Adam Lerner, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Hematology & Medical Oncology

MD, Yale University School of Medicine
AB, Amherst College



Dr. Lerner is a Professor of Medicine, Pathology and Laboratory Medicine at Chobanian and Avedisian School of Medicine (BUSM) and a medical oncologist at Boston Medical Center (BMC). He received his MD from Yale School of Medicine, followed by an internal medicine residency at Boston City Hospital. He did his fellowship in Medical Oncology at the Dana Farber Cancer Institute, Harvard Medical School, and subsequently remained there while carrying out research in the cellular and molecular biology of T lymphocytes. In 1996, he joined the Hematology/Oncology Section at Boston Medical Center. His laboratory research has focused in two areas: 1) The therapeutic potential of cyclic nucleotide phosphodiesterase inhibitors in lymphoid malignancies; 2) The mechanism by which a novel adapter protein (BCAR3/ AND-34) modulates focal adhesion complex signaling in mesenchymal, epithelial and hematopoietic cells. Clinically, Dr. Lerner cares for patients with hematologic malignancies, cutaneous malignancies and sarcomas.

Expertise includes: CLL; Leukemia; Lymphoid malignancies; Sarcoma; Breast cancer; cAMP signaling.

Diversity, Equity, Inclusion and Accessibility

I am part of a dedicated team of healthcare professionals, researchers, students and staff from different countries and various regions of the U.S. The culture of our Section is defined by the unique perspectives that we each bring with us. As both a large academic medical center and safety-net hospital serving the communities of Boston and its surroundings, our trainees engage in cutting edge research and gain real-world clinical experience by caring for local underserved populations. Our multilingual team is committed to promoting cultural competency, equity and inclusion in science, medicine and healthcare. We strive to maintain a workforce that is as diverse as the communities we serve, and aim to create a safe space for our members to learn, grow and succeed in their life goals. Acknowledging that we all have a role to play, I am dedicated to welcoming and celebrating individuals of all races, ethnicities, social backgrounds, religion, gender, sex, age, ability, sexual orientation, veteran status, and national origin.

Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Research Training in Blood Diseases and Resources
06/01/2014 - 05/31/2021 (Multi-PI)
PI: Adam Lerner, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007501-36

Open-Label, Multi-Center, Randomized Study of Anti-CCR4 Monoclonal Antibody KW-0761 (mogamulizumab) Versus Vorinostat in Subjects with Previously Treated Cutaneous T-Cell Lymphoma
02/03/2014 - 02/02/2021 (PI)
Kyowa Hakko Kirin Pharma, Inc.


A randomized, open-label, phase 3 trial of Brentuximab vedotin (SGN-35) versus physician's choice (Methotrexate or Bexarotene) in patients with CD30-positive cutaneous T-cell lymphoma
08/10/2012 - 08/10/2019 (PI)
Millennium Pharmaceuticals, Inc.


PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF DEBORAH GOVAN
01/01/2013 - 01/28/2016 (PI)
VA Boston Healthcare System


Research Training in Blood Diseases and Resources
09/19/2008 - 05/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007501-31

Access Program with Denileukin diftitox for the treatment of patients currently receiving treatment with commercially available Ontak
11/01/2011 - 10/31/2012 (PI)
Eisai Medical Research Institute, Inc.


A Phase III Study of Taxoprexin Injection vs. Dacarbazine in Patients with Metastatic Malignant Melanoma
03/27/2006 - 03/26/2008 (PI)
CuraGen Corporation

The National Lymphocare Study: An Observational Study of Treatment, Outcomes, and Prognosis in Patients with Follicular Non-Hodgkin’s Lymphoma
11/03/2005 - 11/02/2007 (PI)
Genentech, Inc.

A Phase III Study of Taxoprexin Injection vs. Dacarbazine in Patients with Metastatic Malignant Melanoma
12/23/2005 - 12/31/2006 (PI)
Luitpold Pharmaceuticals, Inc.

Open-label, Dose Escalation, Followed by Double-blind, Randomized, Two-dose, Parallel Group, Multi-center Clinical Trial of HuMax-CD4, a Fully Human Monoclonal Anti-CD4 Antibody, in Patients with
06/02/2005 - 06/01/2006 (PI)
Genmab Inc.


Showing 10 of 14 results. Show All Results

CRXX-Lerner laboratory CLL Research Collaboration
02/01/2008 - 06/30/2011 (PI)
CombinatorX, Inc.

Using audio to convey mind/body approaches to cancer
06/14/2006 - 03/31/2011 (PI)
Far Reaching Communications NIH
R44 CA86403-02

PDE4 Inhibitors & Glucocorticoids in B-CLL
08/01/2006 - 01/31/2011 (PI)
Memory Pharmaceutical Corp.

Mechanistic Studies of BRC3-induced Anti-estrogen Resistance
01/01/2010 - 12/31/2010 (PI)
Breast Cancer Alliance

Cell Pathways
07/01/2002 - 12/31/2010 (PI)
Cell Pathways Inc

Cyclic AMP - Mediated Apoptosis in Lymphoid Malignancies
07/01/2005 - 06/30/2010 (PI)
NIH-NCI
5 R01 CA106705-05

Tamoxifen Resistance in Breast Cancer
10/31/2002 - 12/31/2009 (PI)
Logica Foundation

Analysis of AND-34 in human breast cancer
07/01/2005 - 06/30/2009 (PI)
NIH-NCI
5 R01 CA114094-04 (A)

Analysis Of And-34
09/01/2001 - 09/30/2005 (PI)
US Army

Apoptosis In Normal And Malign
07/01/2000 - 06/30/2005 (PI)
NIH-NCI
5 R01 CA79838-04 (A)

