Suryaram Gummuluru, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of Rochester
MS, University of Rochester

Our research is broadly focused on the role of dendritic cells (DCs) in the initiation and propagation of HIV-1 replication. Since dendritic cells are believed to be the first immune competent cells to encounter virus in the genital mucosa, a thorough understanding of the HIV-DC interactions is of paramount importance. DCs can capture virus particles independently of CD4 and co-receptor complexes, and retain them in an infectious state for an extended period of time. These virus-bearing DCs may then facilitate a more efficient spread of virus to replication-permissive CD4+ T cells. Our recent work has identified a novel glycosphingolipid dependent mechanism of virus attachment to DCs. The fate of the virus particle post-attachment in DCs remains unclear. Virion trafficking within the DC bypasses conventional endocytic organelles, i.e., endosomes and lysosomes. Virus localization within this novel vesicular compartment not only has the potential to protect the invading HIV from being degraded, but also creates a latent reservoir of virus, which could present a major challenge for eradication by antiretroviral therapy. Furthermore, the mechanism of subsequent return of infectious virus particles to the cell surface and the method of subsequent transmission to T cells remains unclear. Current studies utilizing biochemical and microscopic approaches are underway to monitor HIV-1 trafficking and localization in the DC and its subsequent transfer to T cells.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

CD1a vaginal dendritic cells and HIV-1 acquisition in the female genital tract
05/15/2015 - 04/30/2018 (PI)
Boston Medical Center Corporation NIH NIAID

A novel microfluidic system to investigate mechanism of HIV-induced disruption of BBB function
01/01/2017 - 12/31/2017 (Co-PI)
The Miriam Hospital NIH NIAID

Mechanism of cell-associated HIV-1 transmission
12/01/2015 - 11/30/2017 (PI)
NIH/National Institute of Allergy & Infe

Lifespan/Tufts/brown Center for AIDS Research (CFAR): Core K, Core B, and Core G
07/01/2016 - 06/30/2017 (PI of Sub-Project / SP)
PI: C. Robert Horsburgh Jr, MD
The Miriam Hospital NIH NIAID

Identification of Signals Required for the Establishment of HIV infection and Latency
09/02/2015 - 08/31/2016 (PI)
Boston Medical Center Corporation NIH NIAID

Mechanism of Cell-Associated HIV-1 Transmission
07/01/2010 - 11/30/2015 (PI)
NIH/National Institute of Allergy & Infe

Elucidating Non-Virus Encoded HIV Capture Through Artificial Virus Nanoparticles
07/01/2013 - 06/30/2014 (Co-PI)
PI: Bjorn Reinhard, Dr. rer. nat.
NIH/National Institute of Allergy & Infe

Yr Title Project-Sub Proj Pubs
2017 Mechanism of cell-associated HIV-1 transmission 5R01AI064099-12 14
2016 Mechanism of cell-associated HIV-1 transmission 2R01AI064099-11A1 14
2014 Mechanism of cell-associated HIV-1 transmission 5R01AI064099-10 14
2013 Elucidating Non-Virus Encoded HIV Capture through Artificial Virus Nanoparticles 1R56AI104393-01A1 1
2013 Mechanism of cell-associated HIV-1 transmission 5R01AI064099-09 14
2012 Mechanism of cell-associated HIV-1 transmission 5R01AI064099-08 14
2011 Mechanism of cell-associated HIV-1 transmission 5R01AI064099-07 14
2010 Mechanism of HIV-1 attachment to dendritic cells 5R21AI081596-02 3
2010 Mechanism of cell-associated HIV-1 transmission 2R01AI064099-06A1 14
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Akiyama H, Ramirez NP, Gibson G, Kline C, Watkins S, Ambrose Z, Gummuluru S. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of IFN-a. J Virol. 2017 Aug 09.View Related Profiles. PMID: 28794041.
  2. Ruedas JB, Ladner JT, Ettinger CR, Gummuluru S, Palacios G, Connor JH. Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture. J Virol. 2017 Aug 01; 91(15).View Related Profiles. PMID: 28539437.
  3. Miller CM, Akiyama H, Agosto LM, Emery A, Ettinger CR, Swanstrom RI, Henderson AJ, Gummuluru S. Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells. J Virol. 2017 Jul 01; 91(13).View Related Profiles. PMID: 28424288; DOI: 10.1128/JVI.00051-17;.
  4. Ahi YS, Zhang S, Thappeta Y, Denman A, Feizpour A, Gummuluru S, Reinhard B, Muriaux D, Fivash MJ, Rein A. Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins. MBio. 2016 Nov 22; 7(6). PMID: 27879338; DOI: 10.1128/mBio.01985-16;.
  5. Kijewski SD, Akiyama H, Feizpour A, Miller CM, Ramirez NG, Reinhard BM, Gummuluru S. Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated. Virology. 2016 Oct; 497:328-36.View Related Profiles. PMID: 27521724; PMCID: PMC5026622; DOI: 10.1016/j.virol.2016.07.029;.
  6. Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L, Reinhard BM. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. ACS Nano. 2016 Jan 26; 10(1):1189-200.View Related Profiles. PMID: 26720275; PMCID: PMC4842014; DOI: 10.1021/acsnano.5b06501;.
  7. Yu X, Xu F, Ramirez NG, Kijewski SD, Akiyama H, Gummuluru S, Reinhard BM. Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse. ACS Nano. 2015; 9(4):4182-92.View Related Profiles. PMID: 25853367; PMCID: PMC4423798; DOI: 10.1021/acsnano.5b00415;.
  8. Akiyama H, Ramirez NG, Gudheti MV, Gummuluru S. CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies. PLoS Pathog. 2015 Mar; 11(3):e1004751.View Related Profiles. PMID: 25760631; PMCID: PMC4356592; DOI: 10.1371/journal.ppat.1004751;.
  9. Kijewski SD, Gummuluru S. A mechanistic overview of dendritic cell-mediated HIV-1 trans infection: the story so far. Future Virol. 2015 Mar; 10(3):257-269. PMID: 26213560.
  10. Gummuluru S, Pina Ramirez NG, Akiyama H. CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination. J Infect Dis. 2014 Dec 15; 210 Suppl 3:S641-7.View Related Profiles. PMID: 25414418; PMCID: PMC4303078; DOI: 10.1093/infdis/jiu442;.
Showing 10 of 37 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 20 distinct years, with a maximum of 5 publications in 2014

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

dendritic cells
HIV pathogenesis
Virological synapse
virus attachment, trafficking, and cell-mediated virus transfer

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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