David J. Salant, MB BCh
Boston University School of Medicine
Dept of Medicine

MBBCh, University of the Witwatersrand

Experimental models of immunological glomerular diseases and autoimmunity resembling those seen in man are used to obtain a fundamental understanding of the immunopathogenetic mechanisms of injury.

Antibody-mediated podocyte injury

The primary focus of the Salant laboratory is on the immune basis of glomerular diseases with particular regard to the humoral mechanisms of glomerular cell injury. Current work will elucidate the mechanisms by which antibodies alter the function and morphology of glomerular visceral epithelial cells (podocytes).

1. We have identified the target antigen in human membranous nephropathy as the phospholipase A2 receptor (PLA2R) and shown that about 75% of patients have circulating ant-PLA2R autoantibodies. Current work is directed at defining the mechanisms of podocyte injury induced by anti-PLA2R using a combination of in vitro, in vivo and human genetic techniques. Additional studies will explore the role of anti-PLA2R in the development of recurrent membranous nephropathy post renal transplantation.

2. Ongoing interests include the role of podocyte-specific antibodies, and the effects of complement-mediated injury on podocyte structure, composition of the filtration slit diaphragm and its attachment to the cytoskeleton, and on cell-matrix adhesion using animal models, cell biological and immunochemical methodologies.

Mechanisms of post-inflammatory renal fibrogenesis

We have also developed a murine model of antibody-dependent rapidly progressive glomerulonephritis in which necrotizing and crescentic glomerulonephritis is associated with the activation of chemokine and interstitial-type collagen genes, followed by the development of interstitial fibrosis and renal failure. Since interstitial fibrosis and tubular atrophy are common to all forms of chronic progressive renal diseases and are the most reliable pathological indicators of an adverse long-term prognosis in humans, this mouse model in which the onset of immune injury is rapidly followed (within 5 days) by the induction and proliferation of interstitial cells expressing high levels of mRNA for type I collagen affords a unique opportunity to study the mechanisms of post-inflammatory renal fibrogenesis

Section Chief of Medicine in Nephrology
Boston University School of Medicine

Boston University School of Medicine
Pathology & Laboratory Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Active Staff Privileges
Boston Medical Center

2016-2016 11th International Podocyte Conference: Marilyn Farquhar Award
2015-2015 National Kidney Foundation: Donald W. Seldin Award
2015-2015 American Association for the Advancement of Science: Fellow
2015-2015 Boston University: Innovator of the Year
2013-2013 International Society of Nephrology: Jean Hamburger Award
2013-2013 American Society of Nephrology: John P. Peters Award
2011-2011 International Society of Nephrology: Donald Seldin Plenary Lecture at the World Congress of Nephrology, Vancouver, BC.
1995-1995 American Association of Physicians: Elected
1987-1987 American Society for Clinical Investigation: Elected
1985-1990 American Heart Association: Established Investigator Award

Research Training in Nephrology
07/01/1975 - 06/30/2005 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 T32 DK07053 31

Case Mix Models for End Stage Renal Disease Patients
07/31/1996 - 06/30/2001 (Dept Sponsor)
NIH/National Diabetes & Digestive & Kidney Diseases
5 K08 DK02453 05

Detection of Anti- Fabrazyme Antiboty in Kidney Biopsy Sample
06/21/2018 - 06/21/2021 (PI)
Genzyme Corp

Research Training in Nephrology
07/01/2015 - 06/30/2020 (PI)

Role of PLA2R and Anti-PLA2R in Idiopathic Membranous Nephropathy
09/01/2011 - 07/31/2017 (PI)
5R01 DK090029-05

Alnylam Sponsored Research Agreement
05/07/2014 - 05/31/2016 (PI)
Alnylam Pharmaceuticals

Efficacy of Targeted Complement Regulatory Proteins in Experimental Membranous Nephropathy
01/01/2013 - 11/30/2015 (PI)
Alexion Pharmaceuticals

Research Training in Nephrology
07/01/2010 - 06/30/2015 (PI)

Anti-PLA2R Immunoreactivity
05/18/2009 - 05/31/2013 (PI)
Questcor Pharmaceuticals, Inc.

