Thomas Van Dyke, PhD
Adjunct Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Molecular & Cell Biology

DDS, Case Western Reserve University
MS, State University of New York at Buffalo
PhD, State University of New York at Buffalo



Thomas Van Dyke is Vice President for Clinical and Translational Research and Chair of the Department of Applied Oral Sciences. He provides leadership for Forsyth’s clinical research team and is responsible for expanding Forsyth’s clinical presence in the research community. Dr. Van Dyke drives the Institute’s efforts to expand Forsyth’s connections to industry and corporate partners.

Dr. Van Dyke is a world renowned leader in translational research. His clinical research team has focused largely on drug treatment for periodontitis and issues related to systematic diseases such as diabetes. He has broad connections with corporations and universities worldwide. Dr. Van Dyke joined Forsyth from Boston University were he was Professor, Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine; Program Director, Postdoctoral Periodontology; Director, Clinical Research Center, and Associate Director Boston University School of Medicine General Clinical Research Center.

Thomas E. Van Dyke received his dental degree in 1973 from Case Western Reserve University, Cleveland, OH, USA and a PhD in Oral Biology from State University of New York at Buffalo, NY in 1982. Dr. Van Dyke has published more than 250 papers in basic immunology related to inflammatory periodontal infections. Since 1995, Dr. Van Dyke's research has focused on the regulation of the innate immune response by active endogenous pathways.

He is a Diplomate of the American Board of Periodontology and he received the IADR Award for Basic Research in Periodontology in 2001 and the Norton Ross Award for Excellence in Clinical Research in 2002. He serves, or has served, on the editorial boards of Infection and Immunity, Journal of Periodontology, Journal of Periodontal Research, Journal of Clinical Periodontology, Journal of Dental Research, Journal of the International Academy of Periodontology, Oral Microbiology and Immunology, Journal of Public Health Dentistry, Current Opinions in Periodontology , Magazyn Stomatologiczy Dental Magazine, and he edited Periodontology 2000 Vols. 6 (1994) and 27 (2001). He served as President of the Periodontal Diseases Research Group of the IADR from 1991-1992. His other IADR/AADR service includes Membership Committee, 1983-1986, Science Information Committee, 1990-1993, and Scientific Awards Committee, 2001-2006. Dr. Van Dyke has also served as President of the International Academy of Periodontology (1997-1999).

Dr. Van Dyke has authored/co-authored 250+ original articles, and numerous abstracts and book chapters. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, American Association for the Advancement of Science, American Association of Immunologists, American Dental Association, American Society of Microbiology, International Academy of Periodontology, IADR Periodontal Research Group, International Endotoxin and Innate Immunity Society, Northeast Periodontal Society, and Society for Leukocyte Biology. His research interests are the structural and functional relationship of abnormalities of the inflammatory process with focus on regulation of phagocytic cells, in the etiology and pathogenesis of periodontal diseases. He is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center




Neutrophils and Periodontitis in Diabetes
04/01/2005 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5 R01 DE15566 06

Specialized Center for Anti-Inflammation and Resolution in Periodontal Disease Project 3
09/17/2004 - 07/31/2009 (PI)
Brigham & Women's Hospital NIH NIDCR

Effects of Chewing Gum on Gingivitis and Inflammatory Markers
02/01/2008 - 12/31/2008 (PI)
Wrigley Jr. Company

A 9 Month Multicenter Clinical Trial of the Treatment with Periocline (Minocycline) Gel 2%
07/21/2005 - 10/31/2008 (PI)
Sunstar Butler

CLINICAL RESEARCH STUDY EVALUATING COMMERCIAL PRODUCTS TO CALIBRATE A NEW CLINICAL SITE FOR TEH QUICGLEY HEIN PLAQUE INDEX
10/01/2007 - 09/30/2008 (PI)
Other Industry

Clinical Research Study Evaluating Commercial Products to Calibrate a New Clinical Site for the Quigley Hein Plaque Index
10/01/2007 - 09/30/2008 (PI)
Colgate-Palmolive

Biological Bases of Refractory Periodontal Diseases
06/01/2002 - 04/30/2008 (PI)
Forsyth Institute NIH NIDCR

The Use of Hard Tissue Replacement and Polyanhydride Graft Material Formulations Around Implants Immediately Placed into Extraction Sockets: Immediate Stability and Function - A Proof of Concept Study in a Mini-Pig Model
07/01/2007 - 03/31/2008 (PI)
Bioplant R&D, L.L.C.

