Katya Ravid, DSc
Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine Section

PhD, Technion - Israel Institute of Technology
DSc, Technion - Israel Institute of Technology



Platelet aggregation plays a central role in thrombosis and hemostasis, which are central to vascular disease. In the platelet lineage, the early committed cells undergo a unique cell cycle leading to the formation of polyploid megakaryocytes prior to their fragmentation into platelets. Our research focuses on mechanisms that regulate lineage commitment and the subsequent steps of cellular maturation of bone marrow cells into polyploid megakaryocytes. We reported that polyploidy also develops in aging vascular cells, and in other cell types under stress, and mechanisms of control of polyploidy and its relevance to disease states are investigated. An ongoing related project involves the molecular characterization of platelet and vascular adenosine receptors, and exploration of their role in cellular function and lineage development. The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Professor
Boston University School of Medicine
Department of Biochemistry


Director
Boston University School of Medicine
Department of Medicine
Evans Center for Interdisciplinary Biomedical Research Section

Director
Boston University
Department of BU Interdisciplinary Biomedical Research Office


Director, Master of Science Program in Biomedical Research
Boston University School of Medicine
Department of Medicine


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences


Center Faculty Member
Boston University School of Medicine
Department of Cardiovascular Institute (Whitaker)



2016 Fulbright : Fulbright Research Scholar Award
2016-2017 Aarhus University, Denmark : International Advisory Board
2014 Weizmann Institute: Weizmann Institute Professorship Award
2014 American Association for the Advancement of Science: Elected Fellow
2013 Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2013-2016 American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013 Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2009 University of Sydney : International Visiting Professor Fellowship Award
2006 Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2000-2005 American Heart Association: Established Investigator Award
1997 American Heart Association: Grant-In-Aid Award for Young Investigators
1987 Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1982 Technion: Gutwirth Prize for Outstanding Graduate Students


Lysyl Oxidase Pharmacological Inhibition of Bone Marow Fibrosis
03/01/2016 - 02/28/2018 (PI)
Pharmaxis

Training Program in Cardiovascular Biology: Pre-Doctoral
12/01/2014 - 11/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-13

Mechanisms Regulating Megakaryocyte Development
04/01/2012 - 09/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL080442-09

Nanoplatforms for Imaging Bone Marrow Fibrosis
10/01/2014 - 09/30/2016 (PI)
MPN Research Foundation

Training in Cardiovascular Biology: PREDOCTORAL
07/01/2001 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-10

Adenosine Receptors and Atherogenesis
04/01/2009 - 03/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL093149-04

Mechanisms Regulating Megakaryocte Development
04/01/2012 - 03/31/2013 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL080442-06A1

The A2b Adenosine Receptor as Regulator of Type II Diabetes
09/30/1997 - 03/31/2013 (PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-20

Training in Cardiovascular Biology: Predoctoral
07/01/2011 - 06/30/2012 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-09

Properties of Polypoloid Cells in a Model of Aging
06/01/2003 - 05/31/2005 (PI)
NIH/National Institute on Aging
1 R03 AG22623 01

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-13 45
2016 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-12 45
2015 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-09 14
2015 Training Program in Cardiovascular Biology: Pre-Doctoral 2T32HL007969-11 45
2014 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-08 14
2013 2013 Cell Biology of Megakaryocytes and Platelets GRC &GRS 1R13HL117369-01
2013 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-07 14
2013 Training in Cardiovascular Biology: PREDOCTORAL 5T32HL007969-10 45
2012 Adenosine Receptors and Atherogenesis 5R01HL093149-04 14
2012 Mechanisms Regulating Megakaryocyte Development 2R01HL080442-06A1 14
Showing 10 of 51 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Abbonante V, Di Buduo CA, Gruppi C, De Maria C, Spedden E, De Acutis A, Staii C, Raspanti M, Vozzi G, Kaplan D, Moccia F, Ravid K, Balduini A. A new path to platelet production through matrix sensing. Haematologica. 2017 Apr 14. PMID: 28411253; DOI: 10.3324/haematol.2016.161562;.
  2. Leiva O, Ng SK, Chitalia S, Balduini A, Matsuura S, Ravid K. The role of the extracellular matrix in primary myelofibrosis. Blood Cancer J. 2017 Feb 03; 7(2):e525.View Related Profiles. PMID: 28157219; DOI: 10.1038/bcj.2017.6;.
  3. Lucero HA, Patterson S, Matsuura S, Ravid K. Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse. J Biol Methods. 2016; 3(4).View Related Profiles. PMID: 28008415; DOI: 10.14440/jbm.2016.152;.
  4. Matsuura S, Patterson S, Lucero H, Leiva O, Grant AK, Herrera VL, Ravid K. In vivo magnetic resonance imaging of a mouse model of myelofibrosis. Blood Cancer J. 2016 Nov 11; 6(11):e497.View Related Profiles. PMID: 27834941; DOI: 10.1038/bcj.2016.97;.
  5. Sun Y, Hu W, Yu X, Liu Z, Tarran R, Ravid K, Huang P. Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression. Biochem J. 2016 Jul 15; 473(14):2179-86. PMID: 27208173; DOI: 10.1042/BCJ20160272;.
  6. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501.View Related Profiles. PMID: 26755713; PMCID: PMC4797025; DOI: 10.1182/blood-2015-02-629667;.
  7. Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. J Cell Physiol. 2015 Dec; 230(12):2891-7.View Related Profiles. PMID: 25975415; DOI: 10.1002/jcp.25043;.
  8. Cohen HB, Ward A, Hamidzadeh K, Ravid K, Mosser DM. IFN-? Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. J Immunol. 2015 Oct 15; 195(8):3828-37. PMID: 26355158; PMCID: PMC4686143; DOI: 10.4049/jimmunol.1501139;.
  9. Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15; 195(4):1732-43. PMID: 26136425; PMCID: PMC4576932; DOI: 10.4049/jimmunol.1402288;.
  10. Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 4; 212(5):649-63.View Related Profiles. PMID: 25870200; PMCID: PMC4419349; DOI: 10.1084/jem.20141528;.
Showing 10 of 137 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 137 publications over 33 distinct years, with a maximum of 13 publications in 2008

YearPublications
19802
19831
19841
19851
19881
19891
19912
19921
19932
19941
19953
19964
19973
19982
19997
20003
20013
20028
20033
20045
20054
20064
20072
200813
20099
20107
20117
201210
201310
20147
20154
20164
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adenosine Receptors
Blood Cells
Cell Cycle Control
Hematopoietic Stem Cells
Megakaryocyte
Platelet
Polyploidy
Vascular Biology
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Google Map


Ravid's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department