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PhD, Brown University
MS, University of Connecticut
BA, University of Connecticut

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Quinn JA, Graeber CT, Frackelton AR, Kim M, Schwarzbauer JE, Filardo EJ. Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. Mol Endocrinol. 2009 Jul; 23(7):1052-64. PMID: 19342448; PMCID: PMC2703602; DOI: 10.1210/me.2008-0262;

Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR, Hafer LJ. p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. Clin Cancer Res. 2007 Oct 1; 13(19):5798-804. PMID: 17908971

Wanebo HJ, Frackelton AR, Hafer LJ, Bagdasaryan R, Lis R, Sabo E, Resnick MB. Shc test as a strong prognostic indicator of disease outcome in early stage gastric cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10090.View Related Profiles.

Frackelton, A.
Wanebo, Harold

PMID: 27954030

Frackelton AR, Lu L, Davol PA, Bagdasaryan R, Hafer LJ, Sgroi DC. p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy. Breast Cancer Res. 2006; 8(6):R73. PMID: 17196107; PMCID: PMC1797038

Davol PA, Bagdasaryan R, Elfenbein GJ, Maizel AL, Frackelton AR. Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer. Cancer Res. 2003 Oct 15; 63(20):6772-83. PMID: 14583473

Filardo EJ, Quinn JA, Frackelton AR, Bland KI. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol. 2002 Jan; 16(1):70-84. PMID: 11773440

Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR. Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells. Cell Growth Differ. 2001 Jul; 12(7):379-86. PMID: 11457735

Filardo EJ, Quinn JA, Bland KI, Frackelton AR. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 2000 Oct; 14(10):1649-60. PMID: 11043579

Boney CM, Gruppuso PA, Faris RA, Frackelton AR. The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes. Mol Endocrinol. 2000 Jun; 14(6):805-13. PMID: 10847583

Davol PA, Garza S, Frackelton AR. Combining suramin and a chimeric toxin directed to basic fibroblast growth factor receptors increases therapeutic efficacy against human melanoma in an animal model. Cancer. 1999 Nov 1; 86(9):1733-41. PMID: 10547546

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Davol PA, Frackelton AR. Targeting human prostatic carcinoma through basic fibroblast growth factor receptors in an animal model: characterizing and circumventing mechanisms of tumor resistance. Prostate. 1999 Aug 1; 40(3):178-91. PMID: 10398280

Davol PA, Bizuneh A, Frackelton AR. Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo. Anticancer Res. 1999 May-Jun; 19(3A):1705-13. PMID: 10470104

Stevenson LE, Ravichandran KS, Frackelton AR. Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells. Cell Growth Differ. 1999 Jan; 10(1):61-71. PMID: 9950219

Stevenson LE, Frackelton AR. Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression. Breast Cancer Res Treat. 1998 May; 49(2):119-28. PMID: 9696394

Davol P, Frackelton AR. The mitotoxin, basic fibroblast growth factor-saporin, effectively targets human prostatic carcinoma in an animal model. J Urol. 1996 Sep; 156(3):1174-9. PMID: 8709341

Davol PA, Goulette FA, Frackelton AR, Darnowski JW. Modulation of p53 expression by human recombinant interferon-alpha2a correlates with abrogation of cisplatin resistance in a human melanoma cell line. Cancer Res. 1996 Jun 1; 56(11):2522-6. PMID: 8653690

Nici L, Medina M, Frackelton AR. The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. Am J Physiol. 1996 Feb; 270(2 Pt 1):L242-50. PMID: 8779993

Clark JW, Santos-Moore A, Stevenson LE, Frackelton AR. Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the ras signaling pathway. Int J Cancer. 1996 Jan 17; 65(2):186-91. PMID: 8567115

Davol P, Beitz JG, Mohler M, Ying W, Cook J, Lappi DA, Frackelton AR. Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model. Cancer. 1995 Jul 1; 76(1):79-85. PMID: 8630880

Davol P, Beitz JG, Frackelton AR. Autocrine down-regulation of basic fibroblast growth factor receptors causes mitotoxin resistance in a human melanoma cell line. J Invest Dermatol. 1995 Jun; 104(6):916-21. PMID: 7769258

