Esther S. Bullitt, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Brandeis University



Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.

Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




The multiple states of IpaB Shigella type lll secretion
06/02/2014 - 11/30/2017 (PI)
University of Kansas NIH NIAID
5R01AI099489-06

Towards the Disruption of Viral RNA Replication
07/01/2012 - 06/30/2017 (PI)
NIH/National Institute of General Medical Sciences
5R01GM102474-04

Measurement of Bacteriophage Lengths using Transmission electron microscopy and image analysis
01/01/2012 - 12/31/2016 (PI)
Neurophage pharmaceuticals, Inc.

The multiple states of IpaB Shigella type III secretion
12/04/2012 - 06/01/2014 (PI)
University of Oklahoma NIH NIAID
1R01AI099489-01A1

Towards the Disruption of Viral RNA Replication
07/01/2012 - 06/30/2013 (PI)
NIH/National Institute of General Medical Sciences
1R01GM102474-01




Yr Title Project-Sub Proj Pubs
2016 The Southeastern Consortium for Microscopy of MacroMolecular Machines 1U24GM116788-01
2016 CryoEM Data Collection Facility Consortium at NCMI 1U24GM116787-01
2014 Towards the Disruption of Viral RNA Replication 5R01GM102474-03 2
2014 Towards the Disruption of Viral RNA Replication 3R01GM102474-03S1 2
2013 Towards the Disruption of Viral RNA Replication 5R01GM102474-02 2
2012 Towards the Disruption of Viral RNA Replication 1R01GM102474-01 2
2009 Structure &function of bacterial adhesion pili 3R01GM055722-09S1 3
2009 Improved data collection for FEI TF20 and Philips CM12 electron microscopes 1S10RR025434-01 2
2008 Structure &function of bacterial adhesion pili 5R01GM055722-09 3
2007 STRUCTURE AND FUNCTION OF BACTERIAL ADHESION PILI 5P41RR001209-28-6060 487
Showing 10 of 21 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika virus induced cellular remodelling. Cell Microbiol. 2017 Mar 20.View Related Profiles. PMID: 28318141; DOI: 10.1111/cmi.12740;.
  2. Singh B, Mortezaei N, Savarino SJ, Uhlin BE, Bullitt E, Andersson M. Antibodies Damage the Resilience of Fimbriae, Causing Them To Be Stiff and Tangled. J Bacteriol. 2017 Jan 01; 199(1). PMID: 27795330.
  3. Rossignol ED, Yang JE, Bullitt E. The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection. Viruses. 2015 Oct; 7(10):5305-18.View Related Profiles. PMID: 26473912; PMCID: PMC4632382; DOI: 10.3390/v7102874;.
  4. Singh B, Mortezaei N, Uhlin BE, Savarino SJ, Bullitt E, Andersson M. Antibody-mediated disruption of the mechanics of CS20 fimbriae of enterotoxigenic Escherichia coli. Sci Rep. 2015; 5:13678. PMID: 26411657; PMCID: PMC4585931; DOI: 10.1038/srep13678;.
  5. Mortezaei N, Singh B, Zakrisson J, Bullitt E, Andersson M. Biomechanical and structural features of CS2 fimbriae of enterotoxigenic Escherichia coli. Biophys J. 2015 Jul 7; 109(1):49-56. PMID: 26153701; PMCID: PMC4572467; DOI: 10.1016/j.bpj.2015.05.022;.
  6. Brown JW, Bullitt E, Sriswasdi S, Harper S, Speicher DW, McKnight CJ. The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap. PLoS Comput Biol. 2015 Jun; 11(6):e1004302.View Related Profiles. PMID: 26067675; PMCID: PMC4466138; DOI: 10.1371/journal.pcbi.1004302;.
  7. Mortezaei N, Epler CR, Shao PP, Shirdel M, Singh B, McVeigh A, Uhlin BE, Savarino SJ, Andersson M, Bullitt E. Structure and function of enterotoxigenic Escherichia coli fimbriae from differing assembly pathways. Mol Microbiol. 2015 Jan; 95(1):116-26. PMID: 25355550; PMCID: PMC4275653; DOI: 10.1111/mmi.12847;.
  8. Mortezaei N, Singh B, Bullitt E, Uhlin BE, Andersson M. P-fimbriae in the presence of anti-PapA antibodies: new insight of antibodies action against pathogens. Sci Rep. 2013; 3:3393. PMID: 24292100; PMCID: PMC3848023; DOI: 10.1038/srep03393;.
  9. Wang J, Ptacek JB, Kirkegaard K, Bullitt E. Double-membraned liposomes sculpted by poliovirus 3AB protein. J Biol Chem. 2013 Sep 20; 288(38):27287-98. PMID: 23908350; PMCID: PMC3779724; DOI: 10.1074/jbc.M113.498899;.
  10. Wang J, Lyle JM, Bullitt E. Surface for catalysis by poliovirus RNA-dependent RNA polymerase. J Mol Biol. 2013 Jul 24; 425(14):2529-40. PMID: 23583774; PMCID: PMC3711085; DOI: 10.1016/j.jmb.2013.04.007;.
Showing 10 of 41 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 23 distinct years, with a maximum of 4 publications in 2015

YearPublications
19851
19861
19881
19921
19951
19962
19971
19982
20001
20022
20042
20062
20073
20082
20092
20102
20113
20122
20133
20141
20154
20161
20171
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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