Raphael A. Zoeller Jr, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Texas A&M University



My expertise is in the area of lipid biosynthesis and metabolism and how they relate to human disease. My laboratory uses molecular biology, lipid chemistry & analysis, protein chemistry and forward genetics (mutant isolation).

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Research Assistant Professor
Boston University School of Medicine
Medicine
Biomedical Genetics Section



A High Throughput Screen for Inhibitors of Mammalian Glycerolipid Biosynthesis
04/01/2015 - 03/31/2018 (PI)
NIH/National Institute of General Medical Sciences
5R01GM107675-03

Endothelial Cell Hypoxia Tolerance: Role of Plasmalogens
07/01/2003 - 06/30/2008 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL68232 04

Regulation of Plasmalogen Levels in Animal Cells
07/01/2004 - 06/30/2007 (PI)
American Heart Association - Northeast Affliate

Biosynthesis and Function of Animal Cell Plasmalogens
12/01/1993 - 06/30/2004 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM50571 08




Yr Title Project-Sub Proj Pubs
2017 A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis 5R01GM107675-03
2016 A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis 5R01GM107675-02
2015 A high throughput screen for inhibitors of mammalian glycerolipid biosynthesis 1R01GM107675-01A1
2001 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 5R01GM050571-08 12
2000 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 5R01GM050571-07 12
1999 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 5R01GM050571-06 12
1998 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS 2R01GM050571-05A1 12
1997 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS 5R01GM050571-04 12
1996 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS 5R01GM050571-03 12
1995 BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PHOSPHOLIPIDS 5R01GM050571-02 12
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell. 2012 May 25; 46(4):461-71. PMID: 22633490; DOI: 10.1016/j.molcel.2012.04.033;.
  2. Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS One. 2012; 7(4):e34904. PMID: 22493722; PMCID: PMC3321042; DOI: 10.1371/journal.pone.0034904;.
  3. Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402.View Related Profiles. PMID: 21787864; PMCID: PMC3185221; DOI: 10.1016/j.bbadis.2011.07.007;.
  4. Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL, Ford DA. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. J Lipid Res. 2010 May; 51(5):1085-92. PMID: 20019386; PMCID: PMC2853435; DOI: 10.1194/jlr.M003673;.
  5. Haller JF, Smith C, Liu D, Zheng H, Tornheim K, Han GS, Carman GM, Zoeller RA. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase. J Biol Chem. 2010 Jan 8; 285(2):866-77.View Related Profiles. PMID: 19903819; PMCID: PMC2801288; DOI: 10.1074/jbc.M109.068213;.
  6. Gaposchkin DP, Farber HW, Zoeller RA. On the importance of plasmalogen status in stimulated arachidonic acid release in the macrophage cell line RAW 264.7. Biochim Biophys Acta. 2008 Apr; 1781(4):213-9.View Related Profiles. PMID: 18328831; DOI: 10.1016/j.bbalip.2008.01.007;.
  7. Zheng H, Duclos RI, Smith CC, Farber HW, Zoeller RA. Synthesis and biological properties of the fluorescent ether lipid precursor 1-O-[9'-(1''-pyrenyl)]nonyl-sn-glycerol. J Lipid Res. 2006 Mar; 47(3):633-42.View Related Profiles. PMID: 16369049.
  8. Liu D, Nagan N, Just WW, Rodemer C, Thai TP, Zoeller RA. Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. J Lipid Res. 2005 Apr; 46(4):727-35. PMID: 15687349.
  9. Munn NJ, Arnio E, Liu D, Zoeller RA, Liscum L. Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport. J Lipid Res. 2003 Jan; 44(1):182-92. PMID: 12518037.
  10. Zoeller RA, Grazia TJ, LaCamera P, Park J, Gaposchkin DP, Farber HW. Increasing plasmalogen levels protects human endothelial cells during hypoxia. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H671-9.View Related Profiles. PMID: 12124215.
Showing 10 of 35 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 35 publications over 24 distinct years, with a maximum of 3 publications in 1997

YearPublications
19842
19851
19861
19871
19882
19891
19902
19911
19922
19931
19942
19951
19973
19981
19992
20001
20011
20021
20031
20052
20081
20092
20111
20122
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

glycerolipids
lipids
mutants
obesity
phospholipids
triglycerides
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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