Cheng JC, Frackelton AR, Bearer EL, Kumar PS, Kannan B, Santos-Moore A, Rifai A, Settleman J, Clark JW. Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells. Cell Growth Differ. 1995 Feb; 6(2):139-48. PMID: 7756172; PMCID: PMC3376091

Sato N, Beitz JG, Kato J, Yamamoto M, Clark JW, Calabresi P, Raymond A, Frackelton AR. Platelet-derived growth factor indirectly stimulates angiogenesis in vitro. Am J Pathol. 1993 Apr; 142(4):1119-30. PMID: 7682762; PMCID: PMC1886859

Frackelton AR, Kumar PS, Kannan B, Clark JW. Tyrosine phosphorylated proteins in chronic myelogenous leukemia. Leuk Lymphoma. 1993; 11 Suppl 1:125-9. PMID: 7504542

Buzzi M, Lu L, Lombardi AJ, Posner MR, Brautigan DL, Fast LD, Frackelton AR. Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines. Cancer Res. 1992 Jul 15; 52(14):4027-35. PMID: 1535552

Beitz JG, Davol P, Clark JW, Kato J, Medina M, Frackelton AR, Lappi DA, Baird A, Calabresi P. Antitumor activity of basic fibroblast growth factor-saporin mitotoxin in vitro and in vivo. Cancer Res. 1992 Jan 1; 52(1):227-30. PMID: 1309225

Beitz JG, Kim IS, Calabresi P, Frackelton AR. Receptors for platelet-derived growth factor on microvascular endothelial cells. EXS. 1992; 61:85-90. PMID: 1319780

Beitz JG, Kim IS, Calabresi P, Frackelton AR. Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc Natl Acad Sci U S A. 1991 Mar 1; 88(5):2021-5. PMID: 1848018; PMCID: PMC51158

Frackelton AR, Posner M, Kannan B, Mermelstein F. Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins. Methods Enzymol. 1991; 201:79-92. PMID: 1719350

Sato N, Nariuchi H, Tsuruoka N, Nishihara T, Beitz JG, Calabresi P, Frackelton AR. Actions of TNF and IFN-gamma on angiogenesis in vitro. J Invest Dermatol. 1990 Dec; 95(6 Suppl):85S-89S. PMID: 1701814

Posner MR, Santos DJ, Elboim HS, Tumber MB, Frackelton AR. Human monoclonal antibodies reactive with human myelomonocytic leukemia cells. Cancer Res. 1989 Apr 1; 49(7):1665-70. PMID: 2924315

Huhn RD, Cicione ME, Frackelton AR. Identification of tyrosine-phosphorylated colony-stimulating factor 1 (CSF-1) receptor and a 56-kilodalton protein phosphorylated in intact human cells in response to CSF-1. J Cell Biochem. 1989 Feb; 39(2):129-37. PMID: 2469691

Posner MR, Santos DJ, Elboim HS, Frackelton AR. Human monoclonal antibodies to human leukemias. Initial characterization of specificities and antigens. Prog Clin Biol Res. 1989; 288:95-9. PMID: 2717644

Isfort R, Huhn RD, Frackelton AR, Ihle JN. Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates. J Biol Chem. 1988 Dec 15; 263(35):19203-9. PMID: 2461935

Sengupta A, Liu WK, Yeung YG, Yeung DC, Frackelton AR, Stanley ER. Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8062-6. PMID: 2460861; PMCID: PMC282354

Preis PN, Waldman FM, Frackelton AR, Saya H, Levin VA. Protein-tyrosine kinase activity and pp60v-src expression in whole cells measured by flow cytometry. Cancer Res. 1988 Aug 15; 48(16):4633-8. PMID: 3135116

Tornqvist HE, Gunsalus JR, Nemenoff RA, Frackelton AR, Pierce MW, Avruch J. Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells. J Biol Chem. 1988 Jan 5; 263(1):350-9. PMID: 3275643

Bell JC, Mahadevan L, Colledge WH, Fry MJ, Frackelton AR, Sargent MG, Foulkes JG. Mechanisms of transformation by protein-tyrosine kinases. Adv Exp Med Biol. 1988; 231:475-80. PMID: 2843010

