Catherine Spina

Resident

Columbia New York Presbyterian

Radiation Oncology

Websites

	CUMC Dept. of Radiation Oncology
	LinkedIn

Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Molecular and Translational Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Valencia Lozano I, Buss E, Spina CS, Horowitz DP, Kachnic LA, Price M, Wang YF, Munbodh R. Quantification and dosimetric impact of intra-fractional bladder changes during CBCT-guided online adaptive radiotherapy for pelvic cancer treatments. J Appl Clin Med Phys. 2025 Jun; 26(6):e70074. PMID: 40114528; PMCID: PMC12148773; DOI: 10.1002/acm2.70074;

Horowitz DP, Wang YF, Lee A, Riegel AC, Pasetsky J, Elliston C, Spina C, Deutsch I, Ghiassi-Nejad Z, Yuan Y, Price M, Kachnic LA. Practical Approach to Computed Tomography Guided Online Adaptive Radiation Therapy for Abdominopelvic Tumors. Pract Radiat Oncol. 2025; 15(5):e444-e450. PMID: 40049229

Ager CR, Obradovic A, McCann P, Chaimowitz M, Wang ALE, Shaikh N, Shah P, Pan S, Laplaca CJ, Virk RK, Hill JC, Jugler C, DeFranco G, Bhattacharya N, Scher HI, DeCastro GJ, Anderson CB, McKiernan JM, Spina CS, Stein MN, Runcie K, Drake CG, Califano A, Dallos MC. Neoadjuvant androgen deprivation therapy with or without Fc-enhanced non-fucosylated anti-CTLA-4 (BMS-986218) in high risk localized prostate cancer: a randomized phase 1 trial. medRxiv. 2024 Sep 11. PMID: 39314954; PMCID: PMC11419205; DOI: 10.1101/2024.09.09.24313308;

Rayn K, Deutsch I, Jeffers B, Lee A, Lavrova E, Gallitto M, Mayeda M, Hwang M, Yu J, Spina C, Koutcher L. Multiparametric MRI as a Predictor of PSA Response in Patients Undergoing Stereotactic Body Radiation Therapy for Prostate Cancer. Adv Radiat Oncol. 2024 Mar; 9(3):101408. PMID: 38304110; PMCID: PMC10831170; DOI: 10.1016/j.adro.2023.101408;

Wang YF, Price MJ, Elliston CD, Munbodh R, Spina CS, Horowitz DP, Kachnic LA. Enhancing Safety in AI-Driven Cone Beam CT-based Online Adaptive Radiation Therapy: Development and Implementation of an Interdisciplinary Workflow. Adv Radiat Oncol. 2024 Mar; 9(3):101399. PMID: 38292890; PMCID: PMC10823112; DOI: 10.1016/j.adro.2023.101399;

Ager CR, Zhang M, Chaimowitz M, Bansal S, Tagore S, Obradovic A, Jugler C, Rogava M, Melms JC, McCann P, Spina C, Drake CG, Dallos MC, Izar B. KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. J Immunother Cancer. 2023 Sep; 11(9). PMID: 37657842; PMCID: PMC10476134; DOI: 10.1136/jitc-2023-006782;

Chen L, Shi V, Wang S, Sun L, Freeman R, Yang J, Inkman MJ, Ghosh S, Ruiz F, Jayachandran K, Huang Y, Luo J, Zhang J, Cosper P, Luke CJ, Spina CS, Grigsby PW, Schwarz JK, Markovina S. SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production. J Clin Invest. 2023 Aug 01; 133(15). PMID: 37279067; PMCID: PMC10378164; DOI: 10.1172/JCI163841;

Spina CS, DeLaney TF. The Significance of a Pathologic Complete Response in Patients With Soft Tissue Sarcoma. JAMA Oncol. 2023 May 01; 9(5):619-621. PMID: 36995719

Chen L, Shi V, Wang S, Freeman R, Ruiz F, Jayachandran K, Zhang J, Cosper P, Sun L, Luke CJ, Spina C, Grigsby PW, Schwarz JK, Markovina S. SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses. bioRxiv. 2023 Feb 03. PMID: 36778224

