David Salant | Profiles RNS

David J. Salant, MB BCh

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Nephrology

MBBCh, University of the Witwatersrand

Websites

	Renal Section Faculty
	Boston Medical Center Provider Profile
	Google Scholar
	ResearchGate

ORCID : 0000-0002-3866-3120

Salant is Professor of Medicine and Vice-Chair for Research. He received his medical degree from University of the Witwatersrand in South Africa and completed his clinical training at Johannesburg General Hospital. He received his research training at Boston University with Dr. William G. Couser and joined BU’s nephrology faculty in 1979. Dr. Salant is an internationally renowned physician-scientist and an acclaimed educator. His research primarily explores the immune basis for glomerular diseases and the mechanisms of podocyte injury. He was among the first to identify podocytes as the primary target of injury in antibody-mediated glomerular diseases. In a landmark New England Journal of Medicine paper in 2009, Drs. Salant, Beck and colleagues described their discovery of the target antigen in membranous nephropathy and showed that a high proportion of MN patients have circulating autoantibodies to the phospholipase A2 receptor on human podocytes. Dr. Salant is a past chairman of the ABIM Sub-specialty Board of Examiners in Nephrology, and recipient of several national and international awards for his scientific contributions, including election to the American Society of Clinical Investigation and the Association of American Physicians, an Established Investigator Award from the American Heart Association, the John P. Peters Award from the American Society of Nephrology, the Jean Hamburger Award from the International Society of Nephrology, the Donald W. Seldin Award from the National Kidney Foundation, the Marilyn Farquhar Award at the 11th Annual Podocyte Conference and the Edward N. Gibbs Award and Lectureship from the New York Academy Sciences.

Research Expertise

Experimental models of immunological glomerular diseases and autoimmunity resembling those seen in man are used to obtain a fundamental understanding of the immunopathogenetic mechanisms of injury.

Antibody-mediated podocyte injury:
The primary focus of the Salant laboratory is on the immune basis of glomerular diseases with particular regard to the humoral mechanisms of glomerular cell injury. Current work will elucidate the mechanisms by which antibodies alter the function and morphology of glomerular visceral epithelial cells (podocytes).
1. We have identified the target antigen in human membranous nephropathy as the phospholipase A2 receptor (PLA2R) and shown that about 75% of patients have circulating ant-PLA2R autoantibodies. Current work is directed at defining the mechanisms of podocyte injury induced by anti-PLA2R using a combination of in vitro, in vivo and human genetic techniques. Additional studies will explore the role of anti-PLA2R in the development of recurrent membranous nephropathy post renal transplantation.
2. Ongoing interests include the role of podocyte-specific antibodies, and the effects of complement-mediated injury on podocyte structure, composition of the filtration slit diaphragm and its attachment to the cytoskeleton, and on cell-matrix adhesion using animal models, cell biological and immunochemical methodologies.

Mechanisms of post-inflammatory renal fibrogenesis:
We have also developed a murine model of antibody-dependent rapidly progressive glomerulonephritis in which necrotizing and crescentic glomerulonephritis is associated with the activation of chemokine and interstitial-type collagen genes, followed by the development of interstitial fibrosis and renal failure. Since interstitial fibrosis and tubular atrophy are common to all forms of chronic progressive renal diseases and are the most reliable pathological indicators of an adverse long-term prognosis in humans, this mouse model in which the onset of immune injury is rapidly followed (within 5 days) by the induction and proliferation of interstitial cells expressing high levels of mRNA for type I collagen affords a unique opportunity to study the mechanisms of post-inflammatory renal fibrogenesis

Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

Vice Chair
Boston University Chobanian & Avedisian School of Medicine
Medicine
Research Implementation

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Research Training in Nephrology
07/01/1975 - 06/30/2005 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 T32 DK07053 31

Case Mix Models for End Stage Renal Disease Patients
07/31/1996 - 06/30/2001 (Dept Sponsor)
NIH/National Diabetes & Digestive & Kidney Diseases
5 K08 DK02453 05

Mechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathies
09/14/2020 - 05/31/2024 (PI)
State University of New York at Stony Brook National Institutes
5R01DK121846-04

Detection of Anti- Fabrazyme Antiboty in Kidney Biopsy Sample
06/21/2018 - 09/30/2023 (PI)
Sanofi

Role of PLA2R and Anti-PLA2R in Idiopathic Membranous Nephropathy
09/01/2011 - 07/31/2017 (PI)
NIH-NIDDK
5R01 DK090029-05

Alnylam Sponsored Research Agreement
05/07/2014 - 05/31/2016 (PI)
Alnylam Pharmaceuticals

Efficacy of Targeted Complement Regulatory Proteins in Experimental Membranous Nephropathy
01/01/2013 - 11/30/2015 (PI)
Alexion Pharmaceuticals

Research Training in Nephrology
07/01/2010 - 06/30/2015 (PI)
NIH-NIDDK
5T32DK007053-41

Anti-PLA2R Immunoreactivity
05/18/2009 - 05/31/2013 (PI)
Questcor Pharmaceuticals, Inc.

Podocyte-specific human PLA2R transgenic mouse model of membranous nephropathy
07/02/2010 - 06/30/2012 (PI)
NIH-NIAID
1R21 AI090238-02

Antibody Mediated Glomerular Injury
03/01/2006 - 12/31/2011 (PI)
NIH-NIDDK
5R01 DK030932-26

Research Training in Nephrology
07/01/2005 - 06/30/2010 (PI)
NIH-NIDDK
5 T32 DK007053-36

Showing 10 of 20 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2016	Research Training in Nephrology	5T32DK007053-43	48
2015	Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy	5R01DK090029-05	18
2015	Research Training in Nephrology	2T32DK007053-42	48
2014	Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy	5R01DK090029-04	18
2014	Research Training in Nephrology	5T32DK007053-41	48
2013	Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy	5R01DK090029-03	18
2013	Research Training in Nephrology	5T32DK007053-40	48
2012	Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy	5R01DK090029-02	18
2012	Research Training in Nephrology	5T32DK007053-39	48
2011	Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy	1R01DK090029-01A1	18

Showing 10 of 66 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Liu F, Ryan ST, Fahnoe KC, Morgan JG, Cheung AE, Storek MJ, Best A, Chen HA, Locatelli M, Xu S, Schmidt E, Schmidt-Jiménez LF, Bieber K, Henderson JM, Lian CG, Verschoor A, Ludwig RJ, Benigni A, Remuzzi G, Salant DJ, Kalled SL, Thurman JM, Holers VM, Violette SM, Wawersik S. C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement. Mol Ther. 2024 Apr 03; 32(4):1061-1079.View Related Profiles.

Salant, David
Henderson, Joel

PMID: 38382529

Kistler AD, Salant DJ. Complement activation and effector pathways in membranous nephropathy. Kidney Int. 2024 Mar; 105(3):473-483. PMID: 38142037

Bronstein R, Pace J, Gowthaman Y, Salant DJ, Mallipattu SK. Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease. J Am Soc Nephrol. 2023 May 01; 34(5):737-750. PMID: 36800545; PMCID: PMC10125654; DOI: 10.1681/ASN.0000000000000104;

Kumar S, Fan X, Rasouly HM, Sharma R, Salant DJ, Lu W. ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis. JCI Insight. 2023 Jan 10; 8(1).View Related Profiles.

