Camron D. Bryant, PhD
Associate Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, University of California, Los Angeles




Dr. Bryant is the Director of the Laboratory of Addiction Genetics. Dr. Bryant’s research program is focused on determining the genetic basis of behavioral and molecular traits relevant to substance dependence in mice. The ultimate goal is to improve our understanding of the neurobiological mechanisms of addiction and to translate these findings toward treatment and prevention strategies in humans. A current focus is to determine the genetic basis of the rewarding properties of opioids in mice by combining quantitative trait locus (QTL) analysis of behavior and gene expression in genetic reference populations that yield high resolution QTLs. This multi-pronged approach to gene mapping will accelerate the nomination of candidate genes for validation via direct gene targeting. A separate focus with regard to functional characterization of candidate genes is the dissection of the hypothesized opposing roles of casein kinase-1 (CK-1) isoforms in regulating dopaminergic signaling and the motivational properties of drugs of abuse. Last, Dr. Bryant has a longstanding interest in deciphering the neurobiological basis of the “placebo effect”, a phenomenon that has been hypothesized to be mediated by the reward expectation. He plans to develop and apply a forward genetic analysis toward Pavlovian conditioning mouse models across a variety of conditions that are notoriously sensitive to the placebo effect, including pain, anxiety, depression, and Parkinson’s Disease.

Director, Laboratory of Addiction Genetics
Boston University School of Medicine


Associate Professor
Boston University School of Medicine
Psychiatry


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2016 American College of Neuropsychopharmacology (ACNP): Elected Associate Member
2015 Boston University: Jack Spivack Excellence in Neurosciences Research Award
2014 International Behavioural and Neural Genetics Society (IBANGS): Young Scientist Award
2014 Winter Conference on Brain Research (WCBR): Junior Investigator Travel Fellowship
2013 World Congress of Psychiatric Genetics: Poster abstract selected for oral presentation
2013 International Behavioural and Neural Genetics Society (IBANGS): Outstanding Young Investigator Award for Junior Faculty
2012 International Behavioural and Neural Genetics Society (IBANGS): Travel Award
2011 American College of Neuropsychopharmacology (ACNP): Early Career Travel Award - Abstract selected for Breakout Session oral presentation
2011 NIDA: Travel Award for Miniconvention, “Frontiers in Addiction Research”
2011 International Behavioural and Neural Genetics Society (IBANGS): Travel Award
2011 International Narcotics Research Conference (INRC): Travel Award
2009 International Behavioural and Neural Genetics Society (IBANGS): Travel Award
2008 International Behavioural and Neural Genetics Society (IBANGS): Outstanding Young Investigator Award for Postdocs
2005 INRC: Travel Award
2002 INRC: Travel Award
2000 UCLA: Hatos Center for Neuropharmacology Training Fellowship
1999 UCLA: Achievement Rewards for College Scientists (ARCS) Scholarship
1998-1999 UIUC: Honors Program and thesis in the Department of Psychology


Genetic Basis of Chemotherapy-Induced Neuropathy in a Reduced Complexity Cross
02/07/2018 - 01/31/2022 (Subcontract PI)
Virginia Commonwealth University NIH NCI
5R01CA221260-02

Big Data Computational Methods for Analysis of Drugs of Abuse
09/01/2017 - 06/30/2020 (Subcontract PI)
The Leland Stanford Junior University NIH NIDA
5U01DA044399-03

Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice
07/01/2015 - 06/30/2020 (PI)
NIH/National Institute on Drug Abuse
5R01DA039168-05

Overall NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome
08/01/2019 - 05/31/2020 (Subcontract PI)
The University of Tennessee on behalf of its Health Science Center NIH NIDA
5P30DA044223-03

Genetic basis of binge eating and its motivational components in a reduced complexity cross
09/15/2015 - 08/31/2018 (PI)
NIH/National Institute on Drug Abuse
5R21DA038738-02

Mapping G x E Interactions for Addiction Traits in a Reduced Complexity Cross
07/01/2014 - 06/30/2017 (PI)
NIH/National Institute on Drug Abuse
5R03DA038287-02

