John L. Berk, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

MD, Case Western Reserve University



Expertise in Amyloidosis with specific emphasis in Familial and localized amyloid disease; pulmonary fibrosis.


Expanded Access Protocol of Patisiran for Patients with Hereditary Transthyretin-Mediated Amyloidosis (hATTR Amyloidosis) With Polynenropathy
10/31/2016 - 10/30/2021 (PI)
Alnylam Pharmaceuticals, Inc.

A Phase 3 Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlle Study to Evaluate the Efficacy and Safety of ALN-TTRSC in Patients with Transthyretin Mediated Familial Amyloidotic
07/28/2015 - 07/28/2020 (PI)
Alnylam Pharmaceuticals, Inc.

A PHASE 3 MULTICENTER, RANDOMIZED, DOUBLE-BLIND, EXTENSION STUDY TO EVALUATE THE SAFETY OF DAILY ORAL DOSING OF TAFAMIDIS MEGLUMINE (PF-06291826) 20 MG OR 80 MG IN SUBJECTS DIAGNOSED WITH TRANSTHYRETI
04/04/2017 - 04/03/2020 (PI)
Pfizer, Inc.

Multicenter, Open-Label, Extension Study to Evaluate the Long-term Safety and Efficacy of Patisiran in Patients with Familial Amyloidotic Polyneuropathy Who Have Completed a Prior Clinical Study with
03/29/2016 - 03/28/2019 (PI)
Alnylam Pharmaceuticals, Inc.

Treatment Use of Eprodisate (Klacta) In a Patient Diagnosed with AA Amyloidosis
02/16/2016 - 02/15/2019 (PI)
A.T. Development Switzerland Sarl

A Multicenter, International, Phase 3, Double-Blind, Placebo-Controlled, Randomized Study to Evaluate the Efficacy, Safety, and Tolerability of Daily Oral Dosing of Tafamidis Meglumine (PF-06291826)
10/17/2014 - 10/16/2017 (PI)
Pfizer, Inc.

BU-Alnylam Diflunisal Research Collaboration
10/01/2015 - 10/15/2017 (PI)
Alnylam Pharmaceuticals, Inc.

APOLLO: A Phase 3 Multicenter, Multinational, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of ALN-TTR02 in Transthyretin (TTR)-Mediated Polyneuropathy
07/01/2014 - 09/30/2017 (PI)
Alnylam Pharmaceuticals, Inc.

An Open-Label Extension Study to Assess the Long-Term Safety and Efficacy of ISIS 420915 in Patients with Familial Amyloid Polyneuropathy
09/30/2014 - 09/29/2017 (PI)
Isis Pharmaceuticals, Inc.

A phase 2, open-label, multi-dose, dose escalation trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of intravenous infusions of ALN-TTR02 in patients with TTR Amyloid
08/27/2013 - 08/31/2017 (PI)
Alnylam Pharmaceuticals, Inc.