Salant, David
Kumar, Sudhir
Lu, Weining

PMID: 36445780; PMCID: PMC9870089; DOI: 10.1172/jci.insight.158418;

Pace JA, Bronstein R, Guo Y, Yang Y, Estrada CC, Gujarati N, Salant DJ, Haley J, Bialkowska AB, Yang VW, He JC, Mallipattu SK. Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney. Sci Adv. 2021 Sep 03; 7(36):eabg6600. PMID: 34516901; PMCID: PMC8442927; DOI: 10.1126/sciadv.abg6600;

Edwards A, Salant D, Benzing T. Insights into Glomerular Filtration and Albuminuria. Reply. N Engl J Med. 2021 07 29; 385(5):478.View Related Profiles.

Edwards, Aurelie
Salant, David

PMID: 34320302

Benzing T, Salant D. Insights into Glomerular Filtration and Albuminuria. N Engl J Med. 2021 Apr 15; 384(15):1437-1446. PMID: 33852781

Beck LH, Berasi SP, Copley JB, Gorman D, Levy DI, Lim CN, Henderson JM, Salant DJ, Lu W. PODO: Trial Design: Phase 2 Study of PF-06730512 in Focal Segmental Glomerulosclerosis. Kidney Int Rep. 2021 Jun; 6(6):1629-1633.View Related Profiles.

Levy, Daniel
Salant, David
Henderson, Joel
Beck, Laurence
Lu, Weining

PMID: 34169203; PMCID: PMC8207305; DOI: 10.1016/j.ekir.2021.03.892;

Haddad G, Lorenzen JM, Ma H, de Haan N, Seeger H, Zaghrini C, Brandt S, Kölling M, Wegmann U, Kiss B, Pál G, Gál P, Wüthrich RP, Wuhrer M, Beck LH, Salant DJ, Lambeau G, Kistler AD. Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy. J Clin Invest. 2021 03 01; 131(5).View Related Profiles.

Salant, David
Beck, Laurence

PMID: 33351779; PMCID: PMC7919733; DOI: 10.1172/JCI140453;

Braden GL, Chapman A, Ellison DH, Gadegbeku CA, Gurley SB, Igarashi P, Kelepouris E, Moxey-Mims MM, Okusa MD, Plumb TJ, Quaggin SE, Salant DJ, Segal MS, Shankland SJ, Somlo S. Advancing Nephrology: Division Leaders Advise ASN. Clin J Am Soc Nephrol. 2021 02 08; 16(2):319-327. PMID: 32792352; PMCID: PMC7863658; DOI: 10.2215/CJN.01550220;

Showing 10 of 177 results. Show More

Skopelja-Gardner S, Colonna L, Hermanson P, Sun X, Tanaka L, Tai J, Nguyen Y, Snyder JM, Alpers CE, Hudkins KL, Salant DJ, Peng Y, Elkon KB. Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury. J Immunol. 2020 05 15; 204(10):2627-2640. PMID: 32238460; PMCID: PMC7365257; DOI: 10.4049/jimmunol.1901473;

Pisarek-Horowitz A, Fan X, Kumar S, Rasouly HM, Sharma R, Chen H, Coser K, Bluette CT, Hirenallur-Shanthappa D, Anderson SR, Yang H, Beck LH, Bonegio RG, Henderson JM, Berasi SP, Salant DJ, Lu W. Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure. Am J Pathol. 2020 04; 190(4):799-816.View Related Profiles.

Pisarek-Horowitz, Anna Justyna
Salant, David
Chen, Hui
Henderson, Joel
Beck, Laurence
Bonegio, Ramon
Kumar, Sudhir
Lu, Weining
Fan, Xueping

PMID: 32220420; PMCID: PMC7217334; DOI: 10.1016/j.ajpath.2019.12.009;

Beck LH, Salant DJ. Refining Our Understanding of the PLA2R-Antibody Response in Primary Membranous Nephropathy: Looking Forward, Looking Back. J Am Soc Nephrol. 2020 01; 31(1):8-11.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 31871252; PMCID: PMC6935005; DOI: 10.1681/ASN.2019111195;

Salant DJ. Does Epitope Spreading Influence Responsiveness to Rituximab in PLA2R-Associated Membranous Nephropathy? Clin J Am Soc Nephrol. 2019 Aug 07; 14(8):1122-1124. PMID: 31340980; PMCID: PMC6682826; DOI: 10.2215/CJN.07300619;

Belghasem ME, A'amar O, Roth D, Walker J, Arinze N, Richards SM, Francis JM, Salant DJ, Chitalia VC, Bigio IJ. Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy. Sci Rep. 2019 05 09; 9(1):7168.View Related Profiles.

Roth, Daniel
Salant, David
Bigio, Irving
Francis, Jean
Walker, Joshua
Belghasem, Mostafa
Arinze , Nkiruka
Chitalia, Vipul

PMID: 31073168; PMCID: PMC6509114; DOI: 10.1038/s41598-019-43684-8;

Salant DJ. Unmet challenges in membranous nephropathy. Curr Opin Nephrol Hypertens. 2019 01; 28(1):70-76. PMID: 30451735; PMCID: PMC6289589; DOI: 10.1097/MNH.0000000000000459;

Kasinath V, Yilmam OA, Uehara M, Jiang L, Ordikhani F, Li X, Salant DJ, Abdi R. Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis. Kidney Int. 2019 02; 95(2):310-320. PMID: 30522766; PMCID: PMC6342621; DOI: 10.1016/j.kint.2018.08.040;

Beck LH, Salant DJ. Deep pockets are not necessarily a good thing in membranous nephropathy: evidence for a modifier allele. Kidney Int. 2018 11; 94(5):855-857.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 30348302

Estrada CC, Paladugu P, Guo Y, Pace J, Revelo MP, Salant DJ, Shankland SJ, D'Agati VD, Mehrotra A, Cardona S, Bialkowska AB, Yang VW, He JC, Mallipattu SK. Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation. JCI Insight. 2018 06 21; 3(12). PMID: 29925693; PMCID: PMC6124441; DOI: 10.1172/jci.insight.98214;

Caster DJ, Korte EA, Tan M, Barati MT, Tandon S, Creed TM, Salant DJ, Hata JL, Epstein PN, Huang H, Powell DW, McLeish KR. Neutrophil exocytosis induces podocyte cytoskeletal reorganization and proteinuria in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F595-F606. PMID: 29790391; PMCID: PMC6172569; DOI: 10.1152/ajprenal.00039.2018;

Kolachalama VB, Singh P, Lin CQ, Mun D, Belghasem ME, Henderson JM, Francis JM, Salant DJ, Chitalia VC. Association of Pathological Fibrosis With Renal Survival Using Deep Neural Networks. Kidney Int Rep. 2018 Mar; 3(2):464-475.View Related Profiles.

