Ronald H. Goldstein, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

MD, SUNY Downstate Medical Center



Our laboratory is exploring the regulation of the alveolar matrix during the development of early emphysema and fibrosis. The loss of matrix substances results in emphysema whereas the excessive deposition of matrix substances results in pulmonary fibrosis. Employing the techniques of cellular and molecular biology, we are developing methods to modulating the levels of collagen, elastin and other key matrix substances in the alveolar wall. These approaches are studied in wild type and transgenic murine models of emphysema and fibrosis.

We have extensive experience in the diagnosis and management of individuals with pulmonary fibrosis. In human studies, our clinical experimental interest involves the use of novel substances to treat idiopathic pulmonary fibrosis (IPF). We participate in several clinical studies to evaluate the efficacy of these agents in the pathogenesis of IPF.

Research special interests include: Pulmonary Matrix Biology related to Pulmonary Fibrosis and Emphysema

Clinical special interests include: Pulmonary Fibrosis

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Research Assistant Professor
Boston University School of Medicine
Biochemistry


VA Boston Healthcare System




Pre-Clinical Assessment of the Effect of B2-Agonist Isomers of Formoterol on the Development of Emphysema
01/01/2008 - 09/30/2009 (PI)
Sepracor, Inc.

Regulation of Collagen Formation in Pulmonary Fibrosis
08/01/2002 - 07/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL70182 04

The Role of CTGF in Subepithelial Fibrosis in Asthma
07/01/2000 - 06/30/2006 (Dept Sponsor)
NIH/National Heart, Lung, and Blood Institute
5 K08 HL04232 05

Clinical Centers for Feasibility Studies of Retinoid Treatment in Emphysema (FORTE)
09/30/1999 - 12/31/2004 (Co-PI)
PI: George T. O'Connor, MD
NIH/National Heart, Lung, and Blood Institute
N01 HR 96141

Effect of IL-l and TNF-A on Elastin Production in COPD
09/29/2000 - 08/31/2004 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL66547 04

SCOR in Pathobiology of Fibrotic Lung Disease
12/01/1996 - 06/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 P50 HL56386 05




Yr Title Project-Sub Proj Pubs
2016 Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease 5I01CX000908-04
2014 Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease 5I01CX000908-02
2013 Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease 1I01CX000908-01
2005 Regulation of Collagen Formation in Pulmonary Fibrosis 5R01HL070182-04 4
2005 IL -1 and TNF alpha in the development of COPD 5P01HL046902-14-8 80
2004 Regulation of Collagen Formation in Pulmonary Fibrosis 5R01HL070182-03 4
2003 Regulation of Collagen Formation in Pulmonary Fibrosis 5R01HL070182-02 4
2003 EFFECT OF IL-1 AND TNF ON ELASTIN PRODUCTION IN COPD 5R01HL066547-04 15
2002 Regulation of Collagen Formation in Pulmonary Fibrosis 1R01HL070182-01 4
2002 IL -1 and TNF alpha in the development of COPD 2P01HL046902-11-8 80
Showing 10 of 34 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Maron BA, Hess E, Maddox TM, Opotowsky AR, Tedford RJ, Lahm T, Joynt KE, Kass DJ, Stephens T, Stanislawski MA, Swenson ER, Goldstein RH, Leopold JA, Zamanian RT, Elwing JM, Plomondon ME, Grunwald GK, Barón AE, Rumsfeld JS, Choudhary G. Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation. 2016 Mar 29; 133(13):1240-8. PMID: 26873944; PMCID: PMC4811678; DOI: 10.1161/CIRCULATIONAHA.115.020207;.
  2. Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA. Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice. Pulm Circ. 2015 Dec; 5(4):610-8. PMID: 26697168; DOI: 10.1086/683815;.
  3. Maron BA, Goldstein RH, Rounds SI, Shapiro S, Jankowich M, Garshick E, Moy ML, Gagnon D, Choudhary G. Study design and rationale for investigating phosphodiesterase type 5 inhibition for the treatment of pulmonary hypertension due to chronic obstructive lung disease: the TADA-PHiLD (TADAlafil for Pulmonary Hypertension associated with chronic obstructive Lung Disease) trial. Pulm Circ. 2013 Dec; 3(4):889-97.View Related Profiles. PMID: 25006405; DOI: 10.1086/674759;.
  4. Golan-Gerstl R, Wallach-Dayan SB, Zisman P, Cardoso WV, Goldstein RH, Breuer R. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. Am J Respir Cell Mol Biol. 2012 Sep; 47(3):271-9.View Related Profiles. PMID: 22582174; DOI: 10.1165/rcmb.2010-0284RC;.
  5. Yu J, Taylor L, Rich C, Toselli P, Stone P, Green D, Warburton R, Hill N, Goldstein R, Polgar P. Transgenic expression of an altered angiotensin type I AT1 receptor resulting in marked modulation of vascular type I collagen. J Cell Physiol. 2012 May; 227(5):2013-21.View Related Profiles. PMID: 21751211; PMCID: PMC3247653; DOI: 10.1002/jcp.22929;.
  6. Brooks WW, Shen S, Conrad CH, Goldstein RH, Deng LL, Bing OH. Transcriptional changes associated with recovery from heart failure in the SHR. J Mol Cell Cardiol. 2010 Sep; 49(3):390-401.View Related Profiles. PMID: 20547165; DOI: 10.1016/j.yjmcc.2010.06.002;.
  7. Brooks WW, Shen SS, Conrad CH, Goldstein RH, Bing OH. Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis. Genomics. 2010 Feb; 95(2):84-92. PMID: 20006699; DOI: 10.1016/j.ygeno.2009.12.002;.
  8. Kuang PP, Zhang XH, Rich CB, Foster JA, Subramanian M, Goldstein RH. Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L944-52.View Related Profiles. PMID: 17209135.
  9. Subramanian M, Kuang PP, Wei L, Rishikof DC, Liu H, Goldstein RH. Modulation of amino acid uptake by TGF-beta in lung myofibroblasts. J Cell Biochem. 2006 Sep 1; 99(1):71-8.View Related Profiles. PMID: 16598748.
  10. Kuang PP, Joyce-Brady M, Zhang XH, Jean JC, Goldstein RH. Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity. Am J Physiol Cell Physiol. 2006 Dec; 291(6):C1412-21.View Related Profiles. PMID: 16837650.
Showing 10 of 89 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 86 publications over 29 distinct years, with a maximum of 7 publications in 1996

YearPublications
19802
19823
19864
19872
19893
19902
19915
19921
19934
19944
19952
19967
19974
19983
19995
20003
20014
20026
20033
20042
20056
20063
20071
20091
20101
20122
20131
20151
20161
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72 E. Concord St Housman (R)
Boston MA 02118
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