Zhi Wang, MD
Professor
Boston University School of Medicine
Dept of Otolaryngology-Head & Neck Surgery

MD, Xi'an Jiaotong University
MS, Xi'an Jiaotong University



Research expertise in using laser and other new technologies to develop novel approach for early detection and treatment of head/neck cancer, as well as atraumatic head/neck surgery. Select funded research has included:

Spectroscopic imaging and diagnosis of neoplasia: The goals of this study are to validate newly developed light scattering imaging and tri-model spectroscopic techniques for early diagnosis of cancers.

Laser assisted Celecoxib treatment of oral leukoplakia: The goals of this study to determine if a combination of laser vascular targeting technique and a COX-2 inhibitor will improve treatment efficacy while reducing toxicity for oral cancer chemoprevention.

Voice-preserving treatment of laryngeal papilloma: The goals of this study are to determine if a combined treatment of pulsed dye laser and Celecoxib will reduce the trauma to vocal cords and prevent papilloma from recurring.

Laser atraumatic treatment of ectasias on vocal cords: The goals of this study are to test safety and clinical benefit of a new and less-invasive Alternative for treatment of ectasias and other small vascular lesions on vocal cords.

Imaging evaluation of cancer chemoprevention: The goals of this study are to develop an invasive, in site and timely method for prognosis of cancer chemoprevention, by cell nuclear imaging.

Voice-preserving treatment of laryngeal papilloma: The goals of this study are to determine if a combined treatment of pulsed dye laser and a dietary supplement (DIM) will provide better results for treatment of papilloma in children.


New management of vocal scar with antibody/dye-guided laser
03/25/2013 - 02/29/2016 (PI)
NIH/National Institute on Deafness & Communication Disorders
5R21DC012604-02

Imaging Evaluation of Cancer Chemoprevention
04/01/2006 - 01/31/2010 (PI)
NIH/National Cancer Institute
5 R21 CA106399 02

Laser Atraumatic Treatment of Ectasias on Vocal Cords
08/01/2005 - 07/31/2008 (PI)
NIH/National Institute on Deafness & Communication Disorders
5 R21 DC006853 02

Voice Preserving Treatment of Laryngeal Papilloma
07/01/2005 - 06/30/2008 (PI)
NIH/National Institute on Deafness & Communication Disorders
5 R01 DC06617 02

Laser Assisted Celecoxib Treatment of Oral Leukoplakia
03/01/2005 - 02/28/2008 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R21 DE16021 02

Biofilm Chemoprevention of Head/Neck Skin Cancer
09/30/2004 - 08/31/2007 (PI)
NIH/National Cancer Institute
5 R03 CA112670 02

Application of CO2 Laser Fiber in Head/Neck Surgeries
05/01/2004 - 12/01/2004 (PI)
OmniGuide Communication, Inc.

Pulsed Dye Laser Assisted Cancer Chemoprevention
09/21/2001 - 08/31/2004 (PI)
NIH/National Cancer Institute
5 R03 CA96509 02

Topical “Photo-Chemoprevention” of Oral Leukoplakia
08/01/2001 - 12/31/2003 (PI)
NIH/National Cancer Institute
5 R03 CA91324 03

Laser Photothermolysis of Scar in Vocal Cords
08/01/2001 - 04/30/2003 (PI)
New England Medical Center NIH NIDCD
1 R01 DC04640 01A1




Yr Title Project-Sub Proj Pubs
2014 New management of vocal scar with antibody/ICG guided laser 5R21DC012604-02
2013 New management of vocal scar with antibody/ICG guided laser 1R21DC012604-01A1
2009 Voice-preserved therapy of laryngeal papilloma in children 5R01DC008287-03 1
2008 Voice-preserved therapy of laryngeal papilloma in children 5R01DC008287-02 1
2007 Voice-preserved therapy of laryngeal papilloma in children 1R01DC008287-01A1 1
2007 Imaging Evaluation of Cancer Chemoprevention 5R21CA106399-02
2006 Imaging Evaluation of Cancer Chemoprevention 1R21CA106399-01A2
2006 Laser Atraumatic Treatment of Ectasias on Vocal Cords 5R21DC006853-02
2006 Voice-preserving Treatment of Larynegeal Papilloma 5R01DC006617-02
2006 Laser Assisted Celecoxib Treatment of Oral Leukoplakia 5R21DE016021-02 2
Showing 10 of 20 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Wang Z, Feng L. Optical Diagnosis of Head and Neck Cancers. Rev Recent Clin Trials. 2016; 11(1):2-11. PMID: 26374558.
  2. McGee S, Mardirossian V, Elackattu A, Mirkovic J, Pistey R, Gallagher G, Kabani S, Yu CC, Wang Z, Badizadegan K, Grillone G, Feld MS. Anatomy-based algorithms for detecting oral cancer using reflectance and fluorescence spectroscopy. Ann Otol Rhinol Laryngol. 2009 Nov; 118(11):817-26.View Related Profiles. PMID: 19999369; PMCID: PMC2860948.
  3. Elackattu AP, Feng L, Wang Z. A controlled safety study of diindolylmethane in the immature rat model. Laryngoscope. 2009 Sep; 119(9):1803-8. PMID: 19544380; PMCID: PMC3015182; DOI: 10.1002/lary.20526;.
  4. Fegn L, Wang Z. Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2. J Laryngol Otol. 2009 Aug; 123(8):880-4. PMID: 19216818; PMCID: PMC2714874; DOI: 10.1017/S0022215109004617;.
  5. McGee S, Mirkovic J, Mardirossian V, Elackattu A, Yu CC, Kabani S, Gallagher G, Pistey R, Galindo L, Badizadegan K, Wang Z, Dasari R, Feld MS, Grillone G. Model-based spectroscopic analysis of the oral cavity: impact of anatomy. J Biomed Opt. 2008 Nov-Dec; 13(6):064034.View Related Profiles. PMID: 19123680; PMCID: PMC2629646; DOI: 10.1117/1.2992139;.
  6. Wang Z, Devaiah AK, Feng L, Dasai U, Shapira G, Weisberg O, Torres DS, Shapshay SM. Fiber-guided CO2 laser surgery in an animal model. Photomed Laser Surg. 2006 Oct; 24(5):646-50.View Related Profiles. PMID: 17069498.
  7. Wang Z. The role of COX-2 in oral cancer development, and chemoprevention/ treatment of oral cancer by selective COX-2 inhibitors. Curr Pharm Des. 2005; 11(14):1771-7. PMID: 15892674.
  8. Wang Z, Polavaram R, Gooey J, Davis LH, Shapshay SM. Laser assisted topical 'biofilm' chemoprevention of oral cancer. Cancer Lett. 2004 Nov 8; 215(1):29-34.View Related Profiles. PMID: 15374629.
  9. Wang Z, Polavaram R, Fuentes CF, Shapshay SM. Topical chemoprevention of oral cancer with tretinoin "biofilm". Arch Otolaryngol Head Neck Surg. 2003 Aug; 129(8):869-73. PMID: 12925347.
  10. Wang Z, Polavaram R, Shapshay SM. Topical inhibition of oral carcinoma cell with polymer delivered celecoxib. Cancer Lett. 2003 Jul 30; 198(1):53-8. PMID: 12893430.
Showing 10 of 12 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 12 publications over 8 distinct years, with a maximum of 3 publications in 2003 and 2009

YearPublications
20021
20033
20041
20051
20061
20081
20093
20161
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75 E. Newton St Collamore Building
Boston MA 02118
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