Salant, David
Francis, Jean
Henderson, Joel
Belghasem, Mostafa
Kolachalama, Vijaya
Chitalia, Vipul

PMID: 29725651; PMCID: PMC5932308; DOI: 10.1016/j.ekir.2017.11.002;

Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, Wilkey DW, Ambruzs JM, Messias NC, Cossey LN, Rosales IA, Wooldridge T, Walker PD, Colvin RB, Klein J, Salant DJ, Beck LH. LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease. J Am Soc Nephrol. 2018 02; 29(2):644-653.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 29074737; PMCID: PMC5791069; DOI: 10.1681/ASN.2017060664;

Korte EA, Caster DJ, Barati MT, Tan M, Zheng S, Berthier CC, Brosius FC, Vieyra MB, Sheehan RM, Kosiewicz M, Wysoczynski M, Gaffney PM, Salant DJ, McLeish KR, Powell DW. ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation. Am J Pathol. 2017 Dec; 187(12):2799-2810. PMID: 28935578; PMCID: PMC5718094; DOI: 10.1016/j.ajpath.2017.08.018;

Al-Rabadi L, Quillen K, Shashar M, Al Marji C, Jaberi A, Chitalia V, Henderson J, Salant D, Beck LH. Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. Kidney Int Rep. 2018 Mar; 3(2):476-481.View Related Profiles.

Jaberi, Aala
Salant, David
Henderson, Joel
Quillen, Karen
Beck, Laurence
Chitalia, Vipul

PMID: 29725652; PMCID: PMC5931958; DOI: 10.1016/j.ekir.2017.08.005;

Dai Y, Chen A, Liu R, Gu L, Sharma S, Cai W, Salem F, Salant DJ, Pippin JW, Shankland SJ, Moeller MJ, Ghyselinck NB, Ding X, Chuang PY, Lee K, He JC. Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor a. Kidney Int. 2017 Dec; 92(6):1444-1457. PMID: 28756872; PMCID: PMC5696080; DOI: 10.1016/j.kint.2017.04.026;

Gordon CE, Chitalia VC, Sloan JM, Salant DJ, Coleman DL, Quillen K, Ravid K, Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. Am J Kidney Dis. 2017 Nov; 70(5):715-721.View Related Profiles.

Gordon, Craig
Coleman, David
Salant, David
Sloan, J.
Francis, Jean
Quillen, Karen
Ravid, Katya
Chitalia, Vipul

PMID: 28720207

Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W. SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 11 17; 1(19):e86934.View Related Profiles.

Pisarek-Horowitz, Anna Justyna
Salant, David
Henderson, Joel
Tumelty, Kathleen
Belghasem, Mostafa
Chan, Stefanie
Kumar, Sudhir
Lu, Weining
Fan, Xueping

PMID: 27882344; PMCID: PMC5111509; DOI: 10.1172/jci.insight.86934;

Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki Y, Higashi Y, Salant DJ, Maas RL, Lu W. Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. Kidney Int. 2016 Dec; 90(6):1262-1273.View Related Profiles.

Pisarek-Horowitz, Anna Justyna
Salant, David
Chan, Stefanie
Kumar, Sudhir
Lu, Weining

PMID: 27591083; PMCID: PMC5123919; DOI: 10.1016/j.kint.2016.06.037;

Hoxha E, Beck LH, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA. An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. J Am Soc Nephrol. 2017 Feb; 28(2):520-531.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 27436855; PMCID: PMC5280014; DOI: 10.1681/ASN.2016010050;

Haas ME, Levenson AE, Sun X, Liao WH, Rutkowski JM, de Ferranti SD, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 05; 134(1):61-72. PMID: 27358438; PMCID: PMC5345853; DOI: 10.1161/CIRCULATIONAHA.115.020912;

Francis JM, Beck LH, Salant DJ. Membranous Nephropathy: A Journey From Bench to Bedside. Am J Kidney Dis. 2016 Jul; 68(1):138-47.View Related Profiles.

Salant, David
Francis, Jean
Beck, Laurence

PMID: 27085376; PMCID: PMC4921260; DOI: 10.1053/j.ajkd.2016.01.030;

Al-Rabadi L, Ayalon R, Bonegio RG, Ballard JE, Fujii AM, Henderson JM, Salant DJ, Beck LH. Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. Am J Kidney Dis. 2016 May; 67(5):775-8.View Related Profiles.

Fujii, Alan
Salant, David
Henderson, Joel
Beck, Laurence
Bonegio, Ramon
Ayalon, Rivka

PMID: 26744127; PMCID: PMC4837089; DOI: 10.1053/j.ajkd.2015.10.031;

Verma R, Venkatareddy M, Kalinowski A, Patel SR, Salant DJ, Garg P. Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury. Mol Cell Biol. 2016 Feb; 36(4):596-614. PMID: 26644409; PMCID: PMC4751697; DOI: 10.1128/MCB.00956-15;

Salant DJ. Podocyte Expression of B7-1/CD80: Is it a Reliable Biomarker for the Treatment of Proteinuric Kidney Diseases with Abatacept? J Am Soc Nephrol. 2016 Apr; 27(4):963-5. PMID: 26400567; PMCID: PMC4814196; DOI: 10.1681/ASN.2015080947;

Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J. IL-6 Trans-Signaling Drives Murine Crescentic GN. J Am Soc Nephrol. 2016 Jan; 27(1):132-42. PMID: 26041841; PMCID: PMC4696576; DOI: 10.1681/ASN.2014111147;

Kattah A, Ayalon R, Beck LH, Sethi S, Sandor DG, Cosio FG, Gandhi MJ, Lorenz EC, Salant DJ, Fervenza FC. Anti-phospholipase A2 receptor antibodies in recurrent membranous nephropathy. Am J Transplant. 2015 May; 15(5):1349-59.View Related Profiles.

Sandor, Dana
Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 25766759; PMCID: PMC4472303; DOI: 10.1111/ajt.13133;

Tomas NM, Beck LH, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RA, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11; 371(24):2277-87.View Related Profiles.

Salant, David
Ma, Hong
Beck, Laurence

PMID: 25394321; PMCID: PMC4278759; DOI: 10.1056/NEJMoa1409354;

Timmermans SA, Damoiseaux JG, Heerings-Rewinkel PT, Ayalon R, Beck LH, Schlumberger W, Salant DJ, van Paassen P, Tervaert JW. Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study. Am J Clin Pathol. 2014 Jul; 142(1):29-34.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 24926082; DOI: 10.1309/AJCP8QMOY5GLRSFP;

Beck LH, Salant DJ. Membranous nephropathy: from models to man. J Clin Invest. 2014 Jun 2; 124(6):2307-14.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 24892704; PMCID: PMC4089468; DOI: 10.1172/JCI72270;

Wiggins RC, Alpers CE, Holzman LB, He JC, Salant DJ, Chugh SS, Natarajan R, Trachtman H, Brasile L, Star RA, Rys-Sikora KE, Moxey-Mims MM, Flessner MF. Glomerular disease: looking beyond pathology. Clin J Am Soc Nephrol. 2014 Jun 6; 9(6):1138-40. PMID: 24700796; PMCID: PMC4046719; DOI: 10.2215/CJN.01450214;

Salant DJ. Introduction: Complement-mediated kidney diseases. Semin Nephrol. 2013 Nov; 33(6):477-8. PMID: 24161034; DOI: 10.1016/j.semnephrol.2013.08.010;

Timmermans SA, Ayalon R, van Paassen P, Beck LH, van Rie H, Wirtz JJ, Verseput GH, Frenken LA, Salant DJ, Cohen Tervaert JW. Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy. Am J Kidney Dis. 2013 Dec; 62(6):1223-5.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 24021909; DOI: 10.1053/j.ajkd.2013.07.019;

Dai Y, Gu L, Yuan W, Yu Q, Ni Z, Ross MJ, Kaufman L, Xiong H, Salant DJ, He JC, Chuang PY. Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis. Kidney Int. 2013 Nov; 84(5):950-61. PMID: 23842188; PMCID: PMC3797218; DOI: 10.1038/ki.2013.197;

Salant DJ. Genetic variants in membranous nephropathy: perhaps a perfect storm rather than a straightforward conformeropathy? J Am Soc Nephrol. 2013 Mar; 24(4):525-8. PMID: 23492731; DOI: 10.1681/ASN.2013020166;

Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W. Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26; 2(1):52-61.View Related Profiles.

