Christopher V. Gabel, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, Harvard University
BA, Princeton University

Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Comprehensive Multi-Neuron Imaging of Neurodegeneration in C. elegans
06/01/2023 - 05/31/2026 (PI)
Alzheimer's Association

Modulation of Cellular Metabolism to Maximize Neuronal Regeneration
07/17/2019 - 06/30/2024 (PI)
Comm. of Mass./Department of Public Health

Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage and Regeneration
05/01/2016 - 04/30/2020 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage
05/01/2013 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke

C. elegans model for mammalian lesion-conditioned axon regeneration
09/01/2012 - 08/31/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke

Wedge-based approach for simultaneous multi-channel microscopy
10/01/2014 - 07/31/2015 (Subcontract PI)
Physical Sciences, Inc. NIH NIGMS


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Yadav DK, Chang AC, Grooms NWF, Chung SH, Gabel CV. O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans. Elife. 2024 Feb 09; 13.View Related Profiles. PMID: 38334260; PMCID: PMC10857789; DOI: 10.7554/eLife.86478;
  2. Chang AS, Wirak GS, Li D, Gabel CV, Connor CW. Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System. Anesthesiology. 2023 Jul 01; 139(1):49-62.View Related Profiles. PMID: 37027802; PMCID: PMC10266588; DOI: 10.1097/ALN.0000000000004579;
  3. Wirak GS, Florman J, Alkema MJ, Connor CW, Gabel CV. Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans. Elife. 2022 Jun 15; 11.View Related Profiles. PMID: 35703498; PMCID: PMC9273219; DOI: 10.7554/eLife.72135;
  4. Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997.View Related Profiles. PMID: 33654671; PMCID: PMC7829172; DOI: 10.21037/qims-20-806;
  5. Wirak GS, Gabel CV, Connor CW. Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics. Anesthesiology. 2020 09; 133(3):569-582.View Related Profiles. PMID: 32452864; PMCID: PMC7429306; DOI: 10.1097/ALN.0000000000003335;
  6. Awal MR, Wirak GS, Gabel CV, Connor CW. Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia. Anesthesiology. 2020 07; 133(1):133-144.View Related Profiles. PMID: 32282426; PMCID: PMC7577177; DOI: 10.1097/ALN.0000000000003304;
  7. Song W, Matlock A, Fu S, Qin X, Feng H, Gabel CV, Tian L, Yi J. LED array reflectance microscopy for scattering-based multi-contrast imaging. Opt Lett. 2020 Apr 01; 45(7):1647-1650.View Related Profiles. PMID: 32235964; PMCID: PMC7278208; DOI: 10.1364/OL.387434;
  8. Harreguy MB, Marfil V, Grooms NWF, Gabel CV, Chung SH, Haspel G. Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons. Sci Rep. 2020 03 11; 10(1):4545. PMID: 32161333; PMCID: PMC7066168; DOI: 10.1038/s41598-020-61479-0;
  9. Cai H, Wang YL, Wainner RT, Iftimia NV, Gabel CV, Chung SH. Wedge prism approach for simultaneous multichannel microscopy. Sci Rep. 2019 11 28; 9(1):17795.View Related Profiles. PMID: 31780755; PMCID: PMC6882912; DOI: 10.1038/s41598-019-53581-9;
  10. Wang G, Sun L, Reina CP, Song I, Gabel CV, Driscoll M. CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis. Sci Rep. 2019 09 16; 9(1):13315. PMID: 31527664; PMCID: PMC6746752; DOI: 10.1038/s41598-019-49633-9;
Showing 10 of 43 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 43 publications over 20 distinct years, with a maximum of 4 publications in 2007 and 2013 and 2019 and 2020

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

C. elegans
Femtosecond laser ablation
neuronal damage
neuronal regeneration
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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