Ager CR, Zhang M, Chaimowitz M, Bansal S, Obradovic A, Rogava M, Melms JC, McCann P, Spina C, Drake CG, Dallos MC, Izar B. KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response. bioRxiv. 2023 Jan 02. PMID: 36711647; PMCID: PMC9881861; DOI: 10.1101/2023.01.01.522340;

Showing 10 of 33 results. Show More

Alì A, Leibowitz D, Bhatt N, Doubrovin M, Spina CS, Bates-Pappas GE, Taub RN, McKiernan JM, Mintz A, Molotkov A. Preliminary efficacy of [90Y]DOTA-biotin-avidin radiotherapy against non-muscle invasive bladder cancer. Eur J Nucl Med Mol Imaging. 2023 Feb; 50(3):692-700. PMID: 36350400

Spina CS, Drake CG. Mechanisms of Immune Modulation by Radiation. Semin Radiat Oncol. 2021 07; 31(3):205-216. PMID: 34090647

Hwang ME, Mayeda M, Shaish H, Elliston CD, Spina CS, Wenske S, Deutsch I. Dosimetric feasibility of neurovascular bundle-sparing stereotactic body radiotherapy with periprostatic hydrogel spacer for localized prostate cancer to preserve erectile function. Br J Radiol. 2021 Mar 01; 94(1119):20200433. PMID: 33586999; PMCID: PMC8011244; DOI: 10.1259/bjr.20200433;

Bender DA, Heilbroner SP, Wang TJC, Shu CA, Hyde B, Spina C, Cheng SK. Increased rates of immunosuppressive treatment and hospitalization after checkpoint inhibitor therapy in cancer patients with autoimmune disease. J Immunother Cancer. 2020 12; 8(2). PMID: 33303578; PMCID: PMC7733208; DOI: 10.1136/jitc-2020-001627;

Spina CS, Tsuruoka C, Mao W, Sunaoshi MM, Chaimowitz M, Shang Y, Welch D, Wang YF, Venturini N, Kakinuma S, Drake CG. Differential Immune Modulation With Carbon-Ion Versus Photon Therapy. Int J Radiat Oncol Biol Phys. 2021 03 01; 109(3):813-818. PMID: 33190969

Aggen DH, Ager CR, Obradovic AZ, Chowdhury N, Ghasemzadeh A, Mao W, Chaimowitz MG, Lopez-Bujanda ZA, Spina CS, Hawley JE, Dallos MC, Zhang C, Wang V, Li H, Guo XV, Drake CG. Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses. Clin Cancer Res. 2021 01 15; 27(2):608-621. PMID: 33148676; PMCID: PMC7980495; DOI: 10.1158/1078-0432.CCR-20-1610;

Hwang ME, Mayeda M, Liz M, Goode-Marshall B, Gonzalez L, Elliston CD, Spina CS, Padilla OA, Wenske S, Deutsch I. Stereotactic body radiotherapy with periprostatic hydrogel spacer for localized prostate cancer: toxicity profile and early oncologic outcomes. Radiat Oncol. 2019 Aug 02; 14(1):136. PMID: 31375119; PMCID: PMC6679492; DOI: 10.1186/s13014-019-1346-5;

Spina CS, Drake CG. Combined local and systemic attacks. Nat Biomed Eng. 2018 08; 2(8):564-565. PMID: 31015639

Black PJ, Smith DR, Chaudhary K, Xanthopoulos EP, Chin C, Spina CS, Hwang ME, Mayeda M, Wang YF, Connolly EP, Wang TJC, Wuu CS, Hei TK, Cheng SK, Wu CC. Velocity-based Adaptive Registration and Fusion for Fractionated Stereotactic Radiosurgery Using the Small Animal Radiation Research Platform. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):841-847. PMID: 29891199; PMCID: PMC6202197; DOI: 10.1016/j.ijrobp.2018.04.067;

Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016 Jul 14; 535(7611):246-51. PMID: 27383785; PMCID: PMC4947006; DOI: 10.1038/nature18632;

