Shelley J. Russek, PhD
Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, Boston University
MS, State University of New York at Stony Brook



Research Interests of the Russek Laboratory: Dysregulated Plasticity of the Nervous System

The plasticity of a neuron’s receptor systems at the membrane is a key feature of the brain that enables its development as well as its function throughout life, creating and responding to an ever-changing external and internal world. A glorious biological feature of existence, however, also contributes to mankind’s most devastating disorders. Dysregulated plasticity takes multiple forms, from the unrelenting seizures of an infant that later emerges with brain damage, to the manifestation of autism and schizophrenia, all begging for curative therapies. Our chief interests in the laboratory surround a desire to understand the genetic and epigenetic basis of neurotransmitter and neurotrophin receptor regulation. We believe that such an understanding will enable us to contribute to the future development of therapeutics that can tackle these complex human problems where plasticity has lost its balance in controlling brain inhibition and excitation.

We employ a variety of proteomic and transcriptomic techniques, including confocal fluorescence immunohistochemistry, western blot, proximity ligation assays, siRNA silencing, RNA and chromatin immunoprecipitation (ChIP) high density sequencing, methylation genome analysis, proximity ligation analysis, primary neuronal cultures, and in vivo models (rodent and zebrafish) to test hypotheses of disease etiology and potential strategies for novel molecular therapeutics using novel chemical libraries and re-purposed therapeutics.

Director
Boston University
Graduate Program for Neuroscience


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences



2004 American Epilepsy Society: Innovative Research Award
2001 BU School of Medicine: Dean’s Distinguished Faculty Service Award


GABA(A) Receptor Subunit Regulation in Epileptogenesis
09/01/2015 - 12/31/2017 (PI)
Regents of the University of Colorado, o NIH NINDS
2R01NS051710-11A1

Development of Novel JAK/STAT Inhibitors for Epilepsy Prevention and Treatment
01/01/2014 - 09/16/2016 (PI)
Regents of the University of Colorado, o NIH NINDS
5R21NS083057-02

Development of Novel JAK/STAT Inhibitors for Disease Modification in Epilepsy
01/01/2014 - 12/31/2015 (PI)
Citizens United for Research in Epilepsy

GABA (A) RECEPTOR SUBUNIT REGULATION IN EPILEPTOGENESIS
07/01/2010 - 04/30/2015 (PI)
Regents of the University of Colorado, o NIH NINDS
5R01NS051710-10

JAK/STAT Inhibition to Prevent Epilepsy development and Progression
07/01/2010 - 06/30/2012 (PI)
Cure Lab, Inc.

Steroids - Functional Modulators of Amino Acid Receptors
07/01/1992 - 05/31/2009 (Co-PI)
NIH/National Institute of Mental Health
5 R01 MH49469 15

GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
02/01/2002 - 01/31/2006 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5 R21 NS42363 03

Alcohol Response Elements in Human GAB/AR Gene Clusters
04/01/1998 - 03/31/2003 (Co-PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5 R01 AA11697 05




Yr Title Project-Sub Proj Pubs
2016 GABA(A) Receptor Subunit Regulation in Epileptogenesis 5R01NS051710-12 12
2015 Development of novel JAK/STAT inhibitors for Epilepsy prevention and treatment 5R21NS083057-02 1
2015 GABA(A) Receptor Subunit Regulation in Epileptogenesis 2R01NS051710-11A1 12
2014 Development of novel JAK/STAT inhibitors for Epilepsy prevention and treatment 1R21NS083057-01A1 1
2014 GABA(A) Receptor Subunit Regulation in Epileptogenesis 5R01NS051710-10 12
2013 GABA(A) Receptor Subunit Regulation in Epileptogenesis 5R01NS051710-09 12
2012 GABA(A) Receptor Subunit Regulation in Epileptogenesis 5R01NS051710-08 12
2012 GABA(A) Receptor Subunit Regulation in Epileptogenesis 3R01NS051710-08S1 12
2011 GABA(A) Receptor Subunit Regulation in Epileptogenesis 5R01NS051710-07 12
2010 Molecular Determinants of GABAA Receptor Gene Regulation 5R01NS050393-05 11
Showing 10 of 23 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Thomas AX, Cruz Del Angel Y, Gonzalez MI, Carrel AJ, Carlsen J, Lam PM, Hempstead BL, Russek SJ, Brooks-Kayal AR. Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Jan-Feb; 3(1). PMID: 27057559; PMCID: PMC4814566; DOI: 10.1523/ENEURO.0020-15.2016;.
  2. Huang S, Hokenson K, Bandyopadhyay S, Russek SJ, Kirkwood A. Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. J Neurosci. 2015 Dec 2; 35(48):15916-20.View Related Profiles. PMID: 26631472; PMCID: PMC4666916; DOI: 10.1523/JNEUROSCI.1813-15.2015;.
  3. Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Exp Neurol. 2015 Sep; 271:445-56. PMID: 26172316; DOI: 10.1016/j.expneurol.2015.07.001;.
  4. Grabenstatter HL, Cogswell M, Cruz Del Angel Y, Carlsen J, Gonzalez MI, Raol YH, Russek SJ, Brooks-Kayal AR. Effect of spontaneous seizures on GABAA receptor a4 subunit expression in an animal model of temporal lobe epilepsy. Epilepsia. 2014 Nov; 55(11):1826-33. PMID: 25223733; PMCID: PMC4596257; DOI: 10.1111/epi.12771;.
  5. Smith CC, Martin SC, Sugunan K, Russek SJ, Gibbs TT, Farb DH. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol Pharmacol. 2014 Oct; 86(4):390-8.View Related Profiles. PMID: 25057049; PMCID: PMC4164982; DOI: 10.1124/mol.114.094128;.
  6. Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. J Neurosci Res. 2014 Oct; 92(10):1307-18. PMID: 24801281; PMCID: PMC4134742; DOI: 10.1002/jnr.23402;.
  7. Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis. 2014 Feb; 62:73-85. PMID: 24051278; PMCID: PMC3908775; DOI: 10.1016/j.nbd.2013.09.003;.
  8. Saha S, Hu Y, Martin SC, Bandyopadhyay S, Russek SJ, Farb DH. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol. 2013; 14:37.View Related Profiles. PMID: 23879974; PMCID: PMC3734045; DOI: 10.1186/2050-6511-14-37;.
  9. Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug; 84(2):261-74.View Related Profiles. PMID: 23716622; PMCID: PMC3716320; DOI: 10.1124/mol.113.085696;.
  10. Grabenstatter HL, Russek SJ, Brooks-Kayal AR. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 2012 Dec; 53 Suppl 9:71-8. PMID: 23216580; PMCID: PMC3776022; DOI: 10.1111/epi.12036;.
Showing 10 of 54 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 54 publications over 24 distinct years, with a maximum of 5 publications in 2004 and 2006

YearPublications
19902
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19931
19941
19953
19981
19993
20002
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20032
20045
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20084
20091
20101
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20161
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Autism
Brain Inhibition
Epilepsy
Gene Regulation
Systems Biology
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72 E. Concord St Building A
Boston MA 02118
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