Pisarek-Horowitz, Anna Justyna
Salant, David
Bonegio, Ramon
Lu, Weining
Fan, Xueping

PMID: 22840396; PMCID: PMC3627357; DOI: 10.1016/j.celrep.2012.06.002;

Khosroshahi A, Ayalon R, Beck LH, Salant DJ, Bloch DB, Stone JH. IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor. Int J Rheumatol. 2012; 2012:139409.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 22654915; PMCID: PMC3357948; DOI: 10.1155/2012/139409;

Surindran S, Ayalon R, Hasan N, Beck LH, Salant DJ, Barisoni L, Skolnik EY, Beara-Lasic L. Coexistence of ANCA-associated glomerulonephritis and anti-phospholipase A(2) receptor antibody-positive membranous nephropathy. Clin Kidney J. 2012 Apr; 5(2):162-165.View Related Profiles.

Salant, David
Beck, Laurence
Ayalon, Rivka

PMID: 22833809; PMCID: PMC3341840; DOI: 10.1093/ckj/sfr149;

George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb 1; 122(2):674-92. PMID: 22251701; PMCID: PMC3266791; DOI: 10.1172/JCI60070;

Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med. 2011 Oct; 17(10):1242-50. PMID: 21946538; PMCID: PMC3198052; DOI: 10.1038/nm.2491;

Wang H, Li Q, Liu J, Mendelsohn C, Salant DJ, Lu W. Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism. PLoS One. 2011; 6(9):e24763.View Related Profiles.

Salant, David
Lu, Weining

PMID: 21949750; PMCID: PMC3176762; DOI: 10.1371/journal.pone.0024763;

Beck LH, Fervenza FC, Beck DM, Bonegio RG, Malik FA, Erickson SB, Cosio FG, Cattran DC, Salant DJ. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol. 2011 Aug; 22(8):1543-50.View Related Profiles.

Salant, David
Beck, Laurence
Bonegio, Ramon

PMID: 21784898; PMCID: PMC3148709; DOI: 10.1681/ASN.2010111125;

Cravedi P, Abbate M, Gagliardini E, Galbusera M, Buelli S, Sabadini E, Marasà M, Beck LH, Salant DJ, Benigni A, D'Agati V, Remuzzi G. Membranous nephropathy associated with IgG4-related disease. Am J Kidney Dis. 2011 Aug; 58(2):272-5.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 21658826; DOI: 10.1053/j.ajkd.2011.05.002;

Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol. 2011 Jun; 22(6):1137-43.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 21566055; PMCID: PMC3103733; DOI: 10.1681/ASN.2010090967;

Hofstra JM, Beck LH, Beck DM, Wetzels JF, Salant DJ. Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol. 2011 Jun; 6(6):1286-91.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 21474589; PMCID: PMC3109923; DOI: 10.2215/CJN.07210810;

Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ. The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May; 79(10):1099-112.View Related Profiles.

Salant, David
Beck, Laurence
Bonegio, Ramon
Lu, Weining

PMID: 21270765; PMCID: PMC5033618; DOI: 10.1038/ki.2010.553;

Salant DJ. Targeting complement C5 in atypical hemolytic uremic syndrome. J Am Soc Nephrol. 2011 Jan; 22(1):7-9. PMID: 21127140; DOI: 10.1681/ASN.2010111145;

Salant DJ. Goodpasture's disease--new secrets revealed. N Engl J Med. 2010 Jul 22; 363(4):388-91. PMID: 20660408; DOI: 10.1056/NEJMe1006301;

Klein J, Gonzalez J, Decramer S, Bandin F, Neau E, Salant DJ, Heeringa P, Pesquero JB, Schanstra JP, Bascands JL. Blockade of the kinin B1 receptor ameloriates glomerulonephritis. J Am Soc Nephrol. 2010 Jul; 21(7):1157-64. PMID: 20448019; PMCID: PMC3152233; DOI: 10.1681/ASN.2009090887;

Bechtel W, McGoohan S, Zeisberg EM, Müller GA, Kalbacher H, Salant DJ, Müller CA, Kalluri R, Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med. 2010 May; 16(5):544-50. PMID: 20418885; PMCID: PMC3106179; DOI: 10.1038/nm.2135;

Beck LH, Salant DJ. Membranous nephropathy: recent travels and new roads ahead. Kidney Int. 2010 May; 77(9):765-70.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 20182413; DOI: 10.1038/ki.2010.34;

Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009 Jul 2; 361(1):11-21.View Related Profiles.

Salant, David
Beck, Laurence
Bonegio, Ramon

PMID: 19571279; PMCID: PMC2762083; DOI: 10.1056/NEJMoa0810457;

Salant DJ. In search of the elusive membranous nephropathy antigen. Nephron Physiol. 2009; 112(1):p11-2. PMID: 19451724; DOI: 10.1159/000212068;

Beck LH, Salant DJ. Treatment of membranous lupus nephritis: where are we now? J Am Soc Nephrol. 2009 Apr; 20(4):690-1.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 19279123; DOI: 10.1681/ASN.2009020216;

Beck LH, Salant DJ. Glomerular and tubulointerstitial diseases. Prim Care. 2008 Jun; 35(2):265-96, vi.View Related Profiles.

Salant, David
Beck, Laurence

PMID: 18486716; DOI: 10.1016/j.pop.2008.01.002;

Pradère JP, Gonzalez J, Klein J, Valet P, Grès S, Salant D, Bascands JL, Saulnier-Blache JS, Schanstra JP. Lysophosphatidic acid and renal fibrosis. Biochim Biophys Acta. 2008 Sep; 1781(9):582-7. PMID: 18455518; PMCID: PMC2577601; DOI: 10.1016/j.bbalip.2008.04.001;

Salant DJ. Intravenous methylprednisolone or plasma exchange for adjunctive therapy of severe renal vasculitis? Nat Clin Pract Nephrol. 2008 Jan; 4(1):14-5. PMID: 17955040

Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep; 18(9):2447-56. PMID: 17675665; PMCID: PMC4853920; DOI: 10.1681/ASN.2007030356;

Imai N, Hishikawa K, Marumo T, Hirahashi J, Inowa T, Matsuzaki Y, Okano H, Kitamura T, Salant D, Fujita T. Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. Stem Cells. 2007 Oct; 25(10):2469-75. PMID: 17641247

Salant DJ, Sanchorawala V, D'Agati VD. A case of atypical light chain deposition disease--diagnosis and treatment. Clin J Am Soc Nephrol. 2007 Jul; 2(4):858-67.View Related Profiles.

