Bappaditya Dey, MVSc, PhD
Senior Research Scientist
Boston University
National Emerging Infectious Disease Lab

Dr. Dey’s experience spans various aspects of research in Tuberculosis (TB) including, molecular basis of TB pathogenesis: host-pathogen interaction, immunology of TB and vaccine development and animal models of TB, TB latency and reactivation. He developed several genetically engineered recombinant vaccines, some of which imparted heightened protection among the experimental TB vaccines studied till date. His research on bacterial cyclic-di-nucleotide (CDN) second messengers signaling has led to the elucidation of novel network of Cytoplasmic Surveillance Pathway (CSP) activation that promise to stimulate considerable future research into the consequences of signal transduction interference by intracellular bacterial pathogens and also into novel therapies that may target this newly characterized virulence mechanism. At NIAB, Dr. Dey’s primary research interests are to understand the immune-genetic basis of resistance and susceptibility of different breeds of cattle to TB and other mycobacterial infections, to develop genetic diagnostics, recombinant live attenuated vaccines and engineered probiotic based preventive and therapeutic strategies against animal diseases with public health and economic importance.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Dey RJ, Dey B, Harriff M, Canfield ET, Lewinsohn DM, Bishai WR. Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence. mBio. 2022 Feb 15; e0386521. PMID: 35164552; PMCID: PMC8844931; DOI: 10.1128/mbio.03865-21;
  2. Dey RJ, Dey B, Singh AK, Praharaj M, Bishai W. Bacillus Calmette-Guérin Overexpressing an Endogenous Stimulator of Interferon Genes Agonist Provides Enhanced Protection Against Pulmonary Tuberculosis. J Infect Dis. 2020 03 16; 221(7):1048-1056. PMID: 30901058; PMCID: PMC7931846; DOI: 10.1093/infdis/jiz116;
  3. Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Gyanu Lamichhane, Herman O Sintim & William R Bishai. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. NATURE CHEMICAL BIOLOGY. 2016; doi:10.1038/nchembio.2254. View Publication
  4. Dey RJ, Dey B, Zheng Y, Cheung LS, Zhou J, Sayre D, Kumar P, Guo H, Lamichhane G, Sintim HO, Bishai WR. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017 Feb; 13(2):210-217. PMID: 28106876; DOI: 10.1038/nchembio.2254;
  5. Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. Computer-aided pulmonary image analysis in small animal models. Med Phys. 2015 Jul; 42(7):3896-910. PMID: 26133591; PMCID: PMC4464065; DOI: 10.1118/1.4921618;
  6. Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR. A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat Med. 2015 Apr; 21(4):401-6. PMID: 25730264; PMCID: PMC4390473; DOI: 10.1038/nm.3813;
  7. Dey B, Bishai WR. Crosstalk between Mycobacterium tuberculosis and the host cell. Semin Immunol. 2014 Dec; 26(6):486-96. PMID: 25303934; PMCID: PMC4250340; DOI: 10.1016/j.smim.2014.09.002;
  8. Foster B, Bagci U, Ziyue Xu, Dey B, Luna B, Bishai W, Jain S, Mollura DJ. Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models. IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. PMID: 24235292; PMCID: PMC4196700; DOI: 10.1109/TBME.2013.2288258;
  9. Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013 Jul 23; 3(1):55. PMID: 23879987; PMCID: PMC3734217; DOI: 10.1186/2191-219X-3-55;
  10. Dannenberg AM, Dey B. Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing. Vaccines (Basel). 2013 Jan 25; 1(1):58-76. PMID: 26343850; PMCID: PMC4552198; DOI: 10.3390/vaccines1010058;
Showing 10 of 24 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 12 distinct years, with a maximum of 5 publications in 2013


Contact for Mentoring:

620 Albany St
Boston MA 02118
Google Map

Dey's Networks
Click the "See All" links for more information and interactive visualizations
Similar People
Same Department