Allen Caobi, PhD
Postdoctoral Associate NRSA
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

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I am a Postdoctoral Associate in the laboratory of Dr. Mohsan Saeed, at Boston University’s National Emerging Infectious Diseases Laboratory (NEIDL). I completed my PhD in Biomedical Science at Florida International University, in Miami, Florida. My PhD research focused on three primary aims: 1) Establishing a genomic and proteomic profile of exosomes derived from HIV-infected PBMCs in the context of opiate abuse, with the intention to then observe the effects of these PBMC-derived exosomes on primary neuronal cell function. 2) Development of a nanotherapeutic to ameliorate HIV-associated neuropathology by delivering an exosome containing the desired therapeutic agent (Truvada) and magnetic nano-particles (MNPs) across the blood-brain barrier (BBB). 3) Lastly, I developed an exosome-derived protein biomarker profile to assess neurocognitive impairment (NCI) if people living with HIV or AIDS (PLWHA).

I entered the Saeed Lab in June, 2022. My current research explores the role of viral pathogenicity factors in disease mechanisms. I am particularly focusing on coronaviruses and enteroviruses, both of which encode a number of proteins that modulate host antiviral defenses and create a suitable environment for virus replication. I use various molecular virology approaches to uncover the ways in which these proteins ablate host immunity and contribute to disease development.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122.View Related Profiles. PMID: 40504150; PMCID: PMC12184426; DOI: 10.1073/pnas.2426528122;
     
  2. Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, Kirchdoerfer RN, Saeed M, Baker SC. Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2419620122.View Related Profiles. PMID: 40035769; PMCID: PMC11912388; DOI: 10.1073/pnas.2419620122;
     
  3. Caobi A, Saeed M. Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern. Curr Opin Microbiol. 2024 Jun; 79:102454.View Related Profiles. PMID: 38518551; PMCID: PMC11162932; DOI: 10.1016/j.mib.2024.102454;
     
  4. Andre M, Caobi A, Miles JS, Vashist A, Ruiz MA, Raymond AD. Diagnostic potential of exosomal extracellular vesicles in oncology. BMC Cancer. 2024 Mar 08; 24(1):322. PMID: 38454346; PMCID: PMC10921614; DOI: 10.1186/s12885-024-11819-4;
     
  5. Cruz YC, Suthumphong C, Caobi A, Andre M, Vicens J, Raymond AD, Ruiz M. MicroRNA Expression in Exosome Extracellular Vesicles as Targets for Personalized Medicine in Diffuse Large B Cell Lymphoma Patients with HIV Infection. Curr HIV Res. 2024; 22(6):354-360. PMID: 39377385
     
  6. Caobi A, Bonilla J, Gomez M, Andre M, Yndart A, Fernandez-Lima FA, Nair MP, Raymond AD. HIV-1 and opiates modulate miRNA profiles in extracellular vesicles. Front Immunol. 2023; 14:1259998. PMID: 38022533; PMCID: PMC10666642; DOI: 10.3389/fimmu.2023.1259998;
     
  7. Caobi A, Werne R, Gomez M, Andre M, Thomas C, Lima-Hernandez F, Nair M, Raymond AD. Protein cargo of Nef-containing exosomal extracellular vesicles may predict HIV-associated Neurocognitive Impairment status. Res Sq. 2023 Jun 23. PMID: 37214960; PMCID: PMC10197801; DOI: 10.21203/rs.3.rs-2740135/v2;
     
  8. Esteban-Lopez M, Perry MD, Garbinski LD, Manevski M, Andre M, Ceyhan Y, Caobi A, Paul P, Lau LS, Ramelow J, Owens F, Souchak J, Ales E, El-Hage N. Health effects and known pathology associated with the use of E-cigarettes. Toxicol Rep. 2022; 9:1357-1368. PMID: 36561957; PMCID: PMC9764206; DOI: 10.1016/j.toxrep.2022.06.006;
     
  9. Caobi A, Nair M, Raymond AD. Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans. Viruses. 2020 10 21; 12(10). PMID: 33096825; PMCID: PMC7589806; DOI: 10.3390/v12101200;
     
  10. Caobi A, Dutta RK, Garbinski LD, Esteban-Lopez M, Ceyhan Y, Andre M, Manevski M, Ojha CR, Lapierre J, Tiwari S, Parira T, El-Hage N. The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy. Aging Dis. 2020 Jul; 11(4):895-915. PMID: 32765953; PMCID: PMC7390517; DOI: 10.14336/AD.2019.0927;
     
Showing 10 of 15 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 7 distinct years, with a maximum of 5 publications in 2020

YearPublications
20181
20191
20205
20221
20232
20243
20252

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