Salant, David
Sanchorawala, Vaishali

PMID: 17699503

Sumi E, Iehara N, Akiyama H, Matsubara T, Mima A, Kanamori H, Fukatsu A, Salant DJ, Kita T, Arai H, Doi T. SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells. Am J Pathol. 2007 Jun; 170(6):1854-64. PMID: 17525254; PMCID: PMC1899455; DOI: 10.2353/ajpath.2007.060899;

Meyers CM, Geanacopoulos M, Holzman LB, Salant DJ. Glomerular disease workshop. J Am Soc Nephrol. 2005 Dec; 16(12):3472-6. PMID: 16267152

Cybulsky AV, Quigg RJ, Salant DJ. Experimental membranous nephropathy redux. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F660-71. PMID: 16159900; PMCID: PMC1325222; DOI: 10.1152/ajprenal.00437.2004;

Nakatsue T, Koike H, Han GD, Suzuki K, Miyauchi N, Yuan H, Salant DJ, Gejyo F, Shimizu F, Kawachi H. Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy. Kidney Int. 2005 Jun; 67(6):2239-53. PMID: 15882266

Bonegio RG, Fuhro R, Wang Z, Valeri CR, Andry C, Salant DJ, Lieberthal W. Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy. J Am Soc Nephrol. 2005 Jul; 16(7):2063-72.View Related Profiles.

Andry, Christopher
Salant, David
Bonegio, Ramon
Wang, Zhiyong

PMID: 15917339

Appel GB, Cook HT, Hageman G, Jennette JC, Kashgarian M, Kirschfink M, Lambris JD, Lanning L, Lutz HU, Meri S, Rose NR, Salant DJ, Sethi S, Smith RJ, Smoyer W, Tully HF, Tully SP, Walker P, Welsh M, Würzner R, Zipfel PF. Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. J Am Soc Nephrol. 2005 May; 16(5):1392-403. PMID: 15800116

Trouw LA, Groeneveld TW, Seelen MA, Duijs JM, Bajema IM, Prins FA, Kishore U, Salant DJ, Verbeek JS, van Kooten C, Daha MR. Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. J Clin Invest. 2004 Sep; 114(5):679-88. PMID: 15343386; PMCID: PMC514584

Lin F, Salant DJ, Meyerson H, Emancipator S, Morgan BP, Medof ME. Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis. J Immunol. 2004 Feb 15; 172(4):2636-42. PMID: 14764738

Saran AM, Yuan H, Takeuchi E, McLaughlin M, Salant DJ. Complement mediates nephrin redistribution and actin dissociation in experimental membranous nephropathy. Kidney Int. 2003 Dec; 64(6):2072-8. PMID: 14633129

Adler SG, Salant DJ. An outline of essential topics in glomerular pathophysiology, diagnosis, and treatment for nephrology trainees. Am J Kidney Dis. 2003 Aug; 42(2):395-418. PMID: 12900827

Salant DJ, Topham PS. Role of nephrin in proteinuric renal diseases. Springer Semin Immunopathol. 2003 May; 24(4):423-39. PMID: 12778337

Yanagita M, Ishimoto Y, Arai H, Nagai K, Ito T, Nakano T, Salant DJ, Fukatsu A, Doi T, Kita T. Essential role of Gas6 for glomerular injury in nephrotoxic nephritis. J Clin Invest. 2002 Jul; 110(2):239-46. PMID: 12122116; PMCID: PMC151046

Lin F, Emancipator SN, Salant DJ, Medof ME. Decay-accelerating factor confers protection against complement-mediated podocyte injury in acute nephrotoxic nephritis. Lab Invest. 2002 May; 82(5):563-9. PMID: 12003997

Shinozaki M, Hirahashi J, Lebedeva T, Liew FY, Salant DJ, Maron R, Kelley VR. IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis. J Clin Invest. 2002 Apr; 109(7):951-60. PMID: 11927622; PMCID: PMC150930

Yuan H, Takeuchi E, Taylor GA, McLaughlin M, Brown D, Salant DJ. Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy. J Am Soc Nephrol. 2002 Apr; 13(4):946-56.View Related Profiles.

Salant, David
Yuan, Huaiping

PMID: 11912254

Yuan H, Takeuchi E, Salant DJ. Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F585-91.View Related Profiles.

Salant, David
Yuan, Huaiping

PMID: 11880318

Haskell CA, Hancock WW, Salant DJ, Gao W, Csizmadia V, Peters W, Faia K, Fituri O, Rottman JB, Charo IF. Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection. J Clin Invest. 2001 Sep; 108(5):679-88. PMID: 11544273; PMCID: PMC209384

Chugh S, Yuan H, Topham PS, Haydar SA, Mittal V, Taylor GA, Kalluri R, Salant DJ. Aminopeptidase A: a nephritogenic target antigen of nephrotoxic serum. Kidney Int. 2001 Feb; 59(2):601-13. PMID: 11168941

Kawachi H, Koike H, Kurihara H, Yaoita E, Orikasa M, Shia MA, Sakai T, Yamamoto T, Salant DJ, Shimizu F. Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states. Kidney Int. 2000 May; 57(5):1949-61. PMID: 10792613

Topham PS, Kawachi H, Haydar SA, Chugh S, Addona TA, Charron KB, Holzman LB, Shia M, Shimizu F, Salant DJ. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin. J Clin Invest. 1999 Dec; 104(11):1559-66. PMID: 10587519; PMCID: PMC409863

Topham PS, Csizmadia V, Soler D, Hines D, Gerard CJ, Salant DJ, Hancock WW. Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J Clin Invest. 1999 Dec; 104(11):1549-57. PMID: 10587518; PMCID: PMC409862

Topham PS, Haydar SA, Kuphal R, Lightfoot JD, Salant DJ. Complement-mediated injury reversibly disrupts glomerular epithelial cell actin microfilaments and focal adhesions. Kidney Int. 1999 May; 55(5):1763-75. PMID: 10231439

Salant DJ. ANCA: fuel for the fire or the spark that ignites the flame? Kidney Int. 1999 Mar; 55(3):1125-7. PMID: 10027954

Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Seldin, David
Salant, David
Landesman, Esther
Rifkin, Ian

PMID: 9820486

Reddy S, Salant DJ. Treatment of acute interstitial nephritis. Ren Fail. 1998 Nov; 20(6):829-38. PMID: 9834981

Hébert MJ, Takano T, Papayianni A, Rennke HG, Minto A, Salant DJ, Carroll MC, Brady HR. Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria. Nephrol Dial Transplant. 1998 Nov; 13(11):2799-803. PMID: 9829481

Schiller B, He C, Salant DJ, Lim A, Alexander JJ, Quigg RJ. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. J Exp Med. 1998 Oct 5; 188(7):1353-8. PMID: 9763614; PMCID: PMC2212493

Bailey E, Harper SJ, Pringle JH, Baker F, Furness PN, Salant DJ, Feehally J. Visceral glomerular epithelial cell DNA synthesis in experimental and human membranous disease. Exp Nephrol. 1998 Jul-Aug; 6(4):352-8. PMID: 9690098

Quigg RJ, Kozono Y, Berthiaume D, Lim A, Salant DJ, Weinfeld A, Griffin P, Kremmer E, Holers VM. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor. J Immunol. 1998 May 1; 160(9):4553-60. PMID: 9574562

