Carlos S. Kase, MD
Emeritus Professor
Boston University School of Medicine
Dept of Neurology

MD, Pontificia Universidad Católica de Chile

Born in Buenos Aires, Argentina, Dr. Carlos Kase earned his MD degree in Santiago, Chile, from the Catholic University of Chile in May 1967. He pursued further training in Neurology and Vascular Neurology at Massachusetts General Hospital in Boston from 1972-1973, and 1977-1978. Dr. Kase is board-certified by the American Board of Psychiatry and Neurology in Neurology (1980) and also board-certified in the subspecialty of Vascular Neurology (2005).

Dr. Kase joined the Department of Neurology at Boston University School of Medicine in 1984, where he is currently Professor of Neurology and Neurologist-in-Chief, Boston Medical Center. Prior to this, he joined Dr. J.P. Mohr in forming the Neurology Department at the University of South Alabama in Mobile, Alabama in 1978.

Dr. Kase's professional and research interests are in cerebrovascular diseases, with a special interest in intracerebral hemorrhage, carotid artery disease and lacunar infarctions. He has been actively involved in performing clinical studies and clinico-pathologic correlations in intracerebral hemorrhage and cerebral infarction. His research activities have included participation in multicenter NIH-sponsored studies such as the Stroke Data Bank (NINCDS), the Warfarin Aspirin Recurrent Stroke Study (WARSS), the Warfarin vs. Aspirin for Symptomatic Intracranial Disease (WASID) Study, the Secondary Prevention of Small Subcortical Strokes (SPS3) study, and the Insulin Resistance Intervention after Stroke (IRIS) trial, as well as in a number of therapeutic clinical trials. In addition, Dr. Kase has participated in the Framingham Study since 1984, where he has led a number of important epidemiological studies on risk factors in stroke.

Dr. Kase has received numerous distinguished honors for his work in cerebrovascular disease, including Honorary Membership to the Spanish Society of Neurology and the Mexican Association of Cerebrovascular Disease. In 2001, he received the C. Miller Fisher Award for Excellence in Stroke, awarded by the American Stroke Association, Massachusetts Affiliate. In 2002 he was awarded the title of Doctor Honoris Causa from the Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

Dr. Kase was recognized as a "Top Doctor" in Neurology by Boston Magazine in 2009, 2010, 2011, 2012 and by U.S. News and World Report in 2011.

Active Staff Privileges
Boston Medical Center

Randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of desmoteplase in acute ischemic stroke
09/01/2009 - 12/31/2014 (PI)
Lundbeck, Inc.

A Phase 2, Randomized, Double Blind Placebo Controlled Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of PF-04360365 (Ponezumab)
10/21/2013 - 11/30/2014 (PI)
Pfizer, Inc.

Personnel Agreement for Research Services of Ethan Treglia
01/01/2011 - 09/30/2012 (PI)
VA Boston Healthcare System

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects with a History of Atherosclerotic D
05/01/2008 - 04/30/2012 (PI)
Schering-Plough Research Institute

12/01/2009 - 01/31/2012 (PI)
University of British Columbia NIH NINDS

PREDICT (Predicting hEmatoma growth anD outcome in Intracerebral hemorrhage using contrast bolus CT) study
11/01/2009 - 10/30/2010 (PI)
University of Calgary

PRoFESS- Prevention Regimen for Effectively Avoiding Second Strokes: A Double-Blind, Active and Placebo Controlled Study of Aggrenox vs. Clopidogrel and Aspirin, With and Without Micardis
09/01/2003 - 08/31/2007 (PI)
Boehringer Ingelheim Pharmaceuticals

DIAS 2: Desmoteplase (INN) In Acute Ischemic Stroke: Phase III
05/17/2005 - 12/31/2006 (PI)
Forest Laboratories, Inc./Forest Research Institute

Management of Atherothrombosis with Clopidogrel in High Risk Patients with Recent Transient Ischemic of Ischemic Stroke
09/01/2001 - 08/31/2003 (PI)
Parexel Sanofi Synthelabo

Epidemiologic Study of Acute Ischemic Stroke (ESIS)
09/22/2000 - 07/31/2003 (PI)
Genentech, Inc.

