023.01.07.523119;

Showing 10 of 360 results. Show More

Waxman DJ, Kineman RD. Sex matters in liver fat regulation. Science. 2022 Oct 21; 378(6617):252-253. PMID: 36264790

Kim D, Kim B, Brocker CN, Karri K, Waxman DJ, Gonzalez FJ. Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver. Mol Cell Endocrinol. 2022 Nov 01; 557:111722. PMID: 35917881; PMCID: PMC9561029; DOI: 10.1016/j.mce.2022.111722;

Goldfarb CN, Karri K, Pyatkov M, Waxman DJ. Interplay Between GH-regulated, Sex-biased Liver Transcriptome and Hepatic Zonation Revealed by Single-Nucleus RNA Sequencing. Endocrinology. 2022 Jul 01; 163(7).View Related Profiles.

Waxman, David
Pyatkov, Maxim

PMID: 35512247; PMCID: PMC9154260; DOI: 10.1210/endocr/bqac059;

Shin A, Waxman DJ. Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver. Toxicol Sci. 2022 May 26; 187(2):298-310. PMID: 35285501; PMCID: PMC9425853; DOI: 10.1093/toxsci/kfac032;

Lau-Corona D, Ma H, Vergato C, Sarmento-Cabral A, Del Rio-Moreno M, Kineman RD, Waxman DJ. Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression. Endocrinology. 2022 May 01; 163(5). PMID: 35396838; PMCID: PMC9070516; DOI: 10.1210/endocr/bqac046;

Vergato C, Doshi KA, Roblyer D, Waxman DJ. Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine breast cancer. Cancer Res Commun. 2022 Apr; 2(4):246-257.View Related Profiles.

Roblyer, Darren
Waxman, David

PMID: 36187936; PMCID: PMC9524291; DOI: 10.1158/2767-9764.crc-21-0148;

Tank A, Vergato C, Waxman DJ, Roblyer D. Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model. Sci Rep. 2022 Apr 07; 12(1):5864.View Related Profiles.

Roblyer, Darren
Waxman, David

PMID: 35393476; PMCID: PMC8989878; DOI: 10.1038/s41598-022-09671-2;

Matthews BJ, Melia T, Waxman DJ. Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model. PLoS Genet. 2021 11; 17(11):e1009588. PMID: 34752452; PMCID: PMC8664386; DOI: 10.1371/journal.pgen.1009588;

Goldfarb CN, Waxman DJ. Global analysis of expression, maturation and subcellular localization of mouse liver transcriptome identifies novel sex-biased and TCPOBOP-responsive long non-coding RNAs. BMC Genomics. 2021 Mar 24; 22(1):212. PMID: 33761883; PMCID: PMC7992343; DOI: 10.1186/s12864-021-07478-5;

Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303.View Related Profiles.

Roblyer, Darren
Waxman, David
Bigio, Irving

PMID: 33578267; PMCID: PMC7881266; DOI: 10.1016/j.neo.2021.01.005;

Hao P, Waxman DJ. STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes. Mol Cell Biol. 2021 01 25; 41(2). PMID: 33199496; PMCID: PMC8093489; DOI: 10.1128/MCB.00166-20;

Melia T, Waxman DJ. Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice. PLoS One. 2020; 15(12):e0242665. PMID: 33264334; PMCID: PMC7710091; DOI: 10.1371/journal.pone.0242665;

Tu S, Li M, Chen H, Tan F, Xu J, Waxman DJ, Zhang Y, Shao Z. MAnorm2 for quantitatively comparing groups of ChIP-seq samples. Genome Res. 2021 01; 31(1):131-145. PMID: 33208455; PMCID: PMC7849384; DOI: 10.1101/gr.262675.120;

Brocker CN, Kim D, Melia T, Karri K, Velenosi TJ, Takahashi S, Aibara D, Bonzo JA, Levi M, Waxman DJ, Gonzalez FJ. Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun. 2020 11 17; 11(1):5847. PMID: 33203882; PMCID: PMC7673042; DOI: 10.1038/s41467-020-19554-7;

Matthews BJ, Waxman DJ. Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver. Epigenetics Chromatin. 2020 07 17; 13(1):30. PMID: 32680543; PMCID: PMC7368777; DOI: 10.1186/s13072-020-00350-y;

Tran AP, Ali Al-Radhawi M, Kareva I, Wu J, Waxman DJ, Sontag ED. Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance. Front Immunol. 2020; 11:1376. PMID: 32695118; PMCID: PMC7338613; DOI: 10.3389/fimmu.2020.01376;

Lau-Corona D, Bae WK, Hennighausen L, Waxman DJ. Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2. PLoS Genet. 2020 05; 16(5):e1008796. PMID: 32428001; PMCID: PMC7263639; DOI: 10.1371/journal.pgen.1008796;

Karri K, Waxman DJ. Widespread Dysregulation of Long Noncoding Genes Associated With Fatty Acid Metabolism, Cell Division, and Immune Response Gene Networks in Xenobiotic-exposed Rat Liver. Toxicol Sci. 2020 04 01; 174(2):291-310. PMID: 31926019; PMCID: PMC7098378; DOI: 10.1093/toxsci/kfaa001;

Du B, Waxman DJ. Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models. Cancer Lett. 2020 02 01; 470:170-180. PMID: 31765733; PMCID: PMC6956245; DOI: 10.1016/j.canlet.2019.11.025;

Rampersaud A, Lodato NJ, Shin A, Waxman DJ. Widespread Epigenetic Changes to the Enhancer Landscape of Mouse Liver Induced by a Specific Xenobiotic Agonist Ligand of the Nuclear Receptor CAR. Toxicol Sci. 2019 Oct 01; 171(2):315-338. PMID: 31236583; PMCID: PMC6760311; DOI: 10.1093/toxsci/kfz148;

Melia T, Waxman DJ. Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver. Endocrinology. 2019 05 01; 160(5):989-1007. PMID: 30840070; PMCID: PMC6449536; DOI: 10.1210/en.2018-00949;

Chhabra Y, Nelson CN, Plescher M, Barclay JL, Smith AG, Andrikopoulos S, Mangiafico S, Waxman DJ, Brooks AJ, Waters MJ. Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity. FASEB J. 2019 05; 33(5):6412-6430. PMID: 30779881; PMCID: PMC6463913; DOI: 10.1096/fj.201802328R;

Lodato NJ, Rampersaud A, Waxman DJ. Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility. Toxicol Sci. 2018 07 01; 164(1):115-128. PMID: 29617930; PMCID: PMC6016691; DOI: 10.1093/toxsci/kfy070;

Matthews BJ, Waxman DJ. Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver. Elife. 2018 05 14; 7. PMID: 29757144; PMCID: PMC5986275; DOI: 10.7554/eLife.34077;

Sulheim E, Kim J, van Wamel A, Kim E, Snipstad S, Vidic I, Grimstad IH, Widerøe M, Torp SH, Lundgren S, Waxman DJ, de Lange Davies C. Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models. J Control Release. 2018 06 10; 279:292-305. PMID: 29684498; PMCID: PMC5972071; DOI: 10.1016/j.jconrel.2018.04.026;

Wu J, Waxman DJ. Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy. Cancer Lett. 2018 04 10; 419:210-221. PMID: 29414305; PMCID: PMC5818299; DOI: 10.1016/j.canlet.2018.01.050;

Hao P, Waxman DJ. Functional Roles of Sex-Biased, Growth Hormone-Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver. Endocrinology. 2018 03 01; 159(3):1377-1392. PMID: 29346554; PMCID: PMC5839735; DOI: 10.1210/en.2017-03109;

Lau-Corona D, Suvorov A, Waxman DJ. Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States. Mol Cell Biol. 2017 Oct 01; 37(19). PMID: 28694329; PMCID: PMC5599723; DOI: 10.1128/MCB.00301-17;

Lodato NJ, Melia T, Rampersaud A, Waxman DJ. Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver. Toxicol Sci. 2017 09 01; 159(1):25-41. PMID: 28903501; PMCID: PMC5837275; DOI: 10.1093/toxsci/kfx114;

Connerney J, Lau-Corona D, Rampersaud A, Waxman DJ. Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses. Endocrinology. 2017 05 01; 158(5):1386-1405. PMID: 28323953; PMCID: PMC6283433; DOI: 10.1210/en.2017-00060;

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharm Sin B. 2017 03; 7(2):241-248. PMID: 28388695; PMCID: PMC5343155; DOI: 10.1016/j.apsb.2016.12.006;

Pantziarka P, Hutchinson L, André N, Benzekry S, Bertolini F, Bhattacharjee A, Chiplunkar S, Duda DG, Gota V, Gupta S, Joshi A, Kannan S, Kerbel R, Kieran M, Palazzo A, Parikh A, Pasquier E, Patil V, Prabhash K, Shaked Y, Sholler GS, Sterba J, Waxman DJ, Banavali S. Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai. Ecancermedicalscience. 2016; 10:689. PMID: 27994645; PMCID: PMC5130328; DOI: 10.3332/ecancer.2016.689;

Tabassum S, Zhao Y, Istfan R, Wu J, Waxman DJ, Roblyer D. Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model. Biomed Opt Express. 2016 Oct 01; 7(10):4154-4170.View Related Profiles.