Showing 10 of 13 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2018 Research Training in Blood Diseases and Resources 5T32HL007501-36 119
2017 Research Training in Blood Diseases and Resources 5T32HL007501-35 119
2016 Research Training in Blood Diseases and Resources 5T32HL007501-34 119
2015 Research Training in Blood Diseases and Resources 5T32HL007501-33 119
2014 Research Training in Blood Diseases and Resources 2T32HL007501-32 119
2012 Research Training in Blood Diseases and Resources 5T32HL007501-31 119
2011 EFFECT OF PHOSPHORYLATION ON INTERACTION OF P130CAS WITH AND-34 5P41RR010888-15-5136 259
2011 Research Training in Blood Diseases and Resources 5T32HL007501-30 119
2010 EFFECT OF PHOSPHORYLATION ON INTERACTION OF P130CAS WITH AND-34 5P41RR010888-14-6841 259
2010 Research Training in Blood Diseases and Resources 5T32HL007501-29 119
Showing 10 of 30 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Nachshon A, Cai Q, Matos JD, Mahmood F, Lerner AB, Mitchell JD, Mueller A, Manning WJ. ECG and Atrial Appendage Doppler Discordance Is Common in Patients Undergoing Cardiac Surgery: Prospective Study. JACC Adv. 2024 Jul; 3(7):100977. PMID: 39129997; PMCID: PMC11313039; DOI: 10.1016/j.jacadv.2024.100977;
     
  2. Halpin M, Lerner A, Sagar M, Govender P, Shah B, Weinberg J, Sarosiek S, Sloan JM. A prospective, single-center, randomized phase 2 trial of etoposide in severe COVID-19. medRxiv. 2023 Jun 06.View Related Profiles. PMID: 37333402; PMCID: PMC10274992; DOI: 10.1101/2023.06.05.23290969;
     
  3. Hughes DM, Henshaw L, Blevins F, Edwards C, Lerner A, Sloan JM, Sanchorawala V. Standard 30-minute Monitoring Time and Less Intensive Pre-medications is Safe in Patients Treated With Subcutaneous Daratumumab for Multiple Myeloma and Light Chain Amyloidosis. Clin Lymphoma Myeloma Leuk. 2022 Aug; 22(8):566-568.View Related Profiles. PMID: 35367193
     
  4. Milrod CJ, Mann M, Blevins F, Hughes D, Patel P, Li KY, Lerner A, Sanchorawala V, Sloan JM. Underrepresentation of Black participants and adverse events in clinical trials of lenalidomide for myeloma. Crit Rev Oncol Hematol. 2022 Apr; 172:103644.View Related Profiles. PMID: 35227897; DOI: 10.1016/j.critrevonc.2022.103644;
     
  5. Milrod CJ, Blevins F, Hughes D, Lerner A, Sarosiek S, Sanchorawala V, Sloan JM. Incidence of skin hyperpigmentation in Black patients receiving treatment with immunomodulatory drugs. Blood. 2021 05 27; 137(21):2987-2989.View Related Profiles. PMID: 33728443
     
  6. Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ. SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis. Am J Clin Pathol. 2020 09 08; 154(4):466-474.View Related Profiles. PMID: 32681166; PMCID: PMC7454285; DOI: 10.1093/ajcp/aqaa124;
     
  7. Dennis M, Maoz A, Cirstea D, Patel A, Lerner A, Sarosiek S. Treatment disparities in minority groups with multiple myeloma at a safety-net hospital. Leuk Lymphoma. 2020 10; 61(10):2507-2510.View Related Profiles. PMID: 32460648
     
  8. Leiva O, McMahon L, Sloan JM, Lee J, Lerner A. Recognition of hemophagocytic lymphohistiocytosis in sickle cell vaso-occlusive crises is a potentially lifesaving diagnosis. Haematologica. 2019 04; 104(4):e167-e169.View Related Profiles. PMID: 30705096; PMCID: PMC6442954; DOI: 10.3324/haematol.2018.206458;
     
  9. Min MS, Al-Haseni A, Succaria F, Goldberg L, Lerner A, Sahni D. Anaplastic large cell lymphoma localized to the left breast years after radiotherapy for breast cancer. Dermatol Online J. 2018 Jan 15; 24(1).View Related Profiles. PMID: 29469762
     
  10. de Medeiros AS, Wyman AR, Alaamery MA, Allain C, Ivey FD, Wang L, Le H, Morken JP, Habara A, Le C, Cui S, Lerner A, Hoffman CS. Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays. Cell Signal. 2017 Dec; 40:73-80.View Related Profiles. PMID: 28867658; PMCID: PMC5651194; DOI: 10.1016/j.cellsig.2017.08.011;
     
Showing 10 of 81 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 78 publications over 33 distinct years, with a maximum of 6 publications in 2007 and 2009

YearPublications
19882
19891
19924
19932
19941
19962
19971
19982
19992
20002
20011
20023
20035
20042
20053
20063
20076
20081
20096
20101
20115
20123
20144
20153
20162
20172
20181
20191
20202
20211
20222
20231
20241


2008-2013 NHLBI Award
2005-2010 NCI RO1 Awards
2001-2004 DOD Breast Cancer Idea Award
1998-2001 American Society of Clinical Oncology: Career Development Award
1997-1998 American Cancer Society: Research Award
1997-1999 Translational Research Award: Leukemia Society of America
1992-1995 Special Fellowship: 5 Leukemia Society of America
200-2004 NCI RO1 Award
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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