Minto AW, Kalluri R, Togawa M, Bergijk EC, Killen PD, Salant DJ. Augmented expression of glomerular basement membrane specific type IV collagen isoforms (alpha3-alpha5) in experimental membranous nephropathy. Proc Assoc Am Physicians. 1998 May-Jun; 110(3):207-17. PMID: 9625527

Lu CY, Salant DJ. Renal immunology and pathology. Curr Opin Nephrol Hypertens. 1998 May; 7(3):279-80. PMID: 9617558

Kawachi H, Kurihara H, Topham PS, Brown D, Shia MA, Orikasa M, Shimizu F, Salant DJ. Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes. Am J Physiol. 1997 Dec; 273(6 Pt 2):F984-93. PMID: 9435688

Lloyd CM, Dorf ME, Proudfoot A, Salant DJ, Gutierrez-Ramos JC. Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis. J Leukoc Biol. 1997 Nov; 62(5):676-80. PMID: 9365123

Budde K, Neumayer HH, Salant DJ, Cybulsky AV, Coleman DL, Sterzel RB. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney Int. 1997 Sep; 52(3):733-41.View Related Profiles.

Coleman, David
Salant, David

PMID: 9291194

Lloyd CM, Gonzalo JA, Salant DJ, Just J, Gutierrez-Ramos JC. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest. 1997 Sep 1; 100(5):963-71. PMID: 9276713; PMCID: PMC508271

Obrador GT, Price B, O'Meara Y, Salant DJ. Acute renal failure due to lymphomatous infiltration of the kidneys. J Am Soc Nephrol. 1997 Aug; 8(8):1348-54. PMID: 9259365

Kumar R, Alpern R, Berl T, Blantz R, Chevalier R, Hostetter T, Madias N, Salant D, Wiggins R, Bennett W, Chapman A, Ekonyan G, Falk R, Gennari FJ, Helderman JH, Hruska K, Levey A, Lindheimer M, Miller R, Nissenson A, Schwab S, Schwab T, Schwartz R, Wilcox C. Nephrology core curriculum. The American Society of Nephrology and the American Society of Nephrology Training Program Directors Committee. J Am Soc Nephrol. 1997 Jun; 8(6):1018-27. PMID: 9189871

Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ, Gutierrez-Ramos JC. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med. 1997 Apr 7; 185(7):1371-80. PMID: 9104823; PMCID: PMC2196251

Goldstein DJ, Wheeler DC, Salant DJ. Effects of omega-3 fatty acids on complement-mediated glomerular epithelial cell injury. Kidney Int. 1996 Dec; 50(6):1863-71. PMID: 8943468

Coers W, Reivinen J, Miettinen A, Huitema S, Vos JT, Salant DJ, Weening JJ. Characterization of a rat glomerular visceral epithelial cell line. Exp Nephrol. 1996 May-Jun; 4(3):184-92. PMID: 8773481

Goldstein DJ, Wheeler DC, Sandstrom DJ, Kawachi H, Salant DJ. Fish oil ameliorates renal injury and hyperlipidemia in the Milan normotensive rat model of focal glomerulosclerosis. J Am Soc Nephrol. 1995 Nov; 6(5):1468-75. PMID: 8589325

Kawachi H, Abrahamson DR, St John PL, Goldstein DJ, Shia MA, Matsui K, Shimizu F, Salant DJ. Developmental expression of the nephritogenic antigen of monoclonal antibody 5-1-6. Am J Pathol. 1995 Sep; 147(3):823-33. PMID: 7677194; PMCID: PMC1870958

Panka DJ, Salant DJ, Jacobson BA, Minto AW, Marshak-Rothstein A. The effect of VH residues 6 and 23 on IgG3 cryoprecipitation and glomerular deposition. Eur J Immunol. 1995 Jan; 25(1):279-84.View Related Profiles.

Marshak-Rothstein, Ann
Salant, David

PMID: 7843244

Salant DJ. The structural biology of glomerular epithelial cells in proteinuric diseases. Curr Opin Nephrol Hypertens. 1994 Nov; 3(6):569-74. PMID: 7881977

O'Meara YM, Feehally J, Salant DJ. The nephritogenic immune response. Curr Opin Nephrol Hypertens. 1994 May; 3(3):318-28. PMID: 7922259

Weise WJ, Natori Y, Levine JS, O'Meara YM, Minto AW, Manning EC, Goldstein DJ, Abrahamson DR, Salant DJ. Fish oil has protective and therapeutic effects on proteinuria in passive Heymann nephritis. Kidney Int. 1993 Feb; 43(2):359-68. PMID: 8441231

Minto AW, Fogel MA, Natori Y, O'Meara YM, Abrahamson DR, Smith B, Salant DJ. Expression of type I collagen mRNA in glomeruli of rats with passive Heymann nephritis. Kidney Int. 1993 Jan; 43(1):121-7.View Related Profiles.

Smith, Barbara
Salant, David

PMID: 8433551

O'Meara YM, Salant DJ. Management of glomerular diseases of primary and secondary origin. Curr Opin Nephrol Hypertens. 1992 Oct; 1(1):124-32. PMID: 1365824

Coers W, Huitema S, Smeenk RJ, Salant DJ, Grond J, Weening JJ. Quantification of glomerular epithelial cell adhesion by using anti-DNA antibodies in ELISA. Hybridoma. 1992 Aug; 11(4):529-37. PMID: 1398686

O'Meara YM, Natori Y, Minto AW, Goldstein DJ, Manning EC, Salant DJ. Nephrotoxic antiserum identifies a beta 1-integrin on rat glomerular epithelial cells. Am J Physiol. 1992 Jun; 262(6 Pt 2):F1083-91. PMID: 1377874

Cybulsky AV, Salant DJ. Glomerular cell injury and proteinuria. Lab Invest. 1992 May; 66(5):652-3. PMID: 1573858

Natori Y, O'Meara YM, Manning EC, Minto AW, Levine JS, Weise WJ, Salant DJ. Production and polarized secretion of basement membrane components by glomerular epithelial cells. Am J Physiol. 1992 Jan; 262(1 Pt 2):F131-7. PMID: 1733289

Quigg RJ, Cybulsky AV, Salant DJ. Effect of nephritogenic antibody on complement regulation in cultured rat glomerular epithelial cells. J Immunol. 1991 Aug 1; 147(3):838-45. PMID: 1861077

Fogel MA, Boyd CD, Leardkamolkarn V, Abrahamson DR, Minto AW, Salant DJ. Glomerular basement membrane expansion in passive Heymann nephritis. Absence of increased synthesis of type IV collagen, laminin, or fibronectin. Am J Pathol. 1991 Feb; 138(2):465-75. PMID: 1992771; PMCID: PMC1886206

Cybulsky AV, Bonventre JV, Quigg RJ, Lieberthal W, Salant DJ. Cytosolic calcium and protein kinase C reduce complement-mediated glomerular epithelial injury. Kidney Int. 1990 Nov; 38(5):803-11. PMID: 2266662

Cybulsky AV, Bonventre JV, Quigg RJ, Wolfe LS, Salant DJ. Extracellular matrix regulates proliferation and phospholipid turnover in glomerular epithelial cells. Am J Physiol. 1990 Aug; 259(2 Pt 2):F326-37. PMID: 2386208

