Ana Claudia Amaral
Research Fellow
Harvard Medical School
Dept of Neurology




My research focuses on studying some long-lasting effects of prenatal protein malnutrition on the adult rat brain. I am particularly interested in identifying anatomical, functional, and epigenetic modifications that could underlie the attention-deficit phenotype observed in adult rats that were malnourished in utero.

Research Fellow
Massachusetts General Hospital
Neurology


Pre-Doctoral Trainee (previously held)
Boston University School of Medicine, Graduate Medical Sciences
Anatomy & Neurobiology


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 Sep 05; 99(5):925-940.e7. PMID: 30189209.
     
  2. Marquié M, Verwer EE, Meltzer AC, Kim SJW, Agüero C, Gonzalez J, Makaretz SJ, Siao Tick Chong M, Ramanan P, Amaral AC, Normandin MD, Vanderburg CR, Gomperts SN, Johnson KA, Frosch MP, Gómez-Isla T. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta Neuropathol Commun. 2017 10 19; 5(1):75. PMID: 29047416; DOI: 10.1186/s40478-017-0482-0;.
     
  3. Wegmann S, Bennett RE, Amaral AS, Hyman BT. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods Cell Biol. 2017; 141:307-322. PMID: 28882310.
     
  4. Marquié M, Siao Tick Chong M, Antón-Fernández A, Verwer EE, Sáez-Calveras N, Meltzer AC, Ramanan P, Amaral AC, Gonzalez J, Normandin MD, Frosch MP, Gómez-Isla T. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging. Acta Neuropathol. 2017 Oct; 134(4):619-628. PMID: 28612291; DOI: 10.1007/s00401-017-1740-8;.
     
  5. Estrada LI, Robinson AA, Amaral AC, Giannaris EL, Heyworth NC, Mortazavi F, Ngwenya LB, Roberts DE, Cabral HJ, Killiany RJ, Rosene DL. Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry. J Histochem Cytochem. 2017 Mar; 65(3):153-171.View Related Profiles. PMID: 28080173; DOI: 10.1369/0022155416686934;.
     
  6. Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry. 2016 Nov 15; 80(10):765-774.View Related Profiles. PMID: 27184921; DOI: 10.1016/j.biopsych.2016.03.2100;.
     
  7. Fischer LK, McGaughy JA, Bradshaw SE, Weissner WJ, Amaral AC, Rosene DL, Mokler DJ, Fitzmaurice GM, Galler JR. Prenatal protein level impacts homing behavior in Long-Evans rat pups. Nutr Neurosci. 2016 Jun; 19(5):187-95.View Related Profiles. PMID: 25603489; DOI: 10.1179/1476830515Y.0000000001;.
     
  8. Amaral AC, Jakovcevski M, McGaughy JA, Calderwood SK, Mokler DJ, Rushmore RJ, Galler JR, Akbarian SA, Rosene DL. Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex. Neuroscience. 2015 Feb 12; 286:79-86.View Related Profiles. PMID: 25446346; PMCID: PMC4298467; DOI: 10.1016/j.neuroscience.2014.11.005;.
     
  9. McGaughy JA, Amaral AC, Rushmore RJ, Mokler DJ, Morgane PJ, Rosene DL, Galler JR. Prenatal malnutrition leads to deficits in attentional set shifting and decreases metabolic activity in prefrontal subregions that control executive function. Dev Neurosci. 2014; 36(6):532-41.View Related Profiles. PMID: 25342495; DOI: 10.1159/000366057;.
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 9 publications over 5 distinct years, with a maximum of 4 publications in 2017

YearPublications
20142
20151
20161
20174
20181
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