Tornqvist HE, Pierce MW, Frackelton AR, Nemenoff RA, Avruch J. Identification of insulin receptor tyrosine residues autophosphorylated in vitro. J Biol Chem. 1987 Jul 25; 262(21):10212-9. PMID: 3038872

Huhn RD, Posner MR, Rayter SI, Foulkes JG, Frackelton AR. Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues. Proc Natl Acad Sci U S A. 1987 Jul; 84(13):4408-12. PMID: 2440021; PMCID: PMC305098

Bell JC, Mahadevan LC, Colledge WH, Frackelton AR, Sargent MG, Foulkes JG. Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA. Nature. 1987 Feb 5-11; 325(6104):552-4. PMID: 2433597

Foulkes JG, Chow M, Gorka C, Frackelton AR, Baltimore D. Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus. J Biol Chem. 1985 Jul 5; 260(13):8070-7. PMID: 2989275

Daniel TO, Tremble PM, Frackelton AR, Williams LT. Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody. Proc Natl Acad Sci U S A. 1985 May; 82(9):2684-7. PMID: 2581254; PMCID: PMC397629

Frackelton AR, Tremble PM, Williams LT. Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine. J Biol Chem. 1984 Jun 25; 259(12):7909-15. PMID: 6203898

Friedman B, Frackelton AR, Ross AH, Connors JM, Fujiki H, Sugimura T, Rosner MR. Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1984 May; 81(10):3034-8. PMID: 6328489; PMCID: PMC345215

Frackelton AR, Ross AH, Eisen HN. Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells. Mol Cell Biol. 1983 Aug; 3(8):1343-52. PMID: 6194425; PMCID: PMC369980

Wall KA, Frackelton AR, Reilly EB, Azuma T, Chang TW, Eisen HN. Quantitative of anti-NP (4-hydroxy-3-nitrophenyl)-acetyl idiotype expression on spleen and thymus cells. Eur J Immunol. 1983 Jun; 13(6):441-8. PMID: 6602707

Reilly EB, Frackelton AR, Eisen HN. Synthesis of lambda 1, lambda 2, and lambda 3 light chains by mouse spleen B cells. Eur J Immunol. 1982 Jul; 12(7):552-7. PMID: 6811287

Frackelton AR, Rotman B. Functional diversity of antibodies elicited by bacterial beta-D-galactosidase. Monoclonal activating, inactivating, protecting, and null antibodies to normal enzyme. J Biol Chem. 1980 Jun 10; 255(11):5286-90. PMID: 6768737

Frackelton AR, Weltman JK. Diffusion control of the binding of carcinoembryonic antigen (CEA) with insoluble anti-CEA antibody. J Immunol. 1980 Apr; 124(4):2048-54. PMID: 7365247

Herbert TJ, Weltman JK, Frackelton AR, Dowben RM. Dielectric dispersion of actin. J Mechanochem Cell Motil. 1977 Mar; 4(1):79-85. PMID: 572854

Weltman JK, Frackelton AR, Szaro RP, Rotman B. A galactosidase immunosorbent test for human immunoglobulin E. J Allergy Clin Immunol. 1976 Sep; 58(3):426-31. PMID: 987089

Weltman JK, Frackelton AR. Application of a galactosidase immunosorbent test to carcinoembryonic antigen in plasma. Cancer Res. 1976 Aug; 36(8):2850-3. PMID: 1277195

Frackelton AR, Szaro RP, Weltman JK. A galactosidase immunosorbent test for carcinoembryonic antigen. Cancer Res. 1976 Aug; 36(8):2845-9. PMID: 1277194

Weltman JK, Szaro RP, Frackelton AR, Dowben RM, Bunting JR, Cathou BE. N-(3-pyrene)maleimide: a long lifetime fluorescent sulfhydryl reagent. J Biol Chem. 1973 May 10; 248(9):3173-7. PMID: 4121698

Weltman JK, Szaro RP, Frackelton AR, Dowben RM. Fluorescence changes associated with G-F transformation of actin. FEBS Lett. 1972 Apr 15; 22(1):61-63. PMID: 11946561

Weltman JK, Frackelton AR, Szaro RP, Dowben RM. Synthesis and fluorescence polarization analysis of an organomercurial derivative of actin. J Lab Clin Med. 1971 Nov; 78(5):808. PMID: 5166934

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