Torisawa YS, Spina CS, Mammoto T, Mammoto A, Weaver JC, Tat T, Collins JJ, Ingber DE. Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. Nat Methods. 2014 Jun; 11(6):663-9. PMID: 24793454; DOI: 10.1038/nmeth.2938;

Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014 May 1; 28(9):971-82. PMID: 24732380; PMCID: PMC4018495; DOI: 10.1101/gad.237149.113;

Jasuja R, Costello JC, Singh R, Gupta V, Spina CS, Toraldo G, Jang H, Li H, Serra C, Guo W, Chauhan P, Narula NS, Guarneri T, Ergun A, Travison TG, Collins JJ, Bhasin S. Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy. Aging Cell. 2014 Apr; 13(2):303-10.View Related Profiles.

Spina, Catherine
Toraldo, Gianluca
Jang, Hyeran
Bhasin, Shalender
Travison, Thomas

PMID: 24305501; PMCID: PMC4331775; DOI: 10.1111/acel.12174;

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013 Jul 3; 5(192):192ra85.View Related Profiles.

Spina, Catherine
Liesa Roig, Marc
Shirihai, Orian

PMID: 23825301; PMCID: PMC3760005; DOI: 10.1126/scitranslmed.3006055;

Morones-Ramirez JR, Winkler JA, Spina CS, Collins JJ. Silver enhances antibiotic activity against gram-negative bacteria. Sci Transl Med. 2013 Jun 19; 5(190):190ra81. PMID: 23785037; PMCID: PMC3771099; DOI: 10.1126/scitranslmed.3006276;

Modi SR, Lee HH, Spina CS, Collins JJ. Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature. 2013 Jul 11; 499(7457):219-22. PMID: 23748443; PMCID: PMC3710538; DOI: 10.1038/nature12212;

Brynildsen MP, Winkler JA, Spina CS, MacDonald IC, Collins JJ. Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production. Nat Biotechnol. 2013 Feb; 31(2):160-5. PMID: 23292609; PMCID: PMC3568245; DOI: 10.1038/nbt.2458;

Spina CS, Ton L, Yao M, Maehr H, Wolfe MM, Uskokovic M, Adorini L, Holick MF. Selective vitamin D receptor modulators and their effects on colorectal tumor growth. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):757-62.View Related Profiles.

Spina, Catherine
Wolfe, M.
Holick, Michael
Yao, Min

PMID: 17368190

Maehr H, Uskokovic M, Adorini L, Penna G, Mariani R, Panina P, Passini N, Bono E, Perego S, Biffi M, Holick M, Spina C, Suh N. Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):277-81.View Related Profiles.

Spina, Catherine
Holick, Michael

PMID: 17254779

Spina CS, Tangpricha V, Uskokovic M, Adorinic L, Maehr H, Holick MF. Vitamin D and cancer. Anticancer Res. 2006 Jul-Aug; 26(4A):2515-24.View Related Profiles.

Spina, Catherine
Holick, Michael

PMID: 16886659

Tangpricha V, Spina C, Yao M, Chen TC, Wolfe MM, Holick MF. Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice. J Nutr. 2005 Oct; 135(10):2350-4.View Related Profiles.

Spina, Catherine
Holick, Michael
Chen, Tai

PMID: 16177194

Spina C, Tangpricha V, Yao M, Zhou W, Wolfe MM, Maehr H, Uskokovic M, Adorini L, Holick MF. Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs. J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):111-20.View Related Profiles.

Spina, Catherine
Wolfe, M.
Holick, Michael
Yao, Min

PMID: 16154354

Tangpricha V, Turner A, Spina C, Decastro S, Chen TC, Holick MF. Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. Am J Clin Nutr. 2004 Dec; 80(6):1645-9.View Related Profiles.

Spina, Catherine
Holick, Michael
Chen, Tai

PMID: 15585781

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 15 distinct years, with a maximum of 7 publications in 2023

Bar chart showing 33 publications over 15 distinct years, with a maximum of 7 publications in 2023

Year	Publications
2004	1
2005	2
2006	1
2007	2
2013	5
2014	2
2016	1
2018	2
2019	1
2020	3
2021	2
2022	1
2023	7
2024	1
2025	2

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