Roblyer, Darren
Waxman, David

PMID: 27867722; PMCID: PMC5102554; DOI: 10.1364/BOE.7.004154;

Oshida K, Waxman DJ, Corton JC. Correction: Chemical and Hormonal Effects on STAT5b- Dependent Sexual Dimorphism of the Liver Transcriptome. PLoS One. 2016; 11(8):e0161519. PMID: 27529843; PMCID: PMC4987134; DOI: 10.1371/journal.pone.0161519;

Wu J, Jordan M, Waxman DJ. Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators. BMC Cancer. 2016 08 11; 16:623. PMID: 27515027; PMCID: PMC4982114; DOI: 10.1186/s12885-016-2597-2;

Haery L, Mussakhan S, Waxman DJ, Gilmore TD. Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma. Leuk Lymphoma. 2016 11; 57(11):2661-71.View Related Profiles.

Waxman, David
Gilmore, Thomas

PMID: 27003102; PMCID: PMC5045243; DOI: 10.3109/10428194.2016.1160083;

Oshida K, Vasani N, Waxman DJ, Corton JC. Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event. PLoS One. 2016; 11(3):e0148308. PMID: 26959975; PMCID: PMC4784905; DOI: 10.1371/journal.pone.0148308;

Oshida K, Waxman DJ, Corton JC. Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome. PLoS One. 2016; 11(3):e0150284. PMID: 26959237; PMCID: PMC4784907; DOI: 10.1371/journal.pone.0150284;

Jordan M, Waxman DJ. CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model. Cancer Lett. 2016 Apr 01; 373(1):88-96. PMID: 26655275; PMCID: PMC4761486; DOI: 10.1016/j.canlet.2015.11.029;

Melia T, Hao P, Yilmaz F, Waxman DJ. Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone. Mol Cell Biol. 2016 Jan 01; 36(1):50-69. PMID: 26459762; PMCID: PMC4702595; DOI: 10.1128/MCB.00861-15;

Conforto TL, Steinhardt GF, Waxman DJ. Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver. Mol Endocrinol. 2015 Sep; 29(9):1286-302. PMID: 26218442; PMCID: PMC4552435; DOI: 10.1210/me.2015-1028;

Suvorov A, Waxman DJ. Early programing of uterine tissue by bisphenol A: Critical evaluation of evidence from animal exposure studies. Reprod Toxicol. 2015 Nov; 57:59-72. PMID: 26028543; PMCID: PMC4550532; DOI: 10.1016/j.reprotox.2015.05.008;

Doloff JC, Waxman DJ. Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts. BMC Cancer. 2015 May 08; 15:375. PMID: 25952672; PMCID: PMC4523019; DOI: 10.1186/s12885-015-1358-y;

Wu J, Waxman DJ. Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory. Oncoimmunology. 2015 Apr; 4(4):e1005521. PMID: 26137402; PMCID: PMC4485826; DOI: 10.1080/2162402X.2015.1005521;

Kareva I, Waxman DJ, Lakka Klement G. Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance. Cancer Lett. 2015 Mar 28; 358(2):100-106. PMID: 25541061; PMCID: PMC4666022; DOI: 10.1016/j.canlet.2014.12.039;

Wu J, Waxman DJ. Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model. Cancer Lett. 2014 Oct 28; 353(2):272-80. PMID: 25069038; PMCID: PMC4162810; DOI: 10.1016/j.canlet.2014.07.033;

Doloff JC, Chen CS, Waxman DJ. Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2. Mol Cancer. 2014 Jun 26; 13:158. PMID: 24965046; PMCID: PMC4083145; DOI: 10.1186/1476-4598-13-158;

Chen CS, Doloff JC, Waxman DJ. Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression. Neoplasia. 2014 Jan; 16(1):84-96. PMID: 24563621; PMCID: PMC3924543; DOI: 10.1593/neo.131910;

Doloff JC, Waxman DJ. Adenoviral vectors for prodrug activation-based gene therapy for cancer. Anticancer Agents Med Chem. 2014 Jan; 14(1):115-26. PMID: 23869779; PMCID: PMC3947260

Manley E, Waxman DJ. H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity. Cancer Lett. 2014 Apr 28; 346(1):63-73. PMID: 24334139; PMCID: PMC3947657; DOI: 10.1016/j.canlet.2013.12.012;

Yip KS, Suvorov A, Connerney J, Lodato NJ, Waxman DJ. Changes in mouse uterine transcriptome in estrus and proestrus. Biol Reprod. 2013 Jul; 89(1):13.View Related Profiles.

Waxman, David
Connerney, Jeannette

PMID: 23740946; PMCID: PMC4076348; DOI: 10.1095/biolreprod.112.107334;

Sugathan A, Waxman DJ. Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver. Mol Cell Biol. 2013 Sep; 33(18):3594-610. PMID: 23836885; PMCID: PMC3753870; DOI: 10.1128/MCB.00280-13;

Zhang K, Waxman DJ. Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model. Mol Cancer Ther. 2013 May; 12(5):787-98. PMID: 23635653; PMCID: PMC3816513; DOI: 10.1158/1535-7163.MCT-12-1240;

Ling G, Waxman DJ. Isolation of nuclei for use in genome-wide DNase hypersensitivity assays to probe chromatin structure. Methods Mol Biol. 2013; 977:13-9. PMID: 23436350; PMCID: PMC3815455; DOI: 10.1007/978-1-62703-284-1_2;

Ling G, Waxman DJ. DNase I digestion of isolated nulcei for genome-wide mapping of DNase hypersensitivity sites in chromatin. Methods Mol Biol. 2013; 977:21-33. PMID: 23436351; PMCID: PMC3889470; DOI: 10.1007/978-1-62703-284-1_3;

Jia L, Waxman DJ. Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis. Cancer Lett. 2013 Apr 28; 330(2):241-9. PMID: 23228633; PMCID: PMC3563872; DOI: 10.1016/j.canlet.2012.11.055;

Manley E, Waxman DJ. Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. J Pharmacol Exp Ther. 2013 Feb; 344(2):368-77. PMID: 23192656; PMCID: PMC3558827; DOI: 10.1124/jpet.112.200089;

Conforto TL, Zhang Y, Sherman J, Waxman DJ. Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes. Mol Cell Biol. 2012 Nov; 32(22):4611-27. PMID: 22966202; PMCID: PMC3486175; DOI: 10.1128/MCB.00886-12;

Conforto TL, Waxman DJ. Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood. Biol Sex Differ. 2012; 3:9. PMID: 22475005; PMCID: PMC3350426; DOI: 10.1186/2042-6410-3-9;

Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol. 2012; 13(3):R16. PMID: 22424423; PMCID: PMC3439967; DOI: 10.1186/gb-2012-13-3-r16;

Doloff JC, Waxman DJ. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Res. 2012 Mar 1; 72(5):1103-15. PMID: 22237627; PMCID: PMC3294103; DOI: 10.1158/0008-5472.CAN-11-3380;

Zhang Y, Laz EV, Waxman DJ. Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol. 2012 Feb; 32(4):880-96. PMID: 22158971; PMCID: PMC3272977; DOI: 10.1128/MCB.06312-11;

Mulvey CS, Zhang K, Bobby Liu WH, Waxman DJ, Bigio IJ. Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 2: early spectral changes during apoptosis are linked to apoptotic volume decrease. J Biomed Opt. 2011 Nov; 16(11):117002.View Related Profiles.

Mulvey, Christine
Waxman, David
Bigio, Irving

PMID: 22112134; PMCID: PMC3221718; DOI: 10.1117/1.3644911;

Mulvey CS, Zhang K, Liu WH, Waxman DJ, Bigio IJ. Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures. J Biomed Opt. 2011 Nov; 16(11):117001.View Related Profiles.

