Jose M Cacicedo, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition Section

MA, Boston University
PhD, Boston University School of Medicine



Dr. Cacicedo’s research interests are two-fold 1) the study of macro- and micro-vascular complications caused by diabetes and obesity and 2) the actions of exercise on the vascular wall. Low grade vascular inflammation is an underlying cause of atherosclerotic cardiovascular disease (ASCVD) and physical exercise has been demonstrated to prevent and improve ASCVD and vascular function in patients with and without diabetes. This is evident even in the absence of overt weight loss. Exercise can also help in the control and maintenance of blood glucose levels which is key to the prevention of diabetic microvascular complications such as retinopathy. Thus, an overarching theme to his research is to discover the mechanism(s) of exercise-induced anti-inflammatory actions on the vasculature and determine whether they can be replicated pharmacologically. Discoveries of this nature could serve as critical therapeutics or preventative therapies for vascular disorders associated with diabetes and obesity.

Dr. Cacicedo earned his PhD in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine (BUSM) and is currently an Assistant Professor in the Department of Medicine, Section of Endocrinology at BUSM.

Boston Medical Center





The Role of AMP-Activated Protein Kinase (AMPK) in the Prevention of Diabetic Retinopathy
04/01/2011 - 03/31/2013 (PI)
Mass General Hosp NIH-NIDDK



Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE. Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor ?2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice. Mol Cell Biol. 2017 Aug 01; 37(15). PMID: 28483914; DOI: 10.1128/MCB.00608-16;.
  2. Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14; 9(7).View Related Profiles. PMID: 28708087.
  3. Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Knockdown of GSK3ß increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Oct; 36(5).View Related Profiles. PMID: 27534430; PMCID: PMC5025810; DOI: 10.1042/BSR20160174;.
  4. Weikel KA, Ruderman NB, Cacicedo JM. Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights. Metabolism. 2016 May; 65(5):634-45.View Related Profiles. PMID: 27085772; PMCID: PMC4834453; DOI: 10.1016/j.metabol.2016.01.005;.
  5. Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015 Feb 1; 308(3):C249-63.View Related Profiles. PMID: 25354528; PMCID: PMC4312840; DOI: 10.1152/ajpcell.00265.2014;.
  6. Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One. 2014; 9(5):e97554.View Related Profiles. PMID: 24835252; PMCID: PMC4023984; DOI: 10.1371/journal.pone.0097554;.
  7. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013 Jul 1; 123(7):2764-72.View Related Profiles. PMID: 23863634; PMCID: PMC3696539; DOI: 10.1172/JCI67227;.
  8. Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092.View Related Profiles. PMID: 22514710; PMCID: PMC3325987; DOI: 10.1371/journal.pone.0035092;.
  9. Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13.View Related Profiles. PMID: 22378745; PMCID: PMC3404529; DOI: 10.1152/ajpcell.00296.2011;.
  10. Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801.View Related Profiles. PMID: 22323564; PMCID: PMC3307656; DOI: 10.1194/jlr.P022905;.
Showing 10 of 19 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 11 distinct years, with a maximum of 3 publications in 2012

YearPublications
20031
20041
20051
20082
20102
20112
20123
20131
20142
20162
20172

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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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