Podocyte-specific human PLA2R transgenic mouse model of membranous nephropathy
07/02/2010 - 06/30/2012 (PI)
1R21 AI090238-02

Antibody Mediated Glomerular Injury
03/01/2006 - 12/31/2011 (PI)
5R01 DK030932-26

Research Training in Nephrology
07/01/2005 - 06/30/2010 (PI)
5 T32 DK007053-36

Showing 10 of 20 results. Show All Results

Yr Title Project-Sub Proj Pubs
2016 Research Training in Nephrology 5T32DK007053-43 27
2015 Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy 5R01DK090029-05 14
2015 Research Training in Nephrology 2T32DK007053-42 27
2014 Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy 5R01DK090029-04 14
2014 Research Training in Nephrology 5T32DK007053-41 27
2014 Research Training in Nephrology 5T32DK007053-41 27
2013 Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy 5R01DK090029-03 14
2013 Research Training in Nephrology 5T32DK007053-40 27
2012 Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy 5R01DK090029-02 14
2012 Research Training in Nephrology 5T32DK007053-39 27
Showing 10 of 67 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Salant DJ. Unmet challenges in membranous nephropathy. Curr Opin Nephrol Hypertens. 2019 Jan; 28(1):70-76. PMID: 30451735.
  2. Kasinath V, Yilmam OA, Uehara M, Jiang L, Ordikhani F, Li X, Salant DJ, Abdi R. Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis. Kidney Int. 2019 Feb; 95(2):310-320. PMID: 30522766.
  3. Beck LH, Salant DJ. Deep pockets are not necessarily a good thing in membranous nephropathy: evidence for a modifier allele. Kidney Int. 2018 11; 94(5):855-857.View Related Profiles. PMID: 30348302.
  4. Estrada CC, Paladugu P, Guo Y, Pace J, Revelo MP, Salant DJ, Shankland SJ, D'Agati VD, Mehrotra A, Cardona S, Bialkowska AB, Yang VW, He JC, Mallipattu SK. Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation. JCI Insight. 2018 Jun 21; 3(12). PMID: 29925693; DOI: 10.1172/jci.insight.98214;.
  5. Caster DJ, Korte EA, Tan M, Barati MT, Tandon S, Creed TM, Salant DJ, Hata JL, Epstein PN, Huang H, Powell DW, McLeish KR. Neutrophil exocytosis induces podocyte cytoskeletal reorganization and proteinuria in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2018 Sep 01; 315(3):F595-F606. PMID: 29790391.
  6. Kolachalama VB, Singh P, Lin CQ, Mun D, Belghasem ME, Henderson JM, Francis JM, Salant DJ, Chitalia VC. Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks. Kidney Int Rep. 2018 Mar; 3(2):464-475.View Related Profiles. PMID: 29725651.
  7. Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH. LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease. J Am Soc Nephrol. 2018 Feb; 29(2):644-653.View Related Profiles. PMID: 29074737.
  8. Korte EA, Caster DJ, Barati MT, Tan M, Zheng S, Berthier CC, Brosius FC, Vieyra MB, Sheehan RM, Kosiewicz M, Wysoczynski M, Gaffney PM, Salant DJ, McLeish KR, Powell DW. ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation. Am J Pathol. 2017 Dec; 187(12):2799-2810. PMID: 28935578.
  9. Al-Rabadi L, Quillen K, Shashar M, Al Marji C, Jaberi A, Chitalia V, Henderson J, Salant D, Beck LH. Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. Kidney Int Rep. 2018 Mar; 3(2):476-481.View Related Profiles. PMID: 29725652.
  10. Dai Y, Chen A, Liu R, Gu L, Sharma S, Cai W, Salem F, Salant DJ, Pippin JW, Shankland SJ, Moeller MJ, Ghyselinck NB, Ding X, Chuang PY, Lee K, He JC. Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor a. Kidney Int. 2017 Dec; 92(6):1444-1457. PMID: 28756872.
Showing 10 of 162 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 143 publications over 38 distinct years, with a maximum of 8 publications in 1998

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Kidney disease
Kidney stones
Membranous nephropathy
Nephrotic syndrome
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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