Sudha Seshadri, MD
Professor
Boston University School of Medicine
Dept of Neurology

DM, All India Institute of Medical Sciences
MBBS, Christian Medical College
MD, All India Institute of Medical Sciences



I have been an investigator at the Framingham Heart Study (FHS) since 1998, leading the clinical neurology and neurogenetics cores since 2005 and currently serve as PI on 9 NIH grants, 5 R01 grants, 3 U01s and a UH2. As a board certified neurologist and Professor of Neurology at the Boston University School of Medicine, I run a Geriatric Memory Disorders and Dementia clinic, supervise a resident general neurology clinic and cover the in-patient, consult and emergency services for one month in each year. I also served as Co-Director of Medical Education for the Neurology Residency Program between 2005 and 2012. I was Director of the neurology segment of the Biology of Disease/ Disease and Therapy course for 2nd year medical students between 2008-2010 and in 2015-16 and continue to teach the Dementia module. I currently spend 75% of my time on research and mentoring within the context of the Framingham study and have served as primary mentor for over 30 physician and non-physician investigators funded by a wide range of grants, national (K23, AAN, AHA) and international (Fulbright, Bettencourt-Schuller, Sidney-Sax etc.).

In my research capacity, I currently lead the clinical neurology and neurogenetics cores at the FHS, where we explore the cumulated and age-specific impacts of a wide variety of genomic and environmental risk factors underlying stroke, dementia and brain aging across 3 generations of participants. This entails undertaking brain MRI, cognitive tests, brain autopsies, biomarker, candidate gene, genome-wide association, sequencing and expression studies. At FHS, my key contributions have included updating the dementia database with improved tracking, review and new classification systems, studying novel biomarkers such as BDNF, NGF and beta-amyloid, and establishing a brain bank program. In addition I play a major role in consolidating, refining and expanding various aspects of the MRI and stroke databases. Further, as lead neurogenetics investigator I have funded whole exome sequencing on over 1300 Framingham Study participants.

My research focuses on 4 interrelated areas: (a) exploring the correlates of subclinical brain aging including establishing norms for brain MRI and cognitive test performance and relating these measures to novel risk factors (such as visceral fat mass), multiple circulating biomarkers and clinical and subclinical indices of vascular and metabolic disease; (b) the epidemiology of stroke and vascular cognitive impairment including the lifetime risk of stroke, cognitive decline and dementia following stroke, the role of parental stroke and midlife risk factors in determining late-life stroke risk and temporal trends in stroke risk over the past 50 years; (c) the epidemiology of dementia and Alzheimer’s disease (AD) including describing the lifetime risk of AD and relating traditional and novel biomarkers (homocysteine, lipids, diabetes, estrogen, bone mineral density, thyroid function, inflammation) to the risk of dementia and AD. I have been especially interested in exploring the role of reversible lifestyle, vascular and metabolic risk factors in determining dementia risk with a special focus on understanding the putative causal pathways and biomarkers, such as leptin and other adipokines, BDNF and other neurotrophic factors, in mediating this risk, and (d) understanding the genomic and epigenetic variation underlying brain aging, stroke, AD and vascular cognitive impairment.

My most significant research contributions have been (i) developing the concept of lifetime risk as applicable to dementia and other chronic diseases, (ii) helping to establish plasma homocysteine as an important risk marker for dementia and AD (including a first author paper in the NEJM in 2002 that has had over 1400 citations), (iii) relating low plasma leptin levels to the risk of dementia and AD (published in JAMA, 2009 as senior author), (iv) describing a novel gene, NINJ2, associated with ischemic stroke (NEJM, 2009 as corresponding author), (v) describing two genes, BIN1 and EXOCL2, associated with Alzheimer disease in the largest, multi-centric genome-wide association study to date (JAMA, 2010 as first author) and identifying novel genes underlying hippocampal volume in healthy adults (Nature Genetics, 2012 as Senior author).

I have over 280 peer-reviewed publications and reviews. I also established, partially fund and coordinate the neurology phenotype working group within the international Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium started in January 2008. This consortium brings together investigators from several of the leading cohort studies, the FHS, the Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health study (CHS), the Rotterdam study, the Age, Gene, Environment Susceptibility- Reykjavik (AGES-Reykjavik) study and the Austrian Study for Prevention of Stroke (ASPS). In my capacity as coordinator of neuroCHARGE, I am also a founding member of the International Genomics of Alzheimer's Project (IGAP) that brings together 4 major European and US groups who are currently the leaders in AD genomics research, am a PI of the Alzheimer Disease Sequencing Project (ADSP) that assesses rare genetic variation underlying PD in over 11,500 persons, a member of the Steering Committee for the International Stroke Genetics Consortium (ISGC) and Chair of the METASTROKE consortium.

A particular emphasis of mine throughout my career has been and will continue to be mentoring younger colleagues at my own institution and around the world towards academic careers. Collectively, my mentees have over 80 first author papers that I mentored published in leading journals including NEJM, Lancet, Nature Genetics, JAMA, JAMA Internal Medicine, JAMA Neurology, Annals of Neurology, Brain, Stroke and Neurology.