Showing 10 of 17 results. Show All Results



Yr Title Project-Sub Proj Pubs
2009 Effect of diflunisal (IND68092) on familial amyloidosis 5R01NS051306-05 9
2008 Effect of diflunisal (IND68092) on familial amyloidosis 5R01NS051306-04 9
2007 THE EFFECT OF DIFLUNISAL ON HEREDITARY AMYLOIDOSIS 2M01RR000533-39-8163 429
2007 Effect of diflunisal (IND68092) on familial amyloidosis 5R01NS051306-03 9
2007 Effect of diflunisal on familial amyloidosis 5R01FD002532-03 2
2006 Effect of diflunisal (IND68092) on familial amyloidosis 5R01NS051306-02 9
2006 Effect of diflunisal on familial amyloidosis 5R01FD002532-02 2
2005 Effect of diflunisal (IND68092) on familial amyloidosis 1R01NS051306-01 9
2001 ADRENAL INSUFFICIENCY IN PRIMARY SYSTEMIC AMYLOIDOSIS 5M01RR000533-33-353 429
2000 ADRENAL INSUFFICIENCY IN PRIMARY SYSTEMIC AMYLOIDOSIS 5M01RR000533-32-353 429
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Govender P, Keyes CM, Hankinson EA, O''Hara CJ, Sanchorawala V, Berk JL. Transbronchial biopsies safely diagnose amyloid lung disease. Amyloid. 2017 Apr 10; 1-5.View Related Profiles. PMID: 28393574; DOI: 10.1080/13506129.2017.1301917;.
  2. Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model. JAMA Cardiol. 2017 Mar 01; 2(3):305-313.View Related Profiles. PMID: 28196196; DOI: 10.1001/jamacardio.2016.5864;.
  3. Dyck PJ, Kincaid JC, Dyck PJ, Chaudhry V, Goyal NA, Alves C, Salhi H, Wiesman JF, Labeyrie C, Robinson-Papp J, Cardoso M, Laura M, Ruzhansky K, Cortese A, Brannagan TH, Khoury J, Khella S, Waddington-Cruz M, Ferreira J, Wang AK, Pinto MV, Ayache SS, Benson MD, Berk JL, Coelho T, Polydefkis M, Gorevic P, Adams DH, Plante-Bordeneuve V, Whelan C, Merlini G, Heitner S, Drachman BM, Conceição I, Klein CJ, Gertz MA, Ackermann EJ, Hughes SG, Mauermann ML, Bergemann R, Lodermeier KA, Davies JL, Carter RE, Litchy WJ. Assessing mNIS+7Ionis and international neurologists'' proficiency in a familial amyloidotic polyneuropathy trial. Muscle Nerve. 2017 Jan 07.View Related Profiles. PMID: 28063170; DOI: 10.1002/mus.25563;.
  4. Salinaro F, Meier-Ewert HK, Miller EJ, Pandey S, Sanchorawala V, Berk JL, Seldin DC, Ruberg FL. Longitudinal systolic strain, cardiac function improvement, and survival following treatment of light-chain (AL) cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. 2016 Dec 12.View Related Profiles. PMID: 27965280; DOI: 10.1093/ehjci/jew298;.
  5. Castano A, Haq M, Narotsky DL, Goldsmith J, Weinberg RL, Morgenstern R, Pozniakoff T, Ruberg FL, Miller EJ, Berk JL, Dispenzieri A, Grogan M, Johnson G, Bokhari S, Maurer MS. Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis. JAMA Cardiol. 2016 Nov 01; 1(8):880-889.View Related Profiles. PMID: 27557400; DOI: 10.1001/jamacardio.2016.2839;.
  6. Haq M, Pawar S, Berk JL, Miller EJ, Ruberg FL. Can 99m-Tc-Pyrophosphate Aid in Early Detection of Cardiac Involvement in Asymptomatic Variant TTR Amyloidosis? JACC Cardiovasc Imaging. 2016 Aug 20.View Related Profiles. PMID: 27568122; DOI: 10.1016/j.jcmg.2016.06.003;.
  7. Shu J, Lo S, Phillips M, Sun F, Seldin DC, Berenbaum I, Berk JL, Sanchorawala V. Depression and anxiety in patients with AL amyloidosis as assessed by the SF-36 questionnaire: experience in 1226 patients. Amyloid. 2016 Sep; 23(3):188-193.View Related Profiles. PMID: 27460276.
  8. Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AW, Rezk T, Fontana M, Palladini G, Milani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation. 2016 Jun 14; 133(24):2404-12.View Related Profiles. PMID: 27143678; DOI: 10.1161/CIRCULATIONAHA.116.021612;.
  9. Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, Seldin DC. Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016 Jan 19; 133(3):282-90.View Related Profiles. PMID: 26660282; PMCID: PMC4718760; DOI: 10.1161/CIRCULATIONAHA.115.018852;.
  10. Gertz MA, Benson MD, Dyck PJ, Grogan M, Coelho T, Cruz M, Berk JL, Plante-Bordeneuve V, Schmidt HH, Merlini G. Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis. J Am Coll Cardiol. 2015 Dec 1; 66(21):2451-66. PMID: 26610878; DOI: 10.1016/j.jacc.2015.09.075;.
Showing 10 of 67 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 67 publications over 22 distinct years, with a maximum of 7 publications in 2011 and 2015

YearPublications
19871
19911
19931
19942
19962
19983
19993
20002
20012
20023
20032
20043
20054
20071
20101
20117
20125
20135
20144
20157
20165
20173
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

amyloid lung disease
amyloidosis
familial amyloidotic polyneuropathy
pleural effusions
pulmonary fibrosis
tracheobronchial amyloidosis
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72 E. Concord St Housman (R)
Boston MA 02118
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