Maria Isabel Dominguez, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology Section

PhD, Universidad Autónoma de Madrid
MSc, University of the Basque Country



My research interest is to understand the cascade of intracellular events that leads to the activation of Wnt signaling and the biological role of the Wnt pathway during organ development and maintenance. We have two areas of interest:

Our first area of interest is to characterize the molecular mechanism leading to activation (stabilization and nuclear translocation) of ß-catenin, the key intracellular Wnt component that is activated in many human tumors. For this, we are using Xenopus embryos, mammalian cell lines, and mice ablated for CK2 catalytic subunits.

Our second area of interest is to characterize the cellular and molecular mechanisms regulated by Wnt/ß-catenin signaling during embryonic organ morphogenesis. For this we are using mice ablated for CK2 subunits and Xenopus embryos.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center



2013 Department of Medicine, Boston University School of Medicine: Faculty Development Grant
2008 Department of Medicine, Boston University School of Medicine: Faculty Development Grant
2007-2008 Karin Grunebaum Cancer Research Foundation: Junior Faculty Cancer Research Award
2007-2008 Department of Medicine, Boston University School of Medicine: Pilot Project Grant
2003-2004 Department of Medicine, Boston University School of Medicine: Pilot Project Grant
2002-2003 Cancer Center, BU School of Medicine: American Cancer Society Institutional Research Grant
1998 The Company of Biologists: Travel Fellowship to Attend the 7th International Xenopus Meeting
1996-1998 Basque Government: Postdoctoral Fellowship
1994-1996 Spanish Government: Postdoctoral Fellowship
1990-1994 Basque Government: Postgraduate Fellowship
1988-1989 Iberduero S.A.: Postgraduate Fellowship
1987-1988 Basque Government: Undergraduate Fellowship



Control of Embryonic Development by CK2: CK2 as a Core Wnt/beta-catenin component
08/01/2011 - 06/30/2017 (PI)
NIH-NIGMS
5R01 GM098367-04

Effect of CK2 disregulation on heart morphogenesis
07/01/2010 - 06/30/2014 (PI)
American Heart Assoc

Role of Protein Kinese Ck2 Alpha in Cardiac Development
07/01/2007 - 06/30/2010 (PI)
American Heart Assoc


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lee M, Chea K, Pyda R, Chua M, Dominguez I. Comparative Analysis of Non-viral Transfection Methods in Mouse Embryonic Fibroblast Cells. J Biomol Tech. 2017 Apr 29. PMID: 28507462; DOI: 10.7171/jbt.17-2802-003;.
  2. Chua MM, Ortega CE, Sheikh A, Lee M, Abdul-Rassoul H, Hartshorn KL, Dominguez I. CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals (Basel). 2017 Jan 28; 10(1).View Related Profiles. PMID: 28134850; DOI: 10.3390/ph10010018;.
  3. Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M. Dominant-negative Ga subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease. Sci Signal. 2016 Apr 12; 9(423):ra37.View Related Profiles. PMID: 27072656; PMCID: PMC4870087; DOI: 10.1126/scisignal.aad2429;.
  4. Apfel J, Parikh JR, Reischmann P, Ewing RM, Müller O, Xia Y, Dominguez I. Systems Biology of Cancer Editor: Sam Thiagalingam. The Wnt signaling network in Cancer. Cambridge University Press. 2015.
  5. Ortega C, Prince-Wright L, Dominguez I. Proceedings of the CK2-VII meeting. Editors Khalil Ahmed, Olaf Issinger and Ryszard Szyska. Role of CK2 in organ formation. 2015.
  6. Ortega CE, Seidner Y, Dominguez I. Mining CK2 in cancer. PLoS One. 2014; 9(12):e115609. PMID: 25541719; PMCID: PMC4277308; DOI: 10.1371/journal.pone.0115609;.
  7. Siriwardana NS, Meyer R, Havasi A, Dominguez I, Panchenko MV. Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle. 2014; 13(12):1885-901.View Related Profiles. PMID: 24739512; PMCID: PMC4111752; DOI: 10.4161/cc.28759;.
  8. Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci. 2013 Mar; 70(5):893-908.View Related Profiles. PMID: 23052206; PMCID: PMC3696992; DOI: 10.1007/s00018-012-1154-7;.
  9. Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28; 111(8):1012-26.View Related Profiles. PMID: 22904094; PMCID: PMC3518037.
  10. Imbrie GA, Wu H, Seldin DC, Dominguez I. Asymmetric Localization of CK2a During Xenopus Oogenesis. Hum Genet Embryol. 2012 May 05; Suppl 4(1):11328. PMID: 25346867.
Showing 10 of 41 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 20 distinct years, with a maximum of 4 publications in 1993 and 2005 and 2012

YearPublications
19912
19922
19934
19943
19952
20001
20011
20031
20042
20054
20071
20083
20092
20101
20111
20124
20142
20152
20161
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Carcinogens
Cardiovascular Abnormalities
Cell Transformation, Neoplastic
Developmental Biology
Signal Transduction
Wnt Proteins

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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