Mulvey, Christine
Waxman, David
Bigio, Irving

PMID: 22112133; PMCID: PMC3221717; DOI: 10.1117/1.3644389;

Zhang Y, Klein K, Sugathan A, Nassery N, Dombkowski A, Zanger UM, Waxman DJ. Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. PLoS One. 2011; 6(8):e23506. PMID: 21858147; PMCID: PMC3155567; DOI: 10.1371/journal.pone.0023506;

Bagchi G, Zhang Y, Stanley KA, Waxman DJ. Complex modulation of androgen responsive gene expression by methoxyacetic acid. Reprod Biol Endocrinol. 2011; 9:42. PMID: 21453523; PMCID: PMC3083340; DOI: 10.1186/1477-7827-9-42;

Ma J, Chen CS, Blute T, Waxman DJ. Antiangiogenesis enhances intratumoral drug retention. Cancer Res. 2011 Apr 1; 71(7):2675-85. PMID: 21447737; PMCID: PMC3070759; DOI: 10.1158/0008-5472.CAN-10-3242;

Zhang K, Waxman DJ. PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis. Mol Cancer. 2010; 9:319. PMID: 21190562; PMCID: PMC3024252; DOI: 10.1186/1476-4598-9-319;

Liu H, Tian N, Arany I, Bigler SA, Waxman DJ, Shah SV, Baliga R. Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy. J Biol Chem. 2010 Dec 24; 285(52):40901-10. PMID: 20947506; PMCID: PMC3003390; DOI: 10.1074/jbc.M110.165498;

Ling G, Sugathan A, Mazor T, Fraenkel E, Waxman DJ. Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol. 2010 Dec; 30(23):5531-44. PMID: 20876297; PMCID: PMC2976433; DOI: 10.1128/MCB.00601-10;

Doloff JC, Jounaidi Y, Waxman DJ. Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT. Cancer Gene Ther. 2011 Mar; 18(3):153-66. PMID: 20865021; PMCID: PMC3010505; DOI: 10.1038/cgt.2010.52;

Doloff JC, Su T, Waxman DJ. Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+. BMC Cancer. 2010; 10:487. PMID: 20836875; PMCID: PMC2946310; DOI: 10.1186/1471-2407-10-487;

Bagchi G, Zhang Y, Waxman DJ. Impact of methoxyacetic acid on mouse Leydig cell gene expression. Reprod Biol Endocrinol. 2010; 8:65. PMID: 20565877; PMCID: PMC2909983; DOI: 10.1186/1477-7827-8-65;

Tian N, Arany I, Waxman DJ, Baliga R. Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells. Kidney Int. 2010 Jul; 78(2):182-90. PMID: 20407477; PMCID: PMC3053138; DOI: 10.1038/ki.2010.100;

Swanson HI, Njar VC, Yu Z, Castro DJ, Gonzalez FJ, Williams DE, Huang Y, Kong AN, Doloff JC, Ma J, Waxman DJ, Scott EE. Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy. Drug Metab Dispos. 2010 Apr; 38(4):539-44. PMID: 20233842; PMCID: PMC2845935; DOI: 10.1124/dmd.109.031351;

Wauthier V, Sugathan A, Meyer RD, Dombkowski AA, Waxman DJ. Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liver. Mol Endocrinol. 2010 Mar; 24(3):667-78.View Related Profiles.

Waxman, David
Meyer, Rosana

PMID: 20150183; PMCID: PMC2840812; DOI: 10.1210/me.2009-0454;

Ngan CH, Beglov D, Rudnitskaya AN, Kozakov D, Waxman DJ, Vajda S. The structural basis of pregnane X receptor binding promiscuity. Biochemistry. 2009 Dec 8; 48(48):11572-81.View Related Profiles.

Waxman, David
Beglov, Dmitri
Vajda, Sandor

PMID: 19856963; PMCID: PMC2789303; DOI: 10.1021/bi901578n;

Meyer RD, Laz EV, Su T, Waxman DJ. Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol. 2009 Nov; 23(11):1914-26.View Related Profiles.

Waxman, David
Meyer, Rosana

PMID: 19797429; PMCID: PMC2775936; DOI: 10.1210/me.2009-0242;

Waxman DJ, Holloway MG. Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol. 2009 Aug; 76(2):215-28. PMID: 19483103; PMCID: PMC2713118; DOI: 10.1124/mol.109.056705;

Laz EV, Sugathan A, Waxman DJ. Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites. Mol Endocrinol. 2009 Aug; 23(8):1242-54. PMID: 19423653; PMCID: PMC2718744; DOI: 10.1210/me.2008-0449;

Chin M, Herscovitch M, Zhang N, Waxman DJ, Gilmore TD. Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile. Oncogene. 2009 May 21; 28(20):2100-11.View Related Profiles.

Waxman, David
Gilmore, Thomas

PMID: 19377508; PMCID: PMC2796798; DOI: 10.1038/onc.2009.74;

Löfgren S, Baldwin RM, Carlerös M, Terelius Y, Fransson-Steen R, Mwinyi J, Waxman DJ, Ingelman-Sundberg M. Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone. Drug Metab Dispos. 2009 Jul; 37(7):1505-12. PMID: 19339376; PMCID: PMC2698944; DOI: 10.1124/dmd.109.026963;

Ma J, Waxman DJ. Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib. Clin Cancer Res. 2009 Jan 15; 15(2):578-88. PMID: 19147763; PMCID: PMC2729124; DOI: 10.1158/1078-0432.CCR-08-1174;

Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther. 2008 Dec; 7(12):3670-84. PMID: 19074844; PMCID: PMC2637411; DOI: 10.1158/1535-7163.MCT-08-0715;

Doloff JC, Waxman DJ, Jounaidi Y. Human telomerase reverse transcriptase promoter-driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions. Hum Gene Ther. 2008 Dec; 19(12):1383-400. PMID: 18771358; PMCID: PMC2715448; DOI: 10.1089/hum.2008.056;

Lu H, Chen CS, Waxman DJ. Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. Cancer Gene Ther. 2009 May; 16(5):393-404. PMID: 19011599; PMCID: PMC2669851; DOI: 10.1038/cgt.2008.93;

Johnston TP, Waxman DJ. Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice. Can J Physiol Pharmacol. 2008 Sep; 86(9):643-9. PMID: 18758514; PMCID: PMC2615679; DOI: 10.1139/y08-070;

Johnston TP, Waxman DJ. The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. J Pharm Pharmacol. 2008 Jun; 60(6):753-9. PMID: 18498712; PMCID: PMC2496925; DOI: 10.1211/jpp.60.6.0011;

Wauthier V, Waxman DJ. Sex-specific early growth hormone response genes in rat liver. Mol Endocrinol. 2008 Aug; 22(8):1962-74. PMID: 18483176; PMCID: PMC2725767; DOI: 10.1210/me.2007-0549;

Bagchi G, Hurst CH, Waxman DJ. Interactions of methoxyacetic acid with androgen receptor. Toxicol Appl Pharmacol. 2009 Jul 15; 238(2):101-10. PMID: 18486176; PMCID: PMC2742301; DOI: 10.1016/j.taap.2008.03.015;

Holloway MG, Miles GD, Dombkowski AA, Waxman DJ. Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. Mol Endocrinol. 2008 May; 22(5):1274-86. PMID: 18276827; PMCID: PMC2366185; DOI: 10.1210/me.2007-0564;

Ma J, Waxman DJ. Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib. Mol Cancer Ther. 2008 Jan; 7(1):79-89. PMID: 18202011; PMCID: PMC2390754; DOI: 10.1158/1535-7163.MCT-07-0584;

Bagchi G, Waxman DJ. Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. Int J Androl. 2008 Apr; 31(2):269-74. PMID: 18179559; PMCID: PMC3286123; DOI: 10.1111/j.1365-2605.2007.00846.x;

Ma J, Waxman DJ. Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment. Mol Cancer Ther. 2007 Nov; 6(11):2879-90. PMID: 17989319; PMCID: PMC2613795; DOI: 10.1158/1535-7163.MCT-07-0297;

Alton E, Ferrari S, Griesenbach U, Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM, Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM. Progress and prospects: gene therapy clinical trials (part 2). Gene Ther. 2007 Nov; 14(22):1555-63. PMID: 17984995

Chen CS, Jounaidi Y, Su T, Waxman DJ. Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model. Cancer Gene Ther. 2007 Dec; 14(12):935-44. PMID: 17853921; PMCID: PMC2613860; DOI: 10.1038/sj.cgt.7701092;

Clodfelter KH, Miles GD, Wauthier V, Holloway MG, Zhang X, Hodor P, Ray WJ, Waxman DJ. Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiol Genomics. 2007 Sep 19; 31(1):63-74. PMID: 17536022; PMCID: PMC2586676; DOI: 10.1152/physiolgenomics.00055.2007;

Jounaidi Y, Doloff JC, Waxman DJ. Conditionally replicating adenoviruses for cancer treatment. Curr Cancer Drug Targets. 2007 May; 7(3):285-301. PMID: 17504125; PMCID: PMC3354698

Laz EV, Holloway MG, Chen CS, Waxman DJ. Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology. 2007 Jul; 148(7):3327-37. PMID: 17412818; PMCID: PMC2585771; DOI: 10.1210/en.2006-1192;

Holloway MG, Cui Y, Laz EV, Hosui A, Hennighausen L, Waxman DJ. Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology. 2007 May; 148(5):1977-86. PMID: 17317776; PMCID: PMC3282149; DOI: 10.1210/en.2006-1419;

Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman DJ, Ding X. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. J Pharmacol Exp Ther. 2007 Apr; 321(1):9-17. PMID: 17218484; PMCID: PMC2657721

Sun L, Chen CS, Waxman DJ, Liu H, Halpert JR, Kumar S. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Arch Biochem Biophys. 2007 Feb 15; 458(2):167-74. PMID: 17254539; PMCID: PMC1805465; DOI: 10.1016/j.abb.2006.12.021;

Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen CS, Felton JS, Waxman DJ, Gonzalez FJ. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 2007 Mar; 28(3):732-7. PMID: 17052995; PMCID: PMC1829392; DOI: 10.1093/carcin/bgl184;

Clodfelter KH, Waxman DJ, Vajda S. Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. Biochemistry. 2006 Aug 8; 45(31):9393-407.View Related Profiles.

