Deborah A. Siwik, PhD
Research Associate Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine Section

PhD, University of Illinois



Expertise includes: IACUC protocols; Biochemistry and cell biology lab techniques; Cell culture.

Boston Medical Center





Role of EMMPRIN in Hydrogen Peroxide Stimulated Matrix
07/01/2003 - 06/30/2007 (PI)
American Heart Assoc

Regulation Of Matrix
04/01/1999 - 06/30/2005 (PI)
American Heart Assoc



Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Hobai IA, Aziz K, Buys ES, Brouckaert P, Siwik DA, Colucci WS. Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice. Shock. 2016 Dec; 46(6):713-722.View Related Profiles. PMID: 27405063.
  2. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1).View Related Profiles. PMID: 26755553; PMCID: PMC4859372; DOI: 10.1161/JAHA.115.002555;.
  3. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles. PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;.
  4. Calamaras TD, Lee C, Lan F, Ido Y, Siwik DA, Colucci WS. The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling. Free Radic Biol Med. 2015 May; 82:137-46.View Related Profiles. PMID: 25617592; PMCID: PMC4387097; DOI: 10.1016/j.freeradbiomed.2015.01.007;.
  5. Hobai IA, Morse JC, Siwik DA, Colucci WS. Lipopolysaccharide and cytokines inhibit rat cardiomyocyte contractility in vitro. J Surg Res. 2015 Feb; 193(2):888-901.View Related Profiles. PMID: 25439505; PMCID: PMC4268427; DOI: 10.1016/j.jss.2014.09.015;.
  6. Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73.View Related Profiles. PMID: 25109264; PMCID: PMC4268348; DOI: 10.1016/j.yjmcc.2014.07.018;.
  7. Qin F, Siwik DA, Pimentel DR, Morgan RJ, Biolo A, Tu VH, Kang YJ, Cohen RA, Colucci WS. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. Am J Physiol Heart Circ Physiol. 2014 May 15; 306(10):H1453-63.View Related Profiles. PMID: 24633550; PMCID: PMC4024717; DOI: 10.1152/ajpheart.00084.2014;.
  8. Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87.View Related Profiles. PMID: 24469991; PMCID: PMC4046179; DOI: 10.1096/fj.13-233445;.
  9. Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184.View Related Profiles. PMID: 23963753; PMCID: PMC3828801; DOI: 10.1161/JAHA.113.000184;.
  10. Hobai IA, Buys ES, Morse JC, Edgecomb J, Weiss EH, Armoundas AA, Hou X, Khandelwal AR, Siwik DA, Brouckaert P, Cohen RA, Colucci WS. SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1189-200.View Related Profiles. PMID: 23934853; PMCID: PMC3798783.
Showing 10 of 51 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 51 publications over 20 distinct years, with a maximum of 7 publications in 2009

YearPublications
19941
19961
19981
19991
20001
20014
20021
20031
20044
20053
20064
20073
20097
20103
20113
20123
20132
20144
20152
20162
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Extracellular Matrix
Extracellular Matrix Metalloproteinase Inducter
Matrix Metalloproteinase
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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