H2 Antagonist Technology for the Prevention and/or Treatment of Gingivitis and/or Periodontitis
10/01/2002 - 09/30/2007 (PI)
Procter & Gamble

Nitric Oxide Defense Against Porphyromonas Gingivalis
01/01/2003 - 12/31/2006 (Dept Sponsor)
NIH/National Institute of Dental & Craniofacial Research
1 K22 DE14568 01A1

Showing 10 of 35 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Mechanisms of Resolvin E1 in Periodontal Regeneration 5R01DE025020-03 5
2017 Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral Microbiom 5R01DE024468-04 5
2016 Phase 1/2 Clinical Trial to assess the safety and preliminary efficacy of Lipoxin Analog BLXA4-MEOral Rinse for the Treatment of Gingivitis 1U01DE026934-01
2016 Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes 1R01DE025383-01A1 1
2016 Mechanisms of Resolvin E1 in Periodontal Regeneration 5R01DE025020-02 5
2016 Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral Microbiom 5R01DE024468-03 5
2015 Mechanisms of Resolvin E1 in Periodontal Regeneration 1R01DE025020-01 5
2015 Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral Microbiom 5R01DE024468-02 5
2014 Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral Microbiom 1R01DE024468-01 5
2014 Neutrophils and Periodontitis in Diabetes 5R01DE015566-11 39
Showing 10 of 93 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Naqvi AZ, Mu L, Hasturk H, Van Dyke TE, Mukamal KJ, Goodson JM. The Impact of Docosahexaenoic Acid Therapy on Subgingival Plaque Microbiota. J Periodontol. 2017 May 18; 1-13. PMID: 28517974.
  2. Van Dyke TE. Pro-resolving mediators in the regulation of periodontal disease. Mol Aspects Med. 2017 May 18. PMID: 28483532.
  3. Mohamed Ali H, Berggreen E, Nguyen D, Wahab Ali R, Van Dyke TE, Hasturk H, Mustafa M. Dental plaque microbial profiles of children from Khartoum, Sudan, with congenital heart defects. J Oral Microbiol. 2017; 9(1):1281556. PMID: 28326155; DOI: 10.1080/20002297.2017.1281556;.
  4. Freire MO, Dalli J, Serhan CN, Van Dyke TE. Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. J Immunol. 2017 Jan 15; 198(2):718-728. PMID: 27994073; DOI: 10.4049/jimmunol.1601543;.
  5. Konermann A, Van Dyke T, Kantarci A, Jäger A. GABAB Receptors as Modulating Target for Inflammatory Responses of the Periodontal Ligament. Cell Mol Neurobiol. 2016 Nov 03. PMID: 27812916.
  6. Kurgan S, Kansal S, Nguyen D, Stephens D, Koroneos Y, Hasturk H, Van Dyke TE, Kantarci A. Strain-Specific Impact of Fusobacterium nucleatum on Neutrophil Function. J Periodontol. 2017 Apr; 88(4):380-389. PMID: 27762731; DOI: 10.1902/jop.2016.160212;.
  7. Lee CT, Teles R, Kantarci A, Chen T, McCafferty J, Starr JR, Brito LC, Paster BJ, Van Dyke TE. Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis. J Immunol. 2016 Oct 01; 197(7):2796-806. PMID: 27543615; PMCID: PMC5026932; DOI: 10.4049/jimmunol.1600859;.
  8. El-Sharkawy HM, Anees MM, Van Dyke TE. Propolis Improves Periodontal Status and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial. J Periodontol. 2016 Dec; 87(12):1418-1426. PMID: 27468795.
  9. Mendes RT, Nguyen D, Stephens D, Pamuk F, Fernandes D, Van Dyke TE, Kantarci A. Endothelial Cell Response to Fusobacterium nucleatum. Infect Immun. 2016 Jul; 84(7):2141-8. PMID: 27185790; PMCID: PMC4936358; DOI: 10.1128/IAI.01305-15;.
  10. Movila A, Ishii T, Albassam A, Wisitrasameewong W, Howait M, Yamaguchi T, Ruiz-Torruella M, Bahammam L, Nishimura K, Van Dyke T, Kawai T. Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions. J Bone Miner Res. 2016 Sep; 31(9):1688-700. PMID: 27082509; PMCID: PMC5010512; DOI: 10.1002/jbmr.2854;.
Showing 10 of 329 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 327 publications over 38 distinct years, with a maximum of 20 publications in 2013

YearPublications
19802
19812
19825
19831
19843
19854
19865
19874
19883
19893
19905
199111
19927
199311
199413
19955
19969
19978
19986
19997
20007
20015
200212
200313
200412
200517
200611
200712
200816
200914
201013
20118
20128
201320
201418
201513
201611
20173
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100 E. Newton St Goldman SDM
Boston MA 02118
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