Waxman, David
Vajda, Sandor

PMID: 16878974

Kaya T, Mohr SC, Waxman DJ, Vajda S. Computational screening of phthalate monoesters for binding to PPARgamma. Chem Res Toxicol. 2006 Aug; 19(8):999-1009.View Related Profiles.

Waxman, David
Vajda, Sandor

PMID: 16918238

Park SH, Wiwi CA, Waxman DJ. Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. Biochem J. 2006 Jul 1; 397(1):159-68. PMID: 16584384; PMCID: PMC1479742; DOI: 10.1042/BJ20060332;

Günther M, Waxman DJ, Wagner E, Ogris M. Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy. Cancer Gene Ther. 2006 Aug; 13(8):771-9. PMID: 16543915

Waxman DJ, O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol. 2006 Nov; 20(11):2613-29. PMID: 16543404

Jounaidi Y, Chen CS, Veal GJ, Waxman DJ. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11. Mol Cancer Ther. 2006 Mar; 5(3):541-55. PMID: 16546968

Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, Waxman DJ. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol. 2006 Jun; 20(6):1333-51. PMID: 16469768

Waxman DJ, Chang TK. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods Mol Biol. 2006; 320:153-6. PMID: 16719387

Waxman DJ, Chang TK. An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7alpha-hydroxylation. Methods Mol Biol. 2006; 320:149-52. PMID: 16719386

Crespi CL, Chang TK, Waxman DJ. Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection. Methods Mol Biol. 2006; 320:143-7. PMID: 16719385

Waxman DJ, Chang TK. Thin-layer chromatography analysis of human CYP3A-catalyzed testosterone 6beta-hydroxylation. Methods Mol Biol. 2006; 320:133-41. PMID: 16719384

Chang TK, Crespi CL, Waxman DJ. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol. 2006; 320:127-31. PMID: 16719383

Crespi CL, Chang TK, Waxman DJ. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol Biol. 2006; 320:121-5. PMID: 16719382

Crespi CL, Chang TK, Waxman DJ. CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection. Methods Mol Biol. 2006; 320:115-9. PMID: 16719381

Crespi CL, Chang TK, Waxman DJ. High-Performance Liquid Chromatography Analysis of CYP2C8-Catalyzed Paclitaxel 6a-Hydroxylation. Methods Mol Biol. 2006; 320:103-107. PMID: 27699666

Waxman DJ, Chang TK. Thin-Layer Chromatography Analysis of Human CYP3A-Catalyzed Testosterone 6ß-Hydroxylation. Methods Mol Biol. 2006; 320:133-141. PMID: 27699667

Crespi CL, Chang TK, Waxman DJ. Determination of CYP2C9-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography. Methods Mol Biol. 2006; 320:109-13. PMID: 16719380

Crespi CL, Chang TK, Waxman DJ. High-performance liquid chromatography analysis of CYP2C8-catalyzed paclitaxel 6alpha-hydroxylation. Methods Mol Biol. 2006; 320:103-7. PMID: 16719379

Chang TK, Crespi CL, Waxman DJ. Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes. Methods Mol Biol. 2006; 320:97-102. PMID: 16719378

Waxman DJ, Chang TK. Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. Methods Mol Biol. 2006; 320:91-6. PMID: 16719377

Chang TK, Waxman DJ. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006; 320:85-90. PMID: 16719376

Chang TK, Waxman DJ. Catalytic assays for human cytochrome P450: an introduction. Methods Mol Biol. 2006; 320:73-83. PMID: 16719375

Chang TK, Waxman DJ. Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab Rev. 2006; 38(1-2):51-73. PMID: 16684648

Waxman DJ, Chang TK. An Isocratic High-Performance Liquid Chromatography Assay for CYP7A1-Catalyzed Cholesterol 7a-Hydroxylation. Methods Mol Biol. 2006; 320:149-152. PMID: 27699668

Chang TK, Waxman DJ. Catalytic Assays for Human Cytochrome P450 : An Introduction. Methods Mol Biol. 2006; 320:73-83. PMID: 27699679

Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, Gonzalez FJ. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther. 2006 Mar; 316(3):1328-34. PMID: 16291874

Roy P, Waxman DJ. Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer. Toxicol In Vitro. 2006 Mar; 20(2):176-86. PMID: 16293390

Shipley JM, Waxman DJ. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. Toxicol Appl Pharmacol. 2006 Jun 1; 213(2):87-97. PMID: 16257430

Holloway MG, Laz EV, Waxman DJ. Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha. Mol Endocrinol. 2006 Mar; 20(3):647-60. PMID: 16239260

Landsman T, Waxman DJ. Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization. J Biol Chem. 2005 Nov 11; 280(45):37471-80. PMID: 16154995

Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, Waxman DJ. Cancer chemotherapy and drug metabolism. Drug Metab Dispos. 2005 Aug; 33(8):1083-96. PMID: 16049130

Chen CS, Jounaidi Y, Waxman DJ. Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metab Dispos. 2005 Sep; 33(9):1261-7. PMID: 15919850

Kumar S, Chen CS, Waxman DJ, Halpert JR. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. J Biol Chem. 2005 May 20; 280(20):19569-75. PMID: 15774478

Sheu SH, Kaya T, Waxman DJ, Vajda S. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry. 2005 Feb 1; 44(4):1193-209.View Related Profiles.

Waxman, David
Vajda, Sandor

PMID: 15667213

Chang TK, Waxman DJ. Pregnane X receptor-mediated transcription. Methods Enzymol. 2005; 400:588-98. PMID: 16399372

Wiwi CA, Waxman DJ. Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2. J Biol Chem. 2005 Feb 4; 280(5):3259-68. PMID: 15539409

Lu H, Waxman DJ. Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism. Mol Pharmacol. 2005 Jan; 67(1):212-9. PMID: 15465924

Laz EV, Wiwi CA, Waxman DJ. Sexual dimorphism of rat liver nuclear proteins: regulatory role of growth hormone. Mol Cell Proteomics. 2004 Dec; 3(12):1170-80. PMID: 15456855

Shipley JM, Waxman DJ. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol. 2004 Sep 15; 199(3):275-84. PMID: 15364543

Hurst CH, Waxman DJ. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol Appl Pharmacol. 2004 Sep 15; 199(3):266-74. PMID: 15364542

Schlezinger JJ, Howard GJ, Hurst CH, Emberley JK, Waxman DJ, Webster T, Sherr DH. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. J Immunol. 2004 Sep 1; 173(5):3165-77.View Related Profiles.

Sherr, David
Waxman, David
Schlezinger, Jennifer
Webster, Thomas

PMID: 15322177

Wiwi CA, Waxman DJ. Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of liver cytochromes P450. Growth Factors. 2004 Jun; 22(2):79-88. PMID: 15253383

Wiwi CA, Gupte M, Waxman DJ. Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol Endocrinol. 2004 Aug; 18(8):1975-87. PMID: 15155787

Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. Mol Pharmacol. 2004 May; 65(5):1278-85. PMID: 15102956

Su T, Waxman DJ. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. Arch Biochem Biophys. 2004 Apr 15; 424(2):226-34. PMID: 15047195

Shipley JM, Hurst CH, Tanaka SS, DeRoos FL, Butenhoff JL, Seacat AM, Waxman DJ. trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals. Toxicol Sci. 2004 Jul; 80(1):151-60. PMID: 15071170

Chiocca EA, Waxman DJ. Cytochrome p450-based gene therapies for cancer. Methods Mol Med. 2004; 90:203-22. PMID: 14657565

Jounaidi Y, Waxman DJ. Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy. Cancer Res. 2004 Jan 1; 64(1):292-303. PMID: 14729637

Ahluwalia A, Clodfelter KH, Waxman DJ. Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. Mol Endocrinol. 2004 Mar; 18(3):747-60. PMID: 14684848

Waxman DJ, Schwartz PS. Harnessing apoptosis for improved anticancer gene therapy. Cancer Res. 2003 Dec 15; 63(24):8563-72. PMID: 14695163

Waxman DJ, Celenza JL. Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed. Genes Dev. 2003 Nov 1; 17(21):2607-13. PMID: 14597659

Schwartz PS, Chen CS, Waxman DJ. Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy. Cancer Gene Ther. 2003 Aug; 10(8):571-82. PMID: 12872138

Shipley JM, Waxman DJ. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma. Mol Pharmacol. 2003 Aug; 64(2):355-64. PMID: 12869640

