Konstantin Kandror, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, USSR Academy of Sciences



Expertise includes: Insulin action; Adipocyte biology; Membrane traffic.

Adipocytes, skeletal myocytes and some neurons express a specific isoform of the glucose transporter protein, Glut4. Under basal conditions this transporter is localized in intracellular membrane vesicles which fuse with the plasma membrane upon insulin administration. Translocation of Glut4 plays a major role in post-prandial glucose clearance and, more generally, in glucose sensing and metabolic homeostasis in the body. For a number of years, my lab has been involved in the dissection of the “Glut4 pathway” in various insulin-sensitive cells.

Another key physiological function of insulin is to inhibit lipolysis and to promote storage of triglycerides in fat tissue. Recently, we have discovered two novel pathways of regulation of lipolysis by insulin. One of these pathways is mediated by the insulin- and nutrient-sensitive mammalian Target of Rapamycin Complex 1, while the other is mediated by transcriptional factor FoxO1. Currently, we are engaged in the dissection of both pathways at the molecular level.

Fat represents an important secretory tissue in the body. Unlike typical endocrine and exocrine cells, adipocytes produce and secret several physiologically important proteins, such as leptin, adiponectin, lipoprotein lipase, etc. and switch the secretory process from one protein to another in response to changing metabolic conditions. We are exploring connections between food intake, obesity and secretion of adipokines in order to understand the central role of fat tissue in the orchestrating the overall response of the organism to changing metabolic conditions.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Regulation of lipolysis by mTORC1
02/10/2016 - 01/31/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK107498-02

Insulin Regulation of Cell Nutrition
09/01/2015 - 08/31/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-17

Cide Proteins and Regulation of Energy Expenditure
09/01/2015 - 08/31/2017 (PI)
Ohio University NIH NIDDK
7R01DK101711-03

Reprogramming Fatty Acid Handling to Improve Adipocyte Function in Human Obesity
07/01/2016 - 12/31/2016 (PI)
Icahn School of Medicine at Mount Sinai Amer Diabetes Assoc

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
01/01/2015 - 06/30/2016 (PI)
Boston Medical Center Corporation Amer Diabetes Assoc

Insulin regulation of cell nutrition
08/25/2014 - 08/31/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R56DK052057-16

Insulin Regulation of Cell Nutrition
06/01/2008 - 08/24/2014 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-15

AMPK and adipose tissue biology in bariatric surgury patients
07/16/2012 - 06/30/2014 (PI)
Boston Medical Center Corporation NIH NIDDK
1R24DK094749-01

Regulation of Lipolysis VIA the TSC1/2-RHEB-MOTRC1 Pathway
07/01/2011 - 06/30/2014 (PI)
American Diabetes Association

Regulation of Lipolysis by mTORC1
09/15/2011 - 08/31/2013 (PI)
NIH/National Institute on Aging
5R21AG039612-02

Showing 10 of 16 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Regulation of lipolysis by mTORC1 5R01DK107498-02
2016 Regulation of lipolysis by mTORC1 1R01DK107498-01
2016 Insulin regulation of cell nutrition 5R01DK052057-17 6
2015 Insulin regulation of cell nutrition 2R01DK052057-16A1 6
2014 Insulin regulation of cell nutrition 2R56DK052057-16
2013 Insulin regulation of cell nutrition 5R01DK052057-15 6
2012 Regulation of lipolysis by mTORC1 5R21AG039612-02 3
2012 Insulin regulation of cell nutrition 5R01DK052057-14 6
2011 Regulation of lipolysis by mTORC1 1R21AG039612-01A1 3
2011 Insulin regulation of cell nutrition 5R01DK052057-13 6
Showing 10 of 37 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chakrabarti P, Kandror KV. The role of mTOR in lipid homeostasis and diabetes progression. Curr Opin Endocrinol Diabetes Obes. 2015 Oct; 22(5):340-6.View Related Profiles. PMID: 26241026; DOI: 10.1097/MED.0000000000000187;.
  2. Singh M, Shin YK, Yang X, Zehr B, Chakrabarti P, Kandror KV. 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL. J Biol Chem. 2015 Jul 10; 290(28):17331-8.View Related Profiles. PMID: 25814662; PMCID: PMC4498071; DOI: 10.1074/jbc.M114.631895;.
  3. Singh M, Kaur R, Lee MJ, Pickering RT, Sharma VM, Puri V, Kandror KV. Fat-specific protein 27 inhibits lipolysis by facilitating the inhibitory effect of transcription factor Egr1 on transcription of adipose triglyceride lipase. J Biol Chem. 2014 May 23; 289(21):14481-7.View Related Profiles. PMID: 24742676; PMCID: PMC4031504; DOI: 10.1074/jbc.C114.563080;.
  4. Huang G, Buckler-Pena D, Nauta T, Singh M, Asmar A, Shi J, Kim JY, Kandror KV. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Mol Biol Cell. 2013 Oct; 24(19):3115-22. PMID: 23966466; PMCID: PMC3784384; DOI: 10.1091/mbc.E12-10-0765;.
  5. Chakrabarti P, Kim JY, Singh M, Shin YK, Kim J, Kumbrink J, Wu Y, Lee MJ, Kirsch KH, Fried SK, Kandror KV. Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway. Mol Cell Biol. 2013 Sep; 33(18):3659-66.View Related Profiles. PMID: 23858058; PMCID: PMC3753874; DOI: 10.1128/MCB.01584-12;.
  6. Kim JY, Kandror KV. The first luminal loop confers insulin responsiveness to glucose transporter 4. Mol Biol Cell. 2012 Mar; 23(5):910-7. PMID: 22262463; PMCID: PMC3290648; DOI: 10.1091/mbc.E11-10-0839;.
  7. Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One. 2011; 6(11):e28146.View Related Profiles. PMID: 22140527; PMCID: PMC3226650; DOI: 10.1371/journal.pone.0028146;.
  8. Chakrabarti P, English T, Karki S, Qiang L, Tao R, Kim J, Luo Z, Farmer SR, Kandror KV. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL. J Lipid Res. 2011 Sep; 52(9):1693-701.View Related Profiles. PMID: 21743036; PMCID: PMC3151689; DOI: 10.1194/jlr.M014647;.
  9. Chakrabarti P, Kandror KV. Adipose triglyceride lipase: a new target in the regulation of lipolysis by insulin. Curr Diabetes Rev. 2011 Jul; 7(4):270-7.View Related Profiles. PMID: 21644917.
  10. Kandror KV, Pilch PF. The sugar is sIRVed: sorting Glut4 and its fellow travelers. Traffic. 2011 Jun; 12(6):665-71.View Related Profiles. PMID: 21306486; DOI: 10.1111/j.1600-0854.2011.01175.x;.
Showing 10 of 84 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 84 publications over 31 distinct years, with a maximum of 5 publications in 1994 and 2004 and 2009

YearPublications
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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