Bridging Genetic Variation with Behavior: Molecular and Functional Mechanisms.
05/01/2015 - 04/30/2017 (PI)
NIH/National Institute on Drug Abuse
3R00DA029635-05S2

Genetic Basis of Opioid Reward and Aversion in Mice
05/01/2013 - 04/30/2017 (PI)
NIH/National Institute on Drug Abuse
5R00DA029635-05S1



Title


Yr Title Project-Sub Proj Pubs
2020 A Reduced Complexity Cross in BALB/c substrains to identify the genetic basis of oxycodone dependence phenotypes 1U01DA050243-01
2020 Genetic basis of chemotherapy-induced neuropathy in a reduced complexity cross 5R01CA221260-03 2
2019 Genetic basis of chemotherapy-induced neuropathy in a reduced complexity cross 5R01CA221260-02 2
2019 Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice 3R01DA039168-04S1 9
2019 Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice 5R01DA039168-05 9
2018 Genetic basis of chemotherapy-induced neuropathy in a reduced complexity cross 1R01CA221260-01A1 2
2018 Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice 3R01DA039168-03S2 9
2018 Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice 5R01DA039168-04 9
2017 Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice 5R01DA039168-03 9
2017 Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in mice 3R01DA039168-03S1 9
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shab G, Fultz EK, Page A, Coelho MA, Brewin LW, Stailey N, Brown CN, Bryant CD, Kippin TE, Szumlinski KK. The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6?J mice. Behav Brain Res. 2020 Oct 11; 112959. PMID: 33053382
     
  2. Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Al Abdullatif A, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 Aug 26; 11(2):208.View Related Profiles. PMID: 32853540
     
  3. Bryant CD, Smith DJ, Kantak KM, Nowak TS, Williams RW, Damaj MI, Redei EE, Chen H, Mulligan MK. Facilitating Complex Trait Analysis via Reduced Complexity Crosses. Trends Genet. 2020 08; 36(8):549-562.View Related Profiles. PMID: 32482413
     
  4. Ulker E, Caillaud M, Patel T, White A, Rashid D, Alqasem M, Lichtman AH, Bryant CD, Damaj MI. C57BL/6 substrain differences in formalin-induced pain-like behavioral responses. Behav Brain Res. 2020 Jul 15; 390:112698. PMID: 32428630
     
  5. Ruan QT, Yazdani N, Reed ER, Beierle JA, Peterson LP, Luttik KP, Szumlinski KK, Johnson WE, Ash PEA, Wolozin B, Bryant CD. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. FASEB J. 2020 Jul; 34(7):9223-9244.View Related Profiles. PMID: 32401417
     
  6. Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020 04 22; 10(4):333-350.e14.View Related Profiles. PMID: 32325033
     
  7. Babbs RK, Beierle JA, Yao EJ, Kelliher JC, Medeiros AR, Anandakumar J, Shah AA, Chen MM, Johnson WE, Bryant CD. The effect of the demyelinating agent cuprizone on binge-like eating of sweetened palatable food in female and male C57BL/6 substrains. Appetite. 2020 07 01; 150:104678.View Related Profiles. PMID: 32209386
     
  8. Brown CN, Fultz EK, Ferdousian S, Rogers S, Lustig E, Page A, Shahin JR, Flaherty DM, Von Jonquieres G, Bryant CD, Kippin TE, Szumlinski KK. Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice. Front Psychiatry. 2020; 11:11. PMID: 32116834
     
  9. Sern KR, Fultz EK, Coelho MA, Bryant CD, Szumlinski KK. A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice. Subst Abuse. 2020; 14:1178221819897073. PMID: 32009790
     
  10. Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles. PMID: 31704785
     
Showing 10 of 43 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 43 publications over 15 distinct years, with a maximum of 9 publications in 2020

YearPublications
20033
20051
20062
20071
20082
20093
20112
20123
20143
20152
20164
20172
20182
20194
20209


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Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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