Hurst CH, Waxman DJ. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci. 2003 Aug; 74(2):297-308. PMID: 12805656

Apletalina EV, Li HC, Waxman DJ. Evaluation of thyroid hormone effects on liver P450 reductase translation. Arch Biochem Biophys. 2003 Jan 1; 409(1):172-9. PMID: 12464256

Baldwin A, Huang Z, Jounaidi Y, Waxman DJ. Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer. Arch Biochem Biophys. 2003 Jan 1; 409(1):197-206. PMID: 12464259

Schwartz PS, Chen CS, Waxman DJ. Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35. Cancer Res. 2002 Dec 1; 62(23):6928-37. PMID: 12460909

Zhou YC, Davey HW, McLachlan MJ, Xie T, Waxman DJ. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol Appl Pharmacol. 2002 Jul 1; 182(1):1-10. PMID: 12127257

Liu D, Waxman DJ. Post-transcriptional regulation of hepatic NADPH-cytochrome P450 reductase by thyroid hormone: independent effects on poly(A) tail length and mRNA stability. Mol Pharmacol. 2002 May; 61(5):1089-96. PMID: 11961126

Chen L, Waxman DJ. Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer. Curr Pharm Des. 2002; 8(15):1405-16. PMID: 12052216

Tzanakakis ES, Waxman DJ, Hansen LK, Remmel RP, Hu WS. Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer. Cell Biol Toxicol. 2002; 18(1):13-27. PMID: 11991083

Schwartz PS, Waxman DJ. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec; 60(6):1268-79. PMID: 11723234

Park SH, Yamashita H, Rui H, Waxman DJ. Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. Mol Endocrinol. 2001 Dec; 15(12):2157-71. PMID: 11731617

Tannenbaum GS, Choi HK, Gurd W, Waxman DJ. Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity. Endocrinology. 2001 Nov; 142(11):4599-606. PMID: 11606424

Park SH, Waxman DJ. Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression. J Biol Chem. 2001 Nov 16; 276(46):43031-9. PMID: 11562369

Davey HW, Xie T, McLachlan MJ, Wilkins RJ, Waxman DJ, Grattan DR. STAT5b is required for GH-induced liver IGF-I gene expression. Endocrinology. 2001 Sep; 142(9):3836-41. PMID: 11517160

Jounaidi Y, Waxman DJ. Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy. Cancer Res. 2001 Jun 1; 61(11):4437-44. PMID: 11389073

Huang Z, Waxman DJ. Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors. Cancer Gene Ther. 2001 Jun; 8(6):450-8. PMID: 11498765

Li HC, Liu D, Waxman DJ. Transcriptional induction of hepatic NADPH: cytochrome P450 oxidoreductase by thyroid hormone. Mol Pharmacol. 2001 May; 59(5):987-95. PMID: 11306680

Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3375-80. PMID: 11248086; PMCID: PMC30661

Yu LJ, Matias J, Scudiero DA, Hite KM, Monks A, Sausville EA, Waxman DJ. P450 enzyme expression patterns in the NCI human tumor cell line panel. Drug Metab Dispos. 2001 Mar; 29(3):304-12. PMID: 11181500

Ram PA, Waxman DJ. Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone. J Biol Chem. 2000 Dec 15; 275(50):39487-96. PMID: 10991939

Dillon JS, Yaney GC, Zhou Y, Voilley N, Bowen S, Chipkin S, Bliss CR, Schultz V, Schuit FC, Prentki M, Waxman DJ, Corkey BE. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Diabetes. 2000 Dec; 49(12):2012-20.View Related Profiles.

Corkey, Barbara
Waxman, David

PMID: 11118002

Delesque-Touchard N, Park SH, Waxman DJ. Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver. J Biol Chem. 2000 Nov 3; 275(44):34173-82. PMID: 10931833

Choi HK, Waxman DJ. Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression. Endocrinology. 2000 Sep; 141(9):3245-55. PMID: 10965895

Jounaidi Y, Waxman DJ. Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res. 2000 Jul 15; 60(14):3761-9. PMID: 10919648

Huang Z, Raychowdhury MK, Waxman DJ. Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model. Cancer Gene Ther. 2000 Jul; 7(7):1034-42. PMID: 10917206

Huang Z, Roy P, Waxman DJ. Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. Biochem Pharmacol. 2000 Apr 15; 59(8):961-72. PMID: 10692561

Choi HK, Waxman DJ. Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH action. Growth Horm IGF Res. 2000 Apr; 10 Suppl B:S1-8. PMID: 10984246

Hecht JE, Waxman DJ. Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy. Methods Mol Med. 2000; 35:77-83. PMID: 21390800; DOI: 10.1385/1-59259-086-1:77;

Hecht JE, Jounaidi Y, Waxman DJ. Construction of p450-expressing tumor cell lines using retroviruses. Methods Mol Med. 2000; 35:85-94. PMID: 21390801; DOI: 10.1385/1-59259-086-1:85;

D Hecht JE, Waxman DJ. 7 in vitro methods for evaluation of p450-based anticancer gene therapy. Methods Mol Med. 2000; 35:95-105. PMID: 21390802; DOI: 10.1385/1-59259-086-1:95;

Hecht JE, Schreiber Schwartz P, Waxman DJ. 8 tumor models for evaluation of p450 gene therapy in vivo. Methods Mol Med. 2000; 35:107-18. PMID: 21390803; DOI: 10.1385/1-59259-086-1:107;

Waxman DJ. Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression. Novartis Found Symp. 2000; 227:61-74; discussion 75-81. PMID: 10752065

Ram PA, Waxman DJ. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem. 1999 Dec 10; 274(50):35553-61. PMID: 10585430

Davey HW, Park SH, Grattan DR, McLachlan MJ, Waxman DJ. STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression. J Biol Chem. 1999 Dec 10; 274(50):35331-6. PMID: 10585399

Maloney EK, Waxman DJ. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol. 1999 Dec 1; 161(2):209-18. PMID: 10581215

Choi HK, Waxman DJ. Growth hormone, but not prolactin, maintains, low-level activation of STAT5a and STAT5b in female rat liver. Endocrinology. 1999 Nov; 140(11):5126-35. PMID: 10537141

Roy P, Tretyakov O, Wright J, Waxman DJ. Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer. Drug Metab Dispos. 1999 Nov; 27(11):1309-18. PMID: 10534317

Zhou YC, Waxman DJ. STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. J Biol Chem. 1999 Oct 15; 274(42):29874-82. PMID: 10514468

Davey HW, Wilkins RJ, Waxman DJ. STAT5 signaling in sexually dimorphic gene expression and growth patterns. Am J Hum Genet. 1999 Oct; 65(4):959-65. PMID: 10486314; PMCID: PMC1288266

Waxman DJ. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys. 1999 Sep 1; 369(1):11-23. PMID: 10462436

Huang Z, Waxman DJ. High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations. Anal Biochem. 1999 Aug 15; 273(1):117-25. PMID: 10452807

Roy P, Yu LJ, Crespi CL, Waxman DJ. Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun; 27(6):655-66. PMID: 10348794

Waxman DJ, Chen L, Hecht JE, Jounaidi Y. Cytochrome P450-based cancer gene therapy: recent advances and future prospects. Drug Metab Rev. 1999 May; 31(2):503-22. PMID: 10335450

Park SH, Liu X, Hennighausen L, Davey HW, Waxman DJ. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption. J Biol Chem. 1999 Mar 12; 274(11):7421-30. PMID: 10066807

Yu LJ, Drewes P, Gustafsson K, Brain EG, Hecht JE, Waxman DJ. In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. J Pharmacol Exp Ther. 1999 Mar; 288(3):928-37. PMID: 10027828

Gebert CA, Park SH, Waxman DJ. Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation. Mol Endocrinol. 1999 Feb; 13(2):213-27. PMID: 9973252

Zhou YC, Waxman DJ. Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated by stat5b. J Biol Chem. 1999 Jan 29; 274(5):2672-81. PMID: 9915797

Gebert CA, Park SH, Waxman DJ. Termination of growth hormone pulse-induced STAT5b signaling. Mol Endocrinol. 1999 Jan; 13(1):38-56. PMID: 9892011

Jounaidi Y, Hecht JE, Waxman DJ. Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy. Cancer Res. 1998 Oct 1; 58(19):4391-401. PMID: 9766669

Zhou YC, Waxman DJ. Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ Health Perspect. 1998 Aug; 106 Suppl 4:983-8. PMID: 9703482; PMCID: PMC1533341

Brain EG, Yu LJ, Gustafsson K, Drewes P, Waxman DJ. Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo. Br J Cancer. 1998 Jun; 77(11):1768-76. PMID: 9667645; PMCID: PMC2150313

Waxman DJ, Chang TK. Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. Methods Mol Biol. 1998; 107:111-6. PMID: 14577218

Chang TK, Waxman DJ. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 1998; 107:103-9. PMID: 14577217