Showing 10 of 12 results. Show All Results

New England Regional Coordinating Center for the NINDS Stroke Trials Network
09/30/2013 - 07/31/2018 (PI)
Mass General Hosp NIH-NINDS

NIH StrokeNet Clinical Coordinating Center Master Trial Agreement (MTA) - Satellites
09/30/2013 - 07/31/2018 (PI)
Univ of Cincinnati NIH-NINDS

MR WITNESS: A Phase IIa Safety Study of Intravenous Thrombolysis with Altephase in MRI-Selected P…
11/19/2014 - 12/31/2015 (PI)
Mass General Hosp Genentech

Insulin Resistance Intervention After Stroke Trial (IRIS)
09/15/2004 - 08/31/2015 (PI)
Yale University NIH-NINDS

Bumpus Project 4
02/01/2004 - 01/31/2014 (PI)
Bumpus Foundation

MR Rescue
06/01/2007 - 04/30/2013 (PI)
Univ of California, Los Angeles NIH-NINDS

MA Coverdell Stroke Registry Project
06/09/2005 - 06/30/2009 (PI)

A Randomized Trial of Unruptured Brain Arteriovenous (ARUBA)
01/13/2006 - 07/31/2008 (PI)
Columbia University NIH
U01 NS0514843-01

Bumpus Parkinson'S Project 1
02/01/2001 - 02/01/2006 (PI)
Bumpus Foundation

Bumpus Parkinson'S Project 2
02/01/2001 - 02/01/2005 (PI)
Bumpus Foundation

Showing 10 of 11 results. Show All Results

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Yogendrakumar V, Smith EE, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Blas Y, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Bhatia R, Ali M, Lyden P, Hill MD, Dowlatshahi D. Lack of Early Improvement Predicts Poor Outcome Following Acute Intracerebral Hemorrhage. Crit Care Med. 2018 04; 46(4):e310-e317. PMID: 29303797.
  2. Dowlatshahi D, Deshpande A, Aviv RI, Rodriguez-Luna D, Molina CA, Blas YS, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz GJ, Padma V, Roy J, Kase CS, Bhatia R, Hill MD, Demchuk AM. Do Intracerebral Hemorrhage Nonexpanders Actually Expand Into the Ventricular Space? Stroke. 2018 01; 49(1):201-203. PMID: 29167385.
  3. Shoamanesh A, Pearce LA, Bazan C, Catanese L, McClure LA, Sharma M, Marti-Fabregas J, Anderson DC, Kase CS, Hart RG, Benavente OR. Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions. Ann Neurol. 2017 Aug; 82(2):196-207. PMID: 28681535.
  4. Aparicio HJ, Himali JJ, Beiser AS, Davis-Plourde KL, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. J Am Heart Assoc. 2017 Jun 24; 6(6).View Related Profiles. PMID: 28647687.
  5. Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS, D'Agostino RB, Wolf PA, Vasan RS, DeCarli C, O'Donnell CJ, Seshadri S. Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis. 2017 Oct; 265:305-311.View Related Profiles. PMID: 28673480.
  6. Perloff MD, Patel NS, Kase CS, Oza AU, Voetsch B, Romero JR. Cerebellar stroke presenting with isolated dizziness: Brain MRI in 136 patients. Am J Emerg Med. 2017 Nov; 35(11):1724-1729.View Related Profiles. PMID: 28687453.
  7. Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. Stroke. 2017 Jul; 48(7):1760-1765.View Related Profiles. PMID: 28596451.
  8. Stefanidou M, Das RR, Beiser AS, Sundar B, Kelly-Hayes M, Kase CS, Devinsky O, Seshadri S, Friedman D. Incidence of seizures following initial ischemic stroke in a community-based cohort: The Framingham Heart Study. Seizure. 2017 Apr; 47:105-110.View Related Profiles. PMID: 28364691; DOI: 10.1016/j.seizure.2017.03.009;.
  9. Dufouil C, Beiser A, McLure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan L, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, D'Agostino RB, Samieri C, Vasan RS, Chêne G, Howard G, Seshadri S. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. 2017 Mar 21; 135(12):1145-1159.View Related Profiles. PMID: 28159800; DOI: 10.1161/CIRCULATIONAHA.115.021275;.
  10. Romero JR, Preis SR, Beiser A, Himali JJ, Shoamanesh A, Wolf PA, Kase CS, Vasan RS, DeCarli C, Seshadri S. Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study. Stroke. 2017 Mar; 48(3):781-783.View Related Profiles. PMID: 28143923; DOI: 10.1161/STROKEAHA.116.015354;.
Showing 10 of 193 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 188 publications over 38 distinct years, with a maximum of 11 publications in 2013 and 2017

Contact for Mentoring:

75 E. Newton St Collamore Building
Boston MA 02118
Google Map

Kase's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department