Joseph P. Mizgerd, ScD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

ScD, Harvard School of Public Health



Acute lower respiratory tract infections cause a terrible public health burden at present, with potential for worse in the coming years. The outcome of these infections is determined by innate immune responses (such as neutrophil recruitment and activation), necessary for host defense but also contributing to lung injury. Innate immune responses in the lungs require the coordinated expression of diverse mediators including adhesion molecules, chemokines, colony stimulating factors, and cytokines that are absent or present only at low levels in uninfected lungs, but are expressed at high levels during infection. Similar mediators are induced during most lung infections, although individual mediators can have different roles during different infections. The coordinated expression suggests programs of gene regulation. NF-kappaB transcription factors are critical to the gene expression program directing innate immunity in the lungs, with RelA inducing innate immunity genes mediating host defense and p50 counteracting this gene induction to prevent lung injury. Other transcription factors are also important, such as STAT3 which both facilitates host defense and limits lung injury. These transcription factors have cell-specific roles during infection, and elucidating unique cell-specific roles in lung innate immunity is a major ongoing effort. Finally, expression of innate immunity mediators is regulated post-transcriptionally as well. MicroRNAs target innate immunity transcripts, and miRNAs themselves are subject to modifications such as uridylation by Zcchc11 to relieve their repressive activities. An improved knowledge of the molecular mechanisms directing innate immunity in the lungs will provide new directions for preventing and curing acute lower respiratory tract infections.

Director
Boston University School of Medicine
Department of Pulmonary Center


Professor
Boston University School of Medicine
Department of Biochemistry


Professor
Boston University School of Medicine
Department of Microbiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




The B Cell Repertoire as a Window into the Nature and Impact of the Lung Virome
05/01/2017 - 04/30/2018 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Institute
1R61HL137081-01

Pneumonia Biology
01/11/2017 - 12/31/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
1R35HL135756-01

Macrophage protection in pneumococcal pneumonia
08/20/2016 - 07/31/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI122763-01A1

Biology of the Lung: A Multidisciplinary Program
07/01/2016 - 06/30/2017 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
2T32HL007035-41A1

Lung-resident antibacterial heterotypic immunity
07/01/2015 - 06/30/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-02

NF-kB Innate Immunity in the Lungs
08/01/2016 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL068153-13

Cytokine-stimulated systemic defenses during pneumococcal pneumonia
12/01/2004 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL079392-10

Vectored Delivery of Oligoclonal Antibodies for Protection Against Enterotoxin Mediated Diarrheal Diseases
02/01/2016 - 11/30/2016 (PI)
University of Massachusetts, Worcester DOD ARO

NF-kB Innate Immunity in the Lungs
08/05/2013 - 07/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL068153-12

Biology of the Lung: A Multidisciplinary Program
07/01/2011 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-40




Yr Title Project-Sub Proj Pubs
2017 Pneumonia Biology 1R35HL135756-01
2016 Macrophage protection in pneumococcal pneumonia 1R56AI122763-01A1
2016 Lung-resident antibacterial heterotypic immunity 5R01AI115053-02
2016 NF-kB and Innate Immunity in the Lungs 4R01HL068153-13 31
2016 Biology of the Lung: A Multidisciplinary Program 2T32HL007035-41A1 53
2015 Cytokine-stimulated systemic defenses during pneumococcal pneumonia 5R01HL079392-10 26
2015 NF-kB and Innate Immunity in the Lungs 5R01HL068153-12 31
2014 Cytokine-stimulated systemic defenses during pneumococcal pneumonia 5R01HL079392-09 26
2014 NF-kB and Innate Immunity in the Lungs 5R01HL068153-11 31
2014 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-39 53
Showing 10 of 32 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Myeloid-epithelial crosstalk coordinates synthesis of the tissue protective cytokine leukemia inhibitory factor during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 May 18; ajplung.00482.2016.View Related Profiles. PMID: 28522567.
  2. Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP. Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia. Mucosal Immunol. 2017 May 17.View Related Profiles. PMID: 28513594.
  3. Mizgerd JP. Pathogenesis of severe pneumonia: advances and knowledge gaps. Curr Opin Pulm Med. 2017 May; 23(3):193-197. PMID: 28221171; DOI: 10.1097/MCP.0000000000000365;.
  4. Kasotakis G, Galvan M, King E, Sarkar B, Stucchi A, Mizgerd JP, Burke PA, Remick D. Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance. J Trauma Acute Care Surg. 2017 Apr; 82(4):758-765.View Related Profiles. PMID: 28099388; DOI: 10.1097/TA.0000000000001389;.
  5. Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18.View Related Profiles. PMID: 27064756; PMCID: PMC5023025; DOI: 10.1165/rcmb.2015-0261OC;.
  6. Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH. Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis. Mol Cancer Res. 2016 Aug; 14(8):696-706.View Related Profiles. PMID: 27130942; PMCID: PMC4987205; DOI: 10.1158/1541-7786.MCR-16-0069;.
  7. Mizgerd JP. Community-Acquired Pneumonia Requiring Hospitalization. N Engl J Med. 2015 Dec 10; 373(24):2380. PMID: 26650160; DOI: 10.1056/NEJMc1511751#SA1;.
  8. Traber KE, Hilliard KL, Allen E, Wasserman GA, Yamamoto K, Jones MR, Mizgerd JP, Quinton LJ. Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):479-88.View Related Profiles. PMID: 25692402; PMCID: PMC4742898; DOI: 10.1165/rcmb.2014-0342OC;.
  9. Hilliard KL, Allen E, Traber KE, Yamamoto K, Stauffer NM, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):378-90.View Related Profiles. PMID: 25607543; PMCID: PMC4566062; DOI: 10.1165/rcmb.2014-0195OC;.
  10. Hilliard KL, Allen E, Traber KE, Kim Y, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. Activation of Hepatic STAT3 Maintains Pulmonary Defense during Endotoxemia. Infect Immun. 2015 Oct; 83(10):4015-27.View Related Profiles. PMID: 26216424; PMCID: PMC4567648; DOI: 10.1128/IAI.00464-15;.
Showing 10 of 74 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 74 publications over 23 distinct years, with a maximum of 7 publications in 2012

YearPublications
19952
19962
19971
19981
19994
20001
20014
20024
20032
20044
20053
20064
20075
20084
20094
20102
20112
20127
20133
20145
20154
20162
20174
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72 E. Concord St Housman (R)
Boston MA 02118
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