Leardkamolkarn V, Salant DJ, Abrahamson DR. Loss and rearrangement of glomerular basement membrane laminin during acute nephrotoxic nephritis in the rat. Am J Pathol. 1990 Jul; 137(1):187-98. PMID: 2196815; PMCID: PMC1877696

Cybulsky AV, Salant DJ, Quigg RJ, Badalamenti J, Bonventre JV. Complement C5b-9 complex activates phospholipases in glomerular epithelial cells. Am J Physiol. 1989 Nov; 257(5 Pt 2):F826-36. PMID: 2511764

Quigg RJ, Abrahamson DR, Cybulsky AV, Badalamenti J, Minto AW, Salant DJ. Studies with antibodies to cultured rat glomerular epithelial cells. Subepithelial immune deposit formation after in vivo injection. Am J Pathol. 1989 May; 134(5):1125-33. PMID: 2655461; PMCID: PMC1879902

Salant DJ, Quigg RJ, Cybulsky AV. Heymann nephritis: mechanisms of renal injury. Kidney Int. 1989 Apr; 35(4):976-84. PMID: 2651774

Quigg RJ, Nicholson-Weller A, Cybulsky AV, Badalamenti J, Salant DJ. Decay accelerating factor regulates complement activation on glomerular epithelial cells. J Immunol. 1989 Feb 1; 142(3):877-82. PMID: 2464030

Quigg RJ, Cybulsky AV, Jacobs JB, Salant DJ. Anti-Fx1A produces complement-dependent cytotoxicity of glomerular epithelial cells. Kidney Int. 1988 Jul; 34(1):43-52. PMID: 3172636

Yared A, Miyazawa H, Purkerson ML, Klahr S, Salant DJ, Ichikawa I. Effect of diet, age and sex on the renal response to immune injury in the rat. Kidney Int. 1988 Feb; 33(2):561-70. PMID: 3361756

Salant DJ, Cybulsky AV. Experimental glomerulonephritis. Methods Enzymol. 1988; 162:421-61. PMID: 3265756

Cybulsky AV, Quigg RJ, Badalamenti J, Salant DJ. Anti-Fx1A induces association of Heymann nephritis antigens with microfilaments of cultured glomerular visceral epithelial cells. Am J Pathol. 1987 Nov; 129(2):373-84. PMID: 3674205; PMCID: PMC1899723

Yoshioka T, Rennke HG, Salant DJ, Deen WM, Ichikawa I. Role of abnormally high transmural pressure in the permselectivity defect of glomerular capillary wall: a study in early passive Heymann nephritis. Circ Res. 1987 Oct; 61(4):531-8. PMID: 2443267

Salant DJ. Immunopathogenesis of crescentic glomerulonephritis and lung purpura. Kidney Int. 1987 Sep; 32(3):408-25. PMID: 3312762

Cybulsky AV, Lieberthal W, Quigg RJ, Rennke HG, Salant DJ. A role for thromboxane in complement-mediated glomerular injury. Am J Pathol. 1987 Jul; 128(1):45-51. PMID: 3111267; PMCID: PMC1899789

Cybulsky AV, Quigg RJ, Salant DJ. The membrane attack complex in complement-mediated glomerular epithelial cell injury: formation and stability of C5b-9 and C5b-7 in rat membranous nephropathy. J Immunol. 1986 Sep 1; 137(5):1511-6. PMID: 3745914

Salant DJ, Cybulsky AV, Feintzeig ID. Quantitation of exogenous and endogenous components of glomerular immune deposits. Kidney Int. 1986 Aug; 30(2):255-63. PMID: 3531679

Feintzeig ID, Abrahamson DR, Cybulsky AV, Dittmer JE, Salant DJ. Nephritogenic potential of sheep antibodies against glomerular basement membrane laminin in the rat. Lab Invest. 1986 May; 54(5):531-42. PMID: 3517487

Cybulsky AV, Rennke HG, Feintzeig ID, Salant DJ. Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest. 1986 Apr; 77(4):1096-107. PMID: 3514672; PMCID: PMC424443

Madaio MP, Adler S, Groggel GC, Couser WG, Salant DJ. Charge selective properties of the glomerular capillary wall influence antibody binding in rat membranous nephropathy. Clin Immunol Immunopathol. 1986 Apr; 39(1):131-8. PMID: 3485021

Feintzeig ID, Dittmer JE, Cybulsky AV, Salant DJ. Antibody, antigen, and glomerular capillary wall charge interactions: influence of antigen location on in situ immune complex formation. Kidney Int. 1986 Mar; 29(3):649-57. PMID: 3517458

Couser WG, Darby C, Salant DJ, Adler S, Stilmant MM, Lowenstein LM. Anti-GBM antibody-induced proteinuria in isolated perfused rat kidney. Am J Physiol. 1985 Aug; 249(2 Pt 2):F241-50. PMID: 3161341

Salant DJ, Adler S, Darby C, Capparell NJ, Groggel GC, Feintzeig ID, Rennke HG, Dittmer JE. Influence of antigen distribution on the mediation of immunological glomerular injury. Kidney Int. 1985 Jun; 27(6):938-50. PMID: 3894765

Groggel GC, Salant DJ, Darby C, Rennke HG, Couser WG. Role of terminal complement pathway in the heterologous phase of antiglomerular basement membrane nephritis. Kidney Int. 1985 Apr; 27(4):643-51. PMID: 4010151

Weinberg MS, Quigg RJ, Salant DJ, Bernard DB. Anuric renal failure precipitated by indomethacin and triamterene. Nephron. 1985; 40(2):216-8. PMID: 4000350

Madaio MP, Salant DJ, Adler S, Darby C, Couser WG. Effect of antibody charge and concentration on deposition of antibody to glomerular basement membrane. Kidney Int. 1984 Oct; 26(4):397-403. PMID: 6527470

Groggel GC, Adler S, Rennke HG, Couser WG, Salant DJ. Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit. J Clin Invest. 1983 Dec; 72(6):1948-57. PMID: 6227634; PMCID: PMC437035

Adler S, Salant DJ, Dittmer JE, Rennke HG, Madaio MP, Couser WG. Mediation of proteinuria in membranous nephropathy due to a planted glomerular antigen. Kidney Int. 1983 Jun; 23(6):807-15. PMID: 6224959

Madaio MP, Salant DJ, Cohen AJ, Adler S, Couser WG. Comparative study of in situ immune deposit formation in active and passive Heymann nephritis. Kidney Int. 1983 Mar; 23(3):498-505. PMID: 6221142

Couser WG, Salant DJ, Adler S, Madaio MP. Studies of experimental membranous nephropathy. Transplant Proc. 1982 Sep; 14(3):474-81. PMID: 6217598

Couser WG, Salant DJ, Madaio MP, Adler S, Groggel GC. Factors influencing glomerular and tubulointerstitial patterns of injury in SLE. Am J Kidney Dis. 1982 Jul; 2(1 Suppl 1):126-34. PMID: 6213148

Neale TJ, Couser WG, Salant DJ, Lowenstein LM, Wilson CB. Specific uptake of Heymann's nephritic kidney eluate by rat kidney: studies in vivo and in isolated perfused kidneys. Lab Invest. 1982 Apr; 46(4):450-3. PMID: 7040800

