Christopher V. Gabel, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Harvard University




Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Associate Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Modulation of Cellular Metabolism to Maximize Neuronal Regeneration
07/17/2019 - 06/30/2021 (PI)
Comm. of Mass./Department of Public Health


Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage and Regeneration
05/01/2016 - 04/30/2020 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS077929-05

Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage
05/01/2013 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS077929-03

C. elegans model for mammalian lesion-conditioned axon regeneration
09/01/2012 - 08/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R21NS078580-02

Wedge-based approach for simultaneous multi-channel microscopy
10/01/2014 - 07/31/2015 (Subcontract PI)
Physical Sciences, Inc. NIH NIGMS
1R43GM112403-01



Title

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Wirak GS, Gabel CV, Connor CW. Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics. Anesthesiology. 2020 09; 133(3):569-582.View Related Profiles. PMID: 32452864
     
  2. Awal MR, Wirak GS, Gabel CV, Connor CW. Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia. Anesthesiology. 2020 07; 133(1):133-144.View Related Profiles. PMID: 32282426
     
  3. Song W, Matlock A, Fu S, Qin X, Feng H, Gabel CV, Tian L, Yi J. LED array reflectance microscopy for scattering-based multi-contrast imaging. Opt Lett. 2020 Apr 01; 45(7):1647-1650. PMID: 32235964
     
  4. Harreguy MB, Marfil V, Grooms NWF, Gabel CV, Chung SH, Haspel G. Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons. Sci Rep. 2020 03 11; 10(1):4545. PMID: 32161333
     
  5. Cai H, Wang YL, Wainner RT, Iftimia NV, Gabel CV, Chung SH. Wedge prism approach for simultaneous multichannel microscopy. Sci Rep. 2019 11 28; 9(1):17795.View Related Profiles. PMID: 31780755
     
  6. Wang G, Sun L, Reina CP, Song I, Gabel CV, Driscoll M. CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis. Sci Rep. 2019 09 16; 9(1):13315. PMID: 31527664
     
  7. Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422.View Related Profiles. PMID: 31017899
     
  8. Awal MR, Austin D, Florman J, Alkema M, Gabel CV, Connor CW. Breakdown of Neural Function under Isoflurane Anesthesia: In Vivo, Multineuronal Imaging in Caenorhabditis elegans. Anesthesiology. 2018 10; 129(4):733-743.View Related Profiles. PMID: 30004907
     
  9. Taub DG, Awal MR, Gabel CV. O-GlcNAc Signaling Orchestrates the Regenerative Response to Neuronal Injury in Caenorhabditis elegans. Cell Rep. 2018 08 21; 24(8):1931-1938.e3.View Related Profiles. PMID: 30134155
     
  10. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2017 05 03; 94(3):689. PMID: 28472662
     
Showing 10 of 38 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 38 publications over 16 distinct years, with a maximum of 4 publications in 2007 and 2013 and 2020

YearPublications
20032
20041
20063
20074
20082
20102
20111
20122
20134
20142
20152
20162
20172
20182
20193
20204
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

C. elegans
Femtosecond laser ablation
neuronal damage
neuronal regeneration
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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