Bappaditya Dey, MVSc, PhD
Senior Research Scientist
Boston University
Dept of National Emerging Infectious Disease Lab





Dr. Dey’s experience spans various aspects of research in Tuberculosis (TB) including, molecular basis of TB pathogenesis: host-pathogen interaction, immunology of TB and vaccine development and animal models of TB, TB latency and reactivation. He developed several genetically engineered recombinant vaccines, some of which imparted heightened protection among the experimental TB vaccines studied till date. His research on bacterial cyclic-di-nucleotide (CDN) second messengers signaling has led to the elucidation of novel network of Cytoplasmic Surveillance Pathway (CSP) activation that promise to stimulate considerable future research into the consequences of signal transduction interference by intracellular bacterial pathogens and also into novel therapies that may target this newly characterized virulence mechanism. At NIAB, Dr. Dey’s primary research interests are to understand the immune-genetic basis of resistance and susceptibility of different breeds of cattle to TB and other mycobacterial infections, to develop genetic diagnostics, recombinant live attenuated vaccines and engineered probiotic based preventive and therapeutic strategies against animal diseases with public health and economic importance.
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Dey RJ, Dey B, Singh AK, Praharaj M, Bishai W. BCG overexpressing an endogenous STING agonist provides enhanced protection against pulmonary tuberculosis. J Infect Dis. 2019 Mar 15. PMID: 30901058.
     
  2. Dey RJ, Dey B, Zheng Y, Cheung LS, Zhou J, Sayre D, Kumar P, Guo H, Lamichhane G, Sintim HO, Bishai WR. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017 Feb; 13(2):210-217. PMID: 28106876; DOI: 10.1038/nchembio.2254;.
     
  3. Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Gyanu Lamichhane, Herman O Sintim & William R Bishai. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. NATURE CHEMICAL BIOLOGY. 2016; doi:10.1038/nchembio.2254. View Publication
  4. Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. Computer-aided pulmonary image analysis in small animal models. Med Phys. 2015 Jul; 42(7):3896-910. PMID: 26133591; PMCID: PMC4464065; DOI: 10.1118/1.4921618;.
     
  5. Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR. A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis. Nat Med. 2015 Apr; 21(4):401-6. PMID: 25730264; PMCID: PMC4390473; DOI: 10.1038/nm.3813;.
     
  6. Dey B, Bishai WR. Crosstalk between Mycobacterium tuberculosis and the host cell. Semin Immunol. 2014 Dec; 26(6):486-96. PMID: 25303934; PMCID: PMC4250340; DOI: 10.1016/j.smim.2014.09.002;.
     
  7. Foster B, Bagci U, Ziyue Xu, Dey B, Luna B, Bishai W, Jain S, Mollura DJ. Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models. IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. PMID: 24235292; PMCID: PMC4196700; DOI: 10.1109/TBME.2013.2288258;.
     
  8. Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013 Jul 23; 3(1):55. PMID: 23879987; PMCID: PMC3734217; DOI: 10.1186/2191-219X-3-55;.
     
  9. Dannenberg AM, Dey B. Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing. Vaccines (Basel). 2013 Jan 25; 1(1):58-76. PMID: 26343850; PMCID: PMC4552198; DOI: 10.3390/vaccines1010058;.
     
  10. Chauhan P, Jain R, Dey B, Tyagi AK. Adjunctive immunotherapy with a-crystallin based DNA vaccination reduces Tuberculosis chemotherapy period in chronically infected mice. Sci Rep. 2013; 3:1821. PMID: 23660989; PMCID: PMC3650662; DOI: 10.1038/srep01821;.
     
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 11 distinct years, with a maximum of 5 publications in 2013

YearPublications
20053
20061
20081
20093
20113
20121
20135
20141
20152
20162
20191
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620 Albany St
Boston MA 02118
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