Maria Isabel Ramirez, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

PhD, University of Buenos Aires



The main goal of the research in our lab is to identify and understand genetic and epigenetic mechanisms of gene regulation driving the differentiation of distinct epithelial cell lineages during development, and the potential alteration of these mechanisms in lung disease. Correct spatial and temporal patterns of gene expression during lung development are critical for the formation of a functional lung ready for the first breath at birth. In adults, patterns of gene expression also have to be maintained to preserve a healthy lung. Dissecting these basic mechanisms in development will provide the basis to accurately differentiate embryonic stem cells into lung epithelial cell lineages in vitro, to improve fetal lung maturation and to understand altered cell phenotypes in lung disease.

Associate Professor
Boston University School of Medicine
Department of Pathology & Laboratory Medicine
Other Pathology Section

Assistant Dean
Boston University School of Medicine
Department of Diversity & Multicultural Affairs


Member
Boston University
Department of Bioinformatics Graduate Program


Center Faculty Member
Boston University School of Medicine
Department of Pulmonary Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



1998-2001 Boston University School of Medicine: Parker B. Francis Foundation, Lung Research Fellowship
1997 Boston University School of Medicine: Evans Research Days Poster Award 1st Place
1994-1996 University of Massachusetts Medical Center: American Heart Association, Massachusetts Affiliate Postdoctoral Fellowship (Declined)
1994 Universidad de Buenos Aires, Argentina: Fundacion de Ciencias Exactas y Naturales, Thesis Dissertation Award
1992 Universidad de Buenos Aires, Argentina: Argentine Chemical Association, Dr. Herrero-Ducloux Biannual Doctoral Thesis Award
1988-1991 Universidad de Buenos Aires, Argentina: National Council of Science (CONICET), Argentina. Pre-Doctoral Fellowship


Summer Research and Educational Program
02/01/2016 - 01/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
5R25HL118693-05

Molecular and biological function of long non-coding RNA transcripts divergent to lung developmental genes
09/01/2015 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL127426-02

Summer Research and Educational Program
08/20/2013 - 01/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R25HL118693-03

Regulation and Function of the Alveolar Type I Cell T1 (Type II) Gene in Genetically Altered Mice
07/01/1998 - 06/30/2001 (PI)
Parker B. Francis Foundation




Yr Title Project-Sub Proj Pubs
2017 Summer Research and Educational Program 5R25HL118693-05
2016 Molecular and biological function of long non-coding RNA transcripts divergent to lung developmental genes 5R01HL127426-02
2016 Summer Research and Educational Program 4R25HL118693-04
2015 Molecular and biological function of long non-coding RNA transcripts divergent to lung developmental genes 1R01HL127426-01
2012 Chromatin Modifications and DNA Methylation During Early Lung Development 5P01HL047049-20-5545 86
2012 Mouse Genetics 5P01HL047049-20-5548 86
2011 Chromatin Modifications and DNA Methylation During Early Lung Development 5P01HL047049-19-5545 86
2011 Mouse Genetics 5P01HL047049-19-5548 86
2011 Chromatin Modifications and DNA Methylation During Early Lung Development 5P01HL047049-19-5545 86
2011 Mouse Genetics 5P01HL047049-19-5548 86
Showing 10 of 22 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18.View Related Profiles. PMID: 27064756; PMCID: PMC5023025; DOI: 10.1165/rcmb.2015-0261OC;.
  2. Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles. PMID: 25843048; PMCID: PMC4437473; DOI: 10.1016/j.stemcr.2015.02.021;.
  3. Tagne JB, Mohtar OR, Campbell JD, Lakshminarayanan M, Huang J, Hinds AC, Lu J, Ramirez MI. Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb. Respir Res. 2015; 16:22.View Related Profiles. PMID: 25763778; PMCID: PMC4335692; DOI: 10.1186/s12931-015-0186-6;.
  4. Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D. Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1; 306(5):L405-19. PMID: 24375798; PMCID: PMC3949053; DOI: 10.1152/ajplung.00143.2013;.
  5. Krishnan H, Ochoa-Alvarez JA, Shen Y, Nevel E, Lakshminarayanan M, Williams MC, Ramirez MI, Miller WT, Goldberg GS. Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. J Biol Chem. 2013 Apr 26; 288(17):12215-21. PMID: 23530051; PMCID: PMC3636905; DOI: 10.1074/jbc.C112.446823;.
  6. Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI. The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012 Oct 26; 287(44):37282-95.View Related Profiles. PMID: 22955271; PMCID: PMC3481326; DOI: 10.1074/jbc.M112.408401;.
  7. Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol. 2012 Sep 1; 189(5):2450-9.View Related Profiles. PMID: 22844121; PMCID: PMC3424336; DOI: 10.4049/jimmunol.1200634;.
  8. Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6; 10(4):398-411.View Related Profiles. PMID: 22482505; PMCID: PMC3322392; DOI: 10.1016/j.stem.2012.01.019;.
  9. Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. PLoS One. 2012; 7(1):e29907.View Related Profiles. PMID: 22242187; PMCID: PMC3252372; DOI: 10.1371/journal.pone.0029907;.
  10. Cao Y, Vo T, Millien G, Tagne JB, Kotton D, Mason RJ, Williams MC, Ramirez MI. Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene. J Biol Chem. 2010 Jan 15; 285(3):2152-64.View Related Profiles. PMID: 19906647; PMCID: PMC2804371; DOI: 10.1074/jbc.M109.039172;.
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 18 distinct years, with a maximum of 4 publications in 2003 and 2007 and 2012

YearPublications
19881
19901
19911
19921
19931
19941
19951
20021
20034
20041
20061
20074
20081
20092
20124
20132
20152
20161
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Chromatin remodeling
Epigenetics
Gene regulation
Lung development
Lung epithelium
Mouse models
Non-coding RNA

Available to Mentor as: (Review Mentor Role Definitions):
  • Diversity Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')


75 E. Newton St Evans Building
Boston MA 02118
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