Christopher V. Gabel, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Harvard University

Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Associate Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics

Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage and Regeneration
05/01/2016 - 04/30/2018 (PI)
NIH/National Institute of Neurological D

Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage
05/01/2013 - 04/30/2016 (PI)
NIH/National Institute of Neurological D

C. elegans model for mammalian lesion-conditioned axon regeneration
09/01/2012 - 08/31/2015 (PI)
NIH/National Institute of Neurological D

Wedge-based approach for simultaneous multi-channel microscopy
10/01/2014 - 07/31/2015 (PI)
Physical Sciences, Inc. NIH NIGMS

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2017 May 03; 94(3):689. PMID: 28472662.
  2. Melentijevic I, Toth ML, Arnold ML, Guasp RJ, Harinath G, Nguyen KC, Taub D, Parker JA, Neri C, Gabel CV, Hall DH, Driscoll M. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature. 2017 02 16; 542(7641):367-371.View Related Profiles. PMID: 28178240; DOI: 10.1038/nature21362;.
  3. Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21; 92(6):1294-1307. PMID: 28009275; DOI: 10.1016/j.neuron.2016.10.060;.
  4. Chung SH, Awal MR, Shay J, McLoed MM, Mazur E, Gabel CV. Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):E2852-60.View Related Profiles. PMID: 27078101; PMCID: PMC4878464; DOI: 10.1073/pnas.1600564113;.
  5. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18; 88(4):704-19.View Related Profiles. PMID: 26526391; DOI: 10.1016/j.neuron.2015.10.005;.
  6. He S, Philbrook A, McWhirter R, Gabel CV, Taub DG, Carter MH, Hanna IM, Francis MM, Miller DM. Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein. Curr Biol. 2015 Oct 5; 25(19):2541-8.View Related Profiles. PMID: 26387713; PMCID: PMC4596794; DOI: 10.1016/j.cub.2015.08.022;.
  7. Sun L, Shay J, McLoed M, Roodhouse K, Chung SH, Clark CM, Pirri JK, Alkema MJ, Gabel CV. Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation. J Neurosci. 2014 Nov 26; 34(48):15947-56.View Related Profiles. PMID: 25429136; PMCID: PMC4244466; DOI: 10.1523/JNEUROSCI.4238-13.2014;.
  8. Gruner M, Nelson D, Winbush A, Hintz R, Ryu L, Chung SH, Kim K, Gabel CV, van der Linden AM. Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs. PLoS Genet. 2014 Oct; 10(10):e1004707.View Related Profiles. PMID: 25357003; PMCID: PMC4214617; DOI: 10.1371/journal.pgen.1004707;.
  9. Chung SH, Schmalz A, Ruiz RC, Gabel CV, Mazur E. Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development. Cell Rep. 2013 Jul 25; 4(2):316-26.View Related Profiles. PMID: 23871668; DOI: 10.1016/j.celrep.2013.06.027;.
  10. Chung SH, Sun L, Gabel CV. In vivo neuronal calcium imaging in C. elegans. J Vis Exp. 2013; (74).View Related Profiles. PMID: 23603812; DOI: 10.3791/50357;.
Showing 10 of 29 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 13 distinct years, with a maximum of 4 publications in 2007 and 2013

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

C. elegans
Femtosecond laser ablation
neuronal damage
neuronal regeneration
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72 E. Concord St Instructional (L)
Boston MA 02118
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