Chang TK, Waxman DJ. Catalytic assays for human cytochrome P450. Methods Mol Biol. 1998; 107:95-102. PMID: 14577216

Chang TK, Crespi CL, Waxman DJ. Determination of the CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes. Methods Mol Biol. 1998; 107:117-22. PMID: 14577219

Crespi CL, Chang TK, Waxman DJ. High-performance liquid chromatographic analysis of CYP2C8-catalyzed paclitaxel 6 alpha-hydroxylation. Methods Mol Biol. 1998; 107:123-7. PMID: 14577220

Crespi CL, Chang TK, Waxman DJ. Determination of CYP2C9-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography. Methods Mol Biol. 1998; 107:129-33. PMID: 14577221

Crespi CL, Chang TK, Waxman DJ. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol Biol. 1998; 107:141-5. PMID: 14577223

Chang TK, Crespi CL, Waxman DJ. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol. 1998; 107:147-52. PMID: 14577224

Waxman DJ, Chang TK. Thin-layer chromatographic analysis of human CYP3A-catalyzed testosterone 6 beta-hydroxylation. Methods Mol Biol. 1998; 107:153-61. PMID: 14577225

Waxman DJ, Chang TK. An isocratic high-performance liquid chromatographic assay for CYP7A1-catalyzed cholesterol 7 alpha-hydroxylation. Methods Mol Biol. 1998; 107:169-73. PMID: 14577227

Waxman DJ, Chang TK. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods Mol Biol. 1998; 107:175-9. PMID: 14577228

Chen L, Yu LJ, Waxman DJ. Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene. Cancer Res. 1997 Nov 1; 57(21):4830-7. PMID: 9354446

Code EL, Crespi CL, Penman BW, Gonzalez FJ, Chang TK, Waxman DJ. Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos. 1997 Aug; 25(8):985-93. PMID: 9280407

Ram PA, Waxman DJ. Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem. 1997 Jul 11; 272(28):17694-702. PMID: 9211920

Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7239-44. PMID: 9207075; PMCID: PMC23803

O'Leary KA, Li HC, Ram PA, McQuiddy P, Waxman DJ, Kasper CB. Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene. Mol Pharmacol. 1997 Jul; 52(1):46-53. PMID: 9224811

Chang TK, Yu L, Goldstein JA, Waxman DJ. Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun; 7(3):211-21. PMID: 9241661

Chang TK, Yu L, Maurel P, Waxman DJ. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15; 57(10):1946-54. PMID: 9157990

Gebert CA, Park SH, Waxman DJ. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. Mol Endocrinol. 1997 Apr; 11(4):400-14. PMID: 9092792

Waxman DJ, Zhao S, Choi HK. Interaction of a novel sex-dependent, growth hormone-regulated liver nuclear factor with CYP2C12 promoter. J Biol Chem. 1996 Nov 22; 271(47):29978-87. PMID: 8939943

Yu L, Waxman DJ. Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450. Drug Metab Dispos. 1996 Nov; 24(11):1254-62. PMID: 8937861

Yi W, Kim SO, Jiang J, Park SH, Kraft AS, Waxman DJ, Frank SJ. Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol Endocrinol. 1996 Nov; 10(11):1425-43. PMID: 8923468

Waxman DJ. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. J Endocrinol. 1996 Sep; 150 Suppl:S129-47. PMID: 8943797

Peters JM, Zhou YC, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. Mol Pharmacol. 1996 Jul; 50(1):67-74. PMID: 8700121

Chen L, Waxman DJ, Chen D, Kufe DW. Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene. Cancer Res. 1996 Mar 15; 56(6):1331-40. PMID: 8640822

Ram PA, Park SH, Choi HK, Waxman DJ. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J Biol Chem. 1996 Mar 8; 271(10):5929-40. PMID: 8621467

Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 1996 Feb; 6(1):1-42. PMID: 8845856

Waxman DJ, Ram PA, Pampori NA, Shapiro BH. Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. Mol Pharmacol. 1995 Nov; 48(5):790-7. PMID: 7476908

Chen G, Waxman DJ. Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. J Pharmacol Exp Ther. 1995 Sep; 274(3):1271-7. PMID: 7562498

Rifkind AB, Lee C, Chang TK, Waxman DJ. Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Arch Biochem Biophys. 1995 Jul 10; 320(2):380-9. PMID: 7625847

Chang TK, Chen G, Waxman DJ. Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism. J Pharmacol Exp Ther. 1995 Jul; 274(1):270-5. PMID: 7616408

Waxman DJ, Ram PA, Park SH, Choi HK. Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription. J Biol Chem. 1995 Jun 2; 270(22):13262-70. PMID: 7768925

Chen G, Waxman DJ. Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells. Biochem Pharmacol. 1995 May 26; 49(11):1691-701. PMID: 7786310

Chen L, Waxman DJ. Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. Cancer Res. 1995 Feb 1; 55(3):581-9. PMID: 7834628

Nanji AA, Zhao S, Sadrzadeh SM, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. Alcohol Clin Exp Res. 1994 Oct; 18(5):1280-5. PMID: 7847620

Chang TK, Chen H, Waxman DJ. 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levels. Drug Metab Dispos. 1994 Sep-Oct; 22(5):673-9. PMID: 7835216

Ram PA, Waxman DJ. Dehydroepiandrosterone 3 beta-sulphate is an endogenous activator of the peroxisome-proliferation pathway: induction of cytochrome P-450 4A and acyl-CoA oxidase mRNAs in primary rat hepatocyte culture and inhibitory effects of Ca(2+)-channel blockers. Biochem J. 1994 Aug 1; 301 ( Pt 3):753-8. PMID: 8053899; PMCID: PMC1137051

Jean A, Reiss A, Desrochers M, Dubois S, Trottier E, Trottier Y, Wirtanen L, Adesnik M, Waxman DJ, Anderson A. Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and immunological identification of a constitutive P450 2B3-like protein in rat liver. DNA Cell Biol. 1994 Aug; 13(8):781-92. PMID: 8068203

Wei MX, Tamiya T, Chase M, Boviatsis EJ, Chang TK, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther. 1994 Aug; 5(8):969-78.View Related Profiles.

Waxman, David
Kowall, Neil

PMID: 7948146

Nanji AA, Zhao S, Lamb RG, Dannenberg AJ, Sadrzadeh SM, Waxman DJ. Changes in cytochromes P-450, 2E1, 2B1, and 4A, and phospholipases A and C in the intragastric feeding rat model for alcoholic liver disease: relationship to dietary fats and pathologic liver injury. Alcohol Clin Exp Res. 1994 Aug; 18(4):902-8. PMID: 7978103

Shapiro BH, Pampori NA, Lapenson DP, Waxman DJ. Growth hormone-dependent and -independent sexually dimorphic regulation of phenobarbital-induced hepatic cytochromes P450 2B1 and 2B2. Arch Biochem Biophys. 1994 Jul; 312(1):234-9. PMID: 8031133

Nanji AA, Zhao S, Sadrzadeh SM, Waxman DJ. Use of reverse transcription-polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods. Hepatology. 1994 Jun; 19(6):1483-7. PMID: 8188180

Prough RA, Webb SJ, Wu HQ, Lapenson DP, Waxman DJ. Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats. Cancer Res. 1994 Jun 1; 54(11):2878-86. PMID: 8187072

Chang TK, Gonzalez FJ, Waxman DJ. Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch Biochem Biophys. 1994 Jun; 311(2):437-42. PMID: 8203907

Lee YH, Alberta JA, Gonzalez FJ, Waxman DJ. Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. J Biol Chem. 1994 May 20; 269(20):14681-9. PMID: 8182075

Nanji AA, Zhao S, Khwaja S, Sadrzadeh SM, Waxman DJ. Cimetidine prevents alcoholic hepatic injury in the intragastric feeding rat model. J Pharmacol Exp Ther. 1994 May; 269(2):832-7. PMID: 8182552

Chen G, Waxman DJ. Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells. Biochem Pharmacol. 1994 Mar 15; 47(6):1079-87. PMID: 8147907

Weber GF, Waxman DJ. Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases. Arch Biochem Biophys. 1993 Dec; 307(2):369-78. PMID: 8274024

Chang TK, Weber GF, Crespi CL, Waxman DJ. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res. 1993 Dec 1; 53(23):5629-37. PMID: 8242617

Srivastava PK, Waxman DJ. Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver. Biochem J. 1993 Aug 15; 294 ( Pt 1):159-65. PMID: 8363567; PMCID: PMC1134579

Chang TK, Waxman DJ. Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard. Cancer Res. 1993 Jun 1; 53(11):2490-7. PMID: 8495410

Nanji AA, Zhao S, Lamb RG, Sadrzadeh SM, Dannenberg AJ, Waxman DJ. Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: relationship to cytochrome P-450 2E1 induction and conjugated diene formation. Alcohol Clin Exp Res. 1993 Jun; 17(3):598-603. PMID: 8333590

