Nader Rahimi, PhD
Associate Professor
Boston University School of Medicine
Dept of Pathology & Laboratory Medicine

PhD, Queen's University
MS, Queen's University



I have a broad expertise in cell signaling in particular in receptor tyrosine kinases, protein modification (phosphorylation, methylation, ubiquitination, acetylation and proteolytic cleavage modifications). We are also expert in various mouse and cell culture based angiogenesis and tumor models.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Associate Professor
Boston University School of Medicine
Department of Ophthalmology




IGPR-1 in Colon Cancer Chemotherapy
06/19/2015 - 05/31/2017 (PI)
NIH/National Cancer Institute
5R21CA193958-02

Overcoming resistance to anti-angiogenesis therapy
12/08/2014 - 11/30/2016 (PI)
NIH/National Cancer Institute
5R21CA191970-02

VEGFR - 1 and VEGFR - 2 in Angiogenesis
04/01/2002 - 02/29/2008 (PI)
NIH/National Eye Institute
5 R01 EY12997 05

Anti-Angiogenic Signaling Molecules in Retinal Cells
02/01/2002 - 01/31/2005 (PI)
NIH/National Eye Institute
5 R03 EY13706 03

Study of VEGFR-1 and VEGFR-2 in Angiogenesis
01/01/2001 - 12/31/2004 (PI)
Research to Prevent Blindness

Signal Transduction by VEGF Receptor -2 During Angiogenesis
11/01/1999 - 10/30/2000 (PI)
American Cancer Society




Yr Title Project-Sub Proj Pubs
2016 IGPR-1 in colon cancer chemotherapy 5R21CA193958-02 3
2016 Overcoming the resistance to anti-angiogenesis therapy 5R21CA191970-02 3
2015 Overcoming the resistance to anti-angiogenesis therapy 1R21CA191970-01 3
2011 IDENTIFICATION OF PHOSPHORYLATION SITES ON TUMOR CELL INVASION PROTEIN 5P41RR010888-15-5165 236
2011 POTENTIAL ROLE OF BETA-TRCP1 UBIQUITIN E3 LIGASE IN ANGIOGENESIS 5P41RR010888-15-5166 236
2010 Role of Protein Ubiquitination in Angiogenesis 5R01EY017955-03 7
2009 Role of Protein Ubiquitination in Angiogenesis 5R01EY017955-02 7
2008 Role of Protein Ubiquitination in Angiogenesis 1R01EY017955-01A2 7
2006 VEGFR-1 and VEGFR-2 in angiogenesis 5R01EY012997-05 13
2005 VEGFR-1 and VEGFR-2 in angiogenesis 5R01EY012997-04 13
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chandler KB, Leon DR, Meyer RD, Rahimi N, Costello CE. Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2. J Proteome Res. 2017 Feb 03; 16(2):677-688.View Related Profiles. PMID: 27966990; DOI: 10.1021/acs.jproteome.6b00738;.
  2. Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, Mehta M, Laver NM, Costello CE, Rahimi N. IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol. 2016 Dec 04; 428(24 Pt B):5019-5033.View Related Profiles. PMID: 27838321; DOI: 10.1016/j.jmb.2016.11.003;.
  3. Shashar M, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear ß-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 11 01; 7(44):71136-71150.View Related Profiles. PMID: 27661103; DOI: 10.18632/oncotarget.12107;.
  4. Nader Rahimi 24.03.2016. THERAPEUTIC AND RESEARCH APPLICATION OF PDCL3. 2016. View Publication
  5. Maghsoudlou A, Meyer RD, Rezazadeh K, Arafa E, Pudney J, Hartsough E, Rahimi N. RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2. Traffic. 2016 Mar; 17(3):289-300.View Related Profiles. PMID: 26602861; PMCID: PMC4767591; DOI: 10.1111/tra.12353;.
  6. Huang Z, Marsiglia WM, Basu Roy U, Rahimi N, Ilghari D, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C?. Mol Cell. 2016 Jan 7; 61(1):98-110. PMID: 26687682; PMCID: PMC4838190; DOI: 10.1016/j.molcel.2015.11.010;.
  7. Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, Schwartz JH, Chitalia V, Rahimi N. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. Am J Pathol. 2015 Oct; 185(10):2757-67.View Related Profiles. PMID: 26342724; PMCID: PMC4607757; DOI: 10.1016/j.ajpath.2015.06.006;.
  8. Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62.View Related Profiles. PMID: 26059764; PMCID: PMC4600037; DOI: 10.1007/s10456-015-9468-3;.
  9. Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. The c-Cbl ubiquitin ligase regulates nuclear ß-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. J Biol Chem. 2015 May 15; 290(20):12537-46.View Related Profiles. PMID: 25784557; PMCID: PMC4432275; DOI: 10.1074/jbc.M114.616623;.
  10. Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells. Chem Biol Drug Des. 2015 May; 85(5):586-97.View Related Profiles. PMID: 25298192; PMCID: PMC4390552; DOI: 10.1111/cbdd.12446;.
Showing 10 of 50 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 21 distinct years, with a maximum of 5 publications in 2015

YearPublications
19941
19964
19982
19992
20003
20011
20021
20033
20042
20052
20063
20071
20081
20092
20101
20113
20122
20134
20142
20155
20164
Contact for Mentoring:


670 Albany St Biosquare III
Boston MA 02118
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