Framingham Heart Study



2013 American Academy of Neurology: Fellow
2013-2013 Boston University: Jack Spivack Excellence in Neurosciences Award
2012 American Neurological Association: Fellow


Precursors of Stroke Incidence and Prognosis
03/01/2016 - 02/28/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS017950-34

Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults
05/15/2015 - 01/31/2018 (PI)
NIH/National Institute on Aging
5R01AG049607-03

Microgial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
09/30/2016 - 07/31/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1UH2NS100605-01

Consortium to Study the Genetics of Longevity
06/01/2015 - 06/30/2017 (PI)
Sutter Bay Hospitals dba California Pacific Medical Center NIH NIA
5U19AG023122-10

Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer Disease in Framingham Cohorts
09/01/2016 - 05/31/2017 (PI)
NIH/National Institute on Aging
1R01AG054076-01

ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems
09/01/2016 - 05/31/2017 (PI)
NIH/National Institute on Aging
1U01AG052409-01

Collaborative GWAS of Dementia, AD and Related MRI and Cognitive Endophenotypes
06/01/2016 - 05/31/2017 (PI)
NIH/National Institute on Aging
4R01AG033193-07

CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample
06/15/2014 - 05/31/2017 (PI)
NIH/National Institute on Aging
5U01AG049505-03

Epidemiology of Dementia in the Framingham Study
09/01/2010 - 05/31/2017 (PI)
NIH/National Institute on Aging
5R01AG008122-25

An integrated genetic and epigenetic approach to cerebral small vessel disease
04/01/2015 - 03/31/2017 (PI)
University of Texas Health Science Center, Houston NIH NINDS
5R01NS087541-03

Showing 10 of 20 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults 5R01AG049607-03 7
2017 MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults 5R01AG033040-08 24
2017 Precursors of Stroke Incidence and Prognosis 5R01NS017950-34 328
2016 Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium 1UH2NS100605-01
2016 ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems 1U01AG052409-01
2016 Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts 1R01AG054076-01
2016 Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults 5R01AG049607-02 7
2016 CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample 5U01AG049505-03 6
2016 AD Gene Discovery: Exome Chip, New Endophenotypes & Functional Studies in CHARGE 4R01AG033193-07 124
2016 MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults 5R01AG033040-07 24
Showing 10 of 28 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. Stroke. 2017 Jun 08.View Related Profiles. PMID: 28596451.
  2. Pase MP, Satizabal CL, Seshadri S. Role of Improved Vascular Health in the Declining Incidence of Dementia. Stroke. 2017 Jun 08.View Related Profiles. PMID: 28596460.
  3. Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, Weinstein G, Wang TJ, Gerszten RE, Vasan RS, Seshadri S. Association of amine biomarkers with incident dementia and Alzheimer''s disease in the Framingham Study. Alzheimers Dement. 2017 Jun 08.View Related Profiles. PMID: 28602601.
  4. Pase MP, Seshadri S, Jacques PF. Response by Pase et al to Letter Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study". Stroke. 2017 Jun 05. PMID: 28583997.
  5. Tan ZS, Spartano NL, Beiser AS, DeCarli C, Auerbach SH, Vasan RS, Seshadri S. Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 Jun 01; 72(6):789-795.View Related Profiles. PMID: 27422439; DOI: 10.1093/gerona/glw130;.
  6. Wu YT, Beiser AS, Breteler MMB, Fratiglioni L, Helmer C, Hendrie HC, Honda H, Ikram MA, Langa KM, Lobo A, Matthews FE, Ohara T, Pérès K, Qiu C, Seshadri S, Sjölund BM, Skoog I, Brayne C. The changing prevalence and incidence of dementia over time - current evidence. Nat Rev Neurol. 2017 Jun; 13(6):327-339.View Related Profiles. PMID: 28497805.
  7. Maillard P, Mitchell GF, Himali JJ, Beiser A, Fletcher E, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury. Stroke. 2017 Jun; 48(6):1567-1573.View Related Profiles. PMID: 28473633; DOI: 10.1161/STROKEAHA.116.016321;.
  8. Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. 2017 May; 48(5):1139-1146.View Related Profiles. PMID: 28428346; DOI: 10.1161/STROKEAHA.116.016027;.
  9. Lubitz SA, Seshadri S, Benjamin EJ. Response by Lubitz et al to Letter Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study". Stroke. 2017 Jun; 48(6):e143.View Related Profiles. PMID: 28416627; DOI: 10.1161/STROKEAHA.117.017108;.
  10. Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med. 2017 Mar; 14(3):e1002254.View Related Profiles. PMID: 28323826; DOI: 10.1371/journal.pmed.1002254;.
Showing 10 of 284 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 284 publications over 24 distinct years, with a maximum of 48 publications in 2015

YearPublications
19891
19911
19942
19951
19971
19991
20002
20015
20024
20033
20046
20052
20068
20079
20085
200913
201014
201118
201222
201323
201431
201548
201643
201721
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Alzheimer Disease
Epidemiology
GEnetics
Stroke

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:


72 E. Concord St Robinson (B)
Boston MA 02118
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