David J. Waxman, PhD
Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology

PhD, Harvard University
AM, Harvard University




David J. Waxman, PhD is a Biologist with extensive experience in the fields of biochemistry, molecular biology, and enzymology. Over the past 35 years, his lab has made seminal contributions to the research of cancer pharmacology and therapeutics, and steroid-metabolizing enzymes.
Dr. Waxman has spoken at over 130 conferences and has held appointments at a variety of universities including Harvard Medical School, MIT, and the Weizmann Institute.

Member
Boston University
Genome Science Institute


Professor
Boston University
Biology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research



2018 American Society for Pharmacology and Experimental Therapeutics (ASPET): The Bernard B. Brodie Award in Drug Metabolism for Research
1993 Burroughs-Wellcome Endocrine Toxicology Symposium Lectureship
1983 Research Corporation Award
1981-1983 NIH NRSA Postdoctoral Fellowship Award
1980-1981 Damon Runyon-Walter Winchell Cancer Fund Fellowship


Xenobiotic-responsive hepatic long non-coding RNAs
07/07/2020 - 04/30/2025 (PI)
NIH/National Institute of Environmental Health Sciences
5R01ES024421-07

Growth Hormone Regulation of Sex Differences in Liver Metabolism
06/19/2019 - 05/31/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK121998-03

Epigenetic Actions of Environmental Chemicals
08/15/2014 - 07/06/2020 (PI)
NIH/National Institute of Environmental Health Sciences
5R01ES024421-05

Regulation of Sex Differences in Liver Metabolism
09/01/2018 - 09/15/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R56DK033765-35A1

Regulation of Sex Differences in Liver Metabolism
02/01/2016 - 08/31/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK033765-34

Regulation of Sex Differences in Liver Metabolism
02/01/2013 - 01/31/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK033765-32S1

Combination Therapies for Cancer Treatment
12/07/2009 - 11/30/2015 (PI)
NIH/National Cancer Institute
5R01CA049248-24

IGERT: INTEGRATING COMPUTATIONAL SCIENCE INTO RESEARCH IN BIOLOGICAL NETWORKS
07/01/2007 - 06/30/2014 (Co-Investigator)
National Science Foundation
DGE-0654108

SUPERFUND BASIC RESEARCH PROGRAM AT BOSTON UNIVERSITY
04/01/2009 - 03/31/2013 (Co-Investigator)
PI: David M. Ozonoff, MD
NIH/National Institute of Environmental Health Sciences
3P42ES007381-15S5

CYTOCHROME P450-ENDOGENOUS SUBSTRATE METABOLISM
02/01/2008 - 01/31/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK033765-29



Title


Yr Title Project-Sub Proj Pubs
2021 Growth Hormone Regulation of Sex Differences in Liver Metabolism 5R01DK121998-03
2021 Xenobiotic-responsive hepatic long non-coding RNAs 5R01ES024421-07 7
2020 Growth Hormone Regulation of Sex Differences in Liver Metabolism 5R01DK121998-02
2020 Xenobiotic-responsive hepatic long non-coding RNAs 2R01ES024421-06A1 7
2019 Growth Hormone Regulation of Sex Differences in Liver Metabolism 1R01DK121998-01A1
2018 Epigenetic Actions of Environmental Chemicals 5R01ES024421-05 7
2018 Regulation of sex differences in liver metabolism 2R56DK033765-35A1 16
2017 Epigenetic Actions of Environmental Chemicals 5R01ES024421-04 7
2017 Regulation of Sex Differences in Liver Metabolism 5R01DK033765-34 122
2016 Epigenetic Actions of Environmental Chemicals 5R01ES024421-03 7
Showing 10 of 100 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Goldfarb CN, Waxman DJ. Global analysis of expression, maturation and subcellular localization of mouse liver transcriptome identifies novel sex-biased and TCPOBOP-responsive long non-coding RNAs. BMC Genomics. 2021 Mar 24; 22(1):212. PMID: 33761883; DOI: 10.1186/s12864-021-07478-5;
     
  2. Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303.View Related Profiles. PMID: 33578267; DOI: 10.1016/j.neo.2021.01.005;
     
  3. Hao P, Waxman DJ. STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes. Mol Cell Biol. 2021 01 25; 41(2). PMID: 33199496; DOI: 10.1128/MCB.00166-20;
     
  4. Melia T, Waxman DJ. Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice. PLoS One. 2020; 15(12):e0242665. PMID: 33264334; DOI: 10.1371/journal.pone.0242665;
     
  5. Tu S, Li M, Chen H, Tan F, Xu J, Waxman DJ, Zhang Y, Shao Z. MAnorm2 for quantitatively comparing groups of ChIP-seq samples. Genome Res. 2021 01; 31(1):131-145. PMID: 33208455; DOI: 10.1101/gr.262675.120;
     
  6. Brocker CN, Kim D, Melia T, Karri K, Velenosi TJ, Takahashi S, Aibara D, Bonzo JA, Levi M, Waxman DJ, Gonzalez FJ. Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun. 2020 11 17; 11(1):5847. PMID: 33203882; DOI: 10.1038/s41467-020-19554-7;
     
  7. Matthews BJ, Waxman DJ. Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver. Epigenetics Chromatin. 2020 07 17; 13(1):30. PMID: 32680543; DOI: 10.1186/s13072-020-00350-y;
     
  8. Tran AP, Ali Al-Radhawi M, Kareva I, Wu J, Waxman DJ, Sontag ED. Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance. Front Immunol. 2020; 11:1376. PMID: 32695118; DOI: 10.3389/fimmu.2020.01376;
     
  9. Lau-Corona D, Bae WK, Hennighausen L, Waxman DJ. Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2. PLoS Genet. 2020 05; 16(5):e1008796. PMID: 32428001; DOI: 10.1371/journal.pgen.1008796;
     
  10. Karri K, Waxman DJ. Widespread Dysregulation of Long Noncoding Genes Associated With Fatty Acid Metabolism, Cell Division, and Immune Response Gene Networks in Xenobiotic-exposed Rat Liver. Toxicol Sci. 2020 04 01; 174(2):291-310. PMID: 31926019; DOI: 10.1093/toxsci/kfaa001;
     
Showing 10 of 342 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 342 publications over 41 distinct years, with a maximum of 26 publications in 2006

YearPublications
19802
19823
19832
19841
19855
19867
19879
19887
198915
199014
199110
199210
199310
199413
19957
19968
19978
199816
199916
200013
200110
20025
20038
200413
200510
200626
200710
20089
20097
20109
20116
20126
20136
20145
20156
20167
20174
20185
20194
20207
20213

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5 Cummington St
Boston MA 02215
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