Salant DJ, Madaio MP, Adler S, Stilmant MM, Couser WG. Altered glomerular permeability induced by F(ab')2 and Fab' antibodies to rat renal tubular epithelial antigen. Kidney Int. 1982 Jan; 21(1):36-43. PMID: 7043051

Salant DJ, Belok S, Madaio MP, Couser WG. A new role for complement in experimental membranous nephropathy in rats. J Clin Invest. 1980 Dec; 66(6):1339-50. PMID: 7440718; PMCID: PMC371620

Salant DJ, Darby C, Couser WG. Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. J Clin Invest. 1980 Jul; 66(1):71-81. PMID: 7400310; PMCID: PMC371507

Couser WG, Salant DJ. In situ immune complex formation and glomerular injury. Kidney Int. 1980 Jan; 17(1):1-13. PMID: 6990087

Couser WG, Salant DJ, Stilmant MM, Arbeit LA, Darby C, Sliogeris VG. The effects of aminonucleoside of puromycin and nephrotoxic serum on subepithelial immune-deposit formation in passive Heymann nephritis. J Lab Clin Med. 1979 Dec; 94(6):917-32. PMID: 501213

Salant DJ, Belok S, Stilmant MM, Darby C, Couser WG. Determinants of glomerular localization of subepithelial immune deposits: effects of altered antigen to antibody ratio, steroids, vasoactive amine antagonists, and aminonucleoside of puromycin on passive Heymann nephritis in rats. Lab Invest. 1979 Jul; 41(1):89-99. PMID: 376941

Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM. Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest. 1978 Dec; 62(6):1275-87. PMID: 372233; PMCID: PMC371893

Abrahams C, Furman KI, Salant D. Dermal micro-angiopathy in patients with analgesic nephropathy. S Afr Med J. 1978 Sep 2; 54(10):393-6. PMID: 734548

Abrahams C, Furman KI, Salant D. Analgesic abuse and microvascular changes. Am Heart J. 1978 Feb; 95(2):268-9. PMID: 622962

Gomperts ED, Zucker M, Feesey M, Russel D, Salant D, Joffe BI, Mendelsohn D, Seftel H. Antithrombin functional activity after a fatty meal in normal subjects, familial hyperlipidemia, and nephrotic syndrome. J Lab Clin Med. 1977 Sep; 90(3):529-35. PMID: 578151

Kaye V, Stark JH, Salant DJ, Katz J. Evaluation of 125I-DNA for detecting anti-DNA antibodies in the diagnosis of systemic lupus erythematosus. S Afr Med J. 1977 Apr 23; 51(17):577-80. PMID: 68546

Salant DJ, Glover AM, Anderson R, Meyers AM, Rabkin R, Myburgh JA, Rabson AR. Depressed neutrophil chemotaxis in patients with chronic renal failure and after renal transplantation. J Lab Clin Med. 1976 Oct; 88(4):536-45. PMID: 787456

Gomperts ED, Judelman JJ, Hockley J, Mindel A, Goldberg RB, Meyers AM, Salant DJ, Joffe BI, Myburgh JA, Seftel HC. Coagulation studies in long-term survivors after renal allograft transplantation. S Afr Med J. 1976 Jul 31; 50(33):1284-7. PMID: 785621

Goldberg RB, Judelman JJ, Mindel A, Meyers AM, Salant DJ, Myburgh JA, Rabkin R, Joffe BI, Seftel HC. Hyperlipidaemia in renal transplant patients. S Afr Med J. 1976 Jul 31; 50(33):1291-4. PMID: 785623

Botha JR, Myburgh JA, Smit JA, Maier G, Shapiro M, Milne FJ, Salant DJ, Meyers AM. Cross-matching assays of cell-mediated immunity for transplant patients. S Afr Med J. 1976 Jul 31; 50(33):1275-8. PMID: 785619

Levine E, Meyers AM, Salant DJ, Myburgh JA, Milne FJ, Botha JR, Goldberg B. Angiography after renal homotransplantation. S Afr Med J. 1976 Jul 31; 50(33):1295-8. PMID: 785624

Salant DJ, Marcus RG, Milne FJ, Meyers AM, Botha JR, Myburgh JA. Pregnancy in renal transplant recipients. S Afr Med J. 1976 Jul 31; 50(33):1288-90. PMID: 785622

Meyers A, Salant D, Rabkin R, Milne J, Botha R, Myburgh J. Lymphocoeles in renal homograft recipients. Proc Eur Dial Transplant Assoc. 1976; 12:452-60. PMID: 778837

Salant DJ, Glover AM, Anderson R, Meyers AM, Rabkin R, Myburgh JA, Rabson AR. Polymorphonuclear leucocyte function in chronic renal failure and after renal transplantation. Proc Eur Dial Transplant Assoc. 1976; 12:370-9. PMID: 778831

Salant DJ, Rabkin R. An unusual hormonal cause of hypertension and hypokalaemia. S Afr Med J. 1975 Aug 30; 49(37):1525-6. PMID: 1162532

Caro I, Salant DJ. Chronic meningococcaemia. Report of a case. S Afr Med J. 1974 Oct 19; 48(51):2154-6. PMID: 4428298

Caro I and Salant DJ. Chronic meningococcaemia: Report of a case. S Afr Med J. 1974; 48:2154-2156.

Bramwell-Jones DM, Pocock WA, Salant DJ, Barlow JB. Isolated tricuspid bacterial endocarditis resulting in severe tricuspid insufficiency. Chest. 1972 Dec; 62(6):749-52. PMID: 4635429

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 158 publications over 42 distinct years, with a maximum of 8 publications in 1998

Bar chart showing 158 publications over 42 distinct years, with a maximum of 8 publications in 1998

Year	Publications
1980	3
1982	4
1983	3
1984	1
1985	4
1986	6
1987	4
1988	3
1989	4
1990	3
1991	2
1992	5
1993	2
1994	2
1995	3
1996	2
1997	7
1998	8
1999	4
2000	1
2001	2
2002	5
2003	3
2004	2
2005	5
2007	5
2008	2
2009	3
2010	5
2011	7
2012	4
2013	4
2014	4
2015	5
2016	5
2017	5
2018	5
2019	4
2020	3
2021	5
2023	3
2024	1

Media Mentions

Weining Lu, Kidney Researcher, Named BU Innovator of the Year

BU Today 11/14/2019

2018-2018 New York Academy Sciences: Edward N. Gibbs Lectureship and Award

2016-2016 11th International Podocyte Conference: Marilyn Farquhar Award

2015-2015 National Kidney Foundation: Donald W. Seldin Award

2015-2015 American Association for the Advancement of Science: Fellow

2015-2015 Boston University: Innovator of the Year

2013-2013 International Society of Nephrology: Jean Hamburger Award

2013-2013 American Society of Nephrology: John P. Peters Award

2011-2011 International Society of Nephrology: Donald Seldin Plenary Lecture at the World Congress of Nephrology, Vancouver, BC.

1995-1995 American Association of Physicians: Elected

1987-1987 American Society for Clinical Investigation: Elected

1985-1990 American Heart Association: Established Investigator Award

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Kidney disease
Glomerulonephritis
Proteinuria
Lupus
Kidney stones
Membranous nephropathy
Nephrotic syndrome
Autoimmunity

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