Markus M. Bachschmid, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Vascular Biology Section

MS, University of Konstanz
PhD, University of Konstanz



Biochemistry, Pharmacology and Toxicology.

Redox regulation of metabolism by Sirtuin-1 and glutaredoxin-1 in the cardiovascular system and liver.

Boston Medical Center




Redox Control of Hepatic Lipid Metabolism
07/01/2015 - 04/30/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK103750-03

Impaired cysteine-thiol redox signaling in metabolic cardiovascular disease
01/01/2016 - 12/31/2017 (PI)
American Heart Association

Regulation of the Cardiac Sodium Channel by SIRTUIN1
06/01/2016 - 05/31/2017 (PI)
The University of Iowa NIH NHLBI
4R01HL115955-04

Regulation of the Cardiac Sodium Channel by SIRTUIN1
08/15/2013 - 05/31/2017 (PI)
The University of Iowa NIH NHLBI
5R01HL115955-03




Yr Title Project-Sub Proj Pubs
2017 Redox control of hepatic lipid metabolism 5R01DK103750-03 5
2016 Redox control of hepatic lipid metabolism 5R01DK103750-02 5
2015 Redox control of hepatic lipid metabolism 1R01DK103750-01A1 5
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kracun D, Krause KH, Kren V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milkovic L, Miranda-Vizuete A, Mojovic M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavicevic A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanic V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçin AS, Yelisyeyeva O, Žarkovic N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 2017 May 18; 13:94-162.View Related Profiles. PMID: 28577489.
  2. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Feb 16.View Related Profiles. PMID: 27958883; DOI: 10.1089/ars.2016.6716;.
  3. Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nat Med. 2017 Mar; 23(3):361-367. PMID: 28191886; DOI: 10.1038/nm.4284;.
  4. Kumar S, Kim YR, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid MM, Jacobs JS, Kumar A, Irani K. Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1714-1719. PMID: 28137876; DOI: 10.1073/pnas.1614112114;.
  5. Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YM, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; DOI: 10.1016/j.redox.2016.09.003;.
  6. Fry JL, Al Sayah L, Weisbrod RM, Van Roy I, Weng X, Cohen RA, Bachschmid MM, Seta F. Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic Stiffness. Hypertension. 2016 Sep; 68(3):775-84.View Related Profiles. PMID: 27432859; PMCID: PMC4982825; DOI: 10.1161/HYPERTENSIONAHA.116.07622;.
  7. Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ. Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson''s Disease. Antioxid Redox Signal. 2016 Dec 20; 25(18):967-982.View Related Profiles. PMID: 27224303.
  8. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;.
  9. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1a and improve limb revascularization. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):6011-6.View Related Profiles. PMID: 27162359; PMCID: PMC4889374; DOI: 10.1073/pnas.1524198113;.
  10. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1).View Related Profiles. PMID: 26755553; PMCID: PMC4859372; DOI: 10.1161/JAHA.115.002555;.
Showing 10 of 78 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 78 publications over 19 distinct years, with a maximum of 8 publications in 2005

YearPublications
19991
20003
20011
20021
20036
20047
20058
20065
20074
20085
20092
20102
20114
20124
20134
20145
20155
20167
20174
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cardiovascular
diabetes
glutaredoxin-1
HRas
imaging
metabolism
mitochondria
non-alcoholic fatty liver disease
obesity
oxidative stress
proteomics
sirtuin-1
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Google Map


Bachschmid's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department