Shapiro BH, Pampori NA, Ram PA, Waxman DJ. Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate. J Pharmacol Exp Ther. 1993 May; 265(2):979-84. PMID: 8496838

Weber GF, Waxman DJ. Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes. Biochem Pharmacol. 1993 Apr 22; 45(8):1685-94. PMID: 8484807

Chang TK, Teixeira J, Gil G, Waxman DJ. The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation. Biochem J. 1993 Apr 15; 291 ( Pt 2):429-33. PMID: 8484723; PMCID: PMC1132543

Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993 Jan-Feb; 12(1):1-51. PMID: 7678494

Frei E, Holden SA, Gonin R, Waxman DJ, Teicher BA. Antitumor alkylating agents: in vitro cross-resistance and collateral sensitivity studies. Cancer Chemother Pharmacol. 1993; 33(2):113-22. PMID: 8261570

Waxman DJ. Regulation of liver-specific steroid metabolizing cytochromes P450: cholesterol 7a-hydroxylase, bile acid 6ß-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases. J Steroid Biochem Mol Biol. 1992 Dec; 43(8):1055-72. PMID: 22217850; DOI: 10.1016/0960-0760(92)90333-E;

Waxman DJ, Sundseth SS, Srivastava PK, Lapenson DP. Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs. Cancer Res. 1992 Oct 15; 52(20):5797-802. PMID: 1394205

Park SS, Walker W, Aoyama T, Lapenson DP, Waxman DJ, Gonzalez FJ, Gelboin HV. Monoclonal antibodies to rat liver microsomal cytochrome b5. Biochem Pharmacol. 1992 May 28; 43(10):2201-8. PMID: 1599506

LeBlanc GA, Kantoff PW, Ng SF, Frei E, Waxman DJ. Hormonal perturbations in patients with testicular cancer treated with cisplatin. Cancer. 1992 May 1; 69(9):2306-10. PMID: 1562977

Correia MA, Yao K, Wrighton SA, Waxman DJ, Rettie AE. Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms? Arch Biochem Biophys. 1992 May 1; 294(2):493-503. PMID: 1567205

Sundseth SS, Alberta JA, Waxman DJ. Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. J Biol Chem. 1992 Feb 25; 267(6):3907-14. PMID: 1740438

Sundseth SS, Waxman DJ. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J Biol Chem. 1992 Feb 25; 267(6):3915-21. PMID: 1740439

Ram PA, Waxman DJ. Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. J Biol Chem. 1992 Feb 15; 267(5):3294-301. PMID: 1737785

Waxman DJ, Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochem J. 1992 Feb 1; 281 ( Pt 3):577-92. PMID: 1536639; PMCID: PMC1130728

LeBlanc GA, Sundseth SS, Weber GF, Waxman DJ. Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer Res. 1992 Feb 1; 52(3):540-7. PMID: 1732040

Waxman DJ, Lapenson DP, Aoyama T, Gelboin HV, Gonzalez FJ, Korzekwa K. Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct; 290(1):160-6. PMID: 1898086

Jauregui HO, Ng SF, Gann KL, Waxman DJ. Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes. Xenobiotica. 1991 Sep; 21(9):1091-106. PMID: 1788977

Waxman DJ, Pampori NA, Ram PA, Agrawal AK, Shapiro BH. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Natl Acad Sci U S A. 1991 Aug 1; 88(15):6868-72. PMID: 1862110; PMCID: PMC52190

Ng SF, Waxman DJ. N,N',N'-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents. Cancer Res. 1991 May 1; 51(9):2340-5. PMID: 1707751

Pampori NA, Agrawal AK, Waxman DJ, Shapiro BH. Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth hormone regulating expression of sex-dependent forms of cytochrome P450. Biochem Pharmacol. 1991 May 1; 41(9):1299-309. PMID: 2018562

Zimniak P, Holsztynska EJ, Radominska A, Iscan M, Lester R, Waxman DJ. Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids. Biochem J. 1991 Apr 1; 275 ( Pt 1):105-11. PMID: 2018466; PMCID: PMC1150019

Koch JA, Waxman DJ. P450 phosphorylation in isolated hepatocytes and in vivo. Methods Enzymol. 1991; 206:305-15. PMID: 1664478

Waxman DJ. Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes. Methods Enzymol. 1991; 206:249-67. PMID: 1784212

Waxman DJ. P450-catalyzed steroid hydroxylation: assay and product identification by thin-layer chromatography. Methods Enzymol. 1991; 206:462-76. PMID: 1784231

Ram PA, Waxman DJ. Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone. Mol Endocrinol. 1991 Jan; 5(1):13-20. PMID: 2017188

Ram PA, Waxman DJ. Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J Biol Chem. 1990 Nov 5; 265(31):19223-9. PMID: 2172247

Waxman DJ. Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review. Cancer Res. 1990 Oct 15; 50(20):6449-54. PMID: 2208103

Waxman DJ, Morrissey JJ, Naik S, Jauregui HO. Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochem J. 1990 Oct 1; 271(1):113-9. PMID: 2222405; PMCID: PMC1149520

LeBlanc GA, Waxman DJ. Mechanisms of cyclophosphamide action on hepatic P-450 expression. Cancer Res. 1990 Sep 15; 50(18):5720-6. PMID: 2118418

Sundseth SS, Waxman DJ. Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. J Biol Chem. 1990 Sep 5; 265(25):15090-5. PMID: 2394714

Rosowsky A, Wright JE, Holden SA, Waxman DJ. Influence of lipophilicity and carboxyl group content on the rate of hydroxylation of methotrexate derivatives by aldehyde oxidase. Biochem Pharmacol. 1990 Aug 15; 40(4):851-7. PMID: 1696821

Capdevila JH, Karara A, Waxman DJ, Martin MV, Falck JR, Guenguerich FP. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. J Biol Chem. 1990 Jul 5; 265(19):10865-71. PMID: 2358445

Falck JR, Lumin S, Blair I, Dishman E, Martin MV, Waxman DJ, Guengerich FP, Capdevila JH. Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids. J Biol Chem. 1990 Jun 25; 265(18):10244-9. PMID: 2113050

LeBlanc GA, Waxman DJ. Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol. J Biol Chem. 1990 Apr 5; 265(10):5654-61. PMID: 2318830

Waxman DJ, Ram PA, Notani G, LeBlanc GA, Alberta JA, Morrissey JJ, Sundseth SS. Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;. Mol Endocrinol. 1990 Mar; 4(3):447-54. PMID: 2342479

Janeczko R, Waxman DJ, Le Blanc GA, Morville A, Adesnik M. Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450. Mol Endocrinol. 1990 Feb; 4(2):295-303. PMID: 1691818

Ng SF, Waxman DJ. Biotransformation of N,N',N'-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N'-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase. Cancer Res. 1990 Feb 1; 50(3):464-71. PMID: 2105156

Waxman DJ, Morrissey JJ, MacLeod JN, Shapiro BH. Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5 alpha-reductase. Endocrinology. 1990 Feb; 126(2):712-20. PMID: 2298167

Waxman DJ, Lapenson DP, Nagata K, Conlon HD. Participation of two structurally related enzymes in rat hepatic microsomal androstenedione 7 alpha-hydroxylation. Biochem J. 1990 Jan 1; 265(1):187-94. PMID: 2302165; PMCID: PMC1136629

Aoyama T, Korzekwa K, Nagata K, Adesnik M, Reiss A, Lapenson DP, Gillette J, Gelboin HV, Waxman DJ, Gonzalez FJ. Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. J Biol Chem. 1989 Dec 15; 264(35):21327-33. PMID: 2574176

Shapiro BH, MacLeod JN, Pampori NA, Morrissey JJ, Lapenson DP, Waxman DJ. Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450. Endocrinology. 1989 Dec; 125(6):2935-44. PMID: 2510988

Park SS, Waxman DJ, Lapenson DP, Schenkman JB, Gelboin HV. Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism. Biochem Pharmacol. 1989 Sep 15; 38(18):3067-74. PMID: 2783161

Teicher BA, Waxman DJ, Holden SA, Wang YY, Clarke L, Alvarez Sotomayor E, Jones SM, Frei E. Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N'-triethylenethiophosphoramide. Cancer Res. 1989 Sep 15; 49(18):4996-5001. PMID: 2504483

Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem. 1989 Jun 25; 264(18):10388-95. PMID: 2732228

Waxman DJ, Morrissey JJ, LeBlanc GA. Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. Endocrinology. 1989 Jun; 124(6):2954-66. PMID: 2785912

Zimniak P, Holsztynska EJ, Lester R, Waxman DJ, Radominska A. Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes. J Lipid Res. 1989 Jun; 30(6):907-18. PMID: 2794781

Yeowell HN, Waxman DJ, LeBlanc GA, Linko P, Goldstein JA. Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Arch Biochem Biophys. 1989 Jun; 271(2):508-14. PMID: 2499261

Waxman DJ, Lapenson DP, Morrissey JJ, Park SS, Gelboin HV, Doehmer J, Oesch F. Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1). Biochem J. 1989 May 15; 260(1):81-5. PMID: 2789039; PMCID: PMC1138628

