Darren J. Chiu, MD
Postdoctoral Associate
Boston University Chobanian & Avedisian School of Medicine
Computational Biomedicine

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ORCID ORCID Icon : 0000-0002-0183-6139



Darren Chiu, of the Mazzilli Lab, transitioned from Research Technician to Bioinformatics Analyst. Before joining the lab, Darren completed his master’s degree in Immunology at Harvard University, where his research focused on discovering non-coding functional single nucleotide polymorphisms (SNPs) associated with autoimmune diseases and investigating the regulatory mechanism of each SNP on gene expression.

His research and technical projects in the lab previously focused on studying lung pre-cancer, including characterizing the impact of carcinogens on lung epithelium and developing methods for single nuclei sequencing. The other focus of his research was to develop single nuclei isolation protocol for airway brushes and small lung tissue samples. He also developed a protocol to treat cells with carcinogens associated with tobacco cigarettes, the known cause of lung cancer.

Fascinated by the capability of bioinformatics/computational analysis to decipher the biological messages hidden in the samples generated, he decided to pursue an opportunity to learn more computational skills. The current focus of his new role is working with single nuclei and bulk transcriptomics data from lung cancer patient samples to gain biological insights about the cell types and states that drive lung cancer development and pathogenesis. He is also involved in analysis of the targeted B-cell receptor sequencing data to explore the role of B cells in premalignant lung lesions.


The Spatial B Cell Landscape in Lung Squamous Premalignant Lesions
12/01/2023 - 11/30/2025 (PI)
Lung Cancer Research Foundation




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Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kim T, Martínez-Bonet M, Wang Q, Hackert N, Sparks JA, Baglaenko Y, Koh B, Darbousset R, Laza-Briviesca R, Chen X, Aguiar VRC, Chiu DJ, Westra HJ, Gutierrez-Arcelus M, Weirauch MT, Raychaudhuri S, Rao DA, Nigrovic PA. Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development. Nat Commun. 2024 Mar 09; 15(1):2150. PMID: 38459032; PMCID: PMC10923805; DOI: 10.1038/s41467-024-46457-8;
     
  2. Wang Q, Martínez-Bonet M, Kim T, Sparks JA, Ishigaki K, Chen X, Sudman M, Aguiar V, Sim S, Hernandez MC, Chiu DJ, Wactor A, Wauford B, Marion MC, Gutierrez-Arcelus M, Bowes J, Eyre S, Nordal E, Prahalad S, Rygg M, Videm V, Raychaudhuri S, Weirauch MT, Langefeld CD, Thompson SD, Nigrovic PA. Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant. Cell Genom. 2024 Feb 14; 4(2):100502. PMID: 38359789; PMCID: PMC10879129; DOI: 10.1016/j.xgen.2024.100502;
     
  3. Wang Q, Martínez-Bonet M, Kim T, Sparks JA, Ishigaki K, Chen X, Sudman M, Aguiar V, Sim S, Hernandez MC, Chiu DJ, Wactor A, Wauford B, Marion MC, Gutierrez-Arcelus M, Bowes J, Eyre S, Nordal E, Prahalad S, Rygg M, Videm V, Raychaudhuri S, Weirauch MT, Langefeld CD, Thompson SD, Nigrovic PA. Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant. Cell Genom. 2023 Nov 08; 3(11):100420. PMID: 38020975; PMCID: PMC10667332; DOI: 10.1016/j.xgen.2023.100420;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 3 publications over 2 distinct years, with a maximum of 2 publications in 2024

YearPublications
20231
20242

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