Clarke L, Waxman DJ. Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation. Cancer Res. 1989 May 1; 49(9):2344-50. PMID: 2706622

Koch JA, Waxman DJ. Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo. Biochemistry. 1989 Apr 18; 28(8):3145-52. PMID: 2742831

Oesch F, Waxman DJ, Morrissey JJ, Honscha W, Kissel W, Friedberg T. Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. Arch Biochem Biophys. 1989 Apr; 270(1):23-32. PMID: 2539047

Waxman DJ, Morrissey JJ, Leblanc GA. Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: pituitary control of hepatic NADPH cytochrome P-450 reductase. Mol Pharmacol. 1989 Apr; 35(4):519-25. PMID: 2495435

Le Blanc GA, Waxman DJ. Interaction of anticancer drugs with hepatic monooxygenase enzymes. Drug Metab Rev. 1989; 20(2-4):395-439. PMID: 2680389

Bartlomowicz B, Waxman DJ, Utesch D, Oesch F, Friedberg T. Phosphorylation of carcinogen metabolizing enzymes: regulation of the phosphorylation status of the major phenobarbital inducible cytochromes P-450 in hepatocytes. Carcinogenesis. 1989 Jan; 10(1):225-8. PMID: 2535970

Matsunaga T, Nagata K, Holsztynska EJ, Lapenson DP, Smith A, Kato R, Gelboin HV, Waxman DJ, Gonzalez FJ. Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. J Biol Chem. 1988 Dec 5; 263(34):17995-8002. PMID: 3192524

Waxman DJ, Lapenson DP, Krishnan M, Bernard O, Kreibich G, Alvarez F. Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450. Gastroenterology. 1988 Nov; 95(5):1326-31. PMID: 3049217

LeBlanc GA, Waxman DJ. Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes. J Biol Chem. 1988 Oct 25; 263(30):15732-9. PMID: 3139676

Waxman DJ, LeBlanc GA, Morrissey JJ, Staunton J, Lapenson DP. Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. J Biol Chem. 1988 Aug 15; 263(23):11396-406. PMID: 3403535

Waxman DJ, Attisano C, Guengerich FP, Lapenson DP. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. Arch Biochem Biophys. 1988 Jun; 263(2):424-36. PMID: 3259858

Yeowell HN, Waxman DJ, LeBlanc GA, Linko P, Goldstein JA. Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. Mol Pharmacol. 1988 Mar; 33(3):272-8. PMID: 3127689

Waxman DJ. Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochem Pharmacol. 1988 Jan 1; 37(1):71-84. PMID: 3276320

Waxman DJ, Lapenson DP, Park SS, Attisano C, Gelboin HV. Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations. Mol Pharmacol. 1987 Nov; 32(5):615-24. PMID: 3119986

Steinberg P, Lafranconi WM, Wolf CR, Waxman DJ, Oesch F, Friedberg T. Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver. Mol Pharmacol. 1987 Oct; 32(4):463-70. PMID: 3670281

Yeowell HN, Waxman DJ, Wadhera A, Goldstein JA. Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. Mol Pharmacol. 1987 Sep; 32(3):340-7. PMID: 3118178

Schwarz M, Peres G, Buchmann A, Friedberg T, Waxman DJ, Kunz W. Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization. Carcinogenesis. 1987 Sep; 8(9):1355-7. PMID: 3621474

Clarke L, Waxman DJ. Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. Arch Biochem Biophys. 1987 Aug 1; 256(2):585-96. PMID: 3619447

Holsztynska EJ, Waxman DJ. Cytochrome P-450 cholesterol 7 alpha-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors. Arch Biochem Biophys. 1987 Aug 1; 256(2):543-59. PMID: 3039914

Wright JE, Rosowsky A, Waxman DJ, Trites D, Cucchi CA, Flatow J, Frei E. Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro. Biochem Pharmacol. 1987 Jul 1; 36(13):2209-14. PMID: 2440437

McClellan-Green P, Waxman DJ, Caveness M, Goldstein JA. Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats. Arch Biochem Biophys. 1987 Feb 15; 253(1):13-25. PMID: 3545082

Clarke L, Rosowsky A, Waxman DJ. Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs. Mol Pharmacol. 1987 Jan; 31(1):122-7. PMID: 3807889

Friedberg T, Waxman DJ, Atchison M, Kumar A, Haaparanta T, Raphael C, Adesnik M. Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1. Biochemistry. 1986 Dec 2; 25(24):7975-83. PMID: 3801454

Park SS, Waxman DJ, Miller H, Robinson R, Attisano C, Guengerich FP, Gelboin HV. Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450. Biochem Pharmacol. 1986 Sep 1; 35(17):2859-67. PMID: 3488743

Frey AB, Kreibich G, Wadhera AB, Clarke L, Waxman DJ. 3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4. Biochemistry. 1986 Aug 26; 25(17):4797-803. PMID: 3768313

Dannan GA, Guengerich FP, Waxman DJ. Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450. J Biol Chem. 1986 Aug 15; 261(23):10728-35. PMID: 3733730

Waxman DJ. Rat hepatic cholesterol 7 alpha-hydroxylase: biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes. Arch Biochem Biophys. 1986 Jun; 247(2):335-45. PMID: 3717947

Dannan GA, Porubek DJ, Nelson SD, Waxman DJ, Guengerich FP. 17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement. Endocrinology. 1986 May; 118(5):1952-60. PMID: 3516654

Guengerich FP, Martin MV, Beaune PH, Kremers P, Wolff T, Waxman DJ. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem. 1986 Apr 15; 261(11):5051-60. PMID: 3514607

Frey AB, Waxman DJ, Kreibich G. The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies. J Biol Chem. 1985 Dec 5; 260(28):15253-65. PMID: 3877725

Rampersaud A, Waxman DJ, Ryan DE, Levin W, Walz FG. Microheterogeneity of a male-specific rat hepatic cytochrome P-450: existence of three allozymic forms. Arch Biochem Biophys. 1985 Nov 15; 243(1):174-83. PMID: 3840669

Sehgal RK, Sengupta SK, Waxman DJ, Tauber AI. Enzymic and chemical reduction of 2-deaminoactinomycins to free radicals. Anticancer Drug Des. 1985 Oct; 1(1):13-25.View Related Profiles.

Tauber, Alfred
Waxman, David

PMID: 3870877

Tauber AI, Wright J, Higson FK, Edelman SA, Waxman DJ. Purification and characterization of the human neutrophil NADH-cytochrome b5 reductase. Blood. 1985 Sep; 66(3):673-8.View Related Profiles.

Tauber, Alfred
Waxman, David

PMID: 2992639

Waxman DJ, Dannan GA, Guengerich FP. Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry. 1985 Jul 30; 24(16):4409-17. PMID: 4052406

Waxman DJ. Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme. J Biol Chem. 1984 Dec 25; 259(24):15481-90. PMID: 6439721

Waxman DJ, Ko A, Walsh C. Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. J Biol Chem. 1983 Oct 10; 258(19):11937-47. PMID: 6619150

Waxman DJ, Walsh C. Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5. Biochemistry. 1983 Sep 27; 22(20):4846-55. PMID: 6626536

Waxman DJ, Walsh C. Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms. J Biol Chem. 1982 Sep 10; 257(17):10446-57. PMID: 6809749

Light DR, Waxman DJ, Walsh C. Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver flavin adenine dinucleotide containing monooxygenase. Biochemistry. 1982 May 11; 21(10):2490-8. PMID: 7093199

Waxman DJ, Light DR, Walsh C. Chiral sulfoxidations catalyzed by rat liver cytochromes P-450. Biochemistry. 1982 May 11; 21(10):2499-507. PMID: 7093200

Waxman DJ, Yocum RR, Strominger JL. Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis. Philos Trans R Soc Lond B Biol Sci. 1980 May 16; 289(1036):257-71. PMID: 6109322

Waxman DJ, Strominger JL. Sequence of active site peptides from the penicillin-sensitive D-alanine carboxypeptidase of Bacillus subtilis. Mechanism of penicillin action and sequence homology to beta-lactamases. J Biol Chem. 1980 May 10; 255(9):3964-76. PMID: 6768745

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 360 publications over 44 distinct years, with a maximum of 26 publications in 2006

Bar chart showing 360 publications over 44 distinct years, with a maximum of 26 publications in 2006

Year	Publications
1980	2
1982	3
1983	2
1984	1
1985	5
1986	7
1987	9
1988	7
1989	15
1990	14
1991	10
1992	10
1993	10
1994	13
1995	7
1996	8
1997	8
1998	16
1999	16
2000	13
2001	10
2002	5
2003	8
2004	13
2005	10
2006	26
2007	10
2008	9
2009	7
2010	9
2011	6
2012	6
2013	6
2014	5
2015	6
2016	7
2017	4
2018	5
2019	4
2020	